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  1. Identifying those at increased risk of death during TB treatment is a priority in resource-constrained settings. We performed this study to determine predictors of mortality during TB treatment.

    Authors: Dominique J. Pepper, Michael Schomaker, Robert J. Wilkinson, Virginia de Azevedo and Gary Maartens
    Citation: AIDS Research and Therapy 2015 12:35
    Content type: Research Published on:

  2. CCR5-using (r5) HIV-1 predominates during asymptomatic disease followed by occasional emergence of CXCR4-using (x4) or dual tropic (r5x4) virus. We examined the contribution of the x4 and r5 components to repl...

    Authors: Immaculate L Nankya, Denis M Tebit, Awet Abraha, Fred Kyeyune, Richard Gibson, Oyebisi Jegede, Gabrielle Nickel and Eric J Arts
    Citation: AIDS Research and Therapy 2015 12:34
    Content type: Research Published on:

  3. Cryptococcal meningitis is one of the most lethal fungal infections in patients with acquired immune deficiency syndrome (AIDS). The incidence of and mortality from cryptococcal meningitis have markedly decrea...

    Authors: Hideki Hashimoto, Shuji Hatakeyama and Hiroshi Yotsuyanagi
    Citation: AIDS Research and Therapy 2015 12:33
    Content type: Case report Published on:

  4. The objective of this study was to determine the rate of acquired immune deficiency syndrome (AIDS) in Zhejiang province and to identify specific factors associated with progression of this disease.

    Authors: Lin Chen, Jiezhe Yang, Renjie Zhang, Yun Xu, Jinlei Zheng, Jianmin Jiang, Jun Jiang, Lin He, Ning Wang, Philip Chun Yeung and Xiaohong Pan
    Citation: AIDS Research and Therapy 2015 12:32
    Content type: Research Published on:

  5. We evaluated the effectiveness of darunavir (DRV) treatment plus an optimized background regimen in 120 HIV-1 treatment-experienced patients.

    Authors: José Antonio Mata-Marín, Gloria Huerta-García, Juan Carlos Domínguez-Hermosillo, Marcelino Chavez-García, Marco Isaac Banda-Lara, Nohemí Nuñez-Rodríguez, Javier Enrique Cruz-Herrera, Jorge Luis Sandoval-Ramírez, Ivan Martínez-Abarca, Alfredo Francisco Villagómez-Ruíz, Bulmaro Manjarrez-Tellez and Jesús Gaytán-Martínez
    Citation: AIDS Research and Therapy 2015 12:31
    Content type: Research Published on:

  6. Protease inhibitors (PI)s have been associated with distal sensory polyneuropathy (DSP) and metabolic complications in high-income countries. No data exist in Africans where second-line antiretroviral therapy ...

    Authors: John-Randel Vermaak, Joel A. Dave, Naomi Levitt and Jeannine M. Heckmann
    Citation: AIDS Research and Therapy 2015 12:30
    Content type: Research Published on:

  7. Alcohol consumption is prevalent amongst HIV positive population. Importantly, chronic alcohol use is reported to exacerbate HIV pathogenesis. Although alcohol is known to increase oxidative stress, especially...

    Authors: Anusha Ande, Namita Sinha, P. S. S. Rao, Carole P. McArthur, Leo Ayuk, Paul N. Achu, Annette Njinda, Anil Kumar and Santosh Kumar
    Citation: AIDS Research and Therapy 2015 12:29
    Content type: Research Published on:

  8. Human leukocyte antigen (HLA)-B*5701 is strongly associated with developing a hypersensitivity reaction to abacavir (ABC). Limited data exist on HLA-B*5701 prevalence in HIV-1-infected subjects in China. We in...

    Authors: Hongwei Zhang, Tong Zhang, Hongxin Zhao, Ning Han, Haiwei Zhou, Yun He, Qingxia Zhao, Hong Li, Huiqin Li, Mi Zhang, Jianjian Li, Yongtao Sun, Ke Zhao, Qing Liu, Zhiying Liu, Zhen Li…
    Citation: AIDS Research and Therapy 2015 12:28
    Content type: Research Published on:

  9. Although injection drug use drives antiretroviral drug resistance, the prevalence of protease inhibitor (PI) resistance among Kenyan IDUs remains undetermined. We, therefore, explored PI resistance mutations a...

