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  1. The prevalence of Human Immunodeficiency Virus (HIV) among adults and children in Uganda is 6.2% and 0.5% respectively. The prevalence of viral load suppression in Uganda among all adults and children living w...

    Authors: Atwau Pius, Najjuma Nambi Josephine, Sibo Erick, Agoa Winifred, Mukashyaka Rita, Okoli Silverjoseph, Ezatiru Lucy and Nyemara Novatus

    Citation: AIDS Research and Therapy 2021 18:45

    Content type: Research

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  2. This study compares the management and outcome of high grade squamous intraepithelial lesions (HSIL) in HIV-positive and -negative women and identifies risk factors for treatment failure.

    Authors: Christine Gilles, Maude Velghe-lenelle, Yannick Manigart, Déborah Konopnicki and Serge Rozenberg

    Citation: AIDS Research and Therapy 2021 18:44

    Content type: Research

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  3. Persons living with HIV (PLWH) who are members of sero-discordant and sero-concordant relationships may experience psychological stressors or motivators that affect HIV care. We assessed the association betwee...

    Authors: Domonique M. Reed, Allahna L. Esber, Trevor A. Crowell, Kavitha Ganesan, Hannah Kibuuka, Jonah Maswai, John Owuoth, Emmanuel Bahemana, Michael Iroezindu, Julie A. Ake and Christina S. Polyak

    Citation: AIDS Research and Therapy 2021 18:43

    Content type: Research

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  4. B-cell tumors and plasma cell malignancies have been identified in persons living with the human immunodeficiency virus (PLHIV). The literature review has revealed numerous reports of solitary plasmacytomas wi...

    Authors: Syeda Sahra, Abdullah Jahangir, Muhammad Yasir Anwar, Allison Glaser and Ahmad Jahangir

    Citation: AIDS Research and Therapy 2021 18:42

    Content type: Case Report

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  5. Late presentation for HIV care is a well-described issue for the success of ART outcomes and the cause of higher morbidity, mortality and further transmission. Monitoring the level of late presentation and und...

    Authors: Nadine Mayasi Ngongo, Hippolyte Situakibanza Nani-Tuma, Marcel Mbula Mambimbi, Murielle Longokolo Mashi, Ben Bepouka Izizag, Faustin Kitetele Ndolumingu, Nathalie Maes, Michel Moutschen and Gilles Darcis

    Citation: AIDS Research and Therapy 2021 18:41

    Content type: Research

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  6. HIV/AIDS is still one of the major public health concerns globally. It is one of the major contributory causes of deaths among women in the reproductive age (15–49 years) and has resulted in about 14 million o...

    Authors: Eugene Kofuor Maafo Darteh, Susanna Aba Abraham, Abdul-Aziz Seidu, Vijay Kumar Chattu and Sanni Yaya

    Citation: AIDS Research and Therapy 2021 18:40

    Content type: Research

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  7. World health organization defined adherence as the extent to which a person’s behavior – taking medications, following a diet, or executing lifestyle changes correspond with agreed recommendations from the hea...

    Authors: Mehd Abdu and Betelhem Walelgn

    Citation: AIDS Research and Therapy 2021 18:39

    Content type: Research

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  8. Provider-initiated HIV testing and counseling (PITC) is a recommended approach to screen for HIV to all pregnant women during antenatal care (ANC) visits, and all with HIV positive results have to be enrolled ...

    Authors: Deogratius Bintabara, Athanase Lilungulu, Shakilu Jumanne, Mzee M. Nassoro and Bonaventura C. Mpondo

    Citation: AIDS Research and Therapy 2021 18:38

    Content type: Research

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  9. Cytomegalovirus (CMV) infection is one of the main driving forces of T-cell senescence in the general population, whereas its differential impact in people living with HIV (PLWH) is less well characterized. Th...

