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Table 4 HIV-HBV, and HIV-HCV coinfections and their association with HIV viral load suppression among HIV-1 infected patients on ART at Mekelle Hospital in northern Ethiopia in the bivariate and multivariate logistic regression analysis (n = 439)

From: Hepatitis B and C viral coinfections and their association with HIV viral load suppression among HIV-1 infected patients on ART at Mekelle hospital, northern Ethiopia

Variables

Current HIV-1 Viral Load Level

COR (95% CI)

P

value

AOR (95% CI)

P

value

 < 1000 cps/ml*

( n = 396)

 > 1000 cps/ml (n = 43)

HBV status

 Negative

356 (90.1)

39 (9.9)

Ref

 

–

–

 Positive

40 (90.9)

4 (9.1)

0.91 (0.31–2.68)

0.86

–

–

HCV status

 Negative

387 (91.5)

36 (8.5)

Ref

 

Ref

 

 Positive

9 (56.2)

7 (43.8)

8.36 (2.9–23.7)

 < 0.0001

7.14 (2.18–23.3)

0.001

Gender

 Female

262 (92.3)

22 (7.7)

Ref

   

 Male

134 (86.5)

21 (13.5)

1.86 (0.99–3.51)

0.053

2.11 (1.07–4.18)

0.31

Baseline CD4 count in cells/ul

  < 200

40 (10.1)

11 (25.6)

0.75 (.25–2.27)

0.61

0.77 (0.03–18.68)

0.87

 201–500

197 (49.7)

14 ( 32.6)

2.91 (1.03–8.17)

0.04

3.32 (0.13–83.7)

0.46

≥ 501

130 (32.8)

12(27.9)

2.24 (0.77–6.46)

0.14

2.53 (0.09–64.4)

0. 57

 Test and treat

29 (7.3)

6 (14.0)

Ref

 

Ref

 

Baseline HIV-1 viral load

  < 1000cps/ml

368 (97.6)

9 (2.4)

Ref

 

Ref

 

≥ 1000cps/ml

28 (45.1)

34 (54.9)

49.65 (21.67–113.7)

 < 0.0001

52.6 (23.84–116.5)

0.001

Current ART adherence level

 Poor

28 (82.4)

6 (17.6)

Ref

 

Ref

 

 Fair

71(89.9)

8 (10.1)

0.53 (0.16–1.65)

0.27

0.63 (0.19–1.87)

0.29

 Good

297 (91.1)

29 (8.9)

0.46 (0.17–1.19)

0.11

0.57 (0.21–2.23)

0.16

  1. AOR adjusted odds ratio, COR crude odds ratio, CI confidence interval, HBV hepatitis B virus, HCV hepatitis C virus, HIV human immune deficiency virus, Ref reference, WHO world health organization
  2. *a viral load of < 1000 cps/ml was the referent