Articles

Long-term remission of AIDS-related primary central nervous system lymphoma in a patient under antiretroviral therapy: a case report and review of the literature

AIDS-related primary central nervous system lymphoma (AR-PCNSL) is an AIDS-defining disease that usually occurs when the CD4 count is less than 50 cells/μl. The frequency of the disease has substantially decre...

Authors: Pieter-Jan Gijs and Olivier Clerc

Considerations for designing and implementing combination HIV cure trials: findings from a qualitative in-depth interview study in the United States

An increasing number of HIV cure trials involve combining multiple potentially curative interventions. Until now, considerations for designing and implementing complex combination HIV cure trials have not been...

Authors: Karine Dubé, John Kanazawa, Lynda Dee, Jeff Taylor, John A. Sauceda, Sara Gianella, Davey Smith, Steven G. Deeks and Michael J. Peluso

Acquired HIV drug resistance and virologic monitoring in a HIV hyper-endemic setting in KwaZulu-Natal Province, South Africa

Introduction of tenofovir (TDF) plus lamivudine (3TC) and dolutegravir (DTG) in first- and second-line HIV treatment regimens in South Africa warrants characterization of acquired HIV-1 drug resistance (ADR) m...

Authors: Benjamin Chimukangara, Richard J. Lessells, Lavanya Singh, Indra Grigalionyte, Nonhlanhla Yende-Zuma, Rochelle Adams, Halima Dawood, Linda Dlamini, Sibonisile Buthelezi, Sheldon Chetty, Karidia Diallo, Wayne A. Duffus, Mary Mogashoa, Melissa B. Hagen, Jennifer Giandhari, Tulio de Oliveira…

Tocilizumab in HIV patient with severe COVID-19: case report

A 73-year-old male patient who had a history of Human Immunodeficiency Virus (HIV) infection for over 20 years was diagnosed with SARS-CoV-2 infection.

Authors: Pedro Vieira Bertozzi, Amanda de Oliveira Vicente, Amanda Siqueira Pereira, Joao Pedro Espinha de Sant’Ana, Rafaela Braga Cabrera Mano, Luciana Souza Jorge and Rodrigo Afonso da Silva Sardenberg

Treatment outcomes among adults with HIV/non-communicable disease multimorbidity attending integrated care clubs in Cape Town, South Africa

The growing burden of the HIV and non-communicable disease (NCD) syndemic in Sub- Saharan Africa has necessitated introduction of integrated models of care in order to leverage existing HIV care infrastructure...

Authors: Blessings Gausi, Natacha Berkowitz, Nisha Jacob and Tolu Oni

A retrospective study of survival and risk factors for mortality among people living with HIV who received antiretroviral treatment in a resource-limited setting

The availability and accessibility of effective antiretroviral therapy (ART) for people living with HIV (PLWH) has substantially improved in the past two decades in resource-limited settings. Therefore, evalua...

Authors: Weerawat Manosuthi, Lantharita Charoenpong and Chalor Santiwarangkana

HIV Care Coordination promotes care re-engagement and viral suppression among people who have been out of HIV medical care: an observational effectiveness study using a surveillance-based contemporaneous comparison group

Medical care re-engagement is critical to suppressing viral load and preventing HIV transmission, morbidity and mortality, yet few rigorous intervention studies address this outcome. We assessed the effectiven...

Authors: Mary K. Irvine, McKaylee M. Robertson, Denis Nash, Sarah G. Kulkarni, Sarah L. Braunstein and Bruce Levin

Management of HIV-2 resistance to antiretroviral therapy in a HIV-1/HIV-2/HBV co-infected patient

The current standard of care is to start antiretroviral therapy in all patients diagnosed with HIV-1, as for HIV-2 current DHHS guideline suggests ART for HIV-2 as soon as diagnosis is established, although th...

Authors: Margarida Cardoso, Joana Vasconcelos, Teresa Baptista, Isabel Diogo, Fátima Gonçalves, Kamal Mansinho and Perpétua Gomes

A systematic and meta-analysis of heterosexual behaviors and HIV prevalence among Chinese men who have sex with men

Men who have sex with men (MSM) are potentially at high risk for HIV infection, their HIV prevalence far exceeds the national prevalence rate. There are also a number of MSM who have sex with women, mostly unp...

