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  1. Research

    The dynamic changes of interferon lambdas related genes and proteins in JAK/STAT pathway in both acute and chronic HIV-1 infected patients

    Host immune responses during acute HIV-1 infection can influence the viral setpoint, which is a predictor of disease progression. Interferon (IFN)-lambdas are newly classified type III interferons, which use J...

    Guoxian Zhao, Lifeng Liu, Bin Su, Tong Zhang, Peng Chen, Wei Li and Hao Wu

    AIDS Research and Therapy 2017 14:31

    Published on: 17 June 2017

  2. Research

    Clinical characteristics, predictors of immune reconstitution inflammatory syndrome and long-term prognosis in patients with Kaposi sarcoma

    To investigate the predictive factors for the development of Kaposi sarcoma-related immune reconstitution inflammatory syndrome (KS-IRIS) and long-term prognosis in patients starting combined antiretroviral th...

    Patricia Volkow, Gabriela Cesarman-Maus, Pamela Garciadiego-Fossas, Enrique Rojas-Marin and Patricia Cornejo-Juárez

    AIDS Research and Therapy 2017 14:30

    Published on: 30 May 2017

  3. Research

    The developmental effects of HIV and alcohol: a comparison of gestational outcomes among babies from South African communities with high prevalence of HIV and alcohol use

    There is growing evidence of the negative impact of alcohol on morbidity and mortality of individuals living with HIV but limited evidence of in utero effects of HIV and alcohol on exposure on infants.

    Kirsten A. M. Donald, Anne Fernandez, Kasey Claborn, Caroline Kuo, Nastassja Koen, Heather Zar and Dan J. Stein

    AIDS Research and Therapy 2017 14:28

    Published on: 8 May 2017

  4. Research

    Factors associated with pre-treatment HIV RNA: application for the use of abacavir and rilpivirine as the first-line regimen for HIV-infected patients in resource-limited settings

    Abacavir and rilpivirine are alternative antiretroviral drugs for treatment-naïve HIV-infected patients. However, both drugs are only recommended for the patients who have pre-treatment HIV RNA <100,000 copies...

    Sasisopin Kiertiburanakul, David Boettiger, Oon Tek Ng, Nguyen Van Kinh, Tuti Parwati Merati, Anchalee Avihingsanon, Wing-Wai Wong, Man Po Lee, Romanee Chaiwarith, Adeeba Kamarulzaman, Pacharee Kantipong, Fujie Zhang, Jun Yong Choi, Nagalingeswaran Kumarasamy, Rossana Ditangco, Do Duy Cuong…

    AIDS Research and Therapy 2017 14:27

    Published on: 5 May 2017

  5. Research

    COHORT PROFILE: The Complications of Long-Term Antiretroviral Therapy study in Uganda (CoLTART), a prospective clinical cohort

    Antiretroviral therapy (ART) improves the survival and quality of life of HIV-positive individuals, but the effects of long-term ART use do eventually manifest. The Complications of Long-Term Antiretroviral Th...

    Billy Nsubuga Mayanja, Ivan Kasamba, Jonathan Levin, Ivan Namakoola, Patrick Kazooba, Jackson Were, Pontiano Kaleebu and Paula Munderi

    AIDS Research and Therapy 2017 14:26

    Published on: 4 May 2017

  6. Research

    Hospital days attributable to immune reconstitution inflammatory syndrome in persons living with HIV before and after the 2012 DHHS HIV guidelines

    Immune reconstitution inflammatory syndrome (IRIS) can manifest with initiation or reintroduction of antiretroviral therapy (ART) in persons living with HIV (PLWH). In 2012, updated United States treatment gui...

    Peter Liu, Rebecca Dillingham and Kathleen A. McManus

    AIDS Research and Therapy 2017 14:25

    Published on: 2 May 2017

    The Erratum to this article has been published in AIDS Research and Therapy 2017 14:29

  7. Research

    Molecular diagnosis of central nervous system opportunistic infections and mortality in HIV-infected adults in Central China

    CSF PCR is the standard diagnostic technique used in resource-rich settings to detect pathogens of the CNS infection. However, it is not currently used for routine CSF testing in China. Knowledge of CNS opport...

