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  1. AIDS-related KS generally involves cutaneous lesions, that slowly progress over months to years. Neither rapidly progressing of KS nor KS complicated with hemophagocytic syndrome (HPS) has rarely been reported.

    Authors: Pingzheng Mo, Liping Deng, Xiaoping Chen, Yong Xiong and Yongxi Zhang

    Citation: AIDS Research and Therapy 2020 17:58

    Content type: Case Report

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  2. Real-time medication monitoring (RTMM) may potentially enhance adherence to antiretroviral treatment (ART). We describe a participant in an ongoing trial who, shortly after completing trial participation, died...

    Authors: Kennedy Michael Ngowi, Lydia Masika, Furaha Lyamuya, Eva Muro, Blandina T. Mmbaga, Mirjam A. G. Sprangers, Pythia T. Nieuwkerk, Rob E. Aarnoutse, Peter Reiss and I. Marion Sumari-de Boer

    Citation: AIDS Research and Therapy 2020 17:57

    Content type: Case Report

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  3. HIV Self-Testing (HIVST) is universally accepted as an innovative strategy complimenting existing HIV testing services to archive the UNAIDS, 95-95-95 goals by 2030. However, the adoption of HIVST is lagging i...

    Authors: Proches Arobogast Vara, Luyeye Sostenes Buhulula, Fatma Aziz Mohammed and Bernard Njau

    Citation: AIDS Research and Therapy 2020 17:56

    Content type: Research

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  4. Adolescent girls and young women (AGYW) remain disproportionately affected by HIV. In a rural area of South Africa with an annual incidence (2011–2015) of 5 and 7% per annum for 15–19 and 20–24-year olds respe...

    Authors: Sarah E Nakasone, Natsayi Chimbindi, Nondumiso Mthiyane, Busisiwe Nkosi, Thembelihle Zuma, Kathy Baisley, Jaco Dreyer, Deenan Pillay, Sian Floyd, Isolde Birdthistle, Janet Seeley and Maryam Shahmanesh

    Citation: AIDS Research and Therapy 2020 17:55

    Content type: Research

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  5. Cytomegalovirus (CMV) is among the most common opportunistic infections identified in patients with HIV/AIDS. CMV often targets the colon in such patients. However, the role of regulatory T cells (Tregs) and Prog...

    Authors: Lei Sun, Kun Yang, Liang Zhang, Li-ming Qi, Jia-min Chen, Ping Li, Jiang Xiao, Hong-xin Zhao and Peng Wang

    Citation: AIDS Research and Therapy 2020 17:54

    Content type: Research

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  6. In the context of scaling the viral load in resource limited settings, following HIV infected patient’s adults and children with CD4+ T-lymphocyte count still very important in settings where the decentralizat...

    Authors: Bertrand Sagnia, Fabrice Mbakop Ghomsi, Ana Gutierrez, Samuel Sosso, Rachel Kamgaing, Aubin Joseph Nanfack, Nadesh Nji, Georgia Ambada, Abel Lissom, Thibaut Flaurant Tchouangueu, Loveline Ngu Ndengkoh, Irenée Domkam, Godwin Nchinda and Alexis Ndjolo

    Citation: AIDS Research and Therapy 2020 17:53

    Content type: Research

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  7. Hemophagocytic lymphohistiocytosis syndrome (HLS) is an immune-mediated life-threatening disease considered as a medical emergency, with a potentially fatal multisystem inflammatory outcome. We present a patie...

    Authors: Luz A. González-Hernández, Monserrat Alvarez-Zavala, Rodolfo I. Cabrera-Silva, Pedro Martínez-Ayala, Fernando Amador-Lara, Aída S. Ramírez-González, Ana L. Ron-Magaña, Vida V. Ruiz Herrera, Karina Sánchez-Reyes and Jaime F. Andrade-Villanueva

    Citation: AIDS Research and Therapy 2020 17:52

    Content type: Case Report

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  8. The key cause of HIV transmission is failure to provide adequate information about HIV/AIDS which is a substantial public health issue in low and middle-income countries. While global health coverage continues...

