Malim MH, Freimuth WW, Liu J, Boyle TJ, Lyerly HK, Cullen BR, Nabel GJ: Stable expression of transdominant rev protein in human T cells inhibits Human Immunodeficiency Virus replication. J Exp Med. 1992, 176: 1197-1201. 10.1084/jem.176.4.1197
Article
CAS
PubMed
Google Scholar
Bonyhadi ML, Moss K, Voytovich A, Auten J, Kalfoglou C, Plavec I, Forestell S, Su L, Bohnlein E, Kaneshima H: RevM10-expressing T cells derived in vivo from transduced human hematopoietic stem-progenitor cells inhibit human immunodeficiency virus replication. J Virol. 1997, 71: 4707-4716.
PubMed Central
CAS
PubMed
Google Scholar
Ding SF, Lombardi R, Nazari R, Joshi S: A combination anti-HIV-1 gene therapy approach using a single transcription unit that expresses antisense, decoy, and sense RNAs, and transdominant negative mutant Gag and Env proteins. Front Biosci. 2002, 7: a15-28.
Article
CAS
PubMed
Google Scholar
Michienzi A, Li S, Zaia JA, Rossi J: A nucleolar TAR decoy inhibitor of HIV-1 replication. Proc Natl Acad Sci. 2002, 99: 14047-14052. 10.1073/pnas.212229599
Article
PubMed Central
CAS
PubMed
Google Scholar
Akkina R, Banerjea A, bai J, Anderson J, Li MJ, Rossi J: siRNAs, ribozymes, and RNA decoys in modeling stem cell-based gene therapy for HIV/AIDS. Anticancer Res. 2003, 23: 1997-2006.
CAS
PubMed
Google Scholar
Bahner I, Kearns K, Hao QL, Smogorzewska EM, Kohn DB: Transduction of human CD34+ hematopoietic progenitor cells by a retroviral vector expressing an RRE decoy inhibits human immunodeficiency virus type 1 replication in myelomonocytic cells produced in long-term culture. J Virol. 1996, 70: 4352-4360.
PubMed Central
CAS
PubMed
Google Scholar
Lisziewicz J, Sun D, Smythie J, Lusso P, Lori F, Louie A, Markham P, Rossi J, Reitz M, Gallo RC: Inhibition of human immunodeficiency virus type 1 replication by regulated expression of a polymeric tat activation response RNA decoy as a strategy for gene therapy in AIDS. Proc Natl Acad Sci USA. 1993, 90: 8000-8004.
Article
PubMed Central
CAS
PubMed
Google Scholar
Bai J, Gorantla S, Banda N, Cagnon L, Rossi J, Akkina R: Characterization of anti-CCR5 ribozyme-transduced CD34+ hematopoietic progenitor cells in vitro and in a SCID-hu mouse model in vivo. Mol Ther. 2000, 1: 244-254. 10.1006/mthe.2000.0038
Article
CAS
PubMed
Google Scholar
Bai J, Rossi J, Akkina R: Multivalent anti-CCR5 ribozymes for stem cell-based HIV type 1 gene therapy. AIDS Res Hum Retroviruses. 2001, 17: 385-399. 10.1089/088922201750102427
Article
CAS
PubMed
Google Scholar
Bai J, Banda N, Lee NS, Rossi J, Akkina R: RNA-based anti-HIV-1 gene therapeutic constructs in SCID-hu mouse model. Mol Ther. 2002, 6: 770-782. 10.1006/mthe.2002.0800
Article
CAS
PubMed
Google Scholar
Cagnon L, Rossi J: Downregulation of the CCR5 beta-chemokine receptor and inhibition of HIV-1 infection by stable VA1-ribozyme chimeric transcripts. Antisense Nucleic Acid Drug Dev. 2000, 10: 251-261. 10.1089/108729000421439
Article
CAS
PubMed
Google Scholar
Feng Y, Leavitt M, Tritz R, Duarte E, Kang D, Mamounas M, Gilles P, Wong-Staal F, Kennedy S, Merson J, Yu M, Barber JR: Inhibition of CCR5-dependent HIV-1 infection by hairpin ribozyme gene therapy against CC-chemokine receptor 5. Virology. 2000, 276: 271-278. 10.1006/viro.2000.0536
Article
CAS
PubMed
Google Scholar
Elbashir SM, Harborth J, Lendeckel W, Yalcin A, Weber K, Tuschl T: Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature. 2001, 411: 494-498. 10.1038/35078107
Article
CAS
PubMed
Google Scholar
Fire A, xu S, Montgomery MK, Kostas SA, Driver SE, Mello CC: Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature. 1998, 391: 806-811. 10.1038/35888
Article
CAS
PubMed
Google Scholar
Hannon GJ: RNA Interference. Nature. 2002, 418: 244-251. 10.1038/418244a
Article
CAS
PubMed
Google Scholar
Sharp P: RNA interference-2001. Genes Dev. 2001, 15: 485-490. 10.1101/gad.880001
Article
CAS
PubMed
Google Scholar
Lee NS, Dohjima T, Bauer G, Li H, Li M, Ehsani A, Salvaterra P, Rossi J: Expression of small interfering RNAs targeted against HIV-1 rev transcripts in human cells. Nat Biotechnol. 2002, 20: 500-505.
