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Table 3 Categories for ART switch among young people living with HIV attending HIV care services in the Hannan Crusaid HIV Centre in Cape town South Africa, stratified by period of starting ART (< 2010 vs 2010 +)

From: Determinants and reasons for switching anti-retroviral regimen among HIV-infected youth in a large township of South Africa (2002–2019)

Reasons for switching ART

Before 2010

2010 + 

Overall

Freq (%)

Freq (%)

Freq (%)

Formulation switch e.g. TDF/3TC to TDF/FTC

3 (1.0)

165 (52.2)

168 (27.8)

Side effects

101 (34.9)

21 (6.7)

122 (20.0)

Virological Failure

55 (19.0)

53 (16.8)

108 (17.8)

Programmatic e.g. switch from d4T to TDF

38 (13.2)

32 (10.1)

70 (11.6)

Pregnancy

54 (18.7)

13 (4.1)

67 (11.1)

Regimen simplification

6 (2.1)

22 (7.0)

28 (4.6)

Tuberculosis

19 (6.6)

8 (2.5)

27 (4.5)

Defaulted

10 (3.5)

0 (0.0)

10 (1.7)

Psychosis

1 (0.3)

0 (0.0)

1 (0.2)

Hepatitis B

0 (0.0)

1 (0.3)

1 (0.2)

Reason not specified

2 (0.7)

1 (0.3)

3 (0.5)

Total

289

316

605