    Authors: Chilot Desta Agegnehu, Bisrat Misganaw Geremew, Malede Mequanent Sisay, Kindie Fentahun Muchie, Zinash Teferu Engida, Temesgen Worku Gudayu, Daniel Sisay Weldetsadik and Alemneh Mekuriaw Liyew

    Citation: AIDS Research and Therapy 2020 17:51

    Content type: Research

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  9. Real-time, objective measures of adherence to antiretroviral therapy (ART) and pre-exposure prophylaxis (PrEP) are needed to better assess adherence levels and to expedite clinical response for those with subo...

    Authors: Ashley R. Bardon, Jane M. Simoni, Leif M. Layman, Joanne D. Stekler and Paul K. Drain

    Citation: AIDS Research and Therapy 2020 17:50

    Content type: Research

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  10. In resource poor countries like Ethiopia, little is known about the survival of patients treated with antiretroviral therapy which depends on different factors. Evidence shows that mortality has been high part...

    Authors: Abewa Kebede, Fasil Tessema, Gadisa Bekele, Zerihun Kura and Hailu Merga

    Citation: AIDS Research and Therapy 2020 17:49

    Content type: Research

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  11. In Sub-Saharan Africa where HIV disproportionately affects women, heterosexual male sex workers (HMSW) and their female clients are at risk of acquiring or transmitting HIV and other STIs. However, few studies...

    Authors: Richard Muhindo, Andrew Mujugira, Barbara Castelnuovo, Nelson K. Sewankambo, Rosalind Parkes-Ratanshi, Juliet Kiguli, Nazarius Mbona Tumwesigye and Edith Nakku-Joloba

    Citation: AIDS Research and Therapy 2020 17:48

    Content type: Research

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  12. It is well known that people living with HIV (PLWH) is in higher risk for the development of depression and it has also been suggested that the use of efavirenz into the antiretroviral regimens increases even ...

    Authors: Alejandro Checa, Alberto Castillo, Malena Camacho, William Tapia, Isabel Hernandez and Enrique Teran

    Citation: AIDS Research and Therapy 2020 17:47

    Content type: Short Report

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  13. The COVID-19 has been a severe pandemic all around the world. Nowadays the patient with co-infection of HIV and SARS-CoV-2 was rarely reported. Here we reported a special case with HIV and SARS-CoV-2 co-infect...

    Authors: Wu Menghua, Zheng Xin, Liu Jianwei, Zhang Yu and Yao Qinwei

    Citation: AIDS Research and Therapy 2020 17:46

    Content type: Case Report

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  14. The aim of this study was to investigate the effectiveness and tolerability of the combination elvitegravir/cobicistat/tenofovir/emtricitabine plus darunavir (EVG/COB/TFV/FTC + DRV) in treatment-experienced pa...

    Authors: Inés Suárez-García, Cristina Moreno, Marta Ruiz-Algueró, María Jesús Pérez-Elías, Marta Navarro, Marcos Díez Martínez, Pompeyo Viciana, Laura Pérez-Martínez, Miguel Górgolas, Concha Amador, Miguel Alberto de Zárraga and Inma Jarrín

    Citation: AIDS Research and Therapy 2020 17:45

    Content type: Research

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  15. To evaluate the impact of AIDS-defining events (ADE) on long-term mortality of HIV positive individuals on antiretroviral therapy (ART), a retrospective HIV/AIDS treatment cohort study performed in Southwester...

    Authors: Yunxuan Huang, Oulu Zhou, Zhigang Zheng, Yuexiang Xu, Yi Shao, Chunwei Qin, Fengxiang Qin, Jingzhen Lai, Huifang Liu, Rongfeng Chen, Li Ye, Hao Liang, Xionglin Qin and Junjun Jiang

    Citation: AIDS Research and Therapy 2020 17:44

    Content type: Research

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  16. Early detection of viremia in HIV infected patients on anti-retroviral therapy (ART) is important to prevent disease progression as well as accumulation of drug resistance mutations. This makes HIV viral load ...