CAS
PubMed
Google Scholar
Song E, Lee S, Dykxhoorn DM, Novina C, Zhang D, Crawford K, Cerny J, Sharp PA, Leiberman J, Manjunath N, Shankar P: Sustained small interfering RNA-mediated human immunodeficiency virus type 1 inhibition in primary macrophages. J Virol. 2003, 77: 7174-7181. 10.1128/JVI.77.13.7174-7181.2003
Article
PubMed Central
CAS
PubMed
Google Scholar
Novina CD, Murray MF, Dykxhoorn DM, Beresford PJ, Riess J, Lee S, Collman RG, Lieberman J, Shankar P, Sharp PA: siRNA-directed inhibition of HIV-1 infection. Nat Med. 2002, 8: 681-686.
CAS
PubMed
Google Scholar
Jacque J, Triques K, Stevenson M: Modulation of HIV-1 replication by RNA interference. Nature. 2002, 418: 435-438. 10.1038/nature00896
Article
CAS
PubMed
Google Scholar
Martinez MA, Gutierrez A, Armand-Ugon M, Blanco J, Parera M, Gomez J, Clotet B, Este JA: Suppression of chemokine receptor expression by RNA interference allows for inhibition of HIV-1 replication. AIDS. 2002, 16: 2385-2390. 10.1097/00002030-200212060-00002
Article
CAS
PubMed
Google Scholar
Coburn GA, Cullen BR: Potent and specific inhibition of human immunodeficiency virus type-1 replication by RNA interference. J Virol. 2002, 76: 9225-9231. 10.1128/JVI.76.18.9225-9231.2002
Article
PubMed Central
CAS
PubMed
Google Scholar
Anderson J, Banerjea A, Planelles V, Akkina R: Potent suppression of HIV type 1 infection by a short hairpin anti-CXCR4 siRNA. AIDS Res Hum Retroviruses. 2003, 19: 699-706. 10.1089/088922203322280928
Article
CAS
PubMed
Google Scholar
Anderson J, Banerjea A, Akkina R: Bispecific short hairpin siRNA constructs targeted to CD4, CXCR4, and CCR5 confer HIV-1 resistance. Oligonucleotides. 2003, 13: 303-312. 10.1089/154545703322616989
Article
CAS
PubMed
Google Scholar
Capodici J, Kariko K, Weissman D: Inhibition of HIV-1 infection by small interfering RNA-mediated RNA interference. J Immunol. 2002, 169: 5196-5201.