    Authors: Valentine Budambula, Francis O. Musumba, Mark K. Webale, Titus M. Kahiga, Francisca Ongecha-Owuor, James N. Kiarie, George A. Sowayi, Aabid A. Ahmed, Collins Ouma and Tom Were
    Citation: AIDS Research and Therapy 2015 12:27
    Content type: Research Published on:

  10. HIV infected children experience a range of hematological complications which show marked improvement within 6 months of initiating anti-retroviral therapy. The Objectives of the study was to describe the chan...

    Authors: Elizabeth Gathoni Kibaru, Ruth Nduati, Dalton Wamalwa and Nyambura Kariuki
    Citation: AIDS Research and Therapy 2015 12:26
    Content type: Research Published on:

  11. India has a large number of HIV infected patients being followed up at anti-retroviral therapy (ART) centers. The patients are regularly offered CD4 count estimation for deciding their eligibility for ART init...

    Authors: Ashwini Shete, Dharmesh P Singh, Bharati Mahajan, Amol Kokare, Ramesh Paranjape and Madhuri Thakar
    Citation: AIDS Research and Therapy 2015 12:25
    Content type: Research Published on:

  12. A number of metabolic abnormalities, such as dysglycaemia, insulin resistance, lipodystrophy and dyslipidaemia, are associated with the use of antiretroviral drugs. We aimed to assess the effects of long-term ...

    Authors: Zulfa Abrahams, Joel A Dave, Gary Maartens and Naomi S Levitt
    Citation: AIDS Research and Therapy 2015 12:24
    Content type: Research Published on:

  13. It is a challenge to differentiate between HIV-associated neurocognitive disorders (HAND) and other types of neurocognitive disease in the ageing HIV-infected population. Here we describe a 63 year old HIV-inf...

    Authors: Signar Mäkitalo, Åsa Mellgren, Ellen Borgh, Lena Kilander, Tobias Skillbäck, Henrik Zetterberg and Magnus Gisslén
    Citation: AIDS Research and Therapy 2015 12:23
    Content type: Case report Published on:

  14. In Henan, China, first-line antiretroviral treatment (ART) was implemented early in a large number of treatment-experienced patients who were more likely to have a drug resistance. Therefore, we investigated t...

    Authors: Jia Liu, Yasong Wu, Wenjie Yang, Xiujuan Xue, Guoqing Sun, Chunhua Liu, Suian Tian, Dingyong Sun, Qian Zhu and Zhe Wang
    Citation: AIDS Research and Therapy 2015 12:22
    Content type: Research Published on:

  15. Lipodystrophy (LD) is a frequent adverse event of combination antiretroviral therapy (ART) and occurs mainly in patients exposed to first-generation antiretroviral drugs. The aim of this study was to explore a...

    Authors: Charlotte M Verolet, Cécile Delhumeau-Cartier, Marlène Sartori, Simona Toma, Sophie Zawadynski, Minerva Becker, Enos Bernasconi, Laurence Toutous Trellu and Alexandra Calmy
    Citation: AIDS Research and Therapy 2015 12:21
    Content type: Research Published on:

  16. Trends in prevalence of opportunistic infections (OIs) associated with the human immunodeficiency virus (HIV) in resource poor settings have previously not been well documented. The objective of this study was...

    Authors: John Rubaihayo, Nazarius M Tumwesigye and Joseph Konde-Lule
    Citation: AIDS Research and Therapy 2015 12:20
    Content type: Research Published on:

  17. Estimates of the interval from HIV-1 infection to disease progression may be affected by selection bias, and data concerning asymptomatic early seroconverters are limited. We examined the interval until diseas...

    Authors: Dai Watanabe, Sachiko Suzuki, Misa Ashida, Yuka Shimoji, Kazuyuki Hirota, Yoshihiko Ogawa, Keishiro Yajima, Daisuke Kasai, Yasuharu Nishida, Tomoko Uehira and Takuma Shirasaka
    Citation: AIDS Research and Therapy 2015 12:19
    Content type: Research Published on:

  18. A 21 year old MSM patient with newly diagnosed HIV infection was hospitalized in our department after ingestion of an overdose of his antiretroviral therapy (ART) comprising dolutegravir (DTG - Tivicay®) and t...

