Table 1 Comparison of characteristics between responders and non-responders (anti-HBs ≥ 10 mIU/ml)
Predictive factors | Responders (n = 90) | Non-responders (n = 36) | P-value |
|---|---|---|---|
Age at primary vaccination, years (mean ± SD) | 40.9 ± 6.1 | 43.3 ± 7.4 | 0.066 |
Male | 23 (25.6%) | 9 (25.0%) | 0.948 |
Underlying diseases | |||
Diabetes | 10 (11.1%) | 6 (16.7%) | 0.397 |
Dyslipidemia | 12 (13.3%) | 8 (22.2%) | 0.217 |
Hypertension | 6 (16.7%) | 15 (16.7%) | 1.000 |
Risk of HIV acquisition | 0.443 | ||
Heterosexual | 34 (94.4%) | 87 (96.7%) | |
Homosexual (MSM) | 1 (2.8%) | 1 (1.1%) | |
IVDU | 0 | 1 (1.1%) | |
Blood transfusion | 1 (2.8%) | 0 | |
Unknown | 0 | 1 (1.1%) | |
cART regimen | 0.664 | ||
NNRTI-based | 81 (90%) | 33 (91.7%) | |
PI-based | 8 (8.9%) | 2 (5.6%) | |
Others | 1 (1.1%) | 1 (2.8%) | |
History of HIV-drug resistance | 6 (6.7%) | 3 (8.3%) | 0.743 |
Duration of cART, years (median, IQR) | 7.0 (2.7, 8.6) | 6.8 (5.2, 8.5) | 0.797 |
Initial CD4+ cell count, cells/mm3 (median (IQR)) | 482 (395, 627) | 407 (340, 631) | 0.315 |
Current CD4+ cell count, cells/mm3 [median (IQR)] | 609 (480, 818) | 588 (493, 744) | 0.574 |
Vaccination schedule | 0.040 | ||
Standard doses | 24 (26.7%) | 18 (50.0%) | |
Four doses | 33 (36.7%) | 10 (27.8%) | |
Four double doses | 33 (36.7%) | 8 (22.2%) | |