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  1. Access to antiretroviral drugs for HIV-1 infection has increased in sub-Saharan Africa (SSA) during the past few years. Mutations in the HIV-1 genome are often associated with treatment failure as indicated by...

    Authors: Balthazar M Nyombi, Carol Holm-Hansen, Knut I Kristiansen, Gunnar Bjune and Fredrik Müller

    Citation: AIDS Research and Therapy 2008 5:13

    Content type: Research

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  2. Human T-cell leukemia virus type-1 (HTLV-1) induces adult T-cell leukemia/lymphoma (ATL/L), a fatal lymphoproliferative disorder, and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), a chro...

    Authors: Emmanuel Agbottah, Wen-I Yeh, Reem Berro, Zachary Klase, Caitlin Pedati, Kyleen Kehn-Hall, Weilin Wu and Fatah Kashanchi

    Citation: AIDS Research and Therapy 2008 5:12

    Content type: Research

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  3. Human immunodeficiency virus type 1 (HIV-1)-based gene delivery systems are popular due to their superior efficiency of transduction of primary cells. However, these systems cannot be readily used for delivery...

    Authors: Narasimhachar Srinivasakumar

    Citation: AIDS Research and Therapy 2008 5:11

    Content type: Research

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  4. Terpenoid derivatives originating from many plants species, are interesting compounds with numerous biological effects, such as anti-HIV-1 activity. The zinc tetra-ascorbo-camphorate complex (or "C14"), a new ...

    Authors: Héla Saïdi, Mohammad-Ali Jenabian, Bernard Gombert, Charlotte Charpentier, Aurèle Mannarini and Laurent Bélec

    Citation: AIDS Research and Therapy 2008 5:10

    Content type: Research

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  5. Immune restoration disease (IRD) is an adverse consequence of antiretroviral therapy, where the restored pathogen-specific response causes immunopathology. Mycobacteria are the pathogens that most frequently p...

    Authors: Andrew Lim, Lloyd D'Orsogna, Patricia Price and Martyn A French

    Citation: AIDS Research and Therapy 2008 5:9

    Content type: Short report

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  6. Human immunodeficiency virus type 1 (HIV-1) infection and the consequent acquired immunodeficiency syndrome (AIDS) has protean manifestations, including muscle wasting and cardiomyopathy, which contribute to i...

    Authors: Jeffrey S Otis, Yaroslav I Ashikhmin, Lou AnnS Brown and David M Guidot

    Citation: AIDS Research and Therapy 2008 5:8

    Content type: Research

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  7. According to Vietnamese policy, HIV-infected women should have access at least to HIV testing and Nevirapine prophylaxis, or where available, to adequate counselling, HIV infection staging, ARV prophylaxis, an...

    Authors: Thu Anh Nguyen, Pauline Oosterhoff, Yen Pham Ngoc, Pamela Wright and Anita Hardon

    Citation: AIDS Research and Therapy 2008 5:7

    Content type: Research

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  8. Although Venezuela has a National Human Immunodeficiency Virus (HIV) Program offering free diagnosis and treatment, 41% of patients present for diagnosis at a later disease-stage, indicating that access to car...

    Authors: Maeva A Bonjour, Morelba Montagne, Martha Zambrano, Gloria Molina, Catherine Lippuner, Francis G Wadskier, Milvida Castrillo, Renzo N Incani and Adriana Tami

    Citation: AIDS Research and Therapy 2008 5:6

    Content type: Research

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  9. Once-daily (QD) ritonavir 100 mg-boosted fosamprenavir 1400 mg (FPV/r100) or atazanavir 300 mg (ATV/r100), plus tenofovir/emtricitabine (TDF/FTC) 300 mg/200 mg, have not been compared as initial antiretroviral...

    Authors: Kimberly Y Smith, Winkler G Weinberg, Edwin DeJesus, Margaret A Fischl, Qiming Liao, Lisa L Ross, Gary E Pakes, Keith A Pappa and CTracey Lancaster

    Citation: AIDS Research and Therapy 2008 5:5

    Content type: Research

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  10. In a routine service delivery setting in Uganda, we assessed the ability of the WHO clinical stage to accurately identify HIV-infected patients in whom antiretroviral therapy should be started.

    Authors: Shabbar Jaffar, Josephine Birungi, Heiner Grosskurth, Barbara Amuron, Geoffrey Namara, Christine Nabiryo and Alex Coutinho

    Citation: AIDS Research and Therapy 2008 5:4

    Content type: Short report

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  11. Kaposi Sarcoma (KS) is a multifocal angioproliferative neoplasm characterized by inflammation, oedema, neoangiogenesis and spindle cell proliferation. The pathogenesis of human immunodeficiency virus (HIV)-ass...

