Table 5 Comparison of independent variables with ART switch among 605 young people living with HIV attending HIV care services in the Hannan Crusaid HIV Centre in Cape Town South Africa (2002–2019) that switched ART during this time
Variable | Sub category | Rate Per 100 *PYO | Unadjusted HR (95% CI) | ƒLRT p-value | Adjusted HR (95% CI) for all variables | £p-value |
|---|---|---|---|---|---|---|
Overall | – | 11.9 | ||||
Sex | Male | 12.8 | 1.00 | 0.612 | 1.00 | |
Female | 11.7 | 0.94 (0.75–0.1.18) | 1.19 (0.94–1.53) | 0.155 | ||
Age (years) | 10–17 | 15.2 | 1.00 | 0.018 | 1.00 | |
18–24 | 11.4 | 0.76 (0.61–0.95) | 0.78 (0.62–0.98) | 0.032 | ||
WHO stage | l | 7.7 | 1.00 | < 0.001 | 1.00 | |
ll | 13.3 | 1.72 (1.37–2.16) | 1.34 (1.06–1.70) | 0.014 | ||
lll | 17.7 | 2.25 (1.85–2.73) | 1.73 (1.40–2.14) | < 0.001 | ||
lV | 19.4 | 2.46 (1.88–3.21) | 2.09 (1.58–2.77) | < 0.001 | ||
ART status at entry into clinic | Naive | 12.0 | 1.00 | 0.121 | ||
Experienced | 7.5 | 0.60 (0.30–1.21) | ||||
Transfer status | Not transferred | 1.00 | < 0.001 | 1.00 | ||
Transferred out | 1.63 (1.27–2.08) | 1.42 (1.11–1.82) | 0.006 | |||
Baseline CD4 | < 250 | 16.1 | 1.00 | < 0.001 | 1.00 | |
250–499 | 6.0 | 0.38 (0.30–0.47) | 0.51 (0.40–0.66) | < 0.001 | ||
500 + | 3.3 | 0.21 (0.13–0.36) | 0.29 (0.17–0.49) | < 0.001 | ||
Year of ART initiation | Before 2010 | 19.0 | 1.00 | < 0.001 | 1.00 | |
2010 + | 8.8 | 0.46 (0.39–0.55) | 0.97 (0.79–1.19) | 0.777 | ||
NNRTI/PI based | NVP | 22.5 | 1.00 | < 0.001 | 1.00 | |
EFV | 10.1 | 0.45 (0.38–0.55) | 0.62 (0.50–0.76) | |||
LPV/r | 13.5 | 0.59 (0.39–0.89) | 0.62 (0.41–0.94) | < 0.001 | ||
ATV/r | 13.7 | 0.57 (0.14–2.29) | 0.48 (0.12–1.97) | 0.310 |