Authors: Huan Zhao, Xi Li, Junhua Wang, Wen Wang, Chunyan Yang, Jingjuan Li, Xiuling Li, Rui Pu, Lulu Chen, Xiao Zhang, Jun Zhang, Peng Luo and Jiangping Zhang

A realist evaluation of the continuum of HIV services for men who have sex with men

Men who have Sex with Men (MSM) represent the risk group that are disproportionately most affected by the human immunodeficiency virus (HIV) and continue to drop-off from the steps of the continuum of HIV serv...

Authors: Willy Dunbar, Marie Colette Alcide Jean-Pierre, Jacky S. Pétion, Aline Labat, Nathalie Maulet and Yves Coppieters

Determinants of viral suppression among adolescents on antiretroviral treatment in Ehlanzeni district, South Africa: a cross-sectional analysis

Achieving undetectable viral load is crucial for the reduction of HIV transmissions, AIDS-related illnesses and death. Adolescents (10 to19 years) living with HIV (ALHIV) on antiretroviral treatment (ART) have...

Authors: Emeka F. Okonji, Brian van Wyk, Ferdinand C. Mukumbang and Gail D. Hughes

MR spectroscopy in HIV associated neurocognitive disorder in the era of cART: a review

Neuroimaging has been a critical tool for understanding the neuropathological underpinnings observed in HIV. The pathophysiology of HAND is chiefly driven by neuroinflammation. Despite adhering to cART, low le...

Authors: Joga Chaganti and Bruce James Brew

Next generation sequencing based in-house HIV genotyping method: validation report

HIV genotyping has had a significant impact on the care and treatment of HIV/AIDS. At a clinical level, the test guides physicians on the choice of treatment regimens. At the surveillance level, it informs pol...

Authors: Alisen Ayitewala, Isaac Ssewanyana and Charles Kiyaga

Early ART-initiation and longer ART duration reduces HIV-1 proviral DNA levels in children from the CHER trial

Reduction of the reservoir of latent HIV-infected cells might increase the possibility of long-term remission in individuals living with HIV. We investigated factors associated with HIV-1 proviral DNA levels i...

Authors: Helen Payne, Man K. Chan, Sarah A. Watters, Kennedy Otwombe, Nei-Yuan Hsiao, Abdel Babiker, Avy Violari, Mark F. Cotton, Diana M. Gibb and Nigel J. Klein

Expanding access to HIV services during the COVID-19 pandemic—Nigeria, 2020

To accelerate progress toward the UNAIDS 90-90-90 targets, US Centers for Disease Control and Prevention Nigeria country office (CDC Nigeria) initiated an Antiretroviral Treatment (ART) Surge in 2019 to identi...

Authors: Andrew T. Boyd, Ibrahim Jahun, Emilio Dirlikov, Stacie Greby, Solomon Odafe, Alhassan Abdulkadir, Olugbenga Odeyemi, Ibrahim Dalhatu, Obinna Ogbanufe, Andrew Abutu, Olugbenga Asaolu, Moyosola Bamidele, Chibuzor Onyenuobi, Timothy Efuntoye, Johnson O. Fagbamigbe, Uzoma Ene…

Underlying factors related to HIV/AIDS prevention: investigating the willingness to take pre-exposure prophylaxis among men-who-have-sex-with-men in Germany

This study investigates the willingness of men-who-have-sex-with-men (MSM) to use HIV pre-exposure prophylaxis (PrEP). Research in the HIV/AIDS field typically relies on clinical and epidemiological studies, t...

Authors: Michele Pazzini, Zsófia S. Ignácz and Julia Tuppat

Associations between antiretroviral therapy-related experiences and mental health status among people living with HIV in China: a prospective observational cohort study

Mental health problems (e.g., depression and anxiety) are among the most commonly reported comorbidities of HIV. Antiretroviral therapy (ART) coverage has increased sharply. The purposes of this prospective co...