    Authors: L Feller, JN Masipa, NH Wood, EJ Raubenheimer and J Lemmer

    Citation: AIDS Research and Therapy 2008 5:2

    Content type: Case report

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  12. Gut immune components are severely compromised among persons with AIDS, which allows increased translocation of bacterial lipopolysaccharides (LPS) into the systemic circulation. These microbial LPS are report...

    Authors: Esaki Muthu Shankar, Ramachandran Vignesh, Kailapuri G Murugavel, Pachamuthu Balakrishnan, Ramalingam Sekar, Charmaine AC Lloyd, Suniti Solomon and Nagalingeswaran Kumarasamy

    Citation: AIDS Research and Therapy 2007 4:29

    Content type: Hypothesis

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  13. As HIV treatment is scaled-up in resource-poor settings, the timely identification of persons with HIV infection remains an important challenge. Most people with HIV are unaware of their status, and those who ...

    Authors: Louise C Ivers, Kenneth A Freedberg and Joia S Mukherjee

    Citation: AIDS Research and Therapy 2007 4:28

    Content type: Short report

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  14. The objective of this study was to examine missed opportunities for participation in a prevention of mother-to-child transmission (PMTCT) programme in three sites in South Africa. A rapid anthropological asses...

    Authors: Lungiswa L Nkonki, Tanya M Doherty, Zelee Hill, Mickey Chopra, Nikki Schaay and Carl Kendall

    Citation: AIDS Research and Therapy 2007 4:27

    Content type: Research

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  15. Non-nucleoside reverse transcriptase inhibitor (NNRTI) with stavudine and lamivudine is widely used as the first-line antiretroviral therapy (ART) in resource-limited settings. Lipodystrophy is common and opti...

    Authors: Somnuek Sungkanuparph, Sasisopin Kiertiburanakul, Anucha Apisarnthanarak, Kumthorn Malathum, Siriorn Watcharananan and Boonmee Sathapatayavongs

    Citation: AIDS Research and Therapy 2007 4:26

    Content type: Research

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  16. Epidemiologic studies indicate that bacterial vaginosis (BV), a common alteration of lower genital tract flora in women, is associated with increased susceptibility to HIV infection. Other recent studies show ...

    Authors: Gregory T Spear, Elizabeth St John and MReza Zariffard

    Citation: AIDS Research and Therapy 2007 4:25

    Content type: Review

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  17. Internal polymerase III promoters in retroviral vectors have been used extensively to express short RNA sequences, such as ribozymes, RNA aptamers or short interfering RNA inhibitors, in various positions and ...

    Authors: Stephen E Braun, Xuanling Shi, Gang Qiu, Fay Eng Wong, Pheroze J Joshi, Vinayaka R Prasad and RPaul Johnson

    Citation: AIDS Research and Therapy 2007 4:24

    Content type: Research

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  18. Monitoring dynamics in HIV-1 infection and risk behaviours is important in evaluating, adjusting and scaling up prevention programmes. The objective of this study was to estimate trends in the prevalence of HI...

    Authors: Elia J Mmbaga, Akhtar Hussain, Germana H Leyna, Carol Holm-Hansen, Kagoma S Mnyika, Noel E Sam, Elise Klouman and Knut-Inge Klepp

    Citation: AIDS Research and Therapy 2007 4:23

    Content type: Research

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  19. HIV/AIDS incidence and mortality rates have decreased in the U.S. since 1996. Accompanying the longer life spans of those diagnosed with the disease, however, is a tremendous rise in expenditures on medication...

    Authors: Yonghua Jing, Patricia Klein, Christina ML Kelton, Xing Li and Jeff J Guo

    Citation: AIDS Research and Therapy 2007 4:22

    Content type: Research

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  20. Penicillium marneffei is a dimorphic fungus, endemic in South-east Asia. The fungus causes severe disease in immunocompromised patients such as AIDS. However, no case of immune restoration disease of Penicillium ...

    Authors: Swati Gupta, Purva Mathur, Dipesh Maskey, Naveet Wig and Sarman Singh

    Citation: AIDS Research and Therapy 2007 4:21

    Content type: Case report

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  21. When on the market, microbicides are likely to be used by individuals who do not know their HIV status. Hence, assessment of safety and acceptability among HIV positive men and women is important. Acceptabilit...

    Authors: Gita Ramjee, Neetha S Morar, Sarah Braunstein, Barbara Friedland, Heidi Jones and Janneke van de Wijgert

    Citation: AIDS Research and Therapy 2007 4:20

    Content type: Research

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  22. The introduction of HAART has initially improved the quality of life (QoL) of HIV-positive (HIV+) patients, however body fat redistribution (BFR) and metabolic disorders associated with long-term HAART use may...

