Self-care practices and experiences of people living with HIV not receiving antiretroviral therapy in an urban community of Lusaka, Zambia: implications for HIV treatment programmes
© Musheke et al.; licensee BioMed Central Ltd. 2013
Received: 25 September 2012
Accepted: 7 May 2013
Published: 15 May 2013
Despite the increasingly wider availability of antiretroviral therapy (ART), some people living with HIV (PLHIV) and eligible for treatment have opted to adopt self-care practices thereby risking early AIDS-related mortality.
A qualitative study was conducted in urban Zambia to gain insights into PLHIV self-care practices and experiences and explore the implications for successful delivery of ART care. Between March 2010 and September 2011, in-depth interviews were conducted with PLHIV who had dropped out of treatment (n=25) and those that had opted not to initiate medication (n=37). Data was entered into and managed using Atlas ti, and analysed inductively using latent content analysis.
PHIV used therapeutic and physical health maintenance, psychological well-being and healthy lifestyle self-care practices to maintain physical health and mitigate HIV-related symptoms. Herbal remedies, faith healing and self-prescription of antibiotics and other conventional medicines to treat HIV-related ailments were used for therapeutic and physical health maintenance purposes. Psychological well-being self-care practices used were religiosity/spirituality and positive attitudes towards HIV infection. These practices were modulated by close social network relationships with other PLHIV, family members and peers, who acted as sources of emotional, material and financial support. Cessations of sexual relationships, adoption of safe sex to avoid re-infections and uptake of nutritional supplements were the commonly used risk reduction and healthy lifestyle practices respectively.
While these self-care practices may promote physical and psychosocial well-being and mitigate AIDS-related symptoms, at least in the short term, they however undermine PLHIV access to ART care thereby putting PLHIV at risk of early AIDS-related mortality. The use of scientifically unproven herbal remedies raises health and safety concerns; faith healing may create fatalism and resignation with death while the reported self-prescription of antibiotics to treat HIV-related infections raises concerns about future development of microbial drug resistance amongst PLHIV. Collectively, these self-care practices undermine efforts to effectively abate the spread and burden of HIV and reduce AIDS-related mortality. Therefore, there is need for sensitization campaigns on the benefits of ART and the risks associated with widespread self-prescription of antibiotics and use of scientifically unproven herbal remedies.
KeywordsHIV Self-care Faith healing Herbal remedies Zambia
While an estimated 5.9 million people in low and middle-income countries were on antiretroviral therapy (ART) by end of 2009, saving 14.4 million life-years since 1996 , this only represented half the estimated people eligible for treatment . Previous studies indicate that patient retention in ART care is problematic. For instance, in sub-Saharan Africa (SSA), only an estimated 60% of patients were retained in ART programmes after 2 years of starting treatment [3, 4]. This is despite the proven efficacy of ART in reducing AIDS-related deaths [5–8]. The reasons for patient attrition from ART care and failure to initiate treatment are varied and include financial costs associated with accessing treatment [9, 10], fear of side effects [9, 11–15], fear of drug toxicity and long-term harm to the body [14, 15] and feeling healthy [11, 14–17]. Other barriers are stigma [9, 11], belief in faith healing [11, 18–21], use of traditional medicine [17, 18, 20, 22] and perceived burden of being on life-long treatment [12, 14, 23].
Zambia is one of the countries in SSA worst hit by the HIV pandemic, with an estimated HIV prevalence of 14.3% in the Zambian population aged 15–49 years . The national HIV prevalence peaked at around 16% in the 1990s before levelling off and marginally declining to current rates . Since 2005 when Zambia started providing free ART services in public sector health facilities, there has been a steady increase in the number of PLHIV accessing treatment, from 57,164 in 2005 to an estimated 344, 407 (adults and children) at the end of 2010, representing 68.4% of those in need of treatment . Similar to studies elsewhere, barriers to accessing ART in Zambia include financial and logistical costs [26, 27], concerns about side effects [15, 27, 28], negative perceptions of medication [15, 26, 28] and overcrowded health facilities [15, 27]. Other barriers are stigma and fear of straining interpersonal relationships [27, 28], fear of being on life-long treatment and inadequate/lack of food and nutritional support .
While the reasons for non-uptake of ART are known, there is paucity of evidence on how PLHIV eligible for but not on treatment manage their health condition; how PLHIV perceive and experience their health on account of any self-care practices; and the implications of self-care practices for successful delivery of ART care. Therefore, within a wider ethnographic study, this study explored the self-care practices and health experiences of PLHIV not receiving ART care in an urban community of Lusaka, Zambia. Self-care in this paper is defined as “the individual’s ability to manage the symptoms, treatment, physical and psychosocial consequences and lifestyle changes inherent in living with a chronic condition [in this case HIV] ability to monitor one’s condition and to effect the cognitive, behavioural and emotional responses necessary to maintain satisfactory quality of life” .
The study was conducted in a predominantly low-income, high-density urban residential area of Lusaka, Zambia. Observations and interviews with study participants indicate that the area comprises multilingual ethnic groups with Bemba and Nyanja the most widely spoken local languages. Most residents are embedded in strong kin and non-kin social network relationships. Most of the families are large, in part due to the affect of HIV with some individuals growing up as orphans under the care of extended family members. Although not all family members lived together, they still maintained reciprocal social and economic support ties. Other social network relationships are a product of similar religious affiliations and occupational and social lifestyle activities. Due to lack of public social amenities, social lifestyle activities mostly revolve around patronising the ubiquitous bars and drinking places, often a prime source of sexual network relationships.
Most of the residents are poor. A few people are employed in low-paid jobs in the public and private sectors of the formal economy. The majority earned their living in the informal economic sector: as cross-border traders and local market traders mainly selling fruits, vegetables, meat products, charcoal and second-hand clothes either in the city centre markets or in the open-air local markets. Small makeshift shops, locally called ‘tuntemba’ are ubiquitous in the area - along the dusty and seasonally muddy roads and in the local open-air markets or next to homes. Unemployment is also endemic in the area especially among the lowly educated youth. The unemployment situation is further exacerbated by rural–urban migration as people move into the city in search of job opportunities and better life.
Health services are mainly provided by a public sector clinic which provides both in-patient and out-patient health services. The clinic also provides ART services. By mid-2010, the health centre had an estimated catchment population of over 150,000 with over 5,000 people on ART and over 5,000 registered for pre-ART care. Alongside the formal health system are traditional healers and herbalist who also provide ‘health’ care services, including for HIV. There is also a plethora of drug stores, some unlicensed, which provide over-the-counter medication.
Christianity is the dominant religion with a myriad of charismatic evangelical Pentecostal churches, some of which provide healing sessions for people with different ailments, including HIV.