Authors: Jinzhao Xie, Zixin Wang, Quanmin Li, Qiangsheng He, Guohong Xu, Yonghong Li, Kai Zhou, Linghua Li and Jing Gu

HIV diagnosis period influences ART initiation: findings from a prospective cohort study in China

We estimated the predictive effects of ART-related perceptions on the actual ART uptake behavior among ART naïve PLWH stratified by different time of HIV diagnosis under the new strategy.

Authors: Tinglong Yang, Xueying Yang, Linghua Li, Huifang Xu, Lirui Fan, Quanmin Li, Xiaoyan Fan, Weiyi Chen, Xuan Du, Chun Hao, Jinghua Li, Yuantao Hao and Jing Gu

Virologic outcomes of switching to boosted darunavir plus dolutegravir with respect to history of drug resistance

The DUALIS study showed that switching to boosted darunavir (bDRV) plus dolutegravir (DTG; 2DR) was non-inferior to continuous bDRV plus 2 nucleoside/nucleotide reverse-transcriptase inhibitors (NRTIs; 3DR) in...

Authors: Eva Wolf, Christoph Boesecke, Annamaria Balogh, Helen Bidner, Christiane Cordes, Hans Heiken, Ivanka Krznaric, Tim Kümmerle, Hans-Jürgen Stellbrink, Jochen Schneider and Christoph D. Spinner

Acute myocardial infarction associated with abacavir and tenofovir based antiretroviral drug combinations in the United States

Although individual antiretroviral drugs have been shown to be associated with elevated cardiovascular disease (CVD) risk, data are limited on the role of antiretroviral drug combinations. Therefore, we sought...

Authors: Kunchok Dorjee, Manisha Desai, Tsering Choden, Sanjiv M. Baxi, Alan E. Hubbard and Arthur L. Reingold

Lactic acidosis and hyperlactatemia associated with lamivudine accumulation and sepsis in a kidney transplant recipient—a case report and review of the literature

We report a case of sudden, lethal metabolic acidosis in a 70-year-old man on long-term nucleoside reverse transcriptase inhibitor (NRTI) -based antiretroviral therapy (ART) who had developed atypical necrotiz...

Authors: Alexa Hollinger, Nadine Cueni, Catia Marzolini, Michael Dickenmann, Emmanuelle Landmann, Manuel Battegay, Aurélien Emmanuel Martinez, Martin Siegemund and Anne Leuppi-Taegtmeyer

Advanced baseline immunosuppression is associated with elevated levels of plasma markers of fungal translocation and inflammation in long-term treated HIV-infected Tanzanians

For over a decade, antiretroviral therapy (ART) in resource-limited countries was only recommended for patients with advanced HIV disease. We investigated this group of patients in order to determine any relat...

Authors: Godfrey Barabona, Macdonald Mahiti, Mako Toyoda, Doreen Kamori, Salim Masoud, George P. Judicate, Bruno Sunguya, Eligius Lyamuya and Takamasa Ueno

Factors associated with North–South research collaboration focusing on HIV/AIDS: lessons from ClinicalTrials.gov

A North–South (N–S) research collaboration is one way through which research capacity of developing countries can be strengthened. Whereas N–S collaboration in HIV/AIDS area may result in research capacity str...

Authors: Hesborn Wao, Yan Wang, Melvin A. Wao and Juliana A. Were

Tenofovir alafenamide nephrotoxicity: a case report and literature review

Tenofovir alafenamide (TAF), a novel prodrug of tenofovir (TFV), has become the preferred drug for the treatment of HIV-1 and chronic hepatitis B infection in clinical practice. Results from clinical trials sh...

Authors: Thornthun Ueaphongsukkit, Sivaporn Gatechompol, Anchalee Avihingsanon, Jerasit Surintrspanont, Kroonpong Iampenkhae, Yingyos Avihingsanon and Suwasin Udomkarnjananun

Factors associated with testing for HIV and hepatitis C among behaviorally vulnerable men in Germany: a cross-sectional analysis upon enrollment into an observational cohort

HIV and hepatitis C virus (HCV) have shared routes of transmission among men who have sex with men (MSM). Routine testing facilitates early diagnosis and treatment, thereby preventing morbidity and onward tran...

