Validity assessment of the PROMIS fatigue domain among people living with HIV

Gibbons, L. E.; Fredericksen, R.; Batey, D. S.; Dant, L.; Edwards, T. C.; Mayer, K. H.; Mathews, W. C.; Morales, L. S.; Mugavero, M. J.; Yang, F. M.; Paez, E.; Kitahata, M. M.; Patrick, D. L.; Crane, H. M.; Crane, P. K.

doi:10.1186/s12981-017-0146-y

AIDS Research and Therapy

Table 4 Spearman correlation coefficients between fatigue measures and clinical characteristics

From: Validity assessment of the PROMIS fatigue domain among people living with HIV

	HIVSI fatigue		PHQ-9 “tired”		PROMIS-7a		All 24 items
	Coefficient	P value	Coefficient	P value	Coefficient	P value	Coefficient	P value
Factors related to fatigue itself
HIV Symptom Index 1-item Fatigue response	–	–	0.77	<0.0001	0.82	<0.0001	0.85	<0.0001
PHQ-9 item “feeling tired or having little energy”	–	–	–	–	0.75	<0.0001	0.77	<0.0001
Hepatitis-C	0.09	0.0004	0.09	0.0002	0.11	<0.0001	0.12	<0.0001
HIV disease severity
Current CD4 count	−0.04	0.1402	−0.04	0.1562	−0.05	0.0699	−0.04	0.2392
CD4 nadir	0.01	0.8828	0.05	0.0534	0.00	0.8584	0.01	0.3481
Symptom burden
Number of symptoms in inventory	0.69	<0.0001	0.59	<0.0001	0.64	<0.0001	0.66	<0.0001
Specific symptoms
Fever, chills or sweats	0.42	<0.0001	0.37	<0.0001	0.64	<0.0001	0.44	<0.0001
Dizzy or lightheaded	0.51	<0.0001	0.46	<0.0001	0.42	<0.0001	0.54	<0.0001
Pain/numbness/tingling in hands/feet	0.44	<0.0001	0.35	<0.0001	0.52	<0.0001	0.49	<0.0001
Having difficulty remembering	0.57	<0.0001	0.48	<0.0001	0.46	<0.0001	0.62	<0.0001
Nausea or vomiting	0.45	<0.0001	0.37	<0.0001	0.63	<0.0001	0.47	<0.0001
Diarrhea or loose bowel movements	0.41	<0.0001	0.34	<0.0001	0.47	<0.0001	0.42	<0.0001
Feeling sad or depressed	0.65	<0.0001	0.55	<0.0001	0.40	<0.0001	0.66	<0.0001
Feeling nervous or anxious	0.57	<0.0001	0.50	<0.0001	0.63	<0.0001	0.61	<0.0001
Difficulty falling or staying asleep	0.57	<0.0001	0.50	<0.0001	0.58	<0.0001	0.59	<0.0001
Coughing or trouble catching breath	0.39	<0.0001	0.36	<0.0001	0.56	<0.0001	0.44	<0.0001
Headaches	0.42	<0.0001	0.35	<0.0001	0.43	<0.0001	0.46	<0.0001
Appetite loss/change taste of food	0.45	<0.0001	0.43	<0.0001	0.44	<0.0001	0.52	<0.0001
Bloating pains or gas in stomach	0.44	<0.0001	0.37	<0.0001	0.51	<0.0001	0.47	<0.0001
Muscle aches or joint pain	0.47	<0.0001	0.42	<0.0001	0.47	<0.0001	0.52	<0.0001
Sex-loss of interest/satisfaction	0.47	<0.0001	0.41	<0.0001	0.50	<0.0001	0.50	<0.0001
Body changes-fat deposits/wt gain	0.46	<0.0001	0.38	<0.0001	0.50	<0.0001	0.49	<0.0001
Weight loss or wasting	0.32	<0.0001	0.30	<0.0001	0.49	<0.0001	0.39	<0.0001
EQ-5D	0.59	<0.0001	0.56	<0.0001	0.38	<0.0001	0.64	<0.0001
PHQ-9	0.75	<0.0001	0.84	<0.0001	0.63	<0.0001	0.77	<0.0001
Self-rated health (EuroQOL)	−0.53	<0.0001	0.50	<0.0001	0.74	<0.0001	−0.57	<0.0001
Among ART users
Last time missed meds	−0.15	<0.0001	−0.16	<0.0001	−0.18	<0.0001	−0.19	<0.0001
Ability to take meds	−0.19	<0.0001	−0.24	<0.0001	−0.23	<0.0001	−0.23	<0.0001
Take how much of meds	−0.14	0.0001	−0.16	<0.0001	−0.17	<0.0001	−0.17	<0.0001

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