    Authors: Marcel Lee, Florian Eyer, Norbert Felgenhauer, Hartwig HF Klinker and Christoph D Spinner
    Citation: AIDS Research and Therapy 2015 12:18
    Content type: Case report Published on:

  19. To determine the levels of NT-pro BNP in HIV patients over 40 years who are receiving highly active antiretroviral therapy (HAART) and investigating potential independent clinical or laboratory factors.

    Authors: Julián Olalla, Elena Crespo, Javier De la Torre, Marco Sempere, Alfonso Del Arco, José Luis Prada, Rocío Malvarez, Javier Pérez and Javier García-Alegría
    Citation: AIDS Research and Therapy 2015 12:17
    Content type: Research Published on:

  20. Sporotrichosis is an infection caused by a dimorphic fungus of the Sporothrix schenckii complex. Host immunity is an important factor in the clinical manifestations of the disease. Deeply immunocompromised indivi...

    Authors: Ariane Gomes Paixão, Maria Clara Gutierrez Galhardo, Rodrigo Almeida-Paes, Estevão Portela Nunes, Marcelo Luiz Carvalho Gonçalves, Gisele Larias Chequer and Cristiane da Cruz Lamas
    Citation: AIDS Research and Therapy 2015 12:16
    Content type: Case report Published on:

  21. Codes of confidentiality play an essential role in the intimate discourses in many learned professions. Codes with various prescriptions exist. The Hippocratic Oath for example, prescribes rewards to the secre...

    Authors: Amos K Laar, Debra A DeBruin and Susan Craddock
    Citation: AIDS Research and Therapy 2015 12:15
    Content type: Research Published on:

  22. Little evidence exists on the connections between nutrition, diet intake, and quality of life (QoL) among people living with HIV (PLHIV). The study aimed to estimate the prevalence of under-nutrition among PLH...

    Authors: Rajshree Thapa, Archana Amatya, Durga Prasad Pahari, Kiran Bam and M Sophia Newman
    Citation: AIDS Research and Therapy 2015 12:14
    Content type: Research Published on:

  23. We report a rare case of osteonecrosis of the jaw following necrotizing gingivitis in a Japanese AIDS patient. Intraoral examination showed exposed necrotic bone in the left mandible and spontaneous loss of te...

    Authors: Yusuke Zushi, Kazuma Noguchi, Kuniyasu Moridera, Kazuki Takaoka and Hiromitsu Kishimoto
    Citation: AIDS Research and Therapy 2015 12:13
    Content type: Case report Published on:

  24. New evidence has emerged regarding when to commence antiretroviral therapy (ART), optimal treatment regimens, management of HIV co-infection with opportunistic infections, and management of ART failure. The 20...

    Authors: Weerawat Manosuthi, Sumet Ongwandee, Sorakij Bhakeecheep, Manoon Leechawengwongs, Kiat Ruxrungtham, Praphan Phanuphak, Narin Hiransuthikul, Winai Ratanasuwan, Ploenchan Chetchotisakd, Woraphot Tantisiriwat, Sasisopin Kiertiburanakul, Anchalee Avihingsanon, Akechittra Sukkul and Thanomsak Anekthananon
    Citation: AIDS Research and Therapy 2015 12:12
    Content type: Review Published on:

  25. An HIV-1 tropism test is recommended prior to CCR5 antagonist administration to exclude patients harboring non-R5 virus from treatment with this class of antiretrovirals. HIV-1 tropism determination based on p...

    Authors: Russell E Baumann, Amy A Rogers, Hasnah B Hamdan, Harold Burger, Barbara Weiser, Wei Gao, Kathryn Anastos, Mary Young, William A Meyer III, Rick L Pesano and Ron M Kagan
    Citation: AIDS Research and Therapy 2015 12:11
    Content type: Research Published on:

  26. Polymorphisms in cytochrome P450 2B6 (CYP2B6) affect the steady state plasma concentration of nevirapine. CYP2B6 516G>T and 983T>C are common in African populations, but data on their influence on plasma nevir...