    Authors: Eugene Mutimura, Aimee Stewart and Nigel J Crowther

    Citation: AIDS Research and Therapy 2007 4:19

    Content type: Research

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  23. It is critical to understand the pattern of antiretroviral treatment (ART) prescription in different regions of the world as ART procurement needs to be anticipated. We aimed at exploring rates and predictors ...

    Authors: Preeyaporn Srasuebkul, Alexandra Calmy, Jialun Zhou, Nagalingeswaran Kumarasamy, Matthew Law and Poh Lian Lim

    Citation: AIDS Research and Therapy 2007 4:18

    Content type: Research

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  24. Diagnosis of an opportunistic illness (OI) in a person with HIV infection is a sentinel event, indicating opportunities for improving diagnosis of HIV infection and secondary prevention efforts. In the past, r...

    Authors: Patrick S Sullivan, Maxine Denniston, AD McNaghten, Susan E Buskin, Stephanie T Broyles and Eve D Mokotoff

    Citation: AIDS Research and Therapy 2007 4:17

    Content type: Short report

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  25. A segment of the HIV infected population develops abnormal and excessive accumulation of adipose tissue in the trunk, including accumulation of visceral (deep abdominal) adipose tissue. This condition, known a...

    Authors: Kenneth Lichtenstein, Ashok Balasubramanyam, Rajagopal Sekhar and Eric Freedland

    Citation: AIDS Research and Therapy 2007 4:16

    Content type: Review

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  26. Although the introduction of combined therapy with reverse transcriptase and protease inhibitors has resulted in considerable decrease in HIV related mortality; it has also induced the development of multiple ...

    Authors: Amisha Malhotra, Sunanda Gaur, Patricia Whitley-Williams, Caitlin Loomis and Anna Petrova

    Citation: AIDS Research and Therapy 2007 4:15

    Content type: Research

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  27. Human immunodeficiency virus (HIV)-associated adipose redistribution syndrome (HARS) is a fat accumulation disorder characterized by increases in visceral adipose tissue. Patients with HARS may also present wi...

    Authors: Kenneth Lichtenstein, Ashok Balasubramanyam, Rajagopal Sekhar and Eric Freedland

    Citation: AIDS Research and Therapy 2007 4:14

    Content type: Review

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  28. A severely immune-suppressed AIDS patient was suspected of suffering from BK virus (BKV) meningoencephalitis, after being studied for common causes of neurological complications of co-infectious origin. Polyme...

    Authors: José E Vidal, Maria C Fink, Filiberto Cedeno-Laurent, Serena Delbue, Pasquale Ferrante, Rafi F Dauar, Francisco Bonasser Filho, Roberta Schiavon Nogueira, Eduardo E Calore, Claudio S Pannuti, J Roberto Trujillo and Augusto C Penalva de Oliveira

    Citation: AIDS Research and Therapy 2007 4:13

    Content type: Case report

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  29. Sustained use of antiretroviral therapy has been consistently shown to be one of the primary predictors of long-term effectiveness. Switching and discontinuation reflect patient and provider decisions that may...

    Authors: John D Morris, Elizabeth T Golub, Shruti H Mehta, Lisa P Jacobson and Stephen J Gange

    Citation: AIDS Research and Therapy 2007 4:12

    Content type: Research

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  30. During the extended clinically latent period associated with Human Immunodeficiency Virus (HIV) infection the virus itself is far from latent. This phase of infection generally comes to an end with the develop...

    Authors: Simone E Langford, Jintanat Ananworanich and David A Cooper

    Citation: AIDS Research and Therapy 2007 4:11

    Content type: Review

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  31. The immune reconstitution inflammatory syndrome (IRIS) in HIV-infected patients initiating antiretroviral therapy (ART) results from restored immunity to specific infectious or non-infectious antigens. A parad...

    Authors: David M Murdoch, Willem DF Venter, Annelies Van Rie and Charles Feldman

    Citation: AIDS Research and Therapy 2007 4:9

    Content type: Review

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  32. Protease inhibitors, as part of highly active anti-retroviral therapy (HAART), have significantly increased the lifespan of human immunodeficiency virus (HIV) infected patients. Several deleterious side effect...

    Authors: Melinda E Wilson, Kimberly F Allred, Elizabeth M Kordik, Deana K Jasper, Amanda N Rosewell and Anthony J Bisotti

    Citation: AIDS Research and Therapy 2007 4:8

    Content type: Research

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  33. The promise of microbicides as an HIV prevention method will not be realized if not supported by health care providers. They are the primary source of sexual health information for potential users, in both the...