    Authors: Ashwini Shete, Sampada Dhayarkar, Ashwini Dhamanage, Smita Kulkarni, Manisha Ghate, Shashikala Sangle, Uttam Medhe, Vinita Verma, Shobini Rajan, Toshio Hattori and Raman Gangakhedkar

    Citation: AIDS Research and Therapy 2020 17:43

    Content type: Research

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  17. HIV status disclosure facilitates receipt of HIV prevention and treatment services. Although disclosure to sexual partners, family members or friends has been extensively studied, disclosure to community-based...

    Authors: John Charles, Amon Exavery, Asheri Barankena, Erica Kuhlik, Godfrey M. Mubyazi, Ramadhani Abdul, Alison Koler, Levina Kikoyo and Elizabeth Jere

    Citation: AIDS Research and Therapy 2020 17:42

    Content type: Research

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  18. In pregnancy, reduction of HIV plasma viral load (pVL) for the prevention of vertical transmission is time-constrained. The study primary objective is to investigate factors associated with faster initial HIV ...

    Authors: Jasmini Alagaratnam, Helen Peters, Kate Francis, Natasha Kay, Yvonne Gilleece, Fionnuala P. Finnerty, Rosanna E. Grimes, Sarah Parry, Mags Portman, Brenton C. Wait, Rimi Shah, Sherie Roedling, David A. Hawkins, Sarah Chitty, Liat Sarner, Rebecca Marcus…

    Citation: AIDS Research and Therapy 2020 17:41

    Content type: Research

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  19. The US President’s Emergency Plan for AIDS Relief (PEPFAR) was launched to increase access to antiretroviral treatment (ART) among people living with HIV (PLHIV) and to prevent new HIV infections globally. As ...

    Authors: Andrew T. Boyd, Ikwo Oboho, Heather Paulin, Hammad Ali, Catherine Godfrey, Anand Date and J. Sean Cavanaugh

    Citation: AIDS Research and Therapy 2020 17:40

    Content type: Review

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  20. Antiretroviral treatment has played a pivotal role in the reduction of HIV/AIDS-related morbidity and mortality. However, treatment options can be impaired by the development of antiretroviral treatment failur...

    Authors: Jemberu Nega, Solomon Taye, Yihenew Million, Chaturaka Rodrigo and Setegn Eshetie

    Citation: AIDS Research and Therapy 2020 17:39

    Content type: Research

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  21. Vacuolar encephalomyelopathy, a disregarded diagnosis lately, was a major neurological disease in the terminal stages of human immunodeficiency virus (HIV)-1 infection in the pre-antiretroviral therapy (ART) e...

    Authors: Kazumasa Akagi, Kazuko Yamamoto, Asuka Umemura, Shotaro Ide, Tatsuro Hirayama, Takahiro Takazono, Yoshifumi Imamura, Taiga Miyazaki, Noriho Sakamoto, Hirokazu Shiraishi, Hideaki Takahata, Yoshiaki Zaizen, Junya Fukuoka, Minoru Morikawa, Kazuto Ashizawa, Katsuji Teruya…

    Citation: AIDS Research and Therapy 2020 17:38

    Content type: Case Report

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  22. The human neurotropic virus JC Polyomavirus, a member of the Polyomaviridae family, is the opportunistic infectious agent causing progressive multifocal leukoencephalopathy, typically in immunocompromised individ...

    Authors: Vijay Harypursat, Yihong Zhou, Shengquan Tang and Yaokai Chen

    Citation: AIDS Research and Therapy 2020 17:37

    Content type: Review

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  23. The link between food insecurity and depression in people living with HIV/AIDS (PLWHA) has been explored in numerous studies; however, the existing evidence is inconclusive due to inconsistent results. Therefo...

    Authors: Getinet Ayano, Light Tsegay and Melat Solomon

    Citation: AIDS Research and Therapy 2020 17:36

    Content type: Review

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  24. Adolescents living with HIV (ALHIV) in Malawi experience multiple challenges associated with their illness and various social, environmental, economic and cultural factors. In exploring their various medical c...

    Authors: Blessings N. Kaunda-Khangamwa, Prosperina Kapwata, Kennedy Malisita, Alister Munthali, Effie Chipeta, Sam Phiri and Lenore Manderson

    Citation: AIDS Research and Therapy 2020 17:35

    Content type: Research

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  25. Long acting and permanent contraceptive methods by far are the most effective, very safe and convenient methods than short acting contraceptive methods. But in less developed countries, use of long acting reve...

