Skip to main content

Table 2 HIV-1 genetic polymorphisms identified in this study, which have previously been associated with disease progression and/or impaired replicative fitness

From: Impaired human immunodeficiency virus type 1 replicative fitness in atypical viremic non-progressor individuals

Positiona

Viremic non-progressors (VNP)

Typical progressors (TP)

Rapid progressor (RP)

VNP-1

VNP-2

VNP-3

TP-1

TP-2

TP-3

RP

LTR

 287–292

A219G (18%)

A292ins (1%)

C290T (2%)

 

A219G (3%)

A219ins (3%)

T287C (11%)

T292A (99%)

 

 319–324

T319A (99%)

T319A (100%)

A324G (100%)

T319A (99%)

A324G (27%)

T319A (99%)

A324G (99%)

T319A (99%)

320ins (11–57%)

A324G (72%)

T319A (99%)

T319A (100%)

 325–333

329ins (39%)

C333T (11%)

332del (3%)

328ins (1%)

 

G331A (1%)

  

 346–356

G350A (1%)

 

A348T (11%)

355del (2%)

G350A (3%)

   

 361–371

G363A (6%)

G364A (7%)

    

G366A (1%)

T32C (9%)

G363A (10%)

 374–385

A374G (74%)

A378G (1%)

G379A (1%)

G385A (97%)

G377A (3%)

381ins (1%)

A374G (7%)

381ins (1%)

A378G (2%)

380ins (1%)

C381T (99%)

G384A (1%)

374ins (91%)

G384A (100%)

G385A (100%)

A374G (9%)

374ins (52%)

G384A (99%)

 386–397

C386T (97%) C387G (2%)

G389A (30%)

G395A (2%)

380del (1%)

G389A (2%)

 

396ins (99%)

387G (3%) G393A (2%)

 398–409

G399A (7%)

 

398ins (2%)

403ins (1%)

405ins (3%)

T398A (90%)

G409A (8%)

G400A (18%)

 427–431

430del (1%), 431del (1%)

430del (2%)

430del (9%), 431del (1%)

430del (2%)

431del (2%)

  

 455–515

11SNPs (>1%), 13 indels (>1%)

8 SNPS, 11 indels

3 SNPs (>1%), 12 indels (>1%)

3 SNPs (>1%), 5 indels (>1%)

2 SNPs (>1%), 6 indels (>1%)

4 SNPs (>1%), 2 indels (>1%)

5 SNPs (>1%), 3 indels (>1%)

gag

 823–825

E12Q (99%)

      

 988–990

 

S67A (16%)

  

S67A (3%)

S67A (100%)

 

 1093–1095

D102E (98%)

D102E (9%)

  

D102E (73%)

 

D102E (100%)

 1225–1227

 

A146P (86%)

     

 1513–1515

  

T242N (99%)

    

 1531–1533

G284A (99%)

    

G284A (99%)

G284A (99%)

 1954–1956

  

T389I (99%)

   

T389I (100%)

 2233–2235

 

E482D (99%)

     

vif

 5434–5436

R132S (92%)

      

vpr

 5773–5775

F72S (4%)

      

 5788–5790

 

R77Q (99%)

R77Q (99%)

R77Q (99%)

R77Q (99%)

R77Q (99%)

R77Q (99%)

 5806–5826

Ins (7%)

      

rev

 8522–8524

Q74H (99%)

Q74P (99%)

  

Q74P (75%)

  

 8612–8614

 

V104G (99%)

   

V104L (33%)

 

nef

 9208–9210

 

T138C (99%)

     

 8839–8841

 

T15A (99%)

T15A (98%)

T15N (100%)

   

 8950–8952

       

 9100–9102

H102Y (99%)

H102Y (99%)

H102W (99%)

H102W (99%)

H102Y (99%)

H102Y (99%)

H102Y (100%)

 9340–9342

E182Q (99%)

 

E182V (99%)

E182V (99%)

   
  1. a Positions in the HIV-1 genome relative to the HIV-1HXB2 (GenBank: K03455) strain reference. Single-nucleotide polymorphisms (SNPs) in the LTR or amino substitutions in the HIV-1 coding regions are indicated, including their frequency in the virus population (%) quantified by deep sequencing. For example: A219G (18%) in the LTR of the VNP-1 HIV-1 isolate or R77Q (99%) in the vpr gene of the VNP-2 HIV-1 isolate. Indels, insertions and/or deletions
Back to article page

AIDS Research and Therapy

ISSN: 1742-6405

Contact us