Skip to main content

HIV Care Coordination promotes care re-engagement and viral suppression among people who have been out of HIV medical care: an observational effectiveness study using a surveillance-based contemporaneous comparison group



Medical care re-engagement is critical to suppressing viral load and preventing HIV transmission, morbidity and mortality, yet few rigorous intervention studies address this outcome. We assessed the effectiveness of a Ryan White Part A-funded HIV Care Coordination Program relative to ‘usual care,’ for short-term care re-engagement and viral suppression among people without recent HIV medical care.


The Care Coordination Program was launched in 2009 at 28 hospitals, health centers, and community-based organizations in New York City. Designed for people with HIV (PWH) experiencing or at risk for poor HIV outcomes, the Care Coordination Program provides long-term, comprehensive medical case management utilizing interdisciplinary teams, structured health education and patient navigation. The intervention was implemented as a safety-net services program, without a designated comparison group. To evaluate it retrospectively, we created an observational, matched cohort of clients and controls. Using the HIV surveillance registry, we identified individuals meeting program eligibility criteria from December 1, 2009 to March 31, 2013 and excluded those dying prior to 12 months of follow-up. We then matched clients to controls on baseline status (lacking evidence of viral suppression, consistently suppressed, inconsistently suppressed, or newly diagnosed in the past 12 months), start of follow-up and propensity score. For this analysis, we limited to those out of care at baseline (defined as having no viral load test in the 12 months pre-enrollment) and still residing within jurisdiction (defined as having a viral load or CD4 test reported to local surveillance and dated within the 12-month follow-up period). Using a GEE model with binary error distribution and logit link, we compared odds of care re-engagement (defined as having ≥ 2 laboratory events ≥ 90 days apart) and viral suppression (defined as having HIV RNA ≤ 200 copies/mL on the most recent viral load test) at 12-month follow-up.


Among 326 individuals out of care at baseline, 87.2% of clients and 48.2% of controls achieved care re-engagement (Odds Ratio: 4.53; 95%CI 2.66, 7.71); 58.3% of clients and 49.3% of controls achieved viral suppression (Odds Ratio: 2.05; 95%CI 1.30, 3.23).


HIV Care Coordination shows evidence of effectiveness for care and treatment re-engagement.


The individual and population-level benefits of antiretroviral therapy (ART) for HIV depend upon consistent medical care to achieve and maintain viral suppression (VS) [1,2,3]. According to the Centers for Disease Control and Prevention (CDC) Compendium of Evidence-Based Interventions and Best Practices for HIV Prevention, multiple interventions show strong evidence of efficacy for initial linkage to care, subsequent retention in care and VS, but none have generated strong evidence of efficacy for care re-engagement (CR) following a lapse [4]. Promising CR approaches include case management, patient navigation, outreach and uses of population-based data or routine testing to identify candidates for re-linkage [5,6,7,8,9,10,11,12,13,14]. However, studies to date have lacked contemporaneous, comparable out-of-care control groups [7,8,9,10,11,12,13,14,15] or have focused on linkage and retention rather than quantifying CR [5,6,7].

In December 2009, the New York City (NYC) Health Department launched a Ryan White Part A—funded comprehensive medical case management intervention known as the HIV Care Coordination Program (CCP). The CCP has demonstrated effectiveness for VS and for durable VS (defined as regular monitoring and all viral loads ≤ 200 copies/mL in months 13–36 of follow-up) among previously unsuppressed individuals [16,17,18], but it has not been examined for its effect on CR. The objective of this analysis was to assess CCP versus usual-care effectiveness for CR and VS among people with HIV (PWH) lacking recent HIV medical care. We hypothesized that the CCP would show CR and VS benefits over and above usual care for this subgroup of PWH.



The CCP employs a ‘medical home’ model combining interdisciplinary team-based case management, patient navigation and structured health education to promote HIV care continuum engagement. Its components and implementation considerations are described elsewhere [7, 19, 20], and a toolkit for replication is online [21]. During the period analyzed, CCP protocols permitted enrollment of HIV-positive adults or emancipated minors who were eligible for local Ryan White Part A services (living at < 435% of federal poverty level and within the New York grant area) and (a) newly diagnosed; (b) never in care or out of care for at least nine months; (c) irregularly in care; (d) starting a new ART regimen; (e) experiencing ART adherence barriers; or (f) manifesting treatment failure or ART resistance [7].