    Authors: Matthias C. Mueller, Winfried V. Kern, Susanne Usadel, Marie-Christin Pauly, Toni Cathomen and Ulrich Salzer

    Citation: AIDS Research and Therapy 2021 18:37

    Content type: Research

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  10. When considering adherence to antiretroviral therapy (ART) for HIV, many different cut-points are used. The primary goals of this study were to identify a level of self-reported medication adherence that best ...

    Authors: Emma O’Halloran Leach, Huiyin Lu, Joshua Caballero, Jennifer E. Thomas, Emma C. Spencer and Robert L. Cook

    Citation: AIDS Research and Therapy 2021 18:36

    Content type: Research

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  11. Uganda has registered a reduction in new HIV infections among children in recent years. However, mother-to-child transmission of HIV still occurs, especially among pregnant women who present late. To eliminate...

    Authors: Yvette Wibabara, Ivan Lukabwe, Irene Kyamwine, Benon Kwesiga, Alex R. Ario, Linda Nabitaka, Lilian Bulage, Julie Harris and Peter Mudiope

    Citation: AIDS Research and Therapy 2021 18:35

    Content type: Research

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  12. The AIDS Healthcare Foundation (AHF-Checkpoint) in The Netherlands offers rapid HIV testing for key populations by lay providers. We explored the experiences and needs of lay providers and end users of HIV tes...

    Authors: Nori Krabbenborg, Ralph Spijker, Anna Maria Żakowicz, Milo de Moraes, Titia Heijman and Eline Op de Coul

    Citation: AIDS Research and Therapy 2021 18:34

    Content type: Research

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  13. Beliefs about gender roles and high-risk sexual behaviours underlie the human immunodeficiency virus (HIV) epidemic in South Africa. Yet, there is limited information on the relationships between beliefs about...

    Authors: Candice M. Chetty-Makkan, Jonathan M. Grund, Evans Muchiri, Matt A. Price, Mary H. Latka and Salome Charalambous

    Citation: AIDS Research and Therapy 2021 18:33

    Content type: Research

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  14. Adolescents and young adults living with HIV in sub Saharan Africa are at high risk of poor adherence to antiretroviral therapy (ART) and virologic failure (VF).

    Authors: Chiratidzo E. Ndhlovu, Vinie Kouamou, Primrose Nyamayaro, Leanne Dougherty, Nicola Willis, Bisola O. Ojikutu and A. Tariro Makadzange

    Citation: AIDS Research and Therapy 2021 18:32

    Content type: Research

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  15. Brescia Province, northern Italy, was one of the worst epicenters of the COVID-19 pandemic. The division of infectious diseases of ASST (Azienda Socio Sanitaria Territoriale) Spedali Civili Hospital of Brescia...

    Authors: Ilaria Izzo, Canio Carriero, Giulia Gardini, Benedetta Fumarola, Erika Chiari, Francesco Castelli and Eugenia Quiros-Roldan

    Citation: AIDS Research and Therapy 2021 18:31

    Content type: Short Report

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  16. Antiretrovirals, including tenofovir, can suppress human immunodeficiency virus (HIV) infection but cannot completely eradicate it. Patients with HIV infection are administered antiretroviral drugs over a long...

    Authors: Mahoko Ikeda, Yoshitaka Wakabayashi, Koh Okamoto, Shintaro Yanagimoto, Shu Okugawa and Kyoji Moriya

    Citation: AIDS Research and Therapy 2021 18:30

    Content type: Research

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  17. Depression is common among HIV-infected individuals and may contribute to suboptimal adherence to antiretroviral therapy (ART) and subsequent inability to attain viral load (VL) suppression. We evaluated assoc...

    Authors: Brandon Carney, Colton Daniels, Xiaohe Xu, Thankam Sunil, Anuradha Ganesan, Jason M. Blaylock, Karl C. Kronmann, Christina Schofield, Tahaniyat Lalani, Brian Agan and Jason F. Okulicz

    Citation: AIDS Research and Therapy 2021 18:29

    Content type: Short Report

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  18. Coronavirus disease 2019 (COVID-19) was first detected in December 2019. In March 2020, the World Health Organization declared COVID-19 a pandemic. People with underlying medical conditions may be at greater r...