Authors: Trevor A. Crowell, Haoyu Qian, Carsten Tiemann, Clara Lehmann, Christoph Boesecke, Albrecht Stoehr, Jukka Hartikainen, Stefan Esser, Markus Bickel, Christoph D. Spinner, Stephan Schneeweiß, Christiane Cordes, Norbert Brockmeyer, Heiko Jessen, Merlin L. Robb, Nelson L. Michael…

Closing gaps in histoplasmosis: clinical characteristics and factors associated with probable/histoplasmosis in HIV/AIDS hospitalized patients, a retrospective cross-sectional study in two tertiary centers in Pereira, Colombia

The HIV pandemic continues to cause a high burden of morbidity and mortality due to delayed diagnosis. Histoplasmosis is prevalent in Latin America and Colombia, is difficult to diagnose and has a high mortali...

Authors: Julián Andrés Hoyos Pulgarin, John Alexander Alzate Piedrahita, German Alberto Moreno Gómez, Juan Felipe Sierra Palacio, Karen Melissa Ordoñez and Deving Arias Ramos

The impact of gender and the social determinants of health on the clinical course of people living with HIV in Myanmar: an observational study

There is a growing recognition of the impact of gender and the social determinants of health on the clinical course of people living with HIV (PLHIV). However, the relative contribution of these factors to cli...

Authors: Phyo Pyae Nyein, Eithandee Aung, Ne Myo Aung, Mar Mar Kyi, Mark Boyd, Kyaw Swar Lin and Josh Hanson

Correction to: Multilevel model on longitudinal data analysis in determinants of CD4 cell count among antiretroviral therapy attendant of HIV infected adults follow up in Gondar Teaching Referral Hospital, Gonder, Ethiopia

Authors: Kindu Kebede

HIV-exposed infants with EBV infection have a reduced persistence of the immune response to the HBV vaccine

In sub-Saharan African countries Epstein Barr virus (EBV) infection occurs in early childhood. We aim to investigate the factors associated with EBV acquisition and the impact of EBV infection on the humoral r...

Authors: Silvia Baroncelli, Clementina Maria Galluzzo, Giuseppe Liotta, Mauro Andreotti, Stefano Orlando, Fausto Ciccacci, Robert Mphwere, Richard Luhanga, Jean Baptiste Sagno, Roberta Amici, Maria Cristina Marazzi and Marina Giuliano

Association between Veterans Aging Cohort Study (VACS) index and neurocognitive function among people living with HIV–a cross sectional study in coastal South India

HIV is an infectious disease affecting 36.7 million people worldwide. In recent times, Antiretroviral Therapy (ART) has become accessible to the majority of People Living with HIV (PLHIV) and this has transfor...

Authors: Archana Ganapathy, Basavaprabhu Achappa, Vaman Kulkarni, Deepak Madi, Ramesh Holla, Unnikrishnan Bhaskaran, Priya Rathi, Soundarya Mahalingam and Nikhil Victor Dsouza

Willingness to use HIV pre-exposure prophylaxis and associated factors among men who have sex with men in Liuzhou, China

HIV pre-exposure prophylaxis (PrEP) is a key component of HIV combination prevention strategies and has the potential to decrease the incidence of HIV in men who have sex with men (MSM). This study aimed to ev...

Authors: Yuansheng Fu, Akililu Alemu Ashuro, Xianxiang Feng, Ting Wang, Sichen Zhang, Dongqing Ye and Yinguang Fan

Influence of intensified adherence counselling on viral load suppression of people receiving antiretroviral therapy at a health centre IV in southwestern Uganda: a qualitative study

The prevalence of Human Immunodeficiency Virus (HIV) among adults and children in Uganda is 6.2% and 0.5% respectively. The prevalence of viral load suppression in Uganda among all adults and children living w...

Authors: Atwau Pius, Najjuma Nambi Josephine, Sibo Erick, Agoa Winifred, Mukashyaka Rita, Okoli Silverjoseph, Ezatiru Lucy and Nyemara Novatus

Should the management of high grade cervical squamous intraepithelial lesion (HSIL) be different in HIV-positive women?

This study compares the management and outcome of high grade squamous intraepithelial lesions (HSIL) in HIV-positive and -negative women and identifies risk factors for treatment failure.