Research design and study participants
The paper draws on data from two exploratory qualitative lines of enquiry nested within a wider 18-month ethnographic study: namely patient attrition from ART care and barriers to patient initiation of ART. For the former, participants were PLHIV who had not reported for pharmacy pick up for at least 6 months hence being classified by the local ART clinic as lost-to-follow up (LTFU). The revised Zambian ART treatment guidelines have reduced the LTFU threshold to at least 60 days from the previous 180 days . In the latter, participants comprised PLHIV recommended to start treatment by ART providers but declined. Only participants aged ≥18 years old constituted our study participants.
Sampling strategy and recruitment of study participants
Purposive sampling using maximum variation sampling procedure was used to select study participants. The sampling technique allows for selection of participants with unique and diverse characteristics in order to generate in-depth unique insights and shared patterns that cut across cases. In this study, the diverse characteristics used to select study participants were demographic characteristics and length of time on and off HIV treatment. The sampling strategy facilitated collection of wide ranging, in-depth insights into self-care behavioural practices and experiences of PLHIV associated with not being on ART.
Due to the difficulties of identifying PLHIV who had dropped out of ART and those who had refused to initiate treatment, some PLHIV not on ART were first contacted and recruited through ART staff. They were contacted by mobile phone and/or physically followed up using locator information (physical address and mobile phone details) they had provided to ART providers at the time of enrolment for treatment. Other research participants were identified and recruited through community-based lay home-based care providers. Given that PLHIV had formed or belonged to social networks, a few study participants were recruited through snowball sampling in which PLHIV interviewed nominated and contacted on behalf of the researchers, friends and family members that they knew had discontinued HIV treatment or had opted not to start treatment despite it being recommended to them by ART providers. For both categories of PLHIV, only those that agreed to be interviewed were later contacted and followed up for interviews by the researchers.
Data collection and analysis
Face-to-face, one-on-one, open ended in-depth interviews were conducted between March 2010 and September 2011. The main research question asked was: “how do you manage your HIV condition in the absence of ART?’ Follow-up interviews were conducted during the study period. The initial interviews usually lasted between 30–45 minutes and for those re-interviewed, follow-up interviews lasted between 15–20 minutes. All the interviews were recorded using a digital audio recorder. The majority of the interviews were conducted in the local language, Nyanja, and a few in English.
Protection of research participants
Ethical approval was granted by the Ethics Committee of the State of Basel (Ethik-Kommission beider Basel) and the University of Zambia Humanities and Social Sciences Research Ethics Committee as part of a bigger research study, ‘Improving equity of access to HIV care and treatment in Zambia.’ The Ministry of health at national and district levels provided administrative clearance.
To ensure confidentiality and prevent involuntary disclosure of research participants’ HIV status, locations for interviews were based on the preferences of the respondents. Some interviews were conducted at the local public sector clinic and private spaces within the homes of respondents’ friends. A few PLHIV preferred being interviewed at home. This was done in the absence of family members to ensure privacy. Written informed consent was obtained from all research participants, including for quotes to be used anonymously in published reports.
Characteristics of PLHIV not on ART
No. of PLHIV who dropped out of ART
No. of PLHIV never on ART
Source of livelihood
Time on treatment
Duration not on treatment (up to time of interview)
Self-care practices of PLHIV not on ART
Seven (7) self-care practices were identified subsumed under four (4) main themes: Therapeutic and physical health maintenance; psychological well-being; healthy lifestyle and risk reduction practices.
Therapeutic and physical health maintenance practices
Taking herbal therapies
Sustaining physical health involved taking herbal remedies to treat opportunistic infections and mitigate HIV symptoms, ‘wash toxins’ from the body, replace nutrients and improve appetite levels. Garlic (allium sativum), ginger (zingiber officinale), aloe vera gel (also locally available in herbal plant form called tembusha), moringa oleifera, Ngetwa from Tanzania, crocodile fats, Chinese herbal remedies, stametta (aloe mixed with vitamins and herbs) and some herbs simply labeled ‘Back to Eden’ were the most commonly used herbal remedies. Two PLHIV elucidated their experiences of herbal remedies:
“I take some moringa. It is a tree with small leaves; we have it in the backyard of our house.... I just put it in tea or even in vegetables; we cook and mix it with other vegetables. Sometimes we “sashila” (add pounded groundnuts] to moringa and cook it as relish. Or you can even add the moringa to porridge.” (50-year old woman; never been on ART)
“You know with herbs, if you are coughing, you get guava leaves, lemon leaves, boil and drink them and then you are done. Even now, when my daughter is coughing, I would just take garlic, I mix with lemons, honey and make cough syrup and it is done.” (42-year old woman; never been on ART)
For many PLHIV, herbal remedies were taken as a routine part of life regardless of whether they were experiencing illness-related symptoms or not. Some herbal remedies were cheap while others like aloe vera gel were expensive, fetching as high as US$30 per one litre container. Those with financial means were able to buy these herbal remedies from drug stores, pharmacies, herbal medicine traders and herbal medicine shops. Some PLHIV periodically relied on financial support of relatives to procure these herbal remedies. Some herbal remedies like moringa and ginger, comparatively cheap, were routinely added to food or tea or juice to treat or prevent illnesses such as cold and flu, diarrhoea or generally to allegedly ‘boost’ the immune system and reinvigorate the body.
Some PLHIV reported planting these ‘health-enhancing’ herbs, particularly moringa and tembusha at home to ensure easy and unfettered access. While ART required high levels of adherence, this was reportedly not the case with herbal remedies. PLHIV reported taking them if and when they wanted. The flexibility of herbal treatment requirements was in part the reason why some PLHIV found herbal remedies attractive compared to conventional HIV medication which required strict adherence. One woman proudly expressed her affection for these herbal remedies:
“For me, I take tembusha and my CD4 cell count is high; that explains that the herbal remedy is working. So, why should I start ART?” (32-year old woman; never been on ART)
One of the recurring themes was that while the study participants acknowledged the efficacy of ART, the burden of taking treatment for life, stringent adherence requirements and concerns about treatment side effects attracted them to use herbal remedies. One woman said:
“Even if the ARVs work, people say they are for life and that they have side effect. So when people hear that, they decide to go for herbs because no one wants to experience the side effects or to take the medication for life. They say that herbs have no side effects.” (23-year old woman; never been on ART)
Faith healing as HIV cure
Faith healing was also sought for curative purposes. Some PLHIV reported travelling outside Zambia in search of healing while others relied on their faith in God to secure healing:
“When I went [to Nigeria] for healing, I was never the same person again…No one can deceive me that the power of God cannot work or does not work. I saw blind people gaining back their sight; I saw people in wheelchair walk; I saw people who could not hear start hearing. What more evidence does one need to believe that God performs miracles? (48-year old man; stopped ART)
“The thing is that when I pray, God tells me what to do. So God told me in a vision that you are healed and from the time that I prayed and stopped treatment, I have never been sick and have never taken any form of medication. The only secret which is there is to pray, and to believe in God, to have faith in Him.” (45-year old man; stopped ART)
Ironically, some health workers with HIV, including those working in the ART clinic and eligible for ART also opted for faith healing and/or herbal remedies:
“I have also taken anointing water from [....]. They say it cures if you have faith because it is prayed for by the man of God.” (27-year old woman; Pharmacy Technologist)
Using conventional medicine, but only to treat HIV-related infections
Acutely aware of their fledgling health and limitations of other self care strategies, some PLHIV did not completely cut-off ties with the formal health system. In the absence of herbal medication or whenever symptoms did not abate, some PLHIV sought formal health care, but only to use conventional medicine to treat opportunistic infections. Skin infections, respiratory infections and gastrointestinal tract infections were the most commonly reported HIV-related ailments. In other instances, PLHIV got over-the-counter medication, from a plethora of drug outlets in the area and the city centre. Antibiotics such as septrin (co-trimoxazole prophylaxis), flagyl, amoxicillin, anti-diarrhoeal medication were the most reported conventional drugs used. Some PLHIV reportedly used antibiotics used by their spouses on ART. Two PLHIV narrated:
“I just go to the clinic, they give me amoxil, and at times I go to the drug store and buy panadol or septrin or drugs for diarrhoea.... At the clinic, I just pretend as if I was never on ARVs because if I tell them, they [nurses] will just tell me to go to the ART clinic and get ARVs.” (43 years old woman; stopped ART)
“I take two tablets of septrin in the morning every day. When the drugs get finished, I go and buy…. Like today, I took my last drugs and I am planning to go and get some drugs from my friend on credit. She runs a drug store. She gives me on credit each time I do not have money to buy.” (31-year old woman; stopped ART)
Periodic monitoring of CD4 cell count
Coupled with uptake of herbal remedies, faith healing and conventional non-HIV medication, some PLHIV also monitored their immune system through periodically seeking CD4 cell count testing. Those with the financial means went to private clinics while others made private arrangements with public sector clinic staff to access CD4 cell count testing. At private clinics, charges for CD4 count testing ranged between ZMK50, 000 (US$10) and ZMK 150,000 (US$30) per test. Financial support from family members enabled some PLHIV to meet the costs. One PLHIV explained this strategy:
“I do my tests at a private clinic, there at Dr [.....]’s clinic. He tests for CD4 count. The last time I tested my CD4 count, it was in 2009 but time has elapsed since I last did my CD4 count.” (43-year old woman; never been on ART)
Healthy lifestyle practices
Good nutrition was a recurring theme as a self-care practice. While many PLHIV found this hard to sustain due to fragile livelihoods characterised by lack of job opportunities and steady and ‘adequate’ income, this problem was attenuated by improvising local food menus, for instance adding pounded groundnuts to vegetables like rape, cabbage, pumpkin leaves, locally called “kusashila” to nourish their bodies and improve their health condition. Other PLHIV heavily relied on nutritional supplements, sometimes supplied by relatives outside the country – in Europe, South Africa and United States of America:
“I usually depend on a food supplement called ‘Shake herbal life’. It comes from America. It is in powder form. When you want, you can add it to milk or you can add even fruit juice. It is like powdered milk. What I do is, in the morning, I just take a glass of water and put two full tea spoons of the same ‘Shake’ and then I mix it and then I drink. If I have money, instead of water, I put milk, I mix it with milk and then I drink. If I have money and I have bananas, I blend and add it to my water and milk and then I drink. Those are my ARVs.” (38-year old woman; never been on ART)
Risk reduction practices
Safe sex and cessation of sexual relationships
To avoid re-infections particularly through unprotected sex, some PLHIV, especially those not married - either widowed or divorced/separated - reported either practicing safe sex or ceasing sexual relationships altogether. Some PLHIV drew lessons from the experiences of other PLHIV who had reportedly continued to live ‘healthy’ and ‘normal’ lives without ART partly because they had reportedly avoided re-infections. Two PLHIV explained:
“From the time my husband died, I have vowed to abstain from sex. This has helped me because I learnt it from my HIV positive sister who has not been on any form of treatment since 1995 but is still alive and healthy today. Her secret is good diet and no sex.” (42-year old woman; never been on ART)
“Then we developed a culture in the house to say that let us start using condoms. In the house, it is condomising now. Then I think sometimes God comes in, you know. I have been praying to ensure that he would be agreeing to it, you know and for sure, he was not like, no what, what, and so we have been on condoms like that. He has been comfortable with it and we have been living like that.” (38-year old woman; never been on ART)
Psychological well-being self-care practices
“I rely on Jesus Christ”- religiosity and spirituality
Religiosity, particularly Christianity, was found to be woven into the day-to-day lives of some PLHIV, thus becoming a powerful self-care practice. Despite anticipation of stigma in religious circles due to the perceived association of HIV infection with improper sexual behaviour and a sinful lifestyle, through self-identification as Christians, some PLHIV, mostly women, drew on the biblical assurances of healing as a source of comfort and hope. Through organized religion, some PLHIV belonged to Christian denominations that were more accepting to PLHIV, particularly churches whose leaders or pastors professed to offer healing for people with HIV. While hoping for healing, some PLHIV reportedly put ‘everything in the hands of God’. They reported conducting private individual prayers with their pastors, going for collective intercessory prayers in which they opened up to one another and religious leaders about their HIV condition. One PLHIV who disclosed her status to her pastor described her unflinching belief in God:
“As for me, I rely on Jesus Christ…. I just told myself that it is better I face Jesus Christ, God himself since He is the one that gave me life, not a human being. In John 14:1 [Bible], Jesus says ‘I am the way, the truth, and the Life.’ You know if God wants to take my life now, He can do it, whether I am on ARVs or not. I have a lot of friends who were on ARVs but have since died. Why? It is because man cannot preserve life; only God can.” (48 year old HIV positive woman; stopped ART)
Another PLHIV explained her prayer life:
“Even if you take the medicine, if you do not look to God for healing, you cannot get cured. So everything only works if you also involve God. So I also pray to God for me to be cured. I go for prayers every morning. There are inter-denominational prayer meetings here in Chawama, there at Pentecostal holiness in Kuku compound. Prayers are held every morning, everyday, Monday to Saturday. The prayers start at 06 hours up to 7 hours.” (21-year old young woman; stopped ART)
To complement their prayer lives, some PLHIV reported using ‘anointing water’ - water believed to have healing properties after being prayed for by a Pastor believed to have spiritual healing powers - in order to ward off illnesses. They bought it from their churches that sold it or ordered it from Nigeria where a renowned Pentecostal tele-evangelist was reported to have spiritual healing powers. It cost at least US$100 for a 100 mls bottle. At a time when ART was free in public sector clinics, some PLHIV still opted for faith healing despite the associated financial costs. One PLHIV who went to Nigeria for prayers and bought the ‘anointing water’ explained:
“It is called anointing water. I have got it right with me in the car. What happens is that he [Pastor] does not heal you, you heal yourself. The belief that you have got yourself that God can heal you is what heals you. The belief that tomorrow I will walk, that tomorrow my immunity will rise, it will. It is you and God, and I believe it. Belief is not medicine, but it also heals. You do not just need medicine to get healed. You also need belief.” (48-year old man; stopped ART)
‘I avoid thinking about it too much’: positive attitudes towards HIV infection
Some PLHIV acknowledged the relationship between psychological well-being and their immune system. Therefore, developing and maintaining positive attitude towards their HIV condition was viewed as another pre-condition for improved physical well-being. This meant reconstructing their lives to attain a sense of normalcy. PLHIV avoided ‘thinking too much’ about HIV and treated HIV as any other infection: “I just try by all means to ignore it; I just pretend as if it does not exist. I tend to live a normal life”, said a 2 3-year old man, who had never been on ART. “I do exercises; and I keep my mind very free. I avoid thinking about it too much,” said another 24-year old man who has never been on ART. This enabled them to treat HIV not as a fatal condition; rather as something that they could live with and manage while acknowledging episodic periods of good and poor health.
The role of social network relationships
The self-care practices were modulated by kin and non-kin social network relationships. PLHIV treatment seeking behaviour was influenced by relationships with friends/family members and some formal health care providers. For instance, limited disclosure of HIV status to close and trusted friends and family members as well as formation of or belonging to informal networks of PLHIV facilitated coping and self-management of HIV. The social support received could be delineated into two: illness-specific support such as provision of financial resources to access herbal remedies and over-the-counter conventional medication to mitigate the HIV-related symptoms and obtain nutritional supplements. This type of support was mainly provided by family members:
“So me, I just use herbal remedy called ‘palibe kantu’ (there is no problem) which my mother organises for me from the farm in Mumbwa (another district). This herb grows and spreads on the ground like sweet potatoes. So you peel it and boil it and start drinking the water. So she brings that for me from time to time.” (32-year old woman; never been on ART)
The second form of social support mainly provided through religious groupings and networks with other people living with HIV involved psychosocial support. In addition, PLHIV also provided informational support to each other on illness management including which herbal remedies to use for what symptoms or ailments. They also shared information about sources of herbal remedies. As one PLHIV explained:
“You know, you come to know each other when you start treatment because in a day, they enroll may be 10 people which means these ten people will be coming to the clinic on the say day plus those that have already started treatment. So, even when you stop taking ARVs, you reach a stage where you know each other, support each other, and even encourage one another.” (39-year old woman; stopped ART)
In some cases, driven in part by their own treatment and health beliefs, it appeared that some health workers encouraged PLHIV to use faith healing and herbal remedies either in combination with or to the exclusion of ART care. Asked how she reconciled her non-uptake of treatment and counselling PLHIV to start and adhere to ART, one lay ART support worker explained:
“You know, me even when I am at the ART clinic, I also encourage those people to say that it is not only ARVs, even herbs, because sometimes you find that somebody is taking ARVs, but still more the CD4 count keeps on dropping. You see, I would also advise them that can you also try this, try herbs.” (42-year old ART support worker; never been on ART)
For better and for worse: PLHIV perceptions and experiences of self-care practices
Some PLHIV reported a rebound in their CD4 cell count or improved physical health due to the use of herbal remedies or after going through prayer sessions and therefore believed that it was possible to live a normal and healthy life if one used herbal medication and/or ‘surrendered’ his life to God for care. One lay health worker who has never been on ART explained her experience:
“When they told me that ‘your CD4 count is low’, I just started using herbs like moringa, and after that, my CD4 count improved a bit up to 460 something.” (32-year old Treatment support worker; never been on ART)
Another PLHIV - an ART support worker - who went to South Africa for prayers instead of seeking ART care also reported a rebound in her CD4 cell count. She recounted:
“We were taught how to receive healing. We were learning about how to have faith, and how to receive healing. And when we [with the husband] came back from there, I was just ok. When I came back, I went to the clinic to check my CD4 count and it had been boosted from 165 to 365. So that is it.” (37-year old woman; never been on ART)
For some PLHIV, a rebound in physical health was not associated with previous use of ART. Instead, they attributed ‘good’ health to the effectiveness of their non-ART related self-care practices. One PLHIV who had gone to Nigeria for healing prayers explained his experience:
“When I went there, I was not walking. Other people were assisting me to walk. But when I came from there, I was walking. He never gave me any herbs; he never gave me any medicine. He just gave me water and prayer.” (48-year old man; stopped ART)
Notwithstanding the perceived effectiveness of these self-care strategies, some PLHIV reported noticeable decline in their health and all PLHIV contemplated starting ART if all other efforts failed. For others, a decline in health status was attributed to either lifestyle behaviour deemed incompatible with their condition or due to psychosocial distress. These included beer drinking, smoking, challenges of maintaining a nutritious diet, pregnancy and psychological distress due to strained family relationships. As two PLHIV explained:
“The only problem why I develop these health problems, I look sick, is that I started drinking again. After two years of stopping treatment, I was ok. But that habit of drinking came back….The only mistake I made was that I started excessive drinking. Again I realized that this beer will kill me. So I stopped. I do not drink beer anymore.” (48-year old man; stopped ART)
“I used to monitor my CD4 count, and it was high… until 2008 when I was pregnant that is when my CD4 count came down.... But I think my CD4 count is also low because most of the time, we are quarrelling with my husband, so I think my mind is often disturbed.” (32-year old woman; never been on ART)
Despite reporting a decline in health status, some PLHIV still remained upbeat, viewing their poor health as temporal - a period which every individual, regardless of their HIV status went through - and not an indication that they needed to start treatment. HIV treatment was viewed as not a guarantor of good health and their lives. To them, the death of PLHIV despite being on ART was emblematic of the shortcomings of ART:
“It happens in life. Sometimes you can have good days and sometimes you can have bad days. So, if my health is not good today, it does not mean that it will be like that forever. Things change; starting treatment does not guarantee that you will become healthy forever. What about those people who have died despite taking ARVs?” (24-year old man; stopped ART)
Herbal remedies may mitigation HIV symptoms but undermine access to treatment
Our findings show that herbal remedies were widely used as a self-care practice. The herbs were reportedly used to ‘cleanse’ the body of toxins, to treatment opportunistic infections, ‘boost’ the immune system and enhance physical functioning. The pressure associated with adhering to ART compared with herbal remedies that were taken on “if and when they want” basis motivated PLHIV to opt for herbal remedies. These herbs were perceived to be as effective as ART, albeit with perceived fewer side effects and no strict dosage and adherence requirements. Our findings are consistent with previous studies that have reported wide use of herbal medication as a self-care strategy [32–37].
Worryingly, the growth of the market for herbal remedies, their popularity and perceived effectiveness without scientific proof, risks undermining the success of ART care and consequently increasing the burden of HIV care in the long term. This could happen in three ways: first, by inhibiting patient (re-) entry into ART care and second, by ‘pulling’ out of ART care PLHIV already receiving medication due to the perception that herbal remedies were effective. Consequently, delayed initiation of ART may create additional therapeutic costs when PLHIV eventually return for ART care, albeit in poor health. The reported decline in health by some PLHIV clearly suggests that it is just a matter of time before PLHIV seek ART care. Third, the perceived effectiveness of herbal remedies could also attract even those already in ART care to use them. For these PLHIV, combining herbal remedies and antiretrovirals could affect the pharmacokinetics of antiretrovirals. This could either lead to higher antiretroviral plasma levels thus putting PLHIV at greater risk of developing serious side effects or lower the optimal therapeutic level of antiretrovirals thereby leading to treatment failure and an enhanced risk of developing drug resistance . For instance, garlic, which is widely used as herbal therapy or nutritional supplement, has been reported to affect the pharmacokinetic concentration of HIV medication [39, 40]. Bepe and colleagues  found that concomitantly using herbal remedies with antiretrovirals elevates some adverse events. Other studies have also reported reduced adherence to ART by those using herbal remedies and other alternative forms of care [42, 43].
Importantly too, with growing demand for these herbal remedies and drawing on the desperation and naiveté of PLHIV, scientifically unproven herbal remedies could pose a health-risk to PLHIV. There have been reports about bogus HIV ‘cures’ or ‘immune boosters’ in Zambia and the dangers they presented to the lives and health of PLHIV. For instance in 2007, one of the purported AIDS ‘cure’ or ‘immune booster’ was found to be a pesticide, tetrasil, used for cleaning swimming pools . Therefore, to ensure successful delivery of ART care, there is need for HIV care providers to step up sensitisation campaigns during ART counselling sessions and more widely about the health risks associated with use of unproven herbal remedies. This is critical not only to improve uptake of and adherence to treatment, avert possible negative interaction effects with antiretroviral treatment, but also to protect the health and lives of PLHIV and ensure patient retention in ART care.
Religiosity and spirituality may simulate counselling but undermine uptake of ART care
Our study also found that some PLHIV sought recourse to religiosity and spirituality as a self-care practice. This is consistent with previous studies that have reported use of religiosity and spirituality as coping strategies by those with chronic health conditions, including HIV [45, 46]. Religiosity has been associated with less psychological distress  and less depression , suggesting that it provides beneficial psychological outcomes. This is despite the reported stigmatizing influence of religious beliefs due to the association of HIV infection with improper sexual relationships [49, 50].
In our study, religion and Christianity in particular was not only used to secure complete healing, but also to provide hope, comfort and assurances in the face of an incurable disease. While PLHIV were exposed to stigmatizing attitudes within religious settings, they often navigated their spiritual lives by moving to churches that preached healing and deliverance and whose leadership was perceived as open and receptive to PLHIV. Some PLHIV that were not publicly open about their HIV status only confided in and sought healing from their religious leaders. Two lessons can be drawn which have implications for successful delivery of ART care: On a positive note, these findings suggest that prayer simulates aspects of counselling  and can therefore be a useful coping mechanism for living with HIV. However, there is a thin line between faith healing as a psychosocial coping strategy and faith healing as a cure, with the latter posing a threat to patient access to and retention in ART care. More so, religious beliefs can trigger a fatalistic attitude and passive resignation with death, thus hindering uptake of treatment. Therefore, during group sensitisation and individual counselling sessions at ART clinics, health workers should tap into PLHIV belief systems to identify and harness those beliefs that promote psychosocial well-being without hindering PLHIV uptake of treatment. At community level, sensitisation efforts are required to encourage PLHIV claiming to have experienced healing through prayers to undergo formal medical tests to substantiate these claims. This is critical to ensure that PLHIV get (back) into ART care.
PLHIV self-prescription of antibiotics raises concerns about development of microbial resistant strains
Due to the experiential limitations of faith healing and herbal remedies in addressing HIV-related ailments, we found that the use of conventional medicine, particularly antibiotics as a self-care strategy was common amongst PLHIV. Since the onset of ART roll-out, western medicines like co-trimoxazole prophylaxis have become widely available in low-income countries to treat microbial infections in PLHIV. The World Health Organisation (WHO) guidelines recommend provision of co-trimoxazole prophylaxis to all HIV symptomatic adults with CD4 count lower than 350 cells per μL in resource-limited settings . Co-trimoxazole prophylaxis has been found to reduce mortality and morbidity amongst PLHIV through prevention and control of opportunistic infections [52, 53]. Based on their knowledge of these conventional medicines and experiences with the formal health system and social network ties, PLHIV opted to obtain antibiotics in order to manage AIDS-related ailments. Our findings suggest that there was widespread use of antibiotics obtained either privately from the public sector clinics or purchased from a plethora of drug stores and pharmacies. The self-prescription of antibiotics raises great concern about future development of microbial resistance to antibiotics amongst PLHIV which could undermine future efforts to deal with HIV-related opportunistic infections. In the past, WHO has raised concerns about bacterial resistance to antibiotics due to their inappropriate use . The reported widespread self-prescription and use of antibiotics by PLHIV therefore calls for sensitization measures about the dangers of self-prescription of antibiotics, especially amongst PLHIV. There is also need for enforcement of pharmaceutical regulations to control self-prescription and use of antibiotics, including clamping down on unregistered drug stores. This is even more critical for effective care of patients in ART care.
Social support may also undermine uptake of ART care
As a corollary, self-care practices were found to be socially delineated and modulated by social support mechanisms. Social support “entails the structure of an individual’s social life (i.e. group memberships, existence of familial ties) and the explicit functions they serve such as emotional support” . Previous studies have reported that social support was a strong predictor of utilization of formal HIV care services  and improved the odds of entry into and use of ART care . Our findings suggest that while social support may serve as a stress-buffer and enables individuals through their social support networks to easily come to terms with their condition and develop a more positive outlook to life in the face of an incurable condition, social support is also a key self-care input factor that undermines access to ART care (Figure 2). For instance, social pressure and influence existed at family and interpersonal level to shun ART. Conversely, social support in the form of material, financial and moral support was provided to access herbal remedies, over-the-counter conventional medication to treat AIDS-related symptoms, and faith healing as cure for HIV. This places PLHIV at risk of AIDS-related morbidity and early mortality (Figure 2).
While the physical and psychological self-care practices complemented by adoption of healthy lifestyles and risk reduction such as practicing safe sex/cessation of sexual relationships to avoid re-infections are vital in the overall management of HIV, these behavioural practices in the absence of ART care are not sufficient to effectively prevent disease progression. The long-term benefits, therefore, reside in encouraging PLHIV to access ART care.
Caution has to be taken when generalising the study findings. Some PLHIV were recruited in the community through their caregivers or snowball sampling and their eligibility for the study was based on self-reports of being eligible for treatment. Snowball sampling may have led to clustering of shared ideas and views. However, over two thirds of the study participants were identified, contacted and recruited through the ART clinic staff who were aware of which individuals had dropped out of ART or declined ART despite being eligible, suggesting that our sample largely comprised of treatment-eligible PLHIV who were independent from each other. Also, this study was descriptive and exploratory, aimed at providing wide ranging insights into how PLHIV managed their health in the absence of ART and how these self-care practices impacted uptake of ART. Thus, the purpose of the study was neither to establish causal relationships (i.e. effect of herbal remedies on immune system) nor to assess the effectiveness of these self-care strategies.
The paucity of data on PLHIV self-care practices meant that the study had to focus on identifying a wide range of themes rather than securing a representative sample of non-uptakers of treatment. To mitigate the potential for bias in the selection of study participants, we endeavoured to ensure that our study sample was diverse in terms of demographic, length of time since diagnosis and treatment-related characteristics. Therefore, similar studies are needed in other settings for comparability of findings. Despite these possible limitations, our findings could be generalised to similar settings in urban areas in the country and provide useful insight to inform policy and practice to improve ART uptake.
This study explored the self-care practices of PLHIV not receiving ART. These PLHIV comprised those to whom ART was recommended by ART providers but for other reasons opted not to initiate treatment and PLHIV who had completely discontinued their medication. Our findings show that the use of herbal remedies and faith healing were dominant self-care practices. In addition, PLHIV used conventional medicines, but only to deal with AIDS-related ailments. It was also common for PLHIV to concomitantly use these different self-care practices. While these self-care practices were perceived by PLHIV to be effective, some PLHIV still reported slow and intermittent decline in health status, an indication that these self-care strategies were not as effective as reported and experienced. For PLHIV that had dropped out of ART, the perceived effectiveness of self-care practices could be attributed to previous use of antiretrovirals. These self-care practices undermine patient uptake of treatment and risk compromising future effectiveness of medical therapies and increase likelihood of microbial resistance and HIV resistant strains amongst PLHIV. In turn, this could increase the costs of ART care and family and community resources. Therefore, to ensure effective delivery of ART care, there is need to compile and include evidence of complementary HIV care practices into counselling guidelines and encourage those self-care practices that do not affect the effectiveness of antiretrovirals and do not put the health of PLHIV at risk. On the other hand, some of the self-care practices like self-prescription and indiscriminate use of antibiotics and use of scientifically unproven herbal remedies may cause long-term harm to PLHIV hence the need for sensitization campaigns and enforcement of pharmaceutical regulations to address them.
The study was funded by the Swiss National Science Foundation (SNSF) through the research study ‘Improving equity of access to HIV care and treatment in Zambia.’ The authors are grateful to the home-based care providers and VCT/ART workers of the local public health centre who helped identify and recruit research participants; the research participants for agreeing to share their time and experiences.
The funder played no role in the design and conduct of the study; the interpretation of the data; and the write up of this paper.
- UNAIDS: Global Report: UNAIDS Report on the Global AIDS Epidemic. 2010, Geneva: UNAIDSGoogle Scholar
- WHO/UNAIDS/UNICEF: Global AIDS Response - Progress Report 2011. 2011, Geneva: WHOGoogle Scholar
- Harries AD, Zachariah R, Lawn SD, Rosen S: Strategies to retain patients on antiretroviral therapy in sub-Saharan Africa. Trop Med Int Health. 2010, 15 (Suppl 1): 70-75.PubMed CentralView ArticlePubMedGoogle Scholar
- Rosen S, Fox MP, Gill CJ: Patient retention in antiretroviral therapy programs in sub-Saharan Africa: a systematic review. PLoS Med. 2007, 4: e298- 10.1371/journal.pmed.0040298PubMed CentralView ArticlePubMedGoogle Scholar
- Hammond R, Harry TC: Efficacy of antiretroviral therapy in Africa: effect on immunological and virological outcome measures: a meta-analysis. Int J STD AIDS. 2008, 19: 291-296. 10.1258/ijsa.2007.007248View ArticlePubMedGoogle Scholar
- Coetzee D, Hildebrand K, Boulle A, Maartens G, Louis F, Labatala V, Reuter H, Ntwana N, Goemaere E: Outcomes after two years of providing antiretroviral treatment in Khayelitsha, South Africa. AIDS. 2004, 18: 887-895. 10.1097/00002030-200404090-00006View ArticlePubMedGoogle Scholar
- Ivers LC, Kendrick D, Doucette K: Efficacy of antiretroviral therapy programs in resource-poor settings: a meta-analysis of the published literature. Clin Infect Dis. 2005, 41: 217-224. 10.1086/431199View ArticlePubMedGoogle Scholar
- Egger M, May M, Chene G, Phillip AN, Ledergerber B, Dabis F, Costagliola D, D’Arminio Monforte A, de Wolf F, Reiss P, Lundgren JD, Justice AC, Staszewski S, Leport C, Hogg RS, Sabin CA, Gill MJ, Salzberger B, Sterne JA: Prognosis of HIV-1-infected patients starting highly active antiretroviral therapy: a collaborative analysis of prospective studies. Lancet. 2002, 360: 119-129. 10.1016/S0140-6736(02)09411-4View ArticlePubMedGoogle Scholar
- Miller CM, Ketlhapile M, Rybasack-Smith H: Why are antiretroviral treatment patients lost to follow-up? A qualitative study from South Africa. Trop Med Int Health. 2010, 15 (Suppl. 1): 48-54.PubMed CentralView ArticlePubMedGoogle Scholar
- Zachariah R, Harries AD, Manzi M, Gomani P, Teck R, Phillips M, Firmenich P: Acceptance of antiretroviral therapy among patients infected with HIV and Tuberculosis in rural Malawi is low and associated with cost of transport. PLoS One. 2010, 1 (1): e121-View ArticleGoogle Scholar
- Beer L, Fagan JL, Valverde E, Bertolli J: Health-related beliefs and decisions about accessing HIV medical care among HIV-infected persons who are not receiving care. AIDS Patient Care STDS. 2009, 23: 785-792. 10.1089/apc.2009.0032View ArticlePubMedGoogle Scholar
- Alfonso V, Bermbach N, Geller J, Montaner JSG: Individual variability in barriers affecting people’s decision to take HAART: A qualitative study identifying barriers to being on HAART. AIDS Patient Care STDS. 2006, 20: 848-857. 10.1089/apc.2006.20.848View ArticlePubMedGoogle Scholar
- Gellaitry G, Cooper V, Davies C, Fisher M, Leake M: Patients’ Perception of information about HAART: impact on treatment decisions. AIDS Care. 2005, 17: 367-376. 10.1080/09540120512331314367View ArticlePubMedGoogle Scholar
- Gold RS, Ridge DT: “I will start treatment when I think time is right”: HIV positive gay men talk about their decision not to access antiretroviral therapy. AIDS Care. 2001, 13: 693-708. 10.1080/09540120120076869View ArticlePubMedGoogle Scholar
- Musheke M, Bond V, Merten S: Individual and contextual factors influencing patient attrition from antiretroviral therapy in an urban community of Lusaka Zambia. J Int AIDS Soc. 2012, 15 (Suppl 1): 17366-PubMed CentralGoogle Scholar
- Katz IT, Essien T, Marinda ET, Gray GE, Bangsberg DR, Martinson NA, De Bruyn G: Antiretroviral therapy refusal among newly diagnosed HIV-infected adults. AIDS. 2011, 25: 2177-2181. 10.1097/QAD.0b013e32834b6464PubMed CentralView ArticlePubMedGoogle Scholar
- Murphy RA, Sunpath H, Taha B, Kappagoda S, Maphasa KTM, Kuritzkes DR, Smeaton L: Low uptake of antiretroviral therapy and high mortality after tuberculosis and opportunistic infection in Kwazulu-Natal, South Africa. Int J Tuberc Lung Dis. 2010, 14 (7): 903-908.PubMed CentralPubMedGoogle Scholar
- Unge C, Ragnarsson A, Ekström AM, Indalo D, Belita A, Carter J, Ilako F, Sodërgard B: The influence of traditional medicine and religion on discontinuation of ART in an urban informal settlement in Nairobi. Kenya. AIDS Care. 2011, 23 (7): 851-858.View ArticlePubMedGoogle Scholar
- Roura M, Nsigaye R, Nhandi B, Wamoyi J, Busza J, Urassa M, Todd J, Zaba B: “Driving the devil away”: qualitative insights into miraculous cures for AIDS in a rural Tanzanian ward. BMC Publ Health. 2010, 10: 427-10.1186/1471-2458-10-427.View ArticleGoogle Scholar
- Wringe A, Roura M, Urassa M, Busza J, Athanas V, Zaba B: Doubts, denial and divine intervention: understanding delayed attendance and poor retention rates at a HIV treatment programme in rural Tanzania. AIDS Care. 2009, 21: 632-637. 10.1080/09540120802385629View ArticlePubMedGoogle Scholar
- Wanyama J, Castelnuovo B, Wandera B, Mwebaze P, Kambungu A, Bangsberg DR, Kamya MR: Belief in divine healing can be a barrier to antiretroviral therapy adherence in Uganda. AIDS. 2007, 21 (11): 1486-1487. 10.1097/QAD.0b013e32823ecf7fView ArticlePubMedGoogle Scholar
- Babb DA, Pemba L, Seatlanyane P: Use of traditional medicine by HIV-infected individuals in South Africa in the era of antiretroviral therapy. Psychol Health Med. 2007, 12 (3): 314-320. 10.1080/13548500600621511View ArticlePubMedGoogle Scholar
- Stevens PE, Hilderbrandt E: Pill taking from the perspective of HIV-infected women who are vulnerable to antiretroviral treatment failure. Qual Health Res. 2009, 19 (5): 593-604. 10.1177/1049732309333272View ArticlePubMedGoogle Scholar
- Central Statistics Office (CSO: Zambia Demographic and Health Survey 2007. 2009, Calverton, Maryland, USA: CSO and Macro International IncGoogle Scholar
- National AIDS Council: Zambia Country Report. Monitoring the Declaration of Commitment on HIV and AIDS and the Universal Access - Biennial report for January 2010 – December 2011. Submitted to the United Nations General Assembly Special Session on AIDS. 2012, Lusaka: NACGoogle Scholar
- Fox MP, Mazimba A, Seidenberg P, Crooks D, Sikateyo B, Rosen S: Barriers to initiation of antiretroviral treatment in rural and urban Zambia: A cross-sectional study of cost, stigma and perception of treatment. J Int AIDS Soc. 2010, 13: 8- 10.1186/1758-2652-13-8PubMed CentralView ArticlePubMedGoogle Scholar
- Grant E, Logie D, Masura M, Gorman D, Murray SA: Factors facilitating and challenging access and adherence to antiretroviral therapy in a township in the Zambian Copperbelt: A qualitative study. AIDS Care. 2008, 20 (10): 1155-1160. 10.1080/09540120701854634View ArticlePubMedGoogle Scholar
- Murray LK, Semrau K, McCauley E, Thea DM, Scott N, Mwiya M, Kankasa C, Bass J, Bolton P: Barriers to acceptance and adherence of antiretroviral therapy in urban Zambian women: A qualitative study. AIDS Care. 2009, 21 (1): 78-86. 10.1080/09540120802032643PubMed CentralView ArticlePubMedGoogle Scholar
- Barlow J, Wright C, Sheasby J, Turner A, Hainsworth J: Self-management approaches for people with chronic conditions: a review. Patient Educ Couns. 2002, 48: 177-187. 10.1016/S0738-3991(02)00032-0View ArticlePubMedGoogle Scholar
- Ministry of Health: Adult and adolescent antiretroviral therapy protocols (2nd edition). 2010, Lusaka: MoHGoogle Scholar
- Graneheim UH, Lundman B: Qualitative content analysis in nursing research: concepts, procedures and measures to achieve trustworthiness. Nurse Educ Today. 2004, 24: 105-112. 10.1016/j.nedt.2003.10.001View ArticlePubMedGoogle Scholar
- Marie Modeste RR, Majeke SJ: Self-care symptom management strategies among women living with HIV in urban Kwazulu-Natal. Health. 2010, 15: 1-Google Scholar
- Monera TG, Maponga CC: Moringa oleifera supplementation by patients on antiretroviral therapy. J Int AIDS Soc. 2010, 13 (Suppl 4): P188-10.1186/1758-2652-13-S4-P188.PubMed CentralView ArticleGoogle Scholar
- Hsiao AF, Wong MD, Kanouse DE, Collins RL, Liu H, Andersen RM, Gifford AL, McCutchan A, Bozzette SA, Shapiro MF, Wenger NS: Complementary and alternative medicine use and substitution for conventional therapy by HIV-infected patients. J Acquir Immune Defic Syndr. 2003, 33: 157-165. 10.1097/00126334-200306010-00007View ArticlePubMedGoogle Scholar
- Thorne S, Paterson B, Russell C, Schultz A: Complementary/alternative medicine in chronic illness as informed self-care decision making. Int J Nurs Stud. 2002, 39: 671-683. 10.1016/S0020-7489(02)00005-6View ArticlePubMedGoogle Scholar
- Duggan J, Peterson WS, Schutz M, Khudar S, Charkraborty J: Use of complementary and alternative therapies in HIV infected individuals. AIDS Patient Care STDS. 2001, 15 (3): 159-167. 10.1089/108729101750123661View ArticlePubMedGoogle Scholar
- Ernst E: Prevalence of use of complementary/alternative medicine: a systematic review. Bull World Health Organ. 2000, 78 (2): 252-257.PubMed CentralPubMedGoogle Scholar
- Van den Bout-van den Beukel CJ, Koopmans PP, van der Ven AJ, De Smet PA, Burger DM: Possible drug metabolism interactions of medicinal herbs with antiretroviral agents. Drug Metab Rev. 2006, 38: 477-514. 10.1080/03602530600754065View ArticlePubMedGoogle Scholar
- Borrelli F, Capasso R, Izzo AA: Garlic (allium sativum L): Adverse effects and drug interactions in humans. Mol Nutr Food Res. 2007, 51: 1386-1397. 10.1002/mnfr.200700072View ArticlePubMedGoogle Scholar
- Piscitelli SC, Burstein AH, Welden N, Gallicano KD, Falloon J: The effect of garlic supplements on the pharmacokinetics of Saquinavir. Clin Inf Dis. 2002, 34: 234-238. 10.1086/324351.View ArticleGoogle Scholar
- Bepe N, Madanhi N, Mudzviti T, Gavi S, Maponga CC, Morse GD: The impact of herbal remedies on adverse effects and quality of life in HIV-infected individuals on antiretroviral therapy. J Infect Dev Ctries. 2011, 5 (1): 048-053.Google Scholar
- Peltzer K, Friend-du Preez N, Ramlagan S, Fomundam H, Anderson H, Chanetsa L: Antiretrovirals and the use of traditional, complementary and alternative medicine by HIV patients in Kwa-Zulu Natal, South Africa. A longitudinal study. Afr J Tradit Complement Altern Med. 2011, 8 (4): 337-345.PubMed CentralPubMedGoogle Scholar
- Owen-Smith A, Diclemente R, Wingood G: Complementary and alternative medicine use decreases adherence to HAART in HIV-positive women. AIDS Care. 2007, 19 (5): 589-593. 10.1080/09540120701203279View ArticlePubMedGoogle Scholar
- Amon JJ: Dangerous medicines: Unproven AIDS cures and counterfeit antiretroviral drugs. Global health. 2008, 4: 5- 10.1186/1744-8603-4-5PubMed CentralView ArticlePubMedGoogle Scholar
- Ridge D, Williams I, Anderson J, Elford J: Like a prayer: the role of spirituality and religion for people living with HIV in the UK. Sociol Health Illn. 2007, 30 (3): 413-428. 10.1111/j.1467-9566.2007.01062.x.View ArticleGoogle Scholar
- Woods TE, Ironson GH: Religion and spirituality in the face of illness: how cancer, cardiac and HIV patients describe their religiosity/spirituality. J Health Psychol. 1999, 4 (3): 393-412. 10.1177/135910539900400308View ArticlePubMedGoogle Scholar
- Simoni JM, Martone MG, Kerwin JF: Spirituality and psychological adaptation among women with HIV/AIDS: implications for counselling. J Counsel Psychol. 2002, 49: 139-147.View ArticleGoogle Scholar
- Simoni JM, Ortiz MZ: Mediational models of spirituality and depressive symptomatology among HIV-positive Puerto Rican women. Cultur Divers Ethnic Minor Psychol. 2003, 9: 3-15.View ArticlePubMedGoogle Scholar
- Zou J, Yamanaka Y, Muze J, Watt M, Ostermann J, Thielman N: Religion and HIV in Tanzania: influence of religious beliefs on HIV stigma, disclosure, and treatment attitudes. BMC Publ Health. 2009, 9: 75-10.1186/1471-2458-9-75.View ArticleGoogle Scholar
- Genrich GL, Brathwaite BA: Response of religious groups to HIV/AIDS as a sexually transmitted infection in Trinidad. BMC Publ Health. 2005, 5: 121-10.1186/1471-2458-5-121.View ArticleGoogle Scholar
- WHO: Guidelines on co-trimoxazole prophylaxis for HIV-related infections among children, adolescents and adults: recommendations for a public health approach. 2006, Geneva: WHOGoogle Scholar
- Walker AS, Ford D, Gilks CF, Munderi P, Ssali F, Reid A, Katabira E, Grosskurth H, Mugyenyi P, Hakim J, Darbyshire JH, Gibb DM, Babiker AG: Daily co-trimoxazole prophylaxis in severely immune-suppressed HIV-infected adults in Africa started on combination antiretroviral therapy: an observational analysis of the DART cohort. Lancet. 2010, 375: 1278-1286. 10.1016/S0140-6736(10)60057-8PubMed CentralView ArticlePubMedGoogle Scholar
- Walker AS, Mulenga V, Ford D, Kabamba D, Sinyinza F, Kankasa C, Chintu C, Gibb DM, : The impact of daily Cotrimoxazole prophylaxis and antiretroviral therapy on mortality and hospital admissions in HIV-infected Zambian children. Clin Infect Dis. 2007, 44: 1361-1367. 10.1086/515396View ArticlePubMedGoogle Scholar
- WHO: Antimicrobial resistance: the facts. Essential drugs monitor Issue Number 28 & 29. 2000, Geneva: WHOGoogle Scholar
- Uchino NN: Social support and health: a review of physiological processes potentially underlying links to disease outcomes. Int J Behav Med. 2006, 29 (4): 377-387. 10.1007/s10865-006-9056-5.View ArticleGoogle Scholar
- Uphold CR, Mkanta WN: Use of health care services among persons living with HIV infection: state of the science and future directions. AIDS Patient Care STDS. 2005, 19 (8): 473-485. 10.1089/apc.2005.19.473View ArticlePubMedGoogle Scholar
- Waddell EN, Messeri PA: Social support, disclosure and use of antiretroviral therapy. AIDS Behav. 2006, 10: 263-272. 10.1007/s10461-005-9042-xView ArticlePubMedGoogle Scholar
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