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  1. Content type: Research

    Extramarital sex is a potential driver of human immunodeficiency virus (HIV) transmission for long-term couples in sub-Saharan Africa. It is increasingly recognized that preventing sexual risk behaviours requi...

    Authors: Sally M. Mtenga, Constanze Pfeiffer, Marcel Tanner, Eveline Geubbels and Sonja Merten

    Citation: AIDS Research and Therapy 2018 15:12

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  2. Content type: Research

    The prevalence of HIV-1 resistance to antiretroviral therapies (ART) has declined in high-income countries over recent years, but drug resistance remains a substantial concern in many low and middle-income cou...

    Authors: Oliver T. Stirrup, David T. Dunn, Anna Tostevin, Caroline A. Sabin, Anton Pozniak, David Asboe, Alison Cox, Chloe Orkin, Fabiola Martin and Patricia Cane

    Citation: AIDS Research and Therapy 2018 15:11

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  3. Content type: Research

    While efficacy data exist, there are limited data on the outcomes of patients on third-line antiretroviral therapy (ART) in sub-Saharan Africa in actual practice. Being able to identify predictors of switch to...

    Authors: Denise Evans, Kamban Hirasen, Rebecca Berhanu, Given Malete, Prudence Ive, David Spencer, Sharlaa Badal-Faesen, Ian M. Sanne and Matthew P. Fox

    Citation: AIDS Research and Therapy 2018 15:10

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  4. Content type: Research

    As part of efforts to improve the prevention of mother-to-child transmission in Northern Uganda, we explored reasons for poor viral suppression among 122 pregnant and lactating women who were in care, received...

    Authors: Tamara Nsubuga-Nyombi, Simon Sensalire, Esther Karamagi, Judith Aloyo, John Byabagambi, Mirwais Rahimzai, Linda Kisaakye Nabitaka and Jacqueline Calnan

    Citation: AIDS Research and Therapy 2018 15:9

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  5. Content type: Research

    Understanding the circumstances of adolescents living with HIV is critical in designing adolescent-friendly services that will facilitate successful transition from pediatric to adult care. This study describe...

    Authors: Graham Toth, Gitau Mburu, Sovannary Tuot, Vohith Khol, Chanrith Ngin, Pheak Chhoun and Siyan Yi

    Citation: AIDS Research and Therapy 2018 15:8

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  6. Content type: Review

    HIV infection causes upregulation of markers of inflammation, immune activation and apoptosis of host adaptive, and innate immune cells particularly monocytes, natural killer (NK) and innate lymphoid cells (IL...

    Authors: Rose Nabatanzi, Stephen Cose, Moses Joloba, Sarah Rowland Jones and Damalie Nakanjako

    Citation: AIDS Research and Therapy 2018 15:7

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  7. Content type: Research

    To assess the prevalence of non-AIDS co-morbidities (NACs) and predictors of adverse health outcomes amongst people living with HIV in order to identify health needs and potential gaps in patient management.

    Authors: Derek J. Chan, Virginia Furner, Don E. Smith, Mithilesh Dronavalli, Rohan I. Bopage, Jeffrey J. Post and Anjali K. Bhardwaj

    Citation: AIDS Research and Therapy 2018 15:6

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  8. Content type: Research

    Criteria for the 2007 WHO algorithm for diagnosing tuberculosis among HIV-infected seriously ill patients are the presence of one or more danger signs (respiratory rate > 30/min, heart rate > 120/min, temperat...

    Authors: Rulan Griesel, Annemie Stewart, Helen van der Plas, Welile Sikhondze, Marc Mendelson and Gary Maartens

    Citation: AIDS Research and Therapy 2018 15:5

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  9. Content type: Research

    Despite the conventional approaches to HIV prevention being the bedrock for early reductions in HIV infections in Uganda, innovations that demonstrate reduction in risk to infection in vulnerable populations n...

    Authors: Esther Karamagi, Simon Sensalire, Juliana Nabwire, John Byabagambi, Alfred O. Awio, George Aluma, Mirwais Rahimzai, Jacqueline Calnan and Sheila Kyobutungi

    Citation: AIDS Research and Therapy 2018 15:4

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  10. Content type: Research

    Deep venous thrombosis (DVT) and its major complication pulmonary embolism (PE) are collectively known as venous thromboembolism. In Uganda, the prevalence of DVT among HIV patients has not been previously pub...

