Table 1 Demographics and Baseline Characteristics Overall and by Age: TANGO and SALSA Pooled ITT-E Population
Parameter | Overall | < 50 y | 50 to < 65 y | ≥ 65 y | ||||
|---|---|---|---|---|---|---|---|---|
DTG/3TC (N = 615) | CAR (N = 619) | DTG/3TC (N = 438) | CAR (N = 432) | DTG/3TC (N = 163) | CAR (N = 158) | DTG/3TC (N = 14) | CAR (N = 29) | |
Sex, female, n (%) | 133 (22) | 117 (19) | 68 (16) | 71 (16) | 59 (36) | 38 (24) | 6 (43) | 8 (28) |
Age, median (range), y | 42 (20–74) | 42 (18–83) | 37 (20–49) | 36 (18–49) | 56 (50–64) | 55 (50–64) | 67 (65–74) | 69 (65–83) |
Weight, median (range), kg | 77 (43–154) | 78 (36–160) | 78 (43–154) | 77 (48–160) | 75 (44–128) | 80 (36–127) | 72 (59–106) | 75 (49–116) |
BMI, median (range), kg/m2 | 25 (17–51) | 26 (14–69) | 25 (17–51) | 25 (17–69) | 25 (18–43) | 27 (14–45) | 26 (18–32) | 27 (19–44) |
Baseline use of ≥ 1 non-ART medication, n (%) | 401 (65) | 425 (69) | 264 (60) | 264 (61) | 125 (77) | 134 (85) | 12 (86) | 27 (93) |
Number of baseline non-ART medications, median (range) | 1 (0–13) | 1 (0–20) | 1 (0–12) | 1 (0–16) | 2 (0–13) | 3 (0–20) | 2 (0–6) | 4 (0–11) |
Baseline polypharmacy (> 5 medications), n (%)a | 55 (9) | 76 (12) | — | — | — | — | — | — |
Baseline comorbidities, n (%) | 457 (74) | 474 (77) | 311 (71) | 307 (71) | 134 (82) | 138 (87) | 12 (86) | 29 (100) |
Baseline CD4 + cell count, median (range), cells/mm3 | 680 (133–2089) | 684 (94–1954) | 685 (154–1904) | 686 (94–1954) | 653 (133–2089) | 677 (119–1530) | 638 (228–1199) | 657 (122–1133) |
Baseline CD4 + /CD8 + ratio, mean (SD) | 1.1 (0.54) | 1.1 (0.50) | 1.0 (0.51) | 1.0 (0.44) | 1.1 (0.61) | 1.1 (0.65) | 1.2 (0.58) | 1.0 (0.46) |
Duration of ART before Day 1, median (range), mo | 41 (4–240) | 45 (7–253) | 37 (4–188) | 41 (7–206) | 61 (7–240) | 57 (9–253) | 58 (8–201) | 74 (20–214) |
Baseline NRTI, n/N (%)b | ||||||||
TDF | 109/605 (18) | 110/606 (18) | 70/431 (16) | 73/422 (17) | 34/160 (21) | 31/155 (20) | 5/14 (36) | 6/29 (21) |
TAF | 451/605 (75) | 462/606 (76) | 340/431 (79) | 333/422 (79) | 104/160 (65) | 109/155 (70) | 7/14 (50) | 20/29 (69) |
ABC | 45/605 (7) | 34/606 (6) | 21/431 (5) | 16/422 (4) | 22/160 (14) | 15/155 (10) | 2/14 (14) | 3/29 (10) |
Baseline third agent, n (%) | ||||||||
INSTI | 387 (63) | 394 (64) | 295 (67) | 285 (66) | 83 (51) | 97 (61) | 9 (64) | 12 (41) |
NNRTI | 174 (28) | 172 (28) | 109 (25) | 110 (25) | 61 (37) | 47 (30) | 4 (29) | 15 (52) |
PI | 54 (9) | 53 (9) | 34 (8) | 37 (9) | 19 (12) | 14 (9) | 1 (7) | 2 (7) |