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  1. Research

    Hospitalization causes and outcomes in HIV patients in the late antiretroviral era in Colombia

    Antiretroviral therapy (ART) has modified the natural history of HIV-infection: the incidence of opportunistic infections (OIs) has decreased and mortality associated to HIV has improved dramatically. The reas...

    María Fernanda Álvarez Barreneche, Carlos Andrés Restrepo Castro, Alicia Hidrón Botero, Juan Pablo Villa Franco, Ivan Mauricio Trompa Romero, Laura Restrepo Carvajal, Alejandro Eusse García, Adriana Ocampo Mesa, Lina María Echeverri Toro, Glenys Patricia Porras Fernández de Castro, Jaime Mauricio Ramírez Rivera and Carlos Andrés Agudelo Restrepo

    AIDS Research and Therapy 2017 14:60

    Published on: 13 November 2017

  2. Research

    HIV treatment simplification to elvitegravir/cobicistat/emtricitabine/tenofovir disproxil fumarate (E/C/F/TDF) plus darunavir: a pharmacokinetic study

    As a simplification strategy for treatment-experienced HIV-infected patients who have achieved virologic suppression on a multi-drug, multi-class antiretroviral regimen, the aim of this study was to evaluate t...

    Marianne Harris, Bruce Ganase, Birgit Watson, P. Richard Harrigan, Julio S. G. Montaner and Mark W. Hull

    AIDS Research and Therapy 2017 14:59

    Published on: 2 November 2017

  3. Short Report

    Drug resistance patterns following pharmacy stock shortage in Nigerian Antiretroviral Treatment Program

    For patients on antiretroviral therapy (ART), treatment interruptions can impact patient outcomes and result in the accumulation of drug resistance mutations leading to virologic failure. There are minimal pub...

    Seema T. Meloni, Beth Chaplin, John Idoko, Oche Agbaji, Sulaimon Akanmu, Godwin Imade, Prosper Okonkwo, Robert L. Murphy and Phyllis J. Kanki

    AIDS Research and Therapy 2017 14:58

    Published on: 13 October 2017

  4. Research

    Validation of a questionnaire to monitor symptoms in HIV-infected patients during hepatitis C treatment

    Clinicians are incorporating patient-reported outcomes in the management of HIV-infected persons co-infected with hepatitis C virus (HCV), but there are no validated inventories to monitor symptoms of patients...

    Edward R. Cachay, Craig Ballard, Bradford Colwell, Francesca Torriani, Charles Hicks and Wm. Christopher Mathews

    AIDS Research and Therapy 2017 14:56

    Published on: 20 September 2017

  5. Review

    Unlocking HIV-1 Env: implications for antibody attack

    Collective evidence supporting a role of Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC) in controlling HIV-1 transmission and disease progression emerged in the last few years. Non-neutralizing antibodie...

    Jonathan Richard, Shilei Ding and Andrés Finzi

    AIDS Research and Therapy 2017 14:42

    Published on: 12 September 2017

  6. Review

    Natural killer (NK) cell receptor-HLA ligand genotype combinations associated with protection from HIV infection: investigation of how protective genotypes influence anti HIV NK cell functions

    The anti-HIV activity of natural killer (NK) cells could be induced fast enough to potentially prevent the establishment of HIV infection. Epidemiological studies identified two genotypes encoding NK receptors...

    Nicole F. Bernard

    AIDS Research and Therapy 2017 14:38

    Published on: 12 September 2017

  7. Review

    Development of targeted adjuvants for HIV-1 vaccines

    Finding new adjuvants is an integrated component of the efforts in developing an effective HIV-1 vaccine. Compared with traditional adjuvants, a modern adjuvant in the context of HIV-1 prevention would elicit ...

    Jun Liu and Mario Ostrowski

    AIDS Research and Therapy 2017 14:43

    Published on: 12 September 2017

  8. Review

    Eradication of HIV-1 latent reservoirs through therapeutic vaccination

    Despite the significant success of combination anti-retroviral therapy to reduce HIV viremia and save lives, HIV-1 infection remains a lifelong infection that must be appropriately managed. Advances in the und...

    Joshua Pankrac, Katja Klein and Jamie F. S. Mann

    AIDS Research and Therapy 2017 14:45

    Published on: 12 September 2017

  9. Review

    A novel HIV vaccine targeting the protease cleavage sites

    HIV preferentially infects activated CD4+ T cells and mutates rapidly. The classical vaccine approach aimed to generate broad immune responses to full HIV proteins largely failed to address the potential adver...

    Hongzhao Li, Robert W. Omange, Francis A. Plummer and Ma Luo

    AIDS Research and Therapy 2017 14:51

    Published on: 12 September 2017

  10. Review

    Development of an HIV vaccine using a vesicular stomatitis virus vector expressing designer HIV-1 envelope glycoproteins to enhance humoral responses

    Vesicular stomatitis virus (VSV), like many other Rhabdoviruses, have become the focus of intense research over the past couple of decades based on their suitability as vaccine vectors, transient gene delivery...

    Trina Racine, Gary P. Kobinger and Eric J. Arts

    AIDS Research and Therapy 2017 14:55

    Published on: 12 September 2017

  11. Short Report

    Factors affecting affect cardiovascular health in Indonesian HIV patients beginning ART

    We present a small longitudinal study of how demographic factors and persistent burdens of HIV and cytomegalovirus (CMV) influence cardiovascular health in young adults beginning ART in an inner-city clinic in...

    Birry Karim, Ika Praseya Wijaya, Rizky Rahmaniyah, Ibnu Ariyanto, Shelley Waters, Riwanti Estiasari and Patricia Price

    AIDS Research and Therapy 2017 14:52

    Published on: 31 August 2017

  12. Research

    A frailty index predicts post-liver transplant morbidity and mortality in HIV-positive patients

    We hypothesized that frailty acts as a measure of health outcomes in the context of LT. The aim of this study was to explore frailty index across LT, as a measure of morbidity and mortality. This was a retrosp...

    Giovanni Guaraldi, Giovanni Dolci, Stefano Zona, Giuseppe Tarantino, Valentina Serra, Roberto Ballarin, Erica Franceschini, Mauro Codeluppi, Thomas D. Brothers, Cristina Mussini and Fabrizio Di Benedetto

    AIDS Research and Therapy 2017 14:37

    Published on: 5 August 2017

  13. Research

    High level of HIV-1 drug resistance mutations in patients with unsuppressed viral loads in rural northern South Africa

    Combination antiretroviral therapy (cART) has significantly reduced HIV morbidity and mortality in both developed and developing countries. However, the sustainability of cART may be compromised by the emergen...

    Elizabeth M. Etta, Lufuno Mavhandu, Cecile Manhaeve, Keanan McGonigle, Patrick Jackson, David Rekosh, Marie-Louise Hammarskjold, Pascal O. Bessong and Denis M. Tebit

    AIDS Research and Therapy 2017 14:36

    Published on: 27 July 2017

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