    Authors: Gita Ramjee, Neetha S Morar, James Mtimkulu, Joanne E Mantell and Varanna Gharbaharan

    Citation: AIDS Research and Therapy 2007 4:7

    Content type: Research

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  34. Antiretroviral therapy (ART) with a generic fixed-dose combination (FDC) of stavudine (d4T)/lamivudine (3TC)/nevirapine (NVP) is widely used in developing countries. The clinical data of this FDC among very ad...

    Authors: Weerawat Manosuthi, Sukanya Chimsuntorn, Sirirat Likanonsakul and Somnuek Sungkanuparph

    Citation: AIDS Research and Therapy 2007 4:6

    Content type: Research

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  35. A case of a 15 year old girl with retroviral rebound syndrome after discontinuation of highly active antiretroviral treatment (HAART) due to side effects is presented. The patient was transmitted with HIV at b...

    Authors: Vanda Friman and Magnus Gisslén

    Citation: AIDS Research and Therapy 2007 4:3

    Content type: Case report

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  36. The association between baseline drug resistance mutations and subsequent increase in viral failure has not been established for HIV-infected children. We evaluated drug resistance mutations at 39 codon sites ...

    Authors: Susan A Fiscus, Andrea Kovacs, Leslie A Petch, Chengcheng Hu, Andrew A Wiznia, Lynne M Mofenson, Ram Yogev, Kenneth McIntosh, Stephen I Pelton, Sonia Napravnik, Kenneth Stanley and Sharon A Nachman

    Citation: AIDS Research and Therapy 2007 4:2

    Content type: Research

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  37. CD4+ T lymphocyte (CD4) cell count testing is the standard method for determining eligibility for antiretroviral therapy (ART), but is not widely available in sub-Saharan Africa. Total lymphocyte counts (TLCs)...

    Authors: David M Moore, Anna Awor, Robert S Downing, Willy Were, Peter Solberg, David Tu, Keith Chan, Robert S Hogg and Jonathan Mermin

    Citation: AIDS Research and Therapy 2007 4:1

    Content type: Research

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  38. We evaluated whether FLAVORx helped thirty Thai children take opened capsule, crushed tablets and liquid generic ARVs with more ease. All children had excellent adherence, evaluated by PACTG Standard Internati...

    Authors: Torsak Bunupuradah, Siripan Wannachai, Arpa Chuamchaitrakool, Jintana Intasan, Thantip Nuchapong, Woodie Neiss, Kenny Kramm, Chitsanu Pancharoen, David Burger and Jintanat Ananworanich

    Citation: AIDS Research and Therapy 2006 3:30

    Content type: Short report

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  39. A 4-week, uninterrupted treatment with 9-(2-phosphonyl-methoxypropyly)adenine (PMPA, commonly called tenofovir) completely prevents simian immunodeficiency virus (SIVmne) infection in cynomolgus macaques if treat...

    Authors: Peter Emau, Yonghou Jiang, Michael B Agy, Baoping Tian, Girma Bekele and Che-Chung Tsai

    Citation: AIDS Research and Therapy 2006 3:29

    Content type: Research

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  40. HLA-G gene is a non-classical MHC class 1 molecule that is highly expressed in the trophoblast at the maternal-fetal interface. In an attempt to elucidate possible immunological mechanisms facilitating protection...

    Authors: Felix O Aikhionbare, K Kumaresan, Falah Shamsa and Vincent C Bond

    Citation: AIDS Research and Therapy 2006 3:28

    Content type: Research

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  41. Women continue to be disproportionately affected by HIV in Tanzania, and factors contributing to this situation need to be identified. The objective of this study was to determine social, behavioral and biolog...

    Authors: Sia E Msuya, Elizabeth Mbizvo, Akhtar Hussain, Jacqueline Uriyo, Noel E Sam and Babill Stray-Pedersen

    Citation: AIDS Research and Therapy 2006 3:27

    Content type: Research

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  42. The CD4+ T cell count estimation is an important monitoring tool for HIV disease progression and efficacy of anti-retroviral treatment (ART). Due to availability of ART at low cost in developing countries, que...

    Authors: Madhuri R Thakar, Kishore B Kumar, Bharati A Mahajan, Sanjay M Mehendale and Ramesh S Paranjape

    Citation: AIDS Research and Therapy 2006 3:26

    Content type: Research

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  43. Current HIV/AIDS statistics show that women account for almost 60% of HIV infections in Sub-Saharan Africa. HIV prevention tools such as male and female condoms, abstinence and monogamy are not always feasible...

    Authors: Gita Ramjee, Robin Shattock, Sinead Delany, Ian McGowan, Neetha Morar and Megan Gottemoeller

    Citation: AIDS Research and Therapy 2006 3:25

    Content type: Short report

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