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Figure 2 | AIDS Research and Therapy

Figure 2

From: HIV-1 resistance conferred by siRNA cosuppression of CXCR4 and CCR5 coreceptors by a bispecific lentiviral vector

Figure 2

Cell surface down regulation of CXCR4 in XHR transduced Magi-CXCR4 cells. Magi-CXCR4 cells that constitutively express CXCR4 were transduced with control GFP or XHR vectors. Cells were stained with PECy5-conjugated antibodies to CXCR4 and analyzed by FACS 72 hours post-transduction. Levels of CXCR4 in non-transduced cells are superimposed (unshaded areas). Transduction efficiency was determined by FACS for EGFP expression. Levels of EGFP in control GFP-alone vector (A) and XHR vector (C) transduced cells. Levels of CXCR4 expression in GFP-alone (B) and XHR (D) vector transduced cells. Percent positive cells are indicated.

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AIDS Research and Therapy

ISSN: 1742-6405

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