Authors: Christine Gilles, Maude Velghe-lenelle, Yannick Manigart, Déborah Konopnicki and Serge Rozenberg

Persons living with HIV in sero-discordant partnerships experience improved HIV care engagement compared with persons living with HIV in sero-concordant partnerships: a cross-sectional analysis of four African countries

Persons living with HIV (PLWH) who are members of sero-discordant and sero-concordant relationships may experience psychological stressors or motivators that affect HIV care. We assessed the association betwee...

Authors: Domonique M. Reed, Allahna L. Esber, Trevor A. Crowell, Kavitha Ganesan, Hannah Kibuuka, Jonah Maswai, John Owuoth, Emmanuel Bahemana, Michael Iroezindu, Julie A. Ake and Christina S. Polyak

Case report of peritoneal carcinomatosis of plasma cell origin in a patient with newly diagnosed HIV: A terminal event

B-cell tumors and plasma cell malignancies have been identified in persons living with the human immunodeficiency virus (PLHIV). The literature review has revealed numerous reports of solitary plasmacytomas wi...

Authors: Syeda Sahra, Abdullah Jahangir, Muhammad Yasir Anwar, Allison Glaser and Ahmad Jahangir

Decrease in late presentation for HIV care in Kinshasa, DRC, 2006–2020

Late presentation for HIV care is a well-described issue for the success of ART outcomes and the cause of higher morbidity, mortality and further transmission. Monitoring the level of late presentation and und...

Authors: Nadine Mayasi Ngongo, Hippolyte Situakibanza Nani-Tuma, Marcel Mbula Mambimbi, Murielle Longokolo Mashi, Ben Bepouka Izizag, Faustin Kitetele Ndolumingu, Nathalie Maes, Michel Moutschen and Gilles Darcis

Knowledge and determinants of women’s knowledge on vertical transmission of HIV and AIDS in South Africa

HIV/AIDS is still one of the major public health concerns globally. It is one of the major contributory causes of deaths among women in the reproductive age (15–49 years) and has resulted in about 14 million o...

Authors: Eugene Kofuor Maafo Darteh, Susanna Aba Abraham, Abdul-Aziz Seidu, Vijay Kumar Chattu and Sanni Yaya

Determinant factors for adherence to antiretroviral therapy among adult HIV patients at Dessie Referral Hospital, South Wollo, Northeast Ethiopia: a case–control study

World health organization defined adherence as the extent to which a person’s behavior – taking medications, following a diet, or executing lifestyle changes correspond with agreed recommendations from the hea...

Authors: Mehd Abdu and Betelhem Walelgn

Does facility readiness promote high-quality of provider-initiated HIV testing and counseling to pregnant women? A national survey for improving policy of prevention of mother-to-child transmission of HIV in Tanzania

Provider-initiated HIV testing and counseling (PITC) is a recommended approach to screen for HIV to all pregnant women during antenatal care (ANC) visits, and all with HIV positive results have to be enrolled ...

Authors: Deogratius Bintabara, Athanase Lilungulu, Shakilu Jumanne, Mzee M. Nassoro and Bonaventura C. Mpondo

Assessing the differential impact of chronic CMV and treated HIV infection on CD8+ T-cell differentiation in a matched cohort study: is CMV the key?

Cytomegalovirus (CMV) infection is one of the main driving forces of T-cell senescence in the general population, whereas its differential impact in people living with HIV (PLWH) is less well characterized. Th...

Authors: Matthias C. Mueller, Winfried V. Kern, Susanne Usadel, Marie-Christin Pauly, Toni Cathomen and Ulrich Salzer

Defining the optimal cut-point of self-reported ART adherence to achieve viral suppression in the era of contemporary HIV therapy: a cross-sectional study

When considering adherence to antiretroviral therapy (ART) for HIV, many different cut-points are used. The primary goals of this study were to identify a level of self-reported medication adherence that best ...

Authors: Emma O’Halloran Leach, Huiyin Lu, Joshua Caballero, Jennifer E. Thomas, Emma C. Spencer and Robert L. Cook

The yield of HIV testing during pregnancy and postnatal period, Uganda, 2015–2018: analysis of surveillance data

Uganda has registered a reduction in new HIV infections among children in recent years. However, mother-to-child transmission of HIV still occurs, especially among pregnant women who present late. To eliminate...