    Rongrong Yang, Hong Zhang, Yong Xiong, Xien Gui, Yongxi Zhang, Liping Deng, Shicheng Gao, Mingqi Luo, Wei Hou and Deyin Guo

    AIDS Research and Therapy 2017 14:24

    Published on: 2 May 2017

  8. Research

    Factors associated with loss to follow-up after occupational HIV exposure in Cape Town, South Africa: a retrospective cohort study

    There is limited data on factors associated with loss to follow-up (LTFU) of health care workers (HCWs) following occupational exposure to HIV, and most studies were conducted in an era when poorly tolerated a...

    Nectarios Sophocles Papavarnavas, Kathryn Manning, Fahd Conrad, Milah Govender and Gary Maartens

    AIDS Research and Therapy 2017 14:23

    Published on: 21 April 2017

  9. Research

    What influences quality of life in older people living with HIV?

    People with HIV with access to treatment are growing older and living healthier lives than in the past, and while health improvements and increased survival rates are welcome, the psychological and social cons...

    Jose Catalan, Veronica Tuffrey, Damien Ridge and Dana Rosenfeld

    AIDS Research and Therapy 2017 14:22

    Published on: 11 April 2017

  10. Research

    Validity assessment of the PROMIS fatigue domain among people living with HIV

    To evaluate psychometric characteristics and cross-sectional and longitudinal validity of the 7-item PROMIS® Fatigue Short Form and additional fatigue items among people living with HIV (PLWH) in a nationally dis...

    L. E. Gibbons, R. Fredericksen, D. S. Batey, L. Dant, T. C. Edwards, K. H. Mayer, W. C. Mathews, L. S. Morales, M. J. Mugavero, F. M. Yang, E. Paez, M. M. Kitahata, D. L. Patrick, H. M. Crane and P. K. Crane

    AIDS Research and Therapy 2017 14:21

    Published on: 11 April 2017

  11. Research

    Comparison of six methods to estimate adherence in an ART-naïve cohort in a resource-poor setting: which best predicts virological and resistance outcomes?

    Incomplete adherence to antiretroviral therapy (ART) results in virologic failure and resistance. It remains unclear which adherence measure best predicts these outcomes. We compared six patient-reported and o...

    Catherine Orrell, Karen Cohen, Rory Leisegang, David R. Bangsberg, Robin Wood and Gary Maartens

    AIDS Research and Therapy 2017 14:20

    Published on: 4 April 2017

  12. Research

    Antiretroviral therapy supply chain quality control and assurance in improving people living with HIV therapeutic outcomes in Cameroon

    Evaluation of medication efficacy and safety is an essential guarantee to successful therapeutic outcome in public health practices. However, larger distribution chain supply in developing countries such as Ca...

    M. P. Ngogang Djobet, David Singhe, Julienne Lohoue, Christopher Kuaban, Jeanne Ngogang and Ernest Tambo

    AIDS Research and Therapy 2017 14:19

    Published on: 4 April 2017

  13. Research

    CLINICAL outcomes and loss to follow-up among people living with HIV participating in the NAMWEZA intervention in Dar es Salaam, Tanzania: a prospective cohort study

    Psychosocial factors have been linked with loss to follow-up (LTFU) and clinical outcomes among people living with HIV (PLH), however little is known about the effect of psychosocial support on LTFU among PLH ...

    Hellen N. Siril, Sylvia F. Kaaya, Mary Kay Smith Fawzi, Expeditho Mtisi, Magreat Somba, Japheth Kilewo, Ferdinand Mugusi, Anna Minja, Anna Kaale and Jim Todd

    AIDS Research and Therapy 2017 14:18

    Published on: 28 March 2017

  14. Research

    Determinants to antiretroviral treatment non-adherence among adult HIV/AIDS patients in northern Ethiopia

    Adhering 95% and above of antiretroviral therapy reduces the rate of disease progression and death among people’s living human immunodeficiency virus. Though manifold factors have reported as determinant facto...

    Berhe Beyene Gebrezgabher, Yigzaw Kebede, Melaku Kindie, Desalegn Tetemke, Mebrahtu Abay and Yalemzewod Assefa Gelaw

    AIDS Research and Therapy 2017 14:16

    Published on: 21 March 2017

  15. Research

    Impaired human immunodeficiency virus type 1 replicative fitness in atypical viremic non-progressor individuals

    Progression rates from initial HIV-1 infection to advanced AIDS vary significantly among infected individuals. A distinct subgroup of HIV-1-infected individuals—termed viremic non-progressors (VNP) or controll...