Data sources

The NYC HIV Surveillance Registry (“the Registry”) contains demographic information and comprehensive HIV-related laboratory reporting [including all CD4 and viral load (VL) results] for individuals with NYC HIV medical care. Vital status is updated through regular matches with death data [22]. Ryan White Part A programmatic data and Registry data are matched semi-annually for merged analysis.

Using the merged dataset, we identified people enrolled in the CCP from December 1, 2009 to March 31, 2013 and excluded clients dying within 12 months post-enrollment [N (number) = 279]. We then identified unenrolled individuals diagnosed with HIV by March 31, 2013 and ≥ 18 years old at diagnosis. All demographic, baseline, outcome and death data were drawn from the Registry.

Comparison group construction

Via a four-step process detailed elsewhere [23] and summarized below, we retrospectively created an observational, matched cohort of CCP and non-CCP PWH.

First, we identified CCP eligibility windows for unenrolled PWH: ranges of time between December 2009 and March 2013 during which they appeared CCP-eligible based on laboratory test data from the Registry [23]. We considered PWH eligible if they were (1) newly diagnosed; (2) out of medical care at least 9 months; (3) treatment naïve [24]; (4) lacking VS or lacking VL tests in the 12 months after ART initiation [24]; (5) experiencing viral rebound following VS; or (6) registering a high VL (≥ 10,000 copies/mL). To ensure comparability with the CCP group, we closed eligibility windows ≥ 12 months prior to any date of death.

Second, from within their eligibility window(s), we randomly assigned each non-CCP individual a pseudo-enrollment date (time point from which to start follow-up). Pseudo-enrollment dates were assigned with probabilities such that their temporal distribution matched that of the CCP clients’ enrollment dates.

Third, we restricted to people with at least one CD4 or VL in the 24 months post-enrollment/pseudo-enrollment. We required one laboratory test as a proxy for ongoing receipt of NYC medical care, to prevent a differential (non-CCP versus CCP) effect of outmigration.

Finally, we matched CCP enrollees to eligible non-CCP PWH on baseline treatment status, enrollment/pseudo-enrollment date, and propensity for CCP enrollment. Correctly specified propensity models balance measured confounders across exposure groups [25]. We estimated the propensity score by modeling exposure status as a function of the confounders of the relationship between exposure and outcome. To begin, we developed an a priori list of variables considered to be potential confounders of the relationship between enrollment in the CCP and the outcome of VS: sex, race/ethnicity, age at enrollment/pseudo-enrollment, country of birth, HIV transmission risk, year of diagnosis, baseline VL, baseline CD4, successful linkage to HIV care within three months of diagnosis, presence of an AIDS diagnosis within one year of HIV diagnosis, number of VL laboratory tests reported in the year prior to enrollment/pseudo-enrollment, residential Zone Improvement Plan (ZIP) code at enrollment/pseudo-enrollment, HIV prevalence and poverty level within ZIP code at enrollment/pseudo-enrollment and interaction terms for baseline CD4 and baseline VL, baseline CD4 and race, sex and risk, and year of diagnosis and risk [23].

Baseline treatment status was defined in terms of VS or diagnosis in the 12 months pre-enrollment/pseudo-enrollment: (1) ‘lacking evidence of VS’ (no VL ≤ 200 copies/mL), (2) ‘consistently suppressed’ (at least two VLs ≥ 90 days apart and all VLs ≤ 200 copies/mL), (3) ‘inconsistently suppressed’ (at least one VL ≤ 200 copies/mL, but not all VLs ≤ 200 copies/mL), or (4) ‘newly diagnosed.’ We used logistic regression to estimate propensity for CCP enrollment within baseline treatment status groups, starting with a model that included all a priori confounders and applying backward selection to identify the model with the lowest value of Akaike’s Information Criterion (AIC) [23]. Within baseline treatment status groups, we matched on propensity scores and enrollment/pseudo-enrollment dates (within three months), using a 1:1 greedy match algorithm that proceeded sequentially from 8 to 1 decimal places of the propensity score [26, 27]. The final model and match was chosen based on having no between-group imbalance (standardized difference ≥ 0.1) in any measured confounder and the greatest number of persons matched [25]. In a previously published sensitivity analysis, we ran models using all hypothesized confounders; the effect estimates did not differ from the approach described above; however, fewer CCP enrollees were matched [23].