Article
PubMed
Google Scholar
Haasnoot PCJ, Cupac D, Berkhout B: Inhibition of virus replication by RNA interference. J Biomed Sci. 2003, 10: 607-616. 10.1159/000073526
Article
PubMed
Google Scholar
Lee MM, Coburn G, McClure MO, Cullen BR: Inhibition of human immunodeficiency virus type 1 replication in primary macrophages by using tat- or CCR5-specific small interfering RNAs expressed from a lentivirus vector. J Virol. 2003, 77: 11964-11972. 10.1128/JVI.77.22.11964-11972.2003
Article
PubMed Central
CAS
PubMed
Google Scholar
Li M, Bauer G, Michienzi A, Yee J, Lee NS, Kim J, Li S, Castanotto D, Zaia J, Rossi J: Inhibition of HIV-1 infection by lentiviral vectors expressing Pol III-promoted anti-HIV RNAs. Mol Ther. 2003, 8: 196-206. 10.1016/S1525-0016(03)00165-5
Article
CAS
PubMed
Google Scholar
Banerjea A, Li M, Bauer G, Remling L, Lee NS, Rossi J, Akkina R: Inhibition of HIV-1 by lentiviral vector-transduced siRNAs in lymphocytes diferentiated in SCID-hu mice and CD34+ progenitor cell-derived macrophages. Mol Ther. 2003, 8: 62-71. 10.1016/S1525-0016(03)00140-0
Article
CAS
PubMed
Google Scholar
Butticaz C, Ciuffi A, Munoz M, Thomas J, Bridge A, Pebernard S, Iggo R, Meylan P, Telenti A: Protection from HIV-1 infection of primary CD4 T cells by CCR5 silencing is effective for the full spetrum of CCR5 expression. Antiviral Therapy. 2003, 8: 373-377.
CAS
PubMed
Google Scholar
Qin X, An DS, Chen ISY, Baltimore D: Inhibiting HIV-1 infection in human T cells by lentiviral-mediated delivery of small interfering RNA against CCR5. Proc Natl Acad Sci USA. 2003, 100: 183-188. 10.1073/pnas.232688199
Article
PubMed Central
CAS
PubMed
Google Scholar
Bieniasz PD, Cullen BR: Chemokine receptors and Human Immunodeficiency Virus infection. Front Biosci. 1998, 3: 44-58.
Google Scholar
Berger EA, Murphy PM, Farber JM: Chemokine receptors as HIV-1 coreceptors: Roles in viral entry, tropism, and disease. Annu Rev Immunol. 1999, 17: 657-700. 10.1146/annurev.immunol.17.1.657
Article
CAS
PubMed
Google Scholar
Liu R, Paxton W, Choe S, Ceradini D, Martin S, Horuk R, MacDonald M, Stuhlman H, Koup R, Landau N: Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply exposed individuals to HIV-1 infection. Cell. 1996, 86: 367-377. 10.1016/S0092-8674(00)80110-5
Article
CAS
PubMed
Google Scholar
Huang Y, Paxton WA, Wolinsky SM, Neumann AU, Zhang L, He T, Kang S, Ceradini D, Jin Z, Yazdanbakhsh K, Kunstman K, Erickson D, Dragon E, Landau NR, Phair J, Ho DD, Koup RA: The role of a mutant CCR5 allele in HIV-1 transmission and disease progression. Nat Med. 1996, 2: 1240-1243. 10.1038/nm1196-1240
Article
CAS
PubMed
Google Scholar
Naif HM, Cunningham AL, Alali M, Li S, Nasr N, Buhler MM, Schols D, Clercq E, tewart G: A human immunodeficiency virus type 1 isolate from an infected person homozygous for CCR5Δ32 exhibits dual tropism by infecting macrophages and MT2 cells via CXCR4. J Virol. 2002, 76: 3114-3124. 10.1128/JVI.76.7.3114-3124.2002
Article
PubMed Central
CAS
PubMed
Google Scholar
Ma Q, Jones D, Borghesani PR, Segal RA, Nagasawa T, Kishimoto T, Bronson RT, Springer TA: Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice. Proc Natl Acad Sci USA. 1998, 95: 9448-9453. 10.1073/pnas.95.16.9448
Article
PubMed Central
CAS
PubMed
Google Scholar
Yam P, Li S, Wu J, Hu J, Zaia J, Yee J: Design of HIV-1 vectors for efficient gene delivery into human hematopoietic cells. Mol Ther. 2002, 6: 770-782. 10.1006/mthe.2002.0800
Article
Google Scholar
Ailles LE, Naldini L: HIV-1 Derived Lentiviral Vectors. Lentiviral Vectors. Edited by: Trono D. 2002, 31-48. Berlin: Springer-Verlag
Chapter
Google Scholar
Castanotto D, Li H, Rossi J: Functional siRNA expression from transfected PCR products. RNA. 2002, 8: 1454-1460. 10.1017/S1355838202021362
Article
PubMed Central
CAS
PubMed
Google Scholar
Kimpton J, Emerman M: Detection of replication-competent and pseudotyped human immunodeficiency virus with a sensitive cell line on the basis of activation of an integrated β-galactosidase gene. J Virol. 1992, 66: 2232-2239.