    Jan Weber, Richard M. Gibson, Lenka Sácká, Dmytro Strunin, Jan Hodek, Jitka Weberová, Marcela Pávová, David J. Alouani, Robert Asaad, Benigno Rodriguez, Michael M. Lederman and Miguel E. Quiñones-Mateu

    AIDS Research and Therapy 2017 14:15

    Published on: 20 March 2017

  16. Research

    Joint longitudinal data analysis in detecting determinants of CD4 cell count change and adherence to highly active antiretroviral therapy at Felege Hiwot Teaching and Specialized Hospital, North-west Ethiopia (Amhara Region)

    Adherence and CD4 cell count change measure the progression of the disease in HIV patients after the commencement of HAART. Lack of information about associated factors on adherence to HAART and CD4 cell count...

    Awoke Seyoum, Principal Ndlovu and Zewotir Temesgen

    AIDS Research and Therapy 2017 14:14

    Published on: 16 March 2017

  17. Research

    Possible misdiagnosis of HIV associated lymphoma as tuberculosis among patients attending Uganda Cancer Institute

    Early diagnosis of HIV associated lymphoma is challenging because the definitive diagnostic procedure of biopsy, requires skills and equipment that are not readily available. As a consequence, diagnosis may be...

    Paul Buyego, Lydia Nakiyingi, Henry Ddungu, Stephen Walimbwa, Damalie Nalwanga, Steven J Reynolds and Rosalind Parkes-Ratanshi

    AIDS Research and Therapy 2017 14:13

    Published on: 14 March 2017

  18. Research

    Effect of Moringa oleifera Lam. leaf powder on the pharmacokinetics of nevirapine in HIV-infected adults: a one sequence cross-over study

    Moringa oleifera Lam., an herb commonly consumed by HIV-infected people on antiretroviral therapy, inhibits cytochrome P450 3A4, 1A2 and 2D6 activity in vitro; and may alter the pharma...

    Tsitsi G. Monera-Penduka, Charles C. Maponga, Alan R. Wolfe, Lubbe Wiesner, Gene D. Morse and Charles F. B. Nhachi

    AIDS Research and Therapy 2017 14:12

    Published on: 14 March 2017

  19. Research

    Characterization of occult hepatitis B virus infection among HIV positive patients in Cameroon

    Occult hepatitis B infection (OBI) among HIV positive patients varies widely in different geographic regions. We undertook a study to determine the prevalence of occult hepatitis B infection among HIV infected...

    George Gachara, Tshifhiwa Magoro, Lufuno Mavhandu, Emmaculate Lum, Helen K. Kimbi, Roland N. Ndip and Pascal O. Bessong

    AIDS Research and Therapy 2017 14:11

    Published on: 8 March 2017

  20. Research

    HIV care in Yangon, Myanmar; successes, challenges and implications for policy

    Approximately 0.8% of adults aged 18–49 in Myanmar are seropositive for Human Immunodeficiency Virus (HIV). Identifying the demographic, epidemiological and clinical characteristics of people living with HIV (...

    Ne Myo Aung, Josh Hanson, Tint Tint Kyi, Zaw Win Htet, David A. Cooper, Mark A. Boyd, Mar Mar Kyi and Htin Aung Saw

    AIDS Research and Therapy 2017 14:10

    Published on: 4 March 2017

  21. Research

    Late presentation increases risk and costs of non-infectious comorbidities in people with HIV: an Italian cost impact study

    Late presentation (LP) at the time of HIV diagnosis is defined as presentation with AIDS whatever the CD4 cell count or with CD4 <350 cells/mm. The objective of our study was to assess the prevalence of non-in...

    Giovanni Guaraldi, Stefano Zona, Marianna Menozzi, Thomas D. Brothers, Federica Carli, Chiara Stentarelli, Giovanni Dolci, Antonella Santoro, Ana Rita Domingues Da Silva, Elisa Rossi, Julian Falutz and Cristina Mussini

    AIDS Research and Therapy 2017 14:8

    Published on: 16 February 2017

  22. Short report

    H1N1 influenza vaccination in HIV-infected women on effective antiretroviral treatment did not induce measurable antigen-driven proliferation of the HIV-1 proviral reservoir

    Antigen-induced activation and proliferation of HIV-1-infected cells is hypothesized to be a mechanism of HIV persistence during antiretroviral therapy. The objective of this study was to determine if prolifer...

    Thor A. Wagner, Hannah C. Huang, Christen E. Salyer, Kelly M. Richardson, Adriana Weinberg, Sharon Nachman and Lisa M. Frenkel

    AIDS Research and Therapy 2017 14:7

    Published on: 13 February 2017

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