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Table 4 Spearman correlation coefficients between fatigue measures and clinical characteristics

From: Validity assessment of the PROMIS fatigue domain among people living with HIV

  HIVSI fatigue PHQ-9 “tired” PROMIS-7a All 24 items
Coefficient P value Coefficient P value Coefficient P value Coefficient P value
Factors related to fatigue itself
 HIV Symptom Index 1-item Fatigue response 0.77 <0.0001 0.82 <0.0001 0.85 <0.0001
 PHQ-9 item “feeling tired or having little energy” 0.75 <0.0001 0.77 <0.0001
 Hepatitis-C 0.09 0.0004 0.09 0.0002 0.11 <0.0001 0.12 <0.0001
HIV disease severity
 Current CD4 count −0.04 0.1402 −0.04 0.1562 −0.05 0.0699 −0.04 0.2392
 CD4 nadir 0.01 0.8828 0.05 0.0534 0.00 0.8584 0.01 0.3481
Symptom burden
 Number of symptoms in inventory 0.69 <0.0001 0.59 <0.0001 0.64 <0.0001 0.66 <0.0001
Specific symptoms
 Fever, chills or sweats 0.42 <0.0001 0.37 <0.0001 0.64 <0.0001 0.44 <0.0001
 Dizzy or lightheaded 0.51 <0.0001 0.46 <0.0001 0.42 <0.0001 0.54 <0.0001
 Pain/numbness/tingling in hands/feet 0.44 <0.0001 0.35 <0.0001 0.52 <0.0001 0.49 <0.0001
 Having difficulty remembering 0.57 <0.0001 0.48 <0.0001 0.46 <0.0001 0.62 <0.0001
 Nausea or vomiting 0.45 <0.0001 0.37 <0.0001 0.63 <0.0001 0.47 <0.0001
 Diarrhea or loose bowel movements 0.41 <0.0001 0.34 <0.0001 0.47 <0.0001 0.42 <0.0001
 Feeling sad or depressed 0.65 <0.0001 0.55 <0.0001 0.40 <0.0001 0.66 <0.0001
 Feeling nervous or anxious 0.57 <0.0001 0.50 <0.0001 0.63 <0.0001 0.61 <0.0001
 Difficulty falling or staying asleep 0.57 <0.0001 0.50 <0.0001 0.58 <0.0001 0.59 <0.0001
 Coughing or trouble catching breath 0.39 <0.0001 0.36 <0.0001 0.56 <0.0001 0.44 <0.0001
 Headaches 0.42 <0.0001 0.35 <0.0001 0.43 <0.0001 0.46 <0.0001
 Appetite loss/change taste of food 0.45 <0.0001 0.43 <0.0001 0.44 <0.0001 0.52 <0.0001
 Bloating pains or gas in stomach 0.44 <0.0001 0.37 <0.0001 0.51 <0.0001 0.47 <0.0001
 Muscle aches or joint pain 0.47 <0.0001 0.42 <0.0001 0.47 <0.0001 0.52 <0.0001
 Sex-loss of interest/satisfaction 0.47 <0.0001 0.41 <0.0001 0.50 <0.0001 0.50 <0.0001
 Body changes-fat deposits/wt gain 0.46 <0.0001 0.38 <0.0001 0.50 <0.0001 0.49 <0.0001
 Weight loss or wasting 0.32 <0.0001 0.30 <0.0001 0.49 <0.0001 0.39 <0.0001
EQ-5D 0.59 <0.0001 0.56 <0.0001 0.38 <0.0001 0.64 <0.0001
PHQ-9 0.75 <0.0001 0.84 <0.0001 0.63 <0.0001 0.77 <0.0001
Self-rated health (EuroQOL) −0.53 <0.0001 0.50 <0.0001 0.74 <0.0001 −0.57 <0.0001
Among ART users
 Last time missed meds −0.15 <0.0001 −0.16 <0.0001 −0.18 <0.0001 −0.19 <0.0001
 Ability to take meds −0.19 <0.0001 −0.24 <0.0001 −0.23 <0.0001 −0.23 <0.0001
 Take how much of meds −0.14 0.0001 −0.16 <0.0001 −0.17 <0.0001 −0.17 <0.0001