    Authors: Sosthene Tsongo Vululi, Samuel Bugeza, Muyinda Zeridah, Henry Ddungu, Akello Betty Openy, Mubiru Frank and Rosalind Parkes-Ratanshi

    Citation: AIDS Research and Therapy 2018 15:3

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  11. Content type: Research

    Mental health (MH) comorbidities reduce retention in care for persons living with HIV (PLWH) and are associated with poor health outcomes. Optimizing retention in primary care is vital, as poor retention is as...

    Authors: Lauren A. Saag, Ashutosh R. Tamhane, D. Scott Batey, Michael J. Mugavero and Ellen F. Eaton

    Citation: AIDS Research and Therapy 2018 15:1

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  12. Content type: Research

    We evaluate the impact of clinic-based PMTCT community support by trained lay health workers in addition to standard clinical care on PMTCT infant outcomes.

    Authors: Karl Peltzer, Stephen M. Weiss, Manasi Soni, Tae Kyoung Lee, Violeta J. Rodriguez, Ryan Cook, Maria Luisa Alcaide, Geoffrey Setswe and Deborah L. Jones

    Citation: AIDS Research and Therapy 2017 14:61

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  13. Content type: Research

    Antiretroviral therapy (ART) has modified the natural history of HIV-infection: the incidence of opportunistic infections (OIs) has decreased and mortality associated to HIV has improved dramatically. The reas...

    Authors: María Fernanda Álvarez Barreneche, Carlos Andrés Restrepo Castro, Alicia Hidrón Botero, Juan Pablo Villa Franco, Ivan Mauricio Trompa Romero, Laura Restrepo Carvajal, Alejandro Eusse García, Adriana Ocampo Mesa, Lina María Echeverri Toro, Glenys Patricia Porras Fernández de Castro, Jaime Mauricio Ramírez Rivera and Carlos Andrés Agudelo Restrepo

    Citation: AIDS Research and Therapy 2017 14:60

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  14. Content type: Research

    As a simplification strategy for treatment-experienced HIV-infected patients who have achieved virologic suppression on a multi-drug, multi-class antiretroviral regimen, the aim of this study was to evaluate t...

    Authors: Marianne Harris, Bruce Ganase, Birgit Watson, P. Richard Harrigan, Julio S. G. Montaner and Mark W. Hull

    Citation: AIDS Research and Therapy 2017 14:59

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  15. Content type: Short Report

    For patients on antiretroviral therapy (ART), treatment interruptions can impact patient outcomes and result in the accumulation of drug resistance mutations leading to virologic failure. There are minimal pub...

    Authors: Seema T. Meloni, Beth Chaplin, John Idoko, Oche Agbaji, Sulaimon Akanmu, Godwin Imade, Prosper Okonkwo, Robert L. Murphy and Phyllis J. Kanki

    Citation: AIDS Research and Therapy 2017 14:58

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  16. Content type: Research

    Plant extracts are sources of valuable compounds with biological activity, especially for the anti-proliferative activity against pathogens or tumor cells. Myricetin is a flavonoid found in several plants that...

    Authors: Joseph T. Ortega, Alirica I. Suárez, Maria L. Serrano, Jani Baptista, Flor H. Pujol and Hector R. Rangel

    Citation: AIDS Research and Therapy 2017 14:57

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  17. Content type: Research

    Clinicians are incorporating patient-reported outcomes in the management of HIV-infected persons co-infected with hepatitis C virus (HCV), but there are no validated inventories to monitor symptoms of patients...

    Authors: Edward R. Cachay, Craig Ballard, Bradford Colwell, Francesca Torriani, Charles Hicks and Wm. Christopher Mathews

    Citation: AIDS Research and Therapy 2017 14:56

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  18. Content type: Review

    Collective evidence supporting a role of Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC) in controlling HIV-1 transmission and disease progression emerged in the last few years. Non-neutralizing antibodie...

    Authors: Jonathan Richard, Shilei Ding and Andrés Finzi

    Citation: AIDS Research and Therapy 2017 14:42

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  19. Content type: Review

    Despite the tremendous success of anti-retroviral therapy (ART) no current treatment can eradicate latent HIV reservoirs from HIV-infected individuals or generate, effective HIV-specific immunity. Technologica...