Out of care and residing in NYC

To preserve the original match to the extent possible, we defined ‘out of care’ as a subcategory of the ‘lacking evidence of VS’ treatment status group: those with no VL reported in the year before enrollment/pseudo-enrollment. Any Registry-reported CD4 or VL test in the first 12 months of follow-up was considered evidence of NYC residency. The post-hoc requirement of a CD4/VL in the first 12 months versus the first 24 months (third step, above) was applied to align with the 12-month CR/VS outcome timeframe.


CR was dichotomized as ≥ 2 laboratory events (CD4 or VL) ≥ 90 days apart in the 12-month period post-enrollment/pseudo-enrollment. VS was dichotomized as a value ≤ 200 copies/mL on the last VL in that period.

Study population and period

From December 1, 2009 to March 31, 2013, 7,337 PWH enrolled in the CCP; 7,058 (96.2%) were living 12 months post-enrollment. Of the 62,828 unenrolled CCP-eligible PWH, 91.9% (57,746) were assigned a pseudo-enrollment date; 74.8% (46,997) had an HIV-related NYC laboratory test in the 24 months following their pseudo-enrollment date; and 10.8% (6,812) were matched to a CCP client, resulting in 6,812/7,058 CCP clients matched (96.5%). Of 5,666 PWH ‘lacking evidence of VS’ at baseline in the matched cohort, 326 were ‘out of care and residing in NYC’: 148 non-CCP and 178 CCP PWH. In all, the records used for this study spanned the period from December 1, 2007 through March 31, 2015. The laboratory observation period started 24 months earlier than the enrollment period because CCP eligibility was based on clinical status in the past 24 months, and it extended 24 months past the end of the enrollment period because the match was restricted to PWH who had an HIV-related NYC laboratory test in the 24 months following enrollment/pseudo-enrollment.

Statistical analysis

In an intention-to-treat approach, we used a generalized estimating equation (GEE) model with binary error distribution and logit link to estimate the CCP versus non-CCP odds ratio (OR) for CR and for VS, accounting for the matched pair design by specifying the pairs as the independent clusters in the GEE model with an exchangeable working correlation structure. The model included three terms: CCP participation (yes or no), out-of-care status at baseline (yes or no) and an interaction term for CCP participation and care status. The CCP effect within the out-of-care group (N = 326) was generated from the interaction term from the entire cohort (N = 13,624) to account for propensity matching and balanced covariates [25, 28]. ORs were estimated with GENMOD procedure in SAS version 9.5.

Human subjects

This study was approved by the institutional review boards at the NYC Department of Health and Mental Hygiene and the City University of New York (CUNY) Graduate School for Public Health and Health Policy. For these retrospective secondary analyses of de-identified data, we received a waiver of informed consent in accordance with the pre-2018 requirements in 45 CFR (Code of Federal Regulations) 46.116(d)(2).


The out-of-care CCP and non-CCP groups were similar on race, age and country of birth (Table 1). Overall (N = 326), 50% were Black, 40% Hispanic/Latinx and 6% White; 70% were United States (US)-born; and 57% were under age 45. The CCP group had a higher proportion of men (71% versus 62%) and men who have sex with men (43% versus 28%) than the non-CCP group. As expected, most CCP and non-CCP PWH with no VL also lacked a CD4 count in the pre-enrollment/pseudo-enrollment year (68% and 56%, respectively).