    Authors: Betselot Yirsaw, Feleke Gebremeskel, Gebrekiros Gebremichael and Tewoderos Shitemaw

    Citation: AIDS Research and Therapy 2020 17:34

    Content type: Research

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  26. Female sex workers (FSW) are considered a key group for HIV transmissions in sub-Saharan Africa. The HIV Care Continuum and HIV drug resistance (HIVDR) among FSW has not been well studied in most countries in ...

    Authors: Jacob Lindman, Mamadu Aliu Djalo, Ansu Biai, Fredrik Månsson, Joakim Esbjörnsson, Marianne Jansson, Patrik Medstrand and Hans Norrgren

    Citation: AIDS Research and Therapy 2020 17:33

    Content type: Research

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  27. Door-to-door distribution of HIV self-testing kits (HIVST) has the potential to increase uptake of HIV testing services (HTS). However, very few studies have explored the social response to and implications of...

    Authors: Chiti Bwalya, Musonda Simwinga, Bernadette Hensen, Lwiindi Gwanu, Able Hang’andu, Chama Mulubwa, Mwelwa Phiri, Richard Hayes, Sarah Fidler, Alwyn Mwinga, Helen Ayles and Virginia Bond

    Citation: AIDS Research and Therapy 2020 17:32

    Content type: Research

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  28. In the era of “test and treat strategy”, CD4 testing remains an important tool for monitoring HIV-infected individuals. Since conventional methods of CD4 count measurement are costly and cumbersome, POC CD4 co...

    Authors: Elmir Elharti, Halima Abbadi, Rajae Bensghir, Kamal Marhoum El Filali, Hajar Elmrabet and Hicham Oumzil

    Citation: AIDS Research and Therapy 2020 17:31

    Content type: Research

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  29. Despite initial high motivation, individuals receiving antiretroviral therapy (ART) for several years may experience incomplete adherence over time, increasing their risk of HIV-related morbidity and mortality...

    Authors: Larissa Jennings Mayo-Wilson, Bianca Devoto, Jessica Coleman, Barbara Mukasa, Angela Shelton, Sarah MacCarthy, Uzaib Saya, Harriet Chemusto and Sebastian Linnemayr

    Citation: AIDS Research and Therapy 2020 17:30

    Content type: Research

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  30. This study aimed to investigate the measures of retention in care (RIC) in persons living with HIV (PLWH) and type 2 diabetes mellitus (T2DM) by age group (younger vs. older adults).

    Authors: Julie Ann Zuniga, Alexandra A. García, Junse Lee and Jungmin Park

    Citation: AIDS Research and Therapy 2020 17:29

    Content type: Research

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  31. Tuberculosis (TB) and human immunodeficiency virus (HIV) co-infection constitute a deadly infectious disease synergy disease and major public health problem throughout the world. The risk of developing active ...

    Authors: Simon Sensalire, Esther Karungi Karamagi Nkolo, Juliana Nabwire, Anna Lawino, Dithan Kiragga, Martin Muhire, Herbert Kadama, Cordelia Katureebe, Proscovia Namuwenge, Joshua Musinguzi, Jacqueline Calnan and Dejene Seyoum

    Citation: AIDS Research and Therapy 2020 17:28

    Content type: Research

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  32. The pressing need to expand the biomedical HIV prevention evidence base during pregnancy is now increasingly recognized. Women’s views regarding participation in such trials and initiating PrEP while pregnant ...

    Authors: Kristen Sullivan, Tiwonge Mtande, Elana Jaffe, Nora Rosenberg, Chifundo Zimba, Irving Hoffman, Maggie Little, Ruth Faden and Anne Drapkin Lyerly

    Citation: AIDS Research and Therapy 2020 17:27

    Content type: Research

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  33. The clinical and laboratory characteristics of AIDS-associated Talaromyces marneffei infection, a rare but a fatal mycosis disease of the central nervous system, remain unclear.

