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Fig. 2 | AIDS Research and Therapy

Fig. 2

From: Clinical, molecular, and histological characteristics of severely necrotic and fatal mpox in HIV-infected patients

Fig. 2

Lung tissue with broncho-pneumonic changes. Congestive septi (A) and effacement of alveolar pattern with necrosis (B) Both 40X. Prominent type II pneumocytes (arrow) and congestive septi (C), followed by desquamative changes (wide arrow) and interstitial inflammation and macrophages in alveolar space (D). Necrotic debris in alveoli with few erythrocytes and wide congestive septum (E). Parenchymal necrosis with karyorrhexis and giant histiocytic cells (F). All sequential alveolar changes at 400X. Cytopathic changes in pneumocytes (arrows). Ground glass chromatin in a large cell lining alveoli filled with fibrin, polymorphonuclear cells, macrophages, and lymphocytes (G). Sincitial cell covering alveolar surface close to necrotic area (H). Both Fig. 1000X.

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