    Authors: Margaret Ngwono Oluka, Faith Apolot Okalebo, Anastasia Nkatha Guantai, R Scott McClelland and Susan M Graham
    Citation: AIDS Research and Therapy 2015 12:10
    Content type: Research Published on:

  27. MDD and HIV/AIDS have a high prevalence worldwide with severe consequences for patients. In both conditions, compliance with treatment is key to successfully treat these disorders. In the current study, we exa...

    Authors: Francois N Slabbert, Brian H Harvey, Christiaan B Brink and Martie S Lubbe
    Citation: AIDS Research and Therapy 2015 12:9
    Content type: Research Published on:

  28. Tubular dysfunction is common in HIV-infected people and detection of proteinuria is essential to identify this problem. In low-income countries, resources for detection of proteinuria using the Kidney Disease...

    Authors: José Ignacio López De León, Jose Antonio Mata-Marín, Karen Andrade-Fuentes, Gloria Huerta-Garcia, Juan C Domínguez-Hemosillo and Jesus Gaytán-Martínez
    Citation: AIDS Research and Therapy 2015 12:8
    Content type: Research Published on:

  29. Antimalarials quinacrine (Qc) and chloroquine (Cq) intercalate DNA, potentiate the activity of other drugs and have lysosomotropic, anti-inflammatory and antiviral activities that could increase the effect of ...

    Authors: Klintsy J Torres, Gustavo Reyes-Terán, Julio Sotelo, Helgi Jung-Cook and Lucinda Aguirre-Cruz
    Citation: AIDS Research and Therapy 2015 12:7
    Content type: Short report Published on:

  30. Antiretroviral treatment (ART) has been effective in reducing HIV/AIDS related morbidity and mortality. However, the use and uptake of ART has resulted in adverse reactions, due mainly to the medicine’s toxici...

    Authors: Lieketseng J Masenyetse, Samuel OM Manda and Henry G Mwambi
    Citation: AIDS Research and Therapy 2015 12:6
    Content type: Research Published on:

  31. The emergence of transmitted drug resistance (TDR) compromises the effect of antiretroviral therapy (ART), resulting in treatment failure of human immunodeficiency virus (HIV) disease. Although more than a dec...

    Authors: Tomohiro Kotaki, Siti Qamariyah Khairunisa, Adiana Mutamsari Witaningrum, Muhammad Qushai Yunifiar M, Septhia Dwi Sukartiningrum, Muhammad Noor Diansyah, Retno Pudji Rahayu, Nasronudin and Masanori Kameoka
    Citation: AIDS Research and Therapy 2015 12:5
    Content type: Research Published on:

  32. HIV infection may be associated with an increased recurrence rate of myocardial infarction. Our aim was to determine whether HIV infection is a risk factor for worse outcomes in patients with coronaray artery ...

    Authors: David Carballo, Cécile Delhumeau, Sebastian Carballo, Caroline Bähler, Dragona Radovanovic, Bernard Hirschel, Olivier Clerc, Enos Bernasconi, Dominique Fasel, Patrick Schmid, Alexia Cusini, Jan Fehr, Paul Erne, Pierre-Fréderic Keller, Bruno Ledergerber and Alexandra Calmy
    Citation: AIDS Research and Therapy 2015 12:4
    Content type: Research Published on:

  33. The availability of HIV antiretroviral therapy (ART) has been associated with the development of transmitted drug resistance-associated mutations (TDRM). TDRM can compromise treatment effectiveness in patients...

    Authors: Awachana Jiamsakul, Sunee Sirivichayakul, Rossana Ditangco, Ka-Hing Wong, Patrick CK Li, Jutarat Praparattanapan, Praphan Phanuphak, Edelwisa Segubre-Mercado, Wing-Cheong Yam, Thira Sirisanthana, Thida Singtoroj and Matthew Law
    Citation: AIDS Research and Therapy 2015 12:3
    Content type: Short report Published on:

  34. The Human Immune Deficiency Virus (HIV) can manifest neurologically in both adults and children. Early invasion of the central nervous system by the virus, affecting the developing brain, is believed to result...