Table 1 Characteristics of clients and matched controls who had been out of care at baseline

CCP clients had significantly greater odds of CR and VS at 12-month follow-up (Table 2). The proportion of out-of-care NYC residents re-engaged in care was 88% in the CCP versus 63% in the usual-care group (OR: 4.53; 95% confidence interval [CI] 2.66, 7.71). The proportion achieving VS was 66% in the CCP versus 49% in the usual-care group (OR: 2.05; 95% CI 1.30, 3.23).

Table 2 Odds ratios for care re-engagement and viral suppression, among individuals out of care at baseline


Summary and context

Out-of-care CCP enrollees had four and a half times the odds of CR and twice the odds of VS at 12-month follow-up, compared to similar but unenrolled out-of-care PWH. These findings have implications for programming/policy efforts to end the epidemic, as the CDC estimates that the greatest share of HIV transmission events (43%) involve people aware of their HIV status but not in HIV care [29]. As a rigorously evaluated intervention demonstrating substantial, real-world effectiveness at re-engaging PWH who have been out of HIV care, the CCP could be deployed more broadly for the purpose of reducing delays or interruptions in HIV care, thus reducing HIV transmission and improving both health and survival among PWH.

Recent reviews highlight the dearth of rigorous studies demonstrating intervention effects on CR or even assessing CR as an outcome [4, 30, 31]. A King County, Washington clinic-based study of a data-to-care intervention reported modest re-linkage benefits; compared to historical controls, intervention recipients were re-engaged more quickly (adjusted Hazard Ratio: 1.7 [95% CI 1.2, 2.3]) and more frequently (15% versus 10%, adjusted Relative Risk: 1.6 [1.2, 2.1]) [8]. However, as with other re-engagement studies lacking a contemporaneous comparison group [7, 9, 10, 12, 13, 15], estimates may have been affected by secular trends.

Previously, the CCP was found to improve 12-month VS relative to usual care [16]. Our current results extend those findings: the CCP promotes 12-month CR and VS for previously out-of-care PWH. Comparison with other case management intervention studies is complicated by their varying settings, designs, endpoints and populations. In a randomized trial of a case management-type intervention directed to new clients and clients with poor clinic attendance, greater retention was observed in the intervention versus usual-care group [5]. Another randomized trial showed that patient navigation-enhanced case management increased linkage and retention of PWH discharged from jail [6]. Our findings contribute further evidence of the HIV care continuum benefits of case management and patient navigation-enhanced case management, specifically, for PWH experiencing or at risk for gaps in care and treatment.

Limitations and strengths

This study is subject to the limitations attending observational analyses, including potential uncontrolled confounding. Our reliance on Registry data enabled us to control for numerous demographic and clinical confounders [23], but not for behaviors or for services beyond the CCP. We also lacked direct data on out-migration from NYC. The restriction to PWH with at least one CD4 or VL in the 12 months post-enrollment/pseudo-enrollment was applied to avoid bias from differential out-migration between CCP and non-CCP PWH, and resulted in more conservative CCP effect estimates than the less restricted analysis (results not shown).

Strengths of our multi-site study included leveraging longitudinal outcome data from a single, comprehensive source for all NYC PWH, regardless of care location within NYC or CCP enrollment status. Availability of complete surveillance data on both outcomes supported an intention-to-treat analysis. Furthermore, use of a contemporaneous out-of-care comparison group matched to CCP enrollees on follow-up timing and propensity scores minimized the risk that observed effects could result from secular outcome improvements or group differences on measured confounding variables.


Our findings fill a gap in the literature by providing strong evidence of one case management program’s effectiveness for re-engaging PWH in HIV care and treatment. As care engagement often does not follow a simple linear progression [32], re-engagement strategies are essential to preventing HIV transmission and HIV-related morbidity and mortality. Rigorous, real-world studies assessing effects on re-engagement can guide policymakers in selecting interventions to speed the end of the HIV epidemic.

