Table 2 Factors associated pre-treatment HIV RNA <100,000 copies/mL in derivation population
Factors | Number of patients | Patients (% total) with HIV RNA <100,000 copies/mL | Univariate OR (95% CI) | p-value | Multivariate OR (95% CI) | p- value |
|---|---|---|---|---|---|---|
Years of ageb | ||||||
≤30 | 656 | 360 (54.9) | 1.6 (1.2–2.0) | <0.01 | 1.4 (1.1–1.8) | 0.01 |
31–40 | 1057 | 514 (48.6) | 1.2 (0.9–1.4) | 0.15 | 1.1 (0.9–1.4) | 0.40 |
41–50 | 600 | 273 (45.5) | 1.0 | 1.0 | ||
>50 | 279 | 131 (47.0) | 1.0 (0.8–1.4) | 0.85 | 1.0 (0.7–1.4) | 0.96 |
Sexb | ||||||
Male | 1883 | 908 (48.2) | 1.0 | |||
Female | 709 | 370 (52.2) | 1.2 (1.0–1.5) | 0.02 | ||
HIV exposure | ||||||
Heterosexual | 1456 | 688 (47.3) | 1.0 | |||
Homosexual | 778 | 422 (54.2) | 1.3 (1.0–1.6) | 0.03 | ||
Intravenous drug use | 93 | 41 (44.1) | 0.9 (0.6–1.4) | 0.54 | ||
Other | 265 | 127 (47.9) | 0.9 (0.7–1.3) | 0.70 | ||
Body mass index (kg/m2)b | ||||||
<18.5 | 366 | 134 (36.6) | 1.0 | 1.0 | ||
18.5–24.9 | 1289 | 648 (50.3) | 1.7 (1.3–2.2) | <0.01 | 1.3 (1.0–1.7) | 0.07 |
25.0–29.9 | 213 | 112 (52.6) | 1.8 (1.3–2.6) | <0.01 | 1.2 (0.8–1.7) | 0.47 |
≥30.0 | 41 | 29 (70.7) | 4.1 (2.0–8.4) | <0.01 | 2.5 (1.2–5.2) | 0.02 |
Unknown | 683 | 355 (52.0) | – | – | ||
Anemiab | ||||||
No | 1208 | 741 (61.3) | 2.7 (2.3–3.3) | <0.01 | 1.7 (1.4–2.1) | <0.01 |
Yes | 1176 | 442 (37.6) | 1.0 | 1.0 | ||
Unknown | 208 | 95 (45.7) | – | – | ||
Hepatitis C antibody | ||||||
Negative | 1844 | 916 (49.7) | 1.0 | |||
Positive | 168 | 73 (43.5) | 0.8 (0.6–1.1) | 0.15 | ||
Unknown | 580 | 289 (49.8) | – | |||
Month since HIV diagnosis | ||||||
<6 | 1384 | 614 (44.4) | 1.0 | |||
6–18 | 338 | 189 (55.9) | 1.6 (1.3–2.1) | <0.01 | ||
>18 | 841 | 461 (54.8) | 1.5 (1.3–1.8) | <0.01 | ||
Unknown | 29 | 14 (48.3) | – | |||
CD4 count (cells/mm3)b | ||||||
≥350 | 219 | 147 (67.1) | 4.8 (3.4–6.7) | <0.01 | 2.9 (2.0–4.1) | <0.01 |
200–349 | 694 | 456 (65.7) | 4.2 (3.4–5.3) | <0.01 | 2.7 (2.1–3.4) | <0.01 |
100–199 | 617 | 308 (49.9) | 2.1 (1.7–2.6) | <0.01 | 1.6 (1.2–2.0) | <0.01 |
<100 | 956 | 318 (33.3) | 1.0 | 1.0 | ||
Unknown | 106 | 49 (46.2) | – | – | ||
Total lymphocyte count (cells/mm3)a | ||||||
≥2000 | 593 | 325 (54.8) | 2.9 (2.2–3.7) | <0.01 | 1.7 (1.3–2.3) | |
1500–1999 | 529 | 303 (57.3) | 2.9 (2.3–3.7) | <0.01 | 1.8 (1.4–2.4) | |
1000–1499 | 627 | 331 (52.8) | 2.3 (1.8–2.9) | <0.01 | 1.6 (1.3–2.1) | <0.01 |
<1000 | 557 | 180 (32.3) | 1.0 | 1.0 | ||
Unknown | 286 | 139 (48.6) | – | – | ||
Prior AIDS-defining illnessa | ||||||
None known | 1698 | 987 (58.1) | 3.0 (2.5–3.6) | <0.01 | 1.8 (1.5–2.3) | <0.01 |
Yes | 894 | 291 (32.6) | 1.0 | 1.0 | ||