    Authors: Sivaporn Gatechompol, Anchalee Avihingsanon, Opass Putcharoen, Kiat Ruxrungtham and Daniel R. Kuritzkes

    Citation: AIDS Research and Therapy 2021 18:28

    Content type: Review

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  19. Globally Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome (HIV/AIDS) is an ongoing public health issue associated with high morbidity and mortality. Efforts have been made to reduce HIV/AIDS-re...

    Authors: Kefale Lejadiss Workie, Tilahun Yemanu Birhan and Dessie Abebaw Angaw

    Citation: AIDS Research and Therapy 2021 18:27

    Content type: Research

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  20. Dolutegravir (DTG) monotherapy results in virologic failure and the development of DTG resistance. Here, we evaluated virologic outcomes of patients switched to DTG functional mono- or dual therapy with a non-...

    Authors: Charlotte-Paige Rolle, Vu Nguyen, Federico Hinestrosa and Edwin DeJesus

    Citation: AIDS Research and Therapy 2021 18:26

    Content type: Research

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  21. Integrase inhibitors (INIs)-based antiretroviral therapies (ART) are more recommended than efavirenz (EFV)-based ART for people living with HIV/AIDS (PLWHA). Yet, the advantage of integrase inhibitors in treat...

    Authors: Yuanlu Shu, Ziwei Deng, Hongqiang Wang, Yi Chen, Lijialong Yuan, Ye Deng, Xiaojun Tu, Xiang Zhao, Zhihua Shi, Minjiang Huang and Chengfeng Qiu

    Citation: AIDS Research and Therapy 2021 18:25

    Content type: Review

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  22. The first 90 of UNAIDS 90–90–90 targets to have 90% of the people living with HIV know their status is an important entry point to the HIV treatment cascade and care continuum, but evidence shows that there is...

    Authors: S. Jooste, M. Mabaso, M. Taylor, A. North, Y. L. Shean and L. C. Simbayi

    Citation: AIDS Research and Therapy 2021 18:24

    Content type: Research

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  23. Depression is particularly common among adolescents with HIV/AIDS and has been associated with disruption of the important developmental process, subsequently leading to a wide range of negative mental, physic...

    Authors: Getinet Ayano, Sileshi Demelash, Mebratu Abraha and Light Tsegay

    Citation: AIDS Research and Therapy 2021 18:23

    Content type: Review

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  24. In 2013 the Indonesian government introduced the strategic use of antiretroviral therapy (SUFA) initiative of expanding access to HIV test and treatment, to help achieve the UNAIDS 90–90–90 targets. However, t...

    Authors: Yane N. Tarigan, Richard J. Woodman, Emma R. Miller, Rudi Wisaksana and Paul R. Ward

    Citation: AIDS Research and Therapy 2021 18:22

    Content type: Research

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  25. HIV risk remains high among adolescent girls and young women (AGYW, ages 15–24) in Tanzania. Many AGYW experience stigma and provider bias at health facilities, deterring their use of HIV prevention services. ...

    Authors: Julia Tubert, Laura Packel, Lauren A. Hunter, Rashid Mfaume, Prosper Njau, Angela A. Ramadhani, Jenny X. Liu and Sandra I. McCoy

    Citation: AIDS Research and Therapy 2021 18:21

    Content type: Research

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  26. Patients who default from HIV care are usually poorly adherent to antiretroviral treatment which results in suboptimal viral suppression. The study assessed the outcomes of retention in care and viral suppress...

    Authors: R. Jeffrey Edwards, Nyla Lyons, Wendy Samaroo-Francis, Leon-Omari Lavia, Isshad John, Selena Todd, Jonathan Edwards and Gregory Boyce

    Citation: AIDS Research and Therapy 2021 18:20

    Content type: Research

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  27. Human immunodeficiency virus (HIV) and extended spectrum beta lactamase (ESBL) producing Enterobacteriaceae infections are the major challenges in sub-Saharan Africa. Data on the carriage rate of ESBL producin...

