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Figure 1 | AIDS Research and Therapy

Figure 1

From: HIV-1 resistance conferred by siRNA cosuppression of CXCR4 and CCR5 coreceptors by a bispecific lentiviral vector

Figure 1

Bispecific lentiviral vector (XHR) encoding anti-CXCR4 and CCR5 siRNAs. A) Control transfer vector pHIV-7-GFP encoding a CMV promoter driven EGFP reporter gene. B) To derive the bispecific vector pHIV-XHR-GFP, a U6 promoter driven short hairpin CXCR4 siRNA cassette was cloned into the BamH I site upstream to the CMV-EGFP cassette. The H1-CCR5 siRNA cassette was inserted into an Mlu I site downstream to the U6-CXCR4 siRNA cassette.

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