Fig. 1

Doravirine in vitro susceptibility data for isolates with one, two, or three NNRTI-resistance mutations. The Y-axis indicates the pattern of mutations and the X-axis indicates the fold-reduction in susceptibility on a log₂ scale. Isolates with a fold-reduced susceptibility < 1.0 were jittered about 1.0 whereas those with a fold reduced susceptibility > 128 were jittered at this level. Each of the results were published by the Merck Research Laboratory and included 109 results generated by the Monogram Biosciences PhenoSense assay and 27 results generated by an in-house MT-2 cell reporter gene assay. Blue circles indicate clinical isolates containing common patterns of NNRTI DRMs. Green circles indicate median fold reduced susceptibilities of viruses containing a single NNRTI DRM from a selection of viruses in the Monogram database [10]. Black circles indicate site-directed mutants containing common patterns of NNRTI DRMs. Red circles indicate site-directed mutants containing patterns of NNRTI DRMs that were selected either in vitro or in persons receiving doravirine. Vertical lines indicate 3.0-fold and  10.0-fold reduced susceptibility