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Table 2 Longitudinal evolution of anti-HBs levels after HBV vaccination in infants that acquired EBV infection within 12 or 24 months or remained EBV negative

From: HIV-exposed infants with EBV infection have a reduced persistence of the immune response to the HBV vaccine

Month 12

 

EBV +

EBV−

P values

Number pz

n

47

64

 

Anti-HBs IgG

(mlU/ml)

101.7 ± 51.8

138.4 + 42.9

0.777

Infants with anti-HBs > 10 mIU/ml

(n, %)

41 (87.2 %)

60 (92.2 %)

0.523

Month 24

 

EBV + at month 12

EBV + at month 24

EBV−

 

Number pz

n

45

52

11

 

Anti-HBs IgG

(mlU/ml)

41.4 ± 45.4

49.4 ± 35.8

128.4 ± 71.4

0.139

Infants with anti-HBs > 10 mIU/ml

(n, %)

36 (78.3 %)

45 (86.5 %)

11 (100 %)

0.154

Anti-HBs evolution over time

    

 Maintainance or increase > 100mlU/ml

n, (%)

21 (46.7 %)

15 (28.8 %)

7 (63.6.0 %)

0.039

 Stable levels

> 10 < 100 mlU/ml

n, (%)

3 (6.7 %)

4 (7.7 %)

1 (9.1 %)

 Relevant decrease > 50 %

n, (%)

14 (31.0 %)

27 (51.9 %)

3 (27.3 %)

 Poor response < 10 mlU/ml

n, (%)

7 (15.6 %)

6 (11.5 %)

0 (0.0 %)

  1. The persistency of anti-HBs titres was arbitrarily categorized into 4 types of dynamic responses to the vaccine