    Authors: Kirsten A Donald, Kathleen G Walker, Tracy Kilborn, Henri Carrara, Nelleke G Langerak, Brian Eley and Jo M Wilmshurst
    Citation: AIDS Research and Therapy 2015 12:2
    Content type: Research Published on:

  35. While HIV, AIDS and atypical Mycobacterium infections are closely linked, the use of Integrase-Inhibitor based cART, notably raltegravir-based regimens is more widespread. RAL should be double-dosed to 800 mg ...

    Authors: Christoph D Spinner, Florian Wille, Christiane Schwerdtfeger, Philipp Thies, Ursula Tanase, Guido Von Figura, Roland M Schmid, Werner J Heinz and Hartwig Hf Klinker
    Citation: AIDS Research and Therapy 2015 12:1
    Content type: Short report Published on:

  36. Treatments in patients with multidrug resistance often involve the use of multiple agents with partial antiviral activity and overlapping metabolic toxicities. Enfuvirtide is therefore a welcome addition to th...

    Authors: Gloria Huerta-García, Marcelino Chavez-García, José Antonio Mata-Marín, Jorge Sandoval-Ramírez, Juan Domínguez-Hermosillo, Ana Lourdes Rincón-Rodríguez and Jesús Gaytán-Martínez
    Citation: AIDS Research and Therapy 2014 11:323
    Content type: Research Published on:

  37. Cobicistat is an alternative pharmacoenhancer to ritonavir. In healthy volunteers, darunavir exposure was comparable when darunavir 800 mg once daily was co-administered with cobicistat 150 mg once daily (as s...

    Authors: Karen Tashima, Gordon Crofoot, Frank L Tomaka, Thomas N Kakuda, Anne Brochot, Tom Van de Casteele, Magda Opsomer, William Garner, Nicolas Margot, Joseph M Custodio, Marshall W Fordyce and Javier Szwarcberg
    Citation: AIDS Research and Therapy 2014 11:39
    Content type: Research Published on:

  38. Abnormal NK phenotype and cytotoxic functions have been described in acute myeloid leukemia, chronic lymphocytic leukemia, myeloma and myelodysplastic syndromes. Defective NK cytotoxicity is due to decreased e...

    Authors: Delphine Mercier-Bataille, Carole Sanchez, Céline Baier, Thérèse Le Treut, Nicolas Mounier, Saadia Mokhtari, Daniel Olive, Karine Baumstarck, Gérard Sébahoun, Caroline Besson and Régis T Costello
    Citation: AIDS Research and Therapy 2014 11:38
    Content type: Research Published on:

  39. We report a case of an adult patient with human immunodeficiency virus (HIV), acute respiratory distress syndrome (ARDS) and ventilator associated pneumonia (VAP) caused by multidrug resistant (MDR) bacteria t...

    Authors: Robertas Samalavicius, Mindaugas Serpytis, Donata Ringaitiene, Daiva Grazulyte, Ruta Bertasiute, Bernardas Rimkus, Raimonda Matulionyte, Ruta Ambrazaitiene, Jurate Sipylaite, Tomas Kacergius and Laimonas Griskevicius
    Citation: AIDS Research and Therapy 2014 11:37
    Content type: Case report Published on:

  40. We built a cohort study of HIV patients taking long-term first-line Antiretroviral Therapy in 2003. In this assay, we focused on the development of primary drug resistance mutations against Non-Nucleoside Reve...

    Authors: Yuncong Wang, Hui Xing, Lingjie Liao, Zhe Wang, Bin Su, Quanbi Zhao, Yi Feng, Pengfei Ma, Jia Liu, Jianjun Wu, Yuhua Ruan and Yiming Shao
    Citation: AIDS Research and Therapy 2014 11:36
    Content type: Research Published on:

  41. A number of antiviral agents used against Human Immunodeficiency Virus (HIV) infection and hepatitis B virus (HBV) mono or co-infection have been associated with real nephrotoxicity (including tenofovir disopr...

    Authors: Stephen G Holt, David M Gracey, Miriam T Levy, David W Mudge, Ashley B Irish, Rowan G Walker, Richard Baer, Jacob Sevastos, Riaz Abbas and Mark A Boyd
    Citation: AIDS Research and Therapy 2014 11:35
    Content type: Review Published on:

  42. We report a 57-year old man with diabetes mellitus and hypertension who presented with acute HIV infection. Routine blood tests showed an elevated blood urea nitrogen and creatinine. Renal biopsy showed acute ...