    Authors: Amy E. Baxter, Julia Niessl, Antigoni Morou and Daniel E. Kaufmann

    Citation: AIDS Research and Therapy 2017 14:40

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  20. Content type: Review

    The anti-HIV activity of natural killer (NK) cells could be induced fast enough to potentially prevent the establishment of HIV infection. Epidemiological studies identified two genotypes encoding NK receptors...

    Authors: Nicole F. Bernard

    Citation: AIDS Research and Therapy 2017 14:38

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  21. Content type: Review

    Finding new adjuvants is an integrated component of the efforts in developing an effective HIV-1 vaccine. Compared with traditional adjuvants, a modern adjuvant in the context of HIV-1 prevention would elicit ...

    Authors: Jun Liu and Mario Ostrowski

    Citation: AIDS Research and Therapy 2017 14:43

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  22. Content type: Review

    HIV preferentially infects activated CD4+ T cells and mutates rapidly. The classical vaccine approach aimed to generate broad immune responses to full HIV proteins largely failed to address the potential adver...

    Authors: Hongzhao Li, Robert W. Omange, Francis A. Plummer and Ma Luo

    Citation: AIDS Research and Therapy 2017 14:51

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  23. Content type: Review

    Vesicular stomatitis virus (VSV), like many other Rhabdoviruses, have become the focus of intense research over the past couple of decades based on their suitability as vaccine vectors, transient gene delivery...

    Authors: Trina Racine, Gary P. Kobinger and Eric J. Arts

    Citation: AIDS Research and Therapy 2017 14:55

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  24. Content type: Review

    While the prevalence of Human immunodeficiency virus-1 (HIV-1) infection has stabilized globally, it continues to be the leading cause of death among women of reproductive age. The majority of new infections a...

    Authors: Danielle Vitali, Jocelyn M. Wessels and Charu Kaushic

    Citation: AIDS Research and Therapy 2017 14:39

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  25. Content type: Review

    For over three decades, HIV infection has had a tremendous impact on the lives of individuals and public health. Microbicides and vaccines studies have shown that immune activation at the genital tract is a ri...

    Authors: Julie Lajoie, Lucy Mwangi and Keith R. Fowke

    Citation: AIDS Research and Therapy 2017 14:46

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  26. Content type: Short Report

    We present a small longitudinal study of how demographic factors and persistent burdens of HIV and cytomegalovirus (CMV) influence cardiovascular health in young adults beginning ART in an inner-city clinic in...

    Authors: Birry Karim, Ika Praseya Wijaya, Rizky Rahmaniyah, Ibnu Ariyanto, Shelley Waters, Riwanti Estiasari and Patricia Price

    Citation: AIDS Research and Therapy 2017 14:52

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  27. Content type: Research

    We hypothesized that frailty acts as a measure of health outcomes in the context of LT. The aim of this study was to explore frailty index across LT, as a measure of morbidity and mortality. This was a retrosp...

    Authors: Giovanni Guaraldi, Giovanni Dolci, Stefano Zona, Giuseppe Tarantino, Valentina Serra, Roberto Ballarin, Erica Franceschini, Mauro Codeluppi, Thomas D. Brothers, Cristina Mussini and Fabrizio Di Benedetto

    Citation: AIDS Research and Therapy 2017 14:37

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  28. Content type: Research

    Combination antiretroviral therapy (cART) has significantly reduced HIV morbidity and mortality in both developed and developing countries. However, the sustainability of cART may be compromised by the emergen...

    Authors: Elizabeth M. Etta, Lufuno Mavhandu, Cecile Manhaeve, Keanan McGonigle, Patrick Jackson, David Rekosh, Marie-Louise Hammarskjold, Pascal O. Bessong and Denis M. Tebit

    Citation: AIDS Research and Therapy 2017 14:36

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  29. Content type: Research

    Safety and immunogenicity of the quadrivalent human papillomavirus (qHPV) vaccine were evaluated in HIV-positive Spanish MSM. The prevalence of High Squamous Intraepithelial Lesions (HSIL) and genotypes of hig...

    Authors: Carmen Hidalgo-Tenorio, Jessica Ramírez-Taboada, Concepción Gil-Anguita, Javier Esquivias, Mohamed Omar-Mohamed-Balgahata, Antonio SamPedro, Miguel Lopez-Ruz and Juan Pasquau

    Citation: AIDS Research and Therapy 2017 14:34

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  30. Content type: Research

    Preparing adolescents for transition into adult care and supporting their acquisition of self-health care management skills is a critical determinant of their post-transition HIV care outcomes. However, there ...