    Authors: Yu-Ye Li, Rong-Jing Dong, Samip Shrestha, Pratishtha Upadhyay, Hui-Qin Li, Yi-Qun Kuang, Xin-Ping Yang and Yun-Gui Zhang

    Citation: AIDS Research and Therapy 2020 17:26

    Content type: Case Report

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  34. Metabolic complications in human immunodeficiency virus (HIV)-infected individuals are common. Prediabetes represents a high risk for future diabetes development. This study aimed to determine the prevalence, ...

    Authors: Angsana Phuphuakrat, Hataikarn Nimitphong, Sirimon Reutrakul and Somnuek Sungkanuparph

    Citation: AIDS Research and Therapy 2020 17:25

    Content type: Research

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  35. To explore the use of illicit drugs by people living with HIV (PLHIV) taking antiretroviral therapy (ART) and their relationship with variables relevant to the management of HIV infection, such as knowledge an...

    Authors: María José Fuster-RuizdeApodaca, Vanessa Castro-Granell, Ana Laguía, Ángeles Jaén, Santiago Cenoz and María José Galindo

    Citation: AIDS Research and Therapy 2020 17:24

    Content type: Research

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  36. The anti-retroviral combination of abacavir/lamivudine plus rilpivirine (ABC/3TC/RPV) is not recommended by international guidelines as the first-line regimen. However, it is potent, well-tolerated, and afford...

    Authors: Sharlene Ho, Joshua Guoxian Wong, Oon Tek Ng, Cheng Chuan Lee, Yee Sin Leo, David Chien Boon Lye and Chen Seong Wong

    Citation: AIDS Research and Therapy 2020 17:23

    Content type: Research

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  37. Pre-treatment drug resistance (PDR) among antiretroviral drug-naïve people living with HIV (PLHIV) represents an important indicator for the risk of treatment failure and the spread of drug resistant HIV varia...

    Authors: F. Neuhann, A. de Forest, E. Heger, A. Nhlema, C. Scheller, R. Kaiser, H. M. Steffen, H. Tweya, G. Fätkenheuer and S. Phiri

    Citation: AIDS Research and Therapy 2020 17:22

    Content type: Research

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  38. People living with HIV are living longer, and can experience physical, mental and social health challenges associated with aging and multimorbidity. Rehabilitation is well positioned to address disability and ...

    Authors: Kelly K. O’Brien, Francisco Ibáñez-Carrasco, Patricia Solomon, Richard Harding, Darren Brown, Puja Ahluwalia, Soo Chan Carusone, Larry Baxter, Charles Emlet, Gayle Restall, Alan Casey, Amrita Ahluwalia, Adria Quigley, Alex R. Terpstra and Nkem Ononiwu

    Citation: AIDS Research and Therapy 2020 17:21

    Content type: Research

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  39. Perinatal HIV infection negatively impacts cognitive functioning of children, main domains affected are working memory, processing speed and executive function. Early ART, even when interrupted, improves neuro...

    Authors: Christelle Ackermann, Savvas Andronikou, Muhammad G. Saleh, Martin Kidd, Mark F. Cotton, Ernesta M. Meintjes and Barbara Laughton

    Citation: AIDS Research and Therapy 2020 17:20

    Content type: Research

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  40. Through universal “test and treat approach” (UTT) it is believed that HIV new infection and AIDS related death will be reduced at community level and through time HIV can be eliminated. With this assumption th...

    Authors: Tadele Girum, Fedila Yasin, Abebaw Wasie, Teha Shumbej, Fitsum Bekele and Bereket Zeleke

    Citation: AIDS Research and Therapy 2020 17:19

    Content type: Research

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  41. About 13 years since the introduction of antiretroviral therapy (ART) for children living with HIV (CLHIV) in Zambia, HIV/AIDS testing and treatment guidelines for children have evolved over the years with lim...

    Authors: Tendai Munthali, Charles Michelo, Paul Mee, Crispin Moyo, Andrew Kashoka, Liswaniso Liswaniso, Innocent Chiboma and Jim Todd

    Citation: AIDS Research and Therapy 2020 17:18

    Content type: Research

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  42. Data on the survival status of older adults on antiretroviral treatment (ART) are scarce in sub-Saharan Africa. The objective of this study was to determine the survival status of people aged 50 years and olde...