    Authors: Jintanat Ananworanich, Anandita A Datta, James LK Fletcher, Natavudh Townamchai, Nitiya Chomchey, Eugene Kroon, Irini Sereti, Victor Valcour and Jerome H Kim
    Citation: AIDS Research and Therapy 2014 11:34
    Content type: Case report Published on:

  43. Ongoing HIV-1 replication in lymphoid cells is one explanation of the persistence of HIV-1 reservoirs despite highly active antiretroviral therapy (cART). We tested the potential of cART intensification by Mar...

    Authors: Alain Lafeuillade, Assi Assi, Cécile Poggi, Caroline Bresson-Cuquemelle, Eric Jullian and Catherine Tamalet
    Citation: AIDS Research and Therapy 2014 11:33
    Content type: Research Published on:

  44. Increasing numbers of HIV-infected patients in sub-Saharan Africa are exposed to antiretroviral therapy (ART), but there are few data on lipid changes on first-line ART, and even fewer on second-line.

    Authors: Zvenyika AR Gomo, James G Hakim, Sarah A Walker, Willard Tinago, Gibson Mandozana, Cissy Kityo, Paula Munderi, Elly Katabira, Andrew Reid, Diana M Gibb and Charles F Gilks
    Citation: AIDS Research and Therapy 2014 11:32
    Content type: Research Published on:

  45. Sexually transmitted infections (STIs) contribute largely to the burden of health in South Africa and are recognized as major contributors to the human immunodeficiency virus (HIV) epidemic. Young women are pa...

    Authors: Sarita Naidoo, Handan Wand, Nathlee Samantha Abbai and Gita Ramjee
    Citation: AIDS Research and Therapy 2014 11:31
    Content type: Short report Published on:

  46. The CD5 protein antagonizes phosphorylation events downstream of T cell receptor (TCR) engagement to decrease T cell responsiveness. CD5-negative T cell clones respond preferentially over their CD5+ counterparts ...

    Authors: Stephen J Penney, Maureen E Gallant and Michael D Grant
    Citation: AIDS Research and Therapy 2014 11:30
    Content type: Research Published on:

  47. While Brazil has had a long-standing policy of free access to antiretroviral therapy (ART) for all in need, the epidemiological impact of ART on human immunodeficiency virus (HIV) RNA suppression in this middl...

    Authors: Sandra W Cardoso, Paula M Luz, Luciane Velasque, Thiago Torres, Lara Coelho, Kenneth A Freedberg, Valdilea G Veloso, Rochelle P Walensky and Beatriz Grinsztejn
    Citation: AIDS Research and Therapy 2014 11:29
    Content type: Research Published on:

  48. The 2014 International Symposium on HIV and Emerging Infectious Diseases (ISHEID) provided a forum for investigators to hear the latest research developments in the clinical management of HIV and HCV infection...

    Authors: Alain Lafeuillade, Mark Wainberg, Marie-Lise Gougeon, Sabine Kinloch-de Loes, Philippe Halfon and Hervé Tissot-Dupont
    Citation: AIDS Research and Therapy 2014 11:28
    Content type: Research Published on:

  49. The level (or frequency) of circulating monocyte subpopulations such as classical (CD14hiCD16-) and non-classical (CD14dimCD16+) monocytes varies during the course of HIV disease progression and antiretroviral th...

    Authors: Lillian Seu, Gabriel M Ortiz, Trevor D Burt, Steven G Deeks, Jeffrey N Martin and Joseph M McCune
    Citation: AIDS Research and Therapy 2014 11:27
    Content type: Research Published on:

  50. Voriconazole is metabolized by cytochrome P450 (CYP) 2C19 and CYP 3A4. Drug-drug interactions and genetic polymorphisms modulate their activities.

    Authors: Yassine Bouatou, Caroline Flora Samer, Kuntheavy Roseline Ing Lorenzini, Youssef Daali, Samira Daou, Marc Fathi, Michela Rebsamen, Jules Desmeules, Alexandra Calmy and Monica Escher
    Citation: AIDS Research and Therapy 2014 11:25
    Content type: Case report Published on:

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AIDS Research and Therapy

ISSN: 1742-6405

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