    Authors: Biruk Bayleyegn, Roman Fisaha and Desie Kasew

    Citation: AIDS Research and Therapy 2021 18:19

    Content type: Research

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  28. First ambitious target by 2020 of UNAIDS is that 90% of people living with HIV know their HIV status. In people older than 18 months of age, serological confirmation test is recommended to confirm HIV infection.

    Authors: Edmond Tchiakpe, René K. Keke, Nicole Vidal, Moussa Bachabi, Flore Armande Gangbo, Halimatou Diop‑Ndiaye, Coumba Toure‑Kane and Akadiri Yessoufou

    Citation: AIDS Research and Therapy 2021 18:18

    Content type: Case Report

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  29. Failure on second-line antiretroviral therapy (ART) with protease inhibitor (PI) mutations (VF-M) is on the rise. However, there is a paucity of information on the factors associated with this observation in l...

    Authors: Hellen Musana, Jude Thaddeus Ssensamba, Mary Nakafeero, Henry Mugerwa, Flavia Matovu Kiweewa, David Serwadda and Francis Ssali

    Citation: AIDS Research and Therapy 2021 18:17

    Content type: Research

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  30. Progress toward the global target for 95% virological suppression among those on antiretroviral treatment (ART) is still suboptimal. We describe the viral load (VL) cascade, the incidence of virological failur...

    Authors: Anita Mesic, Alexander Spina, Htay Thet Mar, Phone Thit, Tom Decroo, Annick Lenglet, Moe Pyae Thandar, Thin Thin Thwe, Aung Aung Kyaw, Tobias Homan, Mitchell Sangma, Ronald Kremer, Jane Grieg, Erwan Piriou, Koert Ritmeijer, Josefien Van Olmen…

    Citation: AIDS Research and Therapy 2021 18:16

    Content type: Research

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  31. Antiretroviral therapy (ART) adherence is a primary determinant of sustained viral suppression, HIV transmission risk, disease progression and death. The World Health Organization recommends that adherence sup...

    Authors: Rita Nakalega, Nelson Mukiza, Henry Debem, George Kiwanuka, Ronald Makanga Kakumba, Robert Menge, Irene-Kinera Kagimu, Catherine Nakaye, Juliet Allen Babirye, Hellen Kaganzi, Zubair Lukyamuzi, Samuel Kizito, Cynthia Ndikuno Kuteesa and Andrew Mujugira

    Citation: AIDS Research and Therapy 2021 18:15

    Content type: Research

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  32. HIV testing and early linkage to care are critical for reducing the risk of HIV transmission. HIV self-testing (HIVST) is a useful tool for increasing HIV testing frequency.This study aimed to investigate HIVS...

    Authors: Hang Hong, Hong-bo Shi, Hai-bo Jiang, Hong-jun Dong and Yun-liang Shen

    Citation: AIDS Research and Therapy 2021 18:14

    Content type: Research

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  33. The prevalence of disclosure of status to children living with the Human Immunodeficiency Virus (HIV) is low in most sub-Saharan African countries, leading to poor compliance and adverse psychological outcomes...

    Authors: Margaret Amankwah-Poku, Delight Abla Klutsey and Kwaku Oppong Asante

    Citation: AIDS Research and Therapy 2021 18:13

    Content type: Research

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  34. The frequency of new-onset HIV-associated seizure in the HIV-infected patient is estimated to be between 2 and 11%. Identifying the underlying etiology of new-onset seizure will have a vital impact on the mort...

    Authors: Biniyam A. Ayele, Zemichael Getu and Amen Samuel

    Citation: AIDS Research and Therapy 2021 18:12

    Content type: Case Report

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  35. The widely-expressed molecule CD38 is a single-stranded type II transmembrane glycoprotein that is mainly involved in regulating the differentiation and activation state of the cell. CD38 has broad and complex...

