Episomal 2-long terminal repeat (LTR) HIV-1 cDNA, a by-product of HIV-1 infection, is used in clinical trials as a marker for ongoing viral replication. It would be useful to employ 2-LTR cDNA to monitor crypt...
Authors: Chong Xu, Joseph A Politch, Kenneth H Mayer and Deborah J Anderson
RNA and DNA aptamers specific for HIV-1 reverse transcriptase (RT) can inhibit reverse transcription in vitro. RNA aptamers have been shown to potently block HIV-1 replication in culture. We previously reported m...
Authors: Timothy S Fisher, Pheroze Joshi and Vinayaka R Prasad
Murine leukemia virus (MLV) vector particles can be pseudotyped with a truncated variant of the human immunodeficiency virus type 1 (HIV-1) envelope protein (Env) and selectively target gene transfer to human ...
Authors: Sandra Siegert, Sonja Thaler, Ralf Wagner and Barbara S Schnierle
The neurofilament is a major structural component of myelinated axons. Increased cerebrospinal fluid (CSF) concentrations of the light chain of the neurofilament protein (NFL) can serve as a sensitive indicato...
Authors: Magnus Gisslén, Lars Rosengren, Lars Hagberg, Steven G Deeks and Richard W Price
In Cambodia, nearly half of pregnant women attend antenatal care (ANC), which is an entry point of services for prevention of mother-to-child transmission of HIV (PMTCT). However, most of ANC services are prov...
Authors: Koum Kanal, Thai Leang Chou, Ly Sovann, Yasuo Morikawa, Yumi Mukoyama and Kazuhiro Kakimoto
Observational studies have suggested that low serum vitamin levels are associated with increased mother-to-child transmission (MTCT) of HIV and increased preterm delivery. We aimed to determine the efficacy of...
Authors: Edward J Mills, Ping Wu, Dugald Seely and Gordon H Guyatt
Today, scientists are often encouraged to custom-design vaccines based on a particular country or clade. Here, we review the scientific literature and then suggest that the overwhelming endeavor to produce a u...
Authors: Karen S Slobod, Chris Coleclough, Scott A Brown, John Stambas, Xiaoyan Zhan, Sherri Surman, Bart G Jones, Amy Zirkel, Pamela J Freiden, Brita Brown, Robert Sealy, Mattia Bonsignori and Julia L Hurwitz
Protease inhibitors (PIs) block HIV-1 maturation into an infectious virus particle by inhibiting the protease processing of gag and gag-pol precursor proteins. We have used a simple anti-HIV-1 p24 Western blot...
Authors: Heather A Baird, Andre J Marozsan, Michael M Lederman, Alan Landay, Donna Mildvan, Daniel R Kuritzkes, Harold A Kessler and Eric J Arts
RNA interference (RNAi) mediated by small interfering RNAs (siRNAs) has proved to be a highly effective gene silencing mechanism with great potential for HIV/AIDS gene therapy. Previous work with siRNAs agains...
RNA based antiviral approaches against HIV-1 are among the most promising for long-term gene therapy. These include ribozymes, aptamers (decoys), and small interfering RNAs (siRNAs). Lentiviral vectors are ide...
Authors: Akhil Banerjea, Ming-Jie Li, Leila Remling, John Rossi and Ramesh Akkina
Open Access online publishing is the trend of the future for unrestricted rapid and international dissemination of knowledge. Several journals are published on acquired immune deficiency syndrome (AIDS) resear...