Availability of data and materials

Materials on the Care Coordination intervention and its components are available at the CDC websites: and, as well as through the corresponding author. Due to legal restrictions (New York Public Health Law Article 21, Title III) and the confidential nature of HIV surveillance data in New York, public health authorities in New York City cannot release de-identified individual-level data on reported HIV cases for purposes other than ensuring appropriate HIV care. However, Health Department staff can provide code and assistance to external researchers with further specific data questions or uses, on reasonable request via e-mail to



Antiretroviral therapy


Viral suppression


Centers for Disease Control and Prevention


Care re-engagement


New York City


Care Coordination Program


People with HIV


Viral load




Zone Improvement Plan (United States Postal Service-defined geographic unit)


Akaike’s Information Criterion


General estimating equation


Odds ratio


City University of New York


Code of Federal Regulations (United States)


United States


Confidence interval


National Institute of Mental Health


Health Services and Resources Administration


Costs, Health Outcomes and Real-world Determinants of Success (study name)


  1. Insight Start Study Group, Lundgren JD, Babiker AG, Gordin F, Emery S, Grund B, Sharma S, Avihingsanon A, Cooper DA, Fatkenheuer G, et al. Initiation of antiretroviral therapy in early asymptomatic HIV infection. N Engl J Med. 2015;373(9):795–807.

    Article  Google Scholar 

  2. Cohen MS, Chen YQ, McCauley M, Gamble T, Hosseinipour MC, Kumarasamy N, Hakim JG, Kumwenda J, Grinsztejn B, Pilotto JH, et al. Prevention of HIV-1 infection with early antiretroviral therapy. N Engl J Med. 2011;365(6):493–505.

    Article  CAS  Google Scholar 

  3. The TEMPRANO ANRS 12136 Study Group. A Trial of Early antiretrovirals and isoniazid preventive therapy in Africa. N Engl J Med. 2015;373(9):808–22.

    Article  Google Scholar 

  4. Linkage to, Retention in, and Re-engagement in HIV Care (LRC) Best Practices, by Characteristic. Accessed 18 Feb 2021.

  5. Gardner LI, Giordano TP, Marks G, Wilson TE, Craw JA, Drainoni ML, Keruly JC, Rodriguez AE, Malitz F, Moore RD, et al. Enhanced personal contact with HIV patients improves retention in primary care: a randomized trial in 6 US HIV clinics. Clin Infect Dis. 2014;59(5):725–34.

    Article  Google Scholar 

  6. Myers JJ, Kang Dufour M-S, Koester KA, Morewitz M, Packard R, Monico Klein K, Estes M, Williams B, Riker A, Tulsky J. The effect of patient navigation on the likelihood of engagement in clinical care for HIV-infected individuals leaving jail. Am J Public Health. 2018;108(3):385–92.

    Article  Google Scholar 

  7. Irvine MK, Chamberlin SA, Robbins RS, Myers JE, Braunstein SL, Mitts BJ, Harriman GA, Laraque F, Nash D. Improvements in HIV care engagement and viral load suppression following enrollment in a comprehensive HIV care coordination program. Clin Infect Dis. 2015;60(2):298–310.

    Article  CAS  Google Scholar 

  8. Bove JM, Golden MR, Dhanireddy S, Harrington RD, Dombrowski JC. Outcomes of a clinic-based surveillance-informed intervention to relink patients to HIV care. J Acquir Immune Defic Syndr. 2015;70(3):262–8.

    Article  Google Scholar 

  9. Bradford JB, Coleman S, Cunningham W. HIV system navigation: an emerging model to improve HIV care access. AIDS Patient Care STDs. 2007;21(S1):S-49-S-58.

    Article  Google Scholar 

  10. Flash CA, Pasalar S, Hemmige V, Davila JA, Hallmark CJ, Mcneese M, Miertschin N, Ruggerio MC, Giordano TP. Benefits of a routine opt-out HIV testing and linkage to care program for previously diagnosed patients in publicly funded emergency departments in Houston. TX J Acquir Immune Defic Syndr. 2015;69 Suppl 1(0 1):S8-15.

    Article  Google Scholar 

  11. Magnus M, Herwehe J, Gruber D, Wilbright W, Shepard E, Abrams A, Foxhood J, Smith L, Xiao K, DeYoung K. Improved HIV-related outcomes associated with implementation of a novel public health information exchange. Int J Med Inform. 2012;81(10):e30–8.