    Authors: Liqi Lu, Jie Wang, Qian Yang, Xiuqiao Xie and Yuanshuai Huang

    Citation: AIDS Research and Therapy 2021 18:11

    Content type: Review

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  36. In 2013, the World Health Organisation (WHO) recommended Option B+ as a strategy to prevent mother-to-child transmission (PMTCT) of HIV. In option B+ , lifelong antiretroviral therapy (ART) is offered to all H...

    Authors: Anesu N. Chimwaza, Hannock Tweya, Owen Mugurungi, Angela Mushavi, Solomon Mukungunugwa, Ngwarai Sithole, Justice Nyakura, Mbazi Senkoro, Philip Owiti, Ronald Ncube, Talent Tapera, Winnie Mandewo, Jeffrey K. Edwards, Aveneni Mangombe and Isaac Taramusi

    Citation: AIDS Research and Therapy 2021 18:10

    Content type: Review

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  37. HIV status disclosure facilitates access to HIV-related prevention and treatment services and increases opportunities for social support, HIV risk reduction with partners, and index testing for sexual partners...

    Authors: Amon Exavery, John Charles, Asheri Barankena, Erica Kuhlik, Godfrey Martin Mubyazi, Christina Kyaruzi, Tumainiel Mbwambo, Amal Ally, Remmy Mseya, Levina Kikoyo and Elizabeth Jere

    Citation: AIDS Research and Therapy 2021 18:9

    Content type: Research

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  38. Peer education and HIV risk perception are related to HIV testing uptake among key populations. We aimed to examine the association between peer education, HIV risk perception, and HIV testing uptake, as well ...

    Authors: Yuxi Lin, Chuanxi Li, Lin Wang, Kedi Jiao and Wei Ma

    Citation: AIDS Research and Therapy 2021 18:8

    Content type: Research

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  39. Good adherence to antiretroviral therapy (ART) and retention in care are essential for the effectiveness of an HIV care program. With the current increase in numbers of people living with HIV taking second-lin...

    Authors: Edwin Nuwagira, Boniface A. E. Lumori, Rose Muhindo, Michael Kanyesigye, Abdallah Amir, Winnie Muyindike and Conrad Muzoora

    Citation: AIDS Research and Therapy 2021 18:7

    Content type: Research

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  41. Human immunodeficiency virus attacked an immune cell and the CD4 cell which is responsible for the body’s immune to infectious agents. Acquired immunodeficiency syndrome is one of the major public health probl...

    Authors: Kindu Kebede

    Citation: AIDS Research and Therapy 2021 18:5

    Content type: Research

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  42. There is limited evidence on the modification or stopping of antiretroviral therapy (ART) regimens, including novel antiretroviral drugs. The aim of this study was to evaluate the discontinuation of first ART ...

    Authors: Volkan Korten, Deniz Gökengin, Gülhan Eren, Taner Yıldırmak, Serap Gencer, Haluk Eraksoy, Dilara Inan, Figen Kaptan, Başak Dokuzoğuz, Ilkay Karaoğlan, Ayşe Willke, Mehmet Gönen and Önder Ergönül

    Citation: AIDS Research and Therapy 2021 18:4

    Content type: Research

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  43. Pediatric tuberculosis (TB), human immunodeficiency virus (HIV), and TB-HIV co-infection are health problems with evidence-based diagnostic and treatment algorithms that can reduce morbidity and mortality. Imp...

    Authors: W. Chris Buck, Hanh Nguyen, Mariana Siapka, Lopa Basu, Jessica Greenberg Cowan, Maria Inês De Deus, Megan Gleason, Ferreira Ferreira, Carla Xavier, Benedita Jose, Criménia Muthemba, Beatriz Simione and Peter Kerndt

    Citation: AIDS Research and Therapy 2021 18:3

    Content type: Research

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  44. Pre-exposure prophylaxis (PrEP) for HIV is instrumental in the prevention of HIV for HIV-uninfected persons, by drastically reducing the risk of acquisition in the case of high-risk exposures. Despite its demo...

