Immune cell subsets (%) | Baseline | Change from baseline after pitavastatin | Change from baseline after placebo | P-value |
---|---|---|---|---|
Lymphocytes | 55.50 (50.40–60.89) | − 2.10 (− 8.67–6.60) | −0.30 (− 7.50–16.00) | 0.241 |
T cells | 38.70 (19.91–45.93) | 0.96 (− 9.07 –8.37) | 0.12 (− 14.80 –6.83) | 0.101 |
CD4+ T cells | 19.72 (9.20–22.01) | − 0.78 (− 4.90–6.34) | 1.66 (− 2.98–9.32) | 0.134 |
HLA-DR+CD38+CD4+ T cells | 0.84 (0.46–1.64) | − 0.07 (− 0.47–0.39) | 0.04 (− 0.24–0.88) | 0.205 |
HLA-DR+CD38- CD4+ T cells | 1.37 (0.86–1.95) | − 0.27 (− 0.47–0.24) | 0.02 (− 0.35–0.68) | 0.049 |
HLA-DR-CD38+CD4+ T cells | 8.28 (3.90–11.59) | − 0.35 (− 3.06–2.21) | 0.90 (− 1.24–5.45) | 0.073 |
HLA-DR-CD38-CD4+ T cells | 6.08 (1.75–7.97) | 0.04 (− 1.12 – 2.65) | 0.66 (− 0.91–2.96) | 0.966 |
PD-1+CD4+ T cells | 3.37 (1.07–4.27) | − 0.23 (− 1.06–0.79) | 0.23 (− 0.92–1.64) | 0.022 |
Regulatory T cells | 0.76 (0.39–1.04) | 0.09 (0.00–0.42) | 0.23 (0.06 – 0.52) | 0.097 |
CD8+ T cells | 17.79 (8.51 – 21.32) | − 0.61 (− 4.02–3.47) | 0.73 (− 3.96–5.20) | 0.252 |
HLA-DR+ CD38+ CD8+ T cells | 2.93 (1.64–3.48) | − 0.53 (− 1.08–0.59) | − 0.34 (− 1.26–0.83) | 0.160 |
HLA-DR+CD38-CD8+ T cells | 3.35 (2.38–5.01) | 0.11 (− 0.92–1.59) | 0.55 (− 0.50–1.76) | 0.364 |
HLA-DR-CD38+CD8+ T cells | 2.66 (1.26–5.74) | − 0.41 (− 1.00–0.16) | 0.06 (− 0.72–1.33) | 0.145 |
HLA-DR- CD38-CD8+ T cells | 5.07 (2.06–8.34) | 0.60 (− 1.35–3.04) | − 0.12 (− 0.93–1.74) | 0.703 |
PD-1+CD8+ T cells | 2.88 (0.94 – 4.80) | − 0.17 (− 0.94 – 0.62) | − 0.01 (− 1.11–1.49) | 0.426 |
Monocytes | 3.46 (2.66–4.11) | 1.07 (− 1.12 –1.64) | 0.61 (− 0.76–1.92) | 0.313 |
Classical monocytes | 1.65 (0.90–2.71) | 0.72 (− 0.60–1.81) | 0.65 (− 0.40–2.18) | 0.569 |
Intermediate monocytes | 0.08 (0.04–0.12) | − 0.01 (− 0.05–0.03) | 0.00 (− 0.03–0.05) | 0.966 |
Nonclassical monocytes | 0.31 (0.20–0.47) | 0.03 (− 0.15 –0.) | 0.02 (− 0.11–0.17) | 0.326 |
Patrolling monocytes | 0.02 (0.01–0.03) | 0.00 (− 0.01 –0.02) | 0.00 (− 0.01–0.02) | 0.490 |