    Article  Google Scholar 

  12. Bean MC, Scott L, Richey LE. Use of an outreach coordinator to reengage and retain patients at risk of falling out of HIV care, does the amount of time matter? AIDS Behav. 2018;22(1):321–4.

    Article  Google Scholar 

  13. Seña AC, Donovan J, Swygard H, Clymore J, Mobley V, Sullivan K, LeViere A, Heine A, Quinlivan EB. The North Carolina HIV bridge counselor program: outcomes from a statewide level intervention to link and reengage HIV-infected persons in care in the South. J Acquir Immune Defic Syndr. 2017;76(1):e7–14.

    Article  Google Scholar 

  14. Udeagu C, Huang J, Eason L, Pickett L. Health department-HIV clinic integration of data and human resources to re-engage out of care HIV-positive persons into clinical care in a New York City locale. AIDS Care. 2019;31(11):1420–6.

    Article  CAS  Google Scholar 

  15. Sachdev DD, Mara E, Hughes AJ, Antunez E, Kohn R, Cohen S, Scheer S. “Is a bird in the hand worth five in the bush?:” A comparison of three data to care referral strategies on HIV care continuum outcomes in San Francisco. Open Forum Infect Dis. 2020;7(9):ofaa369.

    Article  Google Scholar 

  16. Nash D, Robertson MM, Penrose K, Chamberlin S, Robbins RS, Braunstein SL, Myers JE, Abraham B, Kulkarni S, Waldron L, et al. Short-term effectiveness of HIV care coordination among persons with recent HIV diagnosis or history of poor HIV outcomes. PLoS ONE. 2018;13(9):e0204017.

    Article  Google Scholar 

  17. Robertson MM, Penrose K, Irvine MK, Robbins RS, Kulkarni S, Braunstein SL, Waldron L, Harriman G, Nash D. Impact of an HIV care coordination program on durable viral suppression. J Acquir Immune Defic Syndr. 2019;80(1):46–55.

    Article  Google Scholar 

  18. Robertson MM, Penrose K, Nash D, Harriman G, Braunstein SL, Levin B, Irvine MK. Impact of an HIV care coordination program on the timeliness of viral suppression and immune recovery among clients newly diagnosed with HIV. AIDS Behav. 2020;24(4):1237–42.

    Article  Google Scholar 

  19. HIV care coordination program. Evidence-informed for retention in HIV care. Accessed 28 Sept 2020.

  20. O’Donnell L, Irvine MK, Wilkes AL, Rwan J, Myint-U A, McLean Leow D, Whittier D, Harriman G, Bessler P, Higa D, et al. STEPS to care: translating an evidence-informed HIV care coordination program into a field-tested online practice improvement toolkit. AIDS Educ Prev. 2020;32(4):296–310.

    Article  Google Scholar 

  21. STEPS to Care. Accessed 18 Feb 2021.

  22. HIV Epidemiology Program. HIV surveillance annual report, 2019. In: HIV/AIDS surveillance and epidemiology reports. New York, NY: New York City Department of Health and Mental Hygiene; 2020.

  23. Robertson MM, Waldron L, Robbins RS, Chamberlin S, Penrose K, Levin B, Kulkarni S, Braunstein SL, Irvine MK, Nash D. Using registry data to construct a comparison group for programmatic effectiveness evaluation: the New York City HIV care coordination program. Am J Epidemiol. 2018;187(9):1980–9.

    Article  Google Scholar 

  24. Braunstein SL, Robertson MM, Myers J, Nash D. Using HIV viral load from surveillance to estimate the timing of antiretroviral therapy initiation. J Acquir Immune Defic Syndr. 2016;73(2):222–7.

    Article  CAS  Google Scholar 

  25. Austin PC. An introduction to propensity score methods for reducing the effects of confounding in observational studies. Multivariate Behav Res. 2011;46(3):399–424.

    Article  Google Scholar 

  26. Stuart EA. Matching methods for causal inference: A review and a look forward. Stat Sci. 2010;25(1):1–21.

    Article  Google Scholar 

  27. Parsons LS. Performing a 1:N case-control match on propensity score. In: SUGI 29. SAS Institute; 2003.

  28. Rubin DB. The design versus the analysis of observational studies for causal effects: parallels with the design of randomized trials. Stat Med. 2007;26(1):20–36.