    Authors: Joseph Mugisha Okello, Stephen Nash, Paul Kowal, Nirmala Naidoo, Somnath Chatterji, Ties Boerma and Janet Seeley

    Citation: AIDS Research and Therapy 2020 17:17

    Content type: Research

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  43. People with HIV (PHIV) with limited access to health services often experience suboptimal antiretroviral therapy (ART) adherence. We investigated whether a daily text messaging intervention improves ART adhere...

    Authors: Elizabeth M. Sherman, Jianli Niu, Shara Elrod, Kevin A. Clauson, Fadi Alkhateeb and Paula Eckardt

    Citation: AIDS Research and Therapy 2020 17:16

    Content type: Research

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  44. Increased intestinal barrier permeability and subsequent gut microbial translocation are significant contributors to inflammatory non-AIDS comorbidities in people living with HIV (PLWH). Evidence in animal mod...

    Authors: Jing Ouyang, Stéphane Isnard, John Lin, Brandon Fombuena, Debashree Chatterjee, Tomas Raul Wiche Salinas, Delphine Planas, Amélie Cattin, Augustine Fert, Etiene Moreira Gabriel, Laurence Raymond Marchand, Yonglong Zhang, Malcolm Finkelman, Yaokai Chen, Daniel E. Kaufmann, Nicolas Cermakian…

    Citation: AIDS Research and Therapy 2020 17:15

    Content type: Short Report

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  45. The high rate of mortality among HIV-vertically infected adolescents might be favoured by HIV drug resistance (HIVDR) emergence, which calls for timeous actions in this underserved population. We thus sought t...

    Authors: Joseph Fokam, Armanda Nangmo, Carlson Wandum, Desire Takou, Maria Mercedes Santoro, Anne-Esther Njom Nlend, Francis Ndongo Ateba, Paul Koki Ndombo, Nelly Kamgaing, Cedric Kamta, Andre Essiane, Virginie Lambo, Charles Fokunang, Dora Mbanya, Vittorio Colizzi, Carlo-Federico Perno…

    Citation: AIDS Research and Therapy 2020 17:14

    Content type: Research

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  46. The objectives of this study were to investigate the relationships between polymorphisms at the interferon lambda (IFNL) locus and CD4+:CD8+ ratio normalisation in people living with HIV (PLWH) on effective antir...

    Authors: Inês T. Freitas, Willard Tinago, Hirofumi Sawa, Julie McAndrews, Brenda Doak, Charlotte Prior-Fuller, Gerard Sheehan, John S. Lambert, Eavan Muldoon, Aoife G. Cotter, William W. Hall, Patrick W. G. Mallon and Michael J. Carr

    Citation: AIDS Research and Therapy 2020 17:13

    Content type: Research

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  47. Once-daily, single-tablet regimens (STRs) have been associated with improved patient outcomes compared to multi-tablet regimens (MTRs). This study evaluated real world adherence and persistence of HIV antiretr...

    Authors: Joshua Cohen, Anne Beaubrun, Richa Bashyal, Ahong Huang, Jieni Li and Onur Baser

    Citation: AIDS Research and Therapy 2020 17:12

    Content type: Research

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  48. The gut microbiota is emerging as a prominent player in maintaining health through several metabolic and immune pathways. Dysregulation of gut microbiota composition, also known as dysbiosis, is involved in th...

    Authors: Jing Ouyang, Stéphane Isnard, John Lin, Brandon Fombuena, André Marette, Bertrand Routy, Yaokai Chen and Jean-Pierre Routy

    Citation: AIDS Research and Therapy 2020 17:10

    Content type: Review

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  49. The aim of this study was to assess trends in drug resistance and associated clinical and programmatic factors at a national level during the rapid scale up of ART.

    Authors: Pengtao Liu, Hui Xing, Lingjie Liao, Yi Feng, Xuebing Leng, Jing Wang, Wei Kan, Jing Yan, Yang Li, Zhongbao Zuo, Yinghui You, Yuhua Ruan and Yiming Shao

    Citation: AIDS Research and Therapy 2020 17:9

    Content type: Research

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