    Authors: Siyan Yi, Chanrith Ngin, Khuondyla Pal, Vohith Khol, Sovannary Tuot, Sokunmealiny Sau, Pheak Chhoun, Gitau Mburu, Sok Chamreun Choub, Kolab Chhim and Penhsun Ly

    Citation: AIDS Research and Therapy 2017 14:33

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  31. Content type: Review

    Current treatment for HIV-1 largely relies on chemotherapy through the administration of antiretroviral drugs. While the search for anti-HIV-1 vaccine remain elusive, the use of highly active antiretroviral th...

    Authors: Alexander Kwarteng, Samuel Terkper Ahuno and Godwin Kwakye-Nuako

    Citation: AIDS Research and Therapy 2017 14:32

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  32. Content type: Research

    Host immune responses during acute HIV-1 infection can influence the viral setpoint, which is a predictor of disease progression. Interferon (IFN)-lambdas are newly classified type III interferons, which use J...

    Authors: Guoxian Zhao, Lifeng Liu, Bin Su, Tong Zhang, Peng Chen, Wei Li and Hao Wu

    Citation: AIDS Research and Therapy 2017 14:31

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  33. Content type: Research

    To investigate the predictive factors for the development of Kaposi sarcoma-related immune reconstitution inflammatory syndrome (KS-IRIS) and long-term prognosis in patients starting combined antiretroviral th...

    Authors: Patricia Volkow, Gabriela Cesarman-Maus, Pamela Garciadiego-Fossas, Enrique Rojas-Marin and Patricia Cornejo-Juárez

    Citation: AIDS Research and Therapy 2017 14:30

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  34. Content type: Research

    There is growing evidence of the negative impact of alcohol on morbidity and mortality of individuals living with HIV but limited evidence of in utero effects of HIV and alcohol on exposure on infants.

    Authors: Kirsten A. M. Donald, Anne Fernandez, Kasey Claborn, Caroline Kuo, Nastassja Koen, Heather Zar and Dan J. Stein

    Citation: AIDS Research and Therapy 2017 14:28

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  35. Content type: Research

    Abacavir and rilpivirine are alternative antiretroviral drugs for treatment-naïve HIV-infected patients. However, both drugs are only recommended for the patients who have pre-treatment HIV RNA <100,000 copies...

    Authors: Sasisopin Kiertiburanakul, David Boettiger, Oon Tek Ng, Nguyen Van Kinh, Tuti Parwati Merati, Anchalee Avihingsanon, Wing-Wai Wong, Man Po Lee, Romanee Chaiwarith, Adeeba Kamarulzaman, Pacharee Kantipong, Fujie Zhang, Jun Yong Choi, Nagalingeswaran Kumarasamy, Rossana Ditangco, Do Duy Cuong…

    Citation: AIDS Research and Therapy 2017 14:27

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  36. Content type: Research

    Antiretroviral therapy (ART) improves the survival and quality of life of HIV-positive individuals, but the effects of long-term ART use do eventually manifest. The Complications of Long-Term Antiretroviral Th...

    Authors: Billy Nsubuga Mayanja, Ivan Kasamba, Jonathan Levin, Ivan Namakoola, Patrick Kazooba, Jackson Were, Pontiano Kaleebu and Paula Munderi

    Citation: AIDS Research and Therapy 2017 14:26

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  37. Content type: Research

    Immune reconstitution inflammatory syndrome (IRIS) can manifest with initiation or reintroduction of antiretroviral therapy (ART) in persons living with HIV (PLWH). In 2012, updated United States treatment gui...

    Authors: Peter Liu, Rebecca Dillingham and Kathleen A. McManus

    Citation: AIDS Research and Therapy 2017 14:25

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    The Erratum to this article has been published in AIDS Research and Therapy 2017 14:29

  38. Content type: Research

    CSF PCR is the standard diagnostic technique used in resource-rich settings to detect pathogens of the CNS infection. However, it is not currently used for routine CSF testing in China. Knowledge of CNS opport...

    Authors: Rongrong Yang, Hong Zhang, Yong Xiong, Xien Gui, Yongxi Zhang, Liping Deng, Shicheng Gao, Mingqi Luo, Wei Hou and Deyin Guo

    Citation: AIDS Research and Therapy 2017 14:24

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