PubMed Central
CAS
PubMed
Google Scholar
Vodicka MA, Goh WC, Wu LI, Rogel ME, Bartz SR, Schweickart VL, Raport CJ, Emerman M: Indicator cell lines for detection of primary strains of human and simian immunodeficiency viruses. Virology. 1997, 233: 193-198. 10.1006/viro.1997.8606
Article
CAS
PubMed
Google Scholar
Morner A, Bjorndal A, KewalRamani V, Littman DR, Inoue R, Thorstensson R, Fenyo EM, Bjorling E: Primary human immunodeficiency virus type 2 (HIV-2) isolates, like HIV-1 isolates, frequently use CCR5 but show promiscuity in coreceptor usage. J Virol. 1999, 73: 2343-2349.
PubMed Central
CAS
PubMed
Google Scholar
VandenDriessche T, Naldini L, Collen D, Chuah MKL: Oncoretroviral and lentiviral vector-mediated gene therapy. Methods in Enzymol. 2002, 346: 573-589.
Article
CAS
Google Scholar
Ketteler R, Glaser S, Sandra O, Martens UM, Klingmuller U: Enhanced trnsgene expression in primitive hematopoietic progenitor cells and embryonic stem cells efficiently trnsduced by optimized retroviral hybrid vectors. Gene Therapy. 2002, 9: 477-487. 10.1038/sj.gt.3301653
Article
CAS
PubMed
Google Scholar
An DS, Koyanagi Y, Zhao J, Akkina R, Bristol G, Yamamoto N, Zack JA, Chen ISY: High-efficiency transduction of huma lymphoid progenitor cells and expression in differentiated T cells. J Virol. 1997, 71: 1397-1404.
PubMed Central
CAS
PubMed
Google Scholar
Mautino MR, Morgan RA: Gene therapy of HIV-1 infection using lentiviral vectors expressing anti-HIV-1 genes. AIDS Patient Care and STDs. 2002, 16: 11-26. 10.1089/108729102753429361
Article
PubMed
Google Scholar
Moss EG, Taylor JM: Small-interfering RNAs in the radar of the interferon system. Nat Cell Biol. 2003, 5: 771-772. 10.1038/ncb0903-771
Article
CAS
PubMed
Google Scholar
Pebernard S, Iggo RD: Determinants of interferon-stimulated gene induction by RNAi vectors. Differentiation. 2004, 72: 103-111. 10.1111/j.1432-0436.2004.07202001.x
Article
CAS
PubMed
Google Scholar
Scacheri PC, Rozenblatt-Rosen O, Caplen NJ, Wolfsberg TG, Umayam L, Lee JC, Hughes CM, Shanmugam KS, Bhattacharjee A, Meyerson M, Collins FS: Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells. Proc Natl Acad Sci USA. 2004, 101: 1892-1897. 10.1073/pnas.0308698100
Article
PubMed Central
CAS
PubMed
Google Scholar
Molyneaux KA, Zinszner H, Kunwar PS, Schaible K, Stebler J, Sunshine MJ, O'Brien W, Raz E, Littman D, Wylie C, Lehmann R: The chemokine SDF1/CXCL12 and its receptor CXCR4 regulate mouse germ cell migration and survival. Development. 2002, 130: 4279-4286. 10.1242/dev.00640.
Article
Google Scholar
Coffield VM, Jiang Q, Su L: A genetic approach to inactivating chemokine receptors using a modified viral protein. Nat Biotechnol. 2003, 21: 1321-1327. 10.1038/nbt889
Article
PubMed Central
CAS
PubMed
Google Scholar
Jackson AL, Bartz SR, Shelter J, Kobayashi SV, Burchard J, Mao M, Li B, Cavet G, Linsley PS: Expression profiling reveals off-target gene regulation by RNAi. Nat Biotechnol. 2003, 21: 635-637. 10.1038/nbt831
Article
CAS
PubMed
Google Scholar