Authors: Yvette Wibabara, Ivan Lukabwe, Irene Kyamwine, Benon Kwesiga, Alex R. Ario, Linda Nabitaka, Lilian Bulage, Julie Harris and Peter Mudiope

Community-based HIV testing in The Netherlands: experiences of lay providers and end users at a rapid HIV test checkpoint

The AIDS Healthcare Foundation (AHF-Checkpoint) in The Netherlands offers rapid HIV testing for key populations by lay providers. We explored the experiences and needs of lay providers and end users of HIV tes...

Authors: Nori Krabbenborg, Ralph Spijker, Anna Maria Żakowicz, Milo de Moraes, Titia Heijman and Eline Op de Coul

High risk sexual behaviours associated with traditional beliefs about gender roles among men interested in medical male circumcision in South Africa

Beliefs about gender roles and high-risk sexual behaviours underlie the human immunodeficiency virus (HIV) epidemic in South Africa. Yet, there is limited information on the relationships between beliefs about...

Authors: Candice M. Chetty-Makkan, Jonathan M. Grund, Evans Muchiri, Matt A. Price, Mary H. Latka and Salome Charalambous

The transient effect of a peer support intervention to improve adherence among adolescents and young adults failing antiretroviral therapy in Harare, Zimbabwe: a randomized control trial

Adolescents and young adults living with HIV in sub Saharan Africa are at high risk of poor adherence to antiretroviral therapy (ART) and virologic failure (VF).

Authors: Chiratidzo E. Ndhlovu, Vinie Kouamou, Primrose Nyamayaro, Leanne Dougherty, Nicola Willis, Bisola O. Ojikutu and A. Tariro Makadzange

Impact of COVID-19 pandemic on HIV viremia: a single-center cohort study in northern Italy

Brescia Province, northern Italy, was one of the worst epicenters of the COVID-19 pandemic. The division of infectious diseases of ASST (Azienda Socio Sanitaria Territoriale) Spedali Civili Hospital of Brescia...

Authors: Ilaria Izzo, Canio Carriero, Giulia Gardini, Benedetta Fumarola, Erika Chiari, Francesco Castelli and Eugenia Quiros-Roldan

Changing trends in lipid profile and biomarkers of renal function and bone metabolism before and after switching from tenofovir disoproxil fumarate to tenofovir alafenamide: a prospective observational study

Antiretrovirals, including tenofovir, can suppress human immunodeficiency virus (HIV) infection but cannot completely eradicate it. Patients with HIV infection are administered antiretroviral drugs over a long...

Authors: Mahoko Ikeda, Yoshitaka Wakabayashi, Koh Okamoto, Shintaro Yanagimoto, Shu Okugawa and Kyoji Moriya

Association between depression and HIV treatment outcomes in a US military population with HIV infection

Depression is common among HIV-infected individuals and may contribute to suboptimal adherence to antiretroviral therapy (ART) and subsequent inability to attain viral load (VL) suppression. We evaluated assoc...

Authors: Brandon Carney, Colton Daniels, Xiaohe Xu, Thankam Sunil, Anuradha Ganesan, Jason M. Blaylock, Karl C. Kronmann, Christina Schofield, Tahaniyat Lalani, Brian Agan and Jason F. Okulicz

COVID-19 and HIV infection co-pandemics and their impact: a review of the literature

Coronavirus disease 2019 (COVID-19) was first detected in December 2019. In March 2020, the World Health Organization declared COVID-19 a pandemic. People with underlying medical conditions may be at greater r...

Authors: Sivaporn Gatechompol, Anchalee Avihingsanon, Opass Putcharoen, Kiat Ruxrungtham and Daniel R. Kuritzkes

Predictors of mortality rate among adult HIV-positive patients on antiretroviral therapy in Metema Hospital, Northwest Ethiopia: a retrospective follow-up study

Globally Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome (HIV/AIDS) is an ongoing public health issue associated with high morbidity and mortality. Efforts have been made to reduce HIV/AIDS-re...

Authors: Kefale Lejadiss Workie, Tilahun Yemanu Birhan and Dessie Abebaw Angaw