    Article  Google Scholar 

  29. Li Z, Purcell DW, Sansom SL, Hayes D, Hall HI. Vital signs: HIV transmission along the continuum of care—United States, 2016. MMWR Morb Mortal Wkly Rep. 2019;68(11):267–72.

    Article  Google Scholar 

  30. Risher KA, Kapoor S, Daramola AM, Paz-Bailey G, Skarbinski J, Doyle K, Shearer K, Dowdy D, Rosenberg E, Sullivan P. Challenges in the evaluation of interventions to improve engagement along the HIV care continuum in the united states: a systematic review. AIDS Behav. 2017;21:1–23.

    Article  Google Scholar 

  31. Higa DH, Crepaz N, Mullins MM. Identifying best practices for increasing linkage to, retention, and re-engagement in HIV medical care: findings from a systematic review, 1996–2014. AIDS Behav. 2016;20(5):951–66.

    Article  Google Scholar 

  32. Hallett TB, Eaton JW. A side door into care cascade for HIV-infected patients? J Acquir Immune Defic Syndr. 2013;63(Suppl 2):S228-232.

    Article  Google Scholar 

Download references


The authors are indebted to: Darrel Higa and Nicole Crepaz, for suggesting this research question; the Ryan White Part A Care Coordination Program staff, for their dedication to the delivery of comprehensive services, their continual participation in reporting on this intervention, and their shared commitment to rigorous evaluation and the integration of findings into practice; Kate Penrose and Graham Harriman, for their contributions to the larger study; and the members of the study Community Advisory Board, for their guidance and critical input at various stages of this work. This work was completed as part of the Costs, Health Outcomes and Real-world Determinants of Success in HIV Care Coordination (CHORDS) Study.


This work was supported by the National Institute of Mental Health (NIMH) of the National Institutes of Health (Grant Number R01 MH101028) and (for the intervention itself) the Health Services and Resources Administration (HRSA) Ryan White Part A services grant (Grant Number HA89HA00015). Disclaimer: The NIMH and HRSA are not involved in the study design, conduct or products, nor in the decision to submit this work for publication.

Author information

Authors and Affiliations



MI, MR and DN conceptualized the study. MR and SB prepared datasets and conducted and confirmed all analyses, with SB serving as the expert on the HIV surveillance data and surveillance-based measures of HIV care continuum outcomes. BL advised as a statistician on the use of the full matched study cohort to generate intervention effect estimates (ORs) for the subgroup of individuals who had been out of HIV medical care, while accounting for propensity matching and balanced covariates. MI and MR jointly drafted the manuscript, and MI revised the manuscript based on feedback from co-authors and reviewers from outside the study team. SK assisted with preparation of the manuscript for publication. All authors participated in the interpretation of results and critically reviewed the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Mary K. Irvine.

Ethics declarations

Ethics approval and consent to participate

This study was approved by the institutional review boards at the NYC Department of Health and Mental Hygiene (Protocol #13-070) and the City University of New York (CUNY) Graduate School for Public Health and Health Policy (Protocol #663413). For these retrospective secondary analyses of de-identified data, we received a waiver of informed consent in accordance with the pre-2018 requirements in 45 CFR 46.116(d)(2).

Consent for publication

Not applicable (all data are presented in aggregate form only).

Competing interests

Financial Interests: MI has received a research grant to her employer/institution from the National Institute of Mental Health (Grant No. R01 MH101028) and (for the intervention) a Ryan White Part A services grant from the Health Services and Resources Administration (Grant No. HA89HA00015). MR, DN and SK have received a research grant to their employer/ institution from the National Institute of Mental Health (Grant No. R01 MH101028). SB and BL: No conflicts.

Non-financial Interests: None (all authors).

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Irvine, M.K., Robertson, M.M., Nash, D. et al. HIV Care Coordination promotes care re-engagement and viral suppression among people who have been out of HIV medical care: an observational effectiveness study using a surveillance-based contemporaneous comparison group. AIDS Res Ther 18, 70 (2021).

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: