In Henan, China, first-line antiretroviral treatment (ART) was implemented early in a large number of treatment-experienced patients who were more likely to have a drug resistance. Therefore, we investigated t...
Lipodystrophy (LD) is a frequent adverse event of combination antiretroviral therapy (ART) and occurs mainly in patients exposed to first-generation antiretroviral drugs. The aim of this study was to explore a...
Authors: Charlotte M Verolet, Cécile Delhumeau-Cartier, Marlène Sartori, Simona Toma, Sophie Zawadynski, Minerva Becker, Enos Bernasconi, Laurence Toutous Trellu and Alexandra Calmy
Trends in prevalence of opportunistic infections (OIs) associated with the human immunodeficiency virus (HIV) in resource poor settings have previously not been well documented. The objective of this study was...
Authors: John Rubaihayo, Nazarius M Tumwesigye and Joseph Konde-Lule
Estimates of the interval from HIV-1 infection to disease progression may be affected by selection bias, and data concerning asymptomatic early seroconverters are limited. We examined the interval until diseas...
A 21 year old MSM patient with newly diagnosed HIV infection was hospitalized in our department after ingestion of an overdose of his antiretroviral therapy (ART) comprising dolutegravir (DTG - Tivicay®) and t...
Authors: Marcel Lee, Florian Eyer, Norbert Felgenhauer, Hartwig HF Klinker and Christoph D Spinner
To determine the levels of NT-pro BNP in HIV patients over 40 years who are receiving highly active antiretroviral therapy (HAART) and investigating potential independent clinical or laboratory factors.
Authors: Julián Olalla, Elena Crespo, Javier De la Torre, Marco Sempere, Alfonso Del Arco, José Luis Prada, Rocío Malvarez, Javier Pérez and Javier García-Alegría
Sporotrichosis is an infection caused by a dimorphic fungus of the Sporothrix schenckii complex. Host immunity is an important factor in the clinical manifestations of the disease. Deeply immunocompromised indivi...
Authors: Ariane Gomes Paixão, Maria Clara Gutierrez Galhardo, Rodrigo Almeida-Paes, Estevão Portela Nunes, Marcelo Luiz Carvalho Gonçalves, Gisele Larias Chequer and Cristiane da Cruz Lamas
Codes of confidentiality play an essential role in the intimate discourses in many learned professions. Codes with various prescriptions exist. The Hippocratic Oath for example, prescribes rewards to the secre...
Authors: Amos K Laar, Debra A DeBruin and Susan Craddock
Little evidence exists on the connections between nutrition, diet intake, and quality of life (QoL) among people living with HIV (PLHIV). The study aimed to estimate the prevalence of under-nutrition among PLH...
Authors: Rajshree Thapa, Archana Amatya, Durga Prasad Pahari, Kiran Bam and M Sophia Newman
We report a rare case of osteonecrosis of the jaw following necrotizing gingivitis in a Japanese AIDS patient. Intraoral examination showed exposed necrotic bone in the left mandible and spontaneous loss of te...
New evidence has emerged regarding when to commence antiretroviral therapy (ART), optimal treatment regimens, management of HIV co-infection with opportunistic infections, and management of ART failure. The 20...
An HIV-1 tropism test is recommended prior to CCR5 antagonist administration to exclude patients harboring non-R5 virus from treatment with this class of antiretrovirals. HIV-1 tropism determination based on p...
Authors: Russell E Baumann, Amy A Rogers, Hasnah B Hamdan, Harold Burger, Barbara Weiser, Wei Gao, Kathryn Anastos, Mary Young, William A Meyer III, Rick L Pesano and Ron M Kagan
Polymorphisms in cytochrome P450 2B6 (CYP2B6) affect the steady state plasma concentration of nevirapine. CYP2B6 516G>T and 983T>C are common in African populations, but data on their influence on plasma nevir...
Authors: Margaret Ngwono Oluka, Faith Apolot Okalebo, Anastasia Nkatha Guantai, R Scott McClelland and Susan M Graham
MDD and HIV/AIDS have a high prevalence worldwide with severe consequences for patients. In both conditions, compliance with treatment is key to successfully treat these disorders. In the current study, we exa...
Authors: Francois N Slabbert, Brian H Harvey, Christiaan B Brink and Martie S Lubbe
Tubular dysfunction is common in HIV-infected people and detection of proteinuria is essential to identify this problem. In low-income countries, resources for detection of proteinuria using the Kidney Disease...
Authors: José Ignacio López De León, Jose Antonio Mata-Marín, Karen Andrade-Fuentes, Gloria Huerta-Garcia, Juan C Domínguez-Hemosillo and Jesus Gaytán-Martínez
Antimalarials quinacrine (Qc) and chloroquine (Cq) intercalate DNA, potentiate the activity of other drugs and have lysosomotropic, anti-inflammatory and antiviral activities that could increase the effect of ...
Authors: Klintsy J Torres, Gustavo Reyes-Terán, Julio Sotelo, Helgi Jung-Cook and Lucinda Aguirre-Cruz
Antiretroviral treatment (ART) has been effective in reducing HIV/AIDS related morbidity and mortality. However, the use and uptake of ART has resulted in adverse reactions, due mainly to the medicine’s toxici...
Authors: Lieketseng J Masenyetse, Samuel OM Manda and Henry G Mwambi
HIV infection may be associated with an increased recurrence rate of myocardial infarction. Our aim was to determine whether HIV infection is a risk factor for worse outcomes in patients with coronaray artery ...
Authors: David Carballo, Cécile Delhumeau, Sebastian Carballo, Caroline Bähler, Dragona Radovanovic, Bernard Hirschel, Olivier Clerc, Enos Bernasconi, Dominique Fasel, Patrick Schmid, Alexia Cusini, Jan Fehr, Paul Erne, Pierre-Fréderic Keller, Bruno Ledergerber and Alexandra Calmy
The emergence of transmitted drug resistance (TDR) compromises the effect of antiretroviral therapy (ART), resulting in treatment failure of human immunodeficiency virus (HIV) disease. Although more than a dec...
Authors: Tomohiro Kotaki, Siti Qamariyah Khairunisa, Adiana Mutamsari Witaningrum, Muhammad Qushai Yunifiar M, Septhia Dwi Sukartiningrum, Muhammad Noor Diansyah, Retno Pudji Rahayu, Nasronudin and Masanori Kameoka
The availability of HIV antiretroviral therapy (ART) has been associated with the development of transmitted drug resistance-associated mutations (TDRM). TDRM can compromise treatment effectiveness in patients...
Authors: Awachana Jiamsakul, Sunee Sirivichayakul, Rossana Ditangco, Ka-Hing Wong, Patrick CK Li, Jutarat Praparattanapan, Praphan Phanuphak, Edelwisa Segubre-Mercado, Wing-Cheong Yam, Thira Sirisanthana, Thida Singtoroj and Matthew Law
The Human Immune Deficiency Virus (HIV) can manifest neurologically in both adults and children. Early invasion of the central nervous system by the virus, affecting the developing brain, is believed to result...
Authors: Kirsten A Donald, Kathleen G Walker, Tracy Kilborn, Henri Carrara, Nelleke G Langerak, Brian Eley and Jo M Wilmshurst
While HIV, AIDS and atypical Mycobacterium infections are closely linked, the use of Integrase-Inhibitor based cART, notably raltegravir-based regimens is more widespread. RAL should be double-dosed to 800 mg ...
Authors: Christoph D Spinner, Florian Wille, Christiane Schwerdtfeger, Philipp Thies, Ursula Tanase, Guido Von Figura, Roland M Schmid, Werner J Heinz and Hartwig Hf Klinker
Treatments in patients with multidrug resistance often involve the use of multiple agents with partial antiviral activity and overlapping metabolic toxicities. Enfuvirtide is therefore a welcome addition to th...
Authors: Gloria Huerta-García, Marcelino Chavez-García, José Antonio Mata-Marín, Jorge Sandoval-Ramírez, Juan Domínguez-Hermosillo, Ana Lourdes Rincón-Rodríguez and Jesús Gaytán-Martínez
Cobicistat is an alternative pharmacoenhancer to ritonavir. In healthy volunteers, darunavir exposure was comparable when darunavir 800 mg once daily was co-administered with cobicistat 150 mg once daily (as s...
Authors: Karen Tashima, Gordon Crofoot, Frank L Tomaka, Thomas N Kakuda, Anne Brochot, Tom Van de Casteele, Magda Opsomer, William Garner, Nicolas Margot, Joseph M Custodio, Marshall W Fordyce and Javier Szwarcberg
Abnormal NK phenotype and cytotoxic functions have been described in acute myeloid leukemia, chronic lymphocytic leukemia, myeloma and myelodysplastic syndromes. Defective NK cytotoxicity is due to decreased e...
Authors: Delphine Mercier-Bataille, Carole Sanchez, Céline Baier, Thérèse Le Treut, Nicolas Mounier, Saadia Mokhtari, Daniel Olive, Karine Baumstarck, Gérard Sébahoun, Caroline Besson and Régis T Costello
We built a cohort study of HIV patients taking long-term first-line Antiretroviral Therapy in 2003. In this assay, we focused on the development of primary drug resistance mutations against Non-Nucleoside Reve...
Authors: Yuncong Wang, Hui Xing, Lingjie Liao, Zhe Wang, Bin Su, Quanbi Zhao, Yi Feng, Pengfei Ma, Jia Liu, Jianjun Wu, Yuhua Ruan and Yiming Shao
We report a case of an adult patient with human immunodeficiency virus (HIV), acute respiratory distress syndrome (ARDS) and ventilator associated pneumonia (VAP) caused by multidrug resistant (MDR) bacteria t...
Authors: Robertas Samalavicius, Mindaugas Serpytis, Donata Ringaitiene, Daiva Grazulyte, Ruta Bertasiute, Bernardas Rimkus, Raimonda Matulionyte, Ruta Ambrazaitiene, Jurate Sipylaite, Tomas Kacergius and Laimonas Griskevicius
A number of antiviral agents used against Human Immunodeficiency Virus (HIV) infection and hepatitis B virus (HBV) mono or co-infection have been associated with real nephrotoxicity (including tenofovir disopr...
Authors: Stephen G Holt, David M Gracey, Miriam T Levy, David W Mudge, Ashley B Irish, Rowan G Walker, Richard Baer, Jacob Sevastos, Riaz Abbas and Mark A Boyd
We report a 57-year old man with diabetes mellitus and hypertension who presented with acute HIV infection. Routine blood tests showed an elevated blood urea nitrogen and creatinine. Renal biopsy showed acute ...
Authors: Jintanat Ananworanich, Anandita A Datta, James LK Fletcher, Natavudh Townamchai, Nitiya Chomchey, Eugene Kroon, Irini Sereti, Victor Valcour and Jerome H Kim
Ongoing HIV-1 replication in lymphoid cells is one explanation of the persistence of HIV-1 reservoirs despite highly active antiretroviral therapy (cART). We tested the potential of cART intensification by Mar...
Authors: Alain Lafeuillade, Assi Assi, Cécile Poggi, Caroline Bresson-Cuquemelle, Eric Jullian and Catherine Tamalet
Increasing numbers of HIV-infected patients in sub-Saharan Africa are exposed to antiretroviral therapy (ART), but there are few data on lipid changes on first-line ART, and even fewer on second-line.
Authors: Zvenyika AR Gomo, James G Hakim, Sarah A Walker, Willard Tinago, Gibson Mandozana, Cissy Kityo, Paula Munderi, Elly Katabira, Andrew Reid, Diana M Gibb and Charles F Gilks
The CD5 protein antagonizes phosphorylation events downstream of T cell receptor (TCR) engagement to decrease T cell responsiveness. CD5-negative T cell clones respond preferentially over their CD5+ counterparts ...
Authors: Stephen J Penney, Maureen E Gallant and Michael D Grant
Sexually transmitted infections (STIs) contribute largely to the burden of health in South Africa and are recognized as major contributors to the human immunodeficiency virus (HIV) epidemic. Young women are pa...
While Brazil has had a long-standing policy of free access to antiretroviral therapy (ART) for all in need, the epidemiological impact of ART on human immunodeficiency virus (HIV) RNA suppression in this middl...
Authors: Sandra W Cardoso, Paula M Luz, Luciane Velasque, Thiago Torres, Lara Coelho, Kenneth A Freedberg, Valdilea G Veloso, Rochelle P Walensky and Beatriz Grinsztejn
The 2014 International Symposium on HIV and Emerging Infectious Diseases (ISHEID) provided a forum for investigators to hear the latest research developments in the clinical management of HIV and HCV infection...
Authors: Alain Lafeuillade, Mark Wainberg, Marie-Lise Gougeon, Sabine Kinloch-de Loes, Philippe Halfon and Hervé Tissot-Dupont
The level (or frequency) of circulating monocyte subpopulations such as classical (CD14hiCD16-) and non-classical (CD14dimCD16+) monocytes varies during the course of HIV disease progression and antiretroviral th...
Authors: Lillian Seu, Gabriel M Ortiz, Trevor D Burt, Steven G Deeks, Jeffrey N Martin and Joseph M McCune
Despite recommendations by the Centers for Disease Control (CDC) that all adults be offered non-targeted HIV screening in all care settings, screening in acute-care settings remains unacceptably low. We perfor...
Authors: Rachel A Bender Ignacio, Jacqueline Chu, Melinda C Power, Jeffrey Douaiher, Jordan D Lane, Jeffrey P Collins and Valerie E Stone
Lipohypertrophy does not appear to be an adverse ART reaction while lipoatrophy is clearly associated with the use of stavudine (d4T) and zidovudine (AZT). In low and middle income countries d4T has only recen...
Authors: Zulfa Abrahams, Joel A Dave, Gary Maartens, Maia Lesosky and Naomi S Levitt
HIV-1 entry into host cells is mediated by interactions between the virus envelope glycoprotein (gp120/gp41) and host-cell receptors. N-glycans represent approximately 50% of the molecular mass of gp120 and serve...
Authors: Milan Raska, Lydie Czernekova, Zina Moldoveanu, Katerina Zachova, Matt C Elliott, Zdenek Novak, Stacy Hall, Michael Hoelscher, Leonard Maboko, Rhubell Brown, Phillip D Smith, Jiri Mestecky and Jan Novak
The role of DCs in primary HIV-1 infection remains uncertain. In this study, we enrolled two different groups of subjects with acute HIV-1 infection. One group progressed to CD4 counts below 200 cells/μl withi...
HCV RNA viral load is an important predictor of sustained virological response and, recently, a significant correlation with liver fibrosis was described. We investigated on possible influence of clinical and ...
Authors: Monica Basso, Marzia Franzetti, Renzo Scaggiante, Andrea Sattin, Carlo Mengoli, Mario Cruciani, Marta Fiscon, Giorgio Palù and Saverio Giuseppe Parisi
Microsporidia have become increasingly recognized as opportunistic pathogens since the genesis of the AIDS epidemic. The incidence of microsporidiosis has decreased with the advent of combination antiretrovira...
Authors: Maude Loignon, Louise-Geneviève Labrecque, Céline Bard, Yves Robitaille and Emil Toma
To optimize treatment regimens, we assessed human immunodeficiency virus (HIV) diversity and the prevalence of transmitted drug resistance (TDR) among men who have sex with men (MSM) in Anhui province, China.
Authors: Yuelan Shen, Bin Su, Jianjun Wu, Yizu Qin, Lin Jin, Lifeng Miao, Aiwen Liu and Xiaoli Cheng
Data on the effectiveness of second-line antiretroviral therapy (ART) in resource-limited countries of Eastern Europe is limited. Objective of this study was to evaluate virological outcomes of second-line ART...
Opioids may have effects on susceptibility to HIV-infection, viral replication and disease progression. Injecting drug users (IDU), as well as anyone receiving opioids for anesthesia and analgesia may suffer t...
Authors: Johannes Prottengeier, Eleni Koutsilieri and Carsten Scheller
Current German and European HIV guidelines recommend early evaluation of HCV treatment in all HIV/HCV co-infected patients. However, there are still considerable barriers to initiate HCV therapy in everyday cl...
Authors: Claudia Beisel, Martin Heuer, Benjamin Otto, Johannes Jochum, Stefan Schmiedel, Sandra Hertling, Olaf Degen, Stefan Lüth, Jan van Lunzen and Julian Schulze zur Wiesch
In response to an article published in 2012 by officials at the US Department of Health and Human Services (DHHS), an independent analysis of state-based federal resource allocation for HIV was conducted to de...
Authors: Willie H Oglesby, Joseph L Smith and Sonia A Alemagno
HIV-1 coreceptor tropism testing is used to evaluate eligibility for CCR5 antagonist therapy. However, HIV-1 RNA-based tests are not suitable for virologically suppressed patients, therefore the use of provira...
Authors: Jennifer Brown, Harold Burger, Barbara Weiser, Richard B Pollard, Xiao-Dong Li, Lynell J Clancy, Russell E Baumann, Amy A Rogers, Hasnah B Hamdan, Rick L Pesano and Ron M Kagan
As the HIV-1 epidemic enters its fourth decade, HIV-1 associated neurological disorders (HAND) continue to be a major concern in the infected population, despite the widespread use of anti-retroviral therapy. ...
Authors: Vasudev R Rao, Arthur P Ruiz and Vinayaka R Prasad