    Authors: Marie Bistoquet, Alain Makinson, Vincent Tribout, Cyril Perrollaz, Gérard Bourrel, Jacques Reynes and Agnès Oude Engberink

    Citation: AIDS Research and Therapy 2021 18:2

    Content type: Research

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  45. South Africa, with one of the highest HIV prevalences in the world, introduced the universal test and treat (UTT) programme in September 2016. Barriers to sustained viral suppression may include drug resistanc...

    Authors: Pascal O. Bessong, Nontokozo D. Matume and Denis M. Tebit

    Citation: AIDS Research and Therapy 2021 18:1

    Content type: Review

    Published on:

  46. Diagnosis of people living with HIV (PLHIV) is the first step toward achieving the new Fast Track Strategy to end AIDS by 2030: 95-95-95. However, reaching PLHIV is especially difficult in resource-limited set...

    Authors: Mohammad Pour, Linda James, Kamlendra Singh, Samuel Mampunza, Franklin Baer, JoAnna Scott, Michael G. Berg, Mary A. Rodgers, Gavin A. Cloherty, John Hackett Jr and Carole P. McArthur

    Citation: AIDS Research and Therapy 2020 17:67

    Content type: Research

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  47. With increased use of antiretroviral therapy (ART), HIV mortality rates are declining and people living with HIV (PLWH) are surviving longer. We characterized CD4 recovery and viral suppression among adults ag...

    Authors: Emmanuel Bahemana, Allahna Esber, Nicole Dear, Kavitha Ganesan, Ajay Parikh, Domonique Reed, Lucas Maganga, Samoel Khamadi, Mucho Mizinduko, Anange Lwilla, Dorothy Mkondoo, Gwamaka Mwaisanga, Nancy Somi, John Owouth, Jonah Maswai, Francis Kiweewa…

    Citation: AIDS Research and Therapy 2020 17:66

    Content type: Research

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  48. Analytical treatment interruptions (ATI) are commonly used clinical endpoints to assess interventions aimed at curing HIV or achieving antiretroviral therapy (ART)-free HIV remission. Understanding the accepta...

    Authors: Jillian S. Y. Lau, Miranda Z. Smith, Brent Allan, Cipriano Martinez, Jennifer Power, Sharon R. Lewin and James H. McMahon

    Citation: AIDS Research and Therapy 2020 17:65

    Content type: Short Report

    Published on:

  49. A substantial number of persons living with HIV (PLWH) in Nigeria do not experience durable viral suppression on first-line antiretroviral therapy (ART). Understanding risk factors for first-line treatment fai...

    Authors: Nicaise Ndembi, Fati Murtala-Ibrahim, Monday Tola, Jibreel Jumare, Ahmad Aliyu, Peter Alabi, Charles Mensah, Alash’le Abimiku, Miguel E. Quiñones-Mateu, Trevor A. Crowell, Soo-Yon Rhee, Robert W. Shafer, Ravindra Gupta, William Blattner, Manhattan E. Charurat and Patrick Dakum

    Citation: AIDS Research and Therapy 2020 17:64

    Content type: Research

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  50. Tuberculosis (Tb) is the most frequent opportunistic infection among people living with HIV infection. The impact of Tb co-infection in the establishment and maintenance of the HIV reservoir is unclear.

    Authors: Jingna Xun, Tangkai Qi, Lei Zou, Qi Tang, Yinzhong Shen, Junyang Yang, Luman Xie, Yongjia Ji, Renfang Zhang, Li Liu, Jiangrong Wang, Corky Steinhart, Zhenyan Wang, Yang Tang, Wei Song, Jianjun Sun…

    Citation: AIDS Research and Therapy 2020 17:63

    Content type: Research

    Published on:

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AIDS Research and Therapy

ISSN: 1742-6405

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