Impaired human immunodeficiency virus type 1 replicative fitness in atypical viremic non-progressor individuals

Table 1 Demographic, clinical and virological parameters

Patient ID	Viremic non-progressors (VNP)			Typical progressors (TP)			Rapid progressor (RP)
Patient ID	VNP-1	VNP-2	VNP-3	TP-1	TP-2	TP-3	RP
Demographics
Age^a	44	50	42	40	43	38	30
Sex^b	M	M	M	M	M	M	M
Race	Black	Caucasian	Black	Caucasian	Black	Black	Black
Risk Factor^c	MSM	Unknown	MSM	MSM	MSM	MSM	MSM
Years HIV+^d	14	17	10	14	15	12	5
Follow up (months)^e	84	37	123	35	19	31	18
CD4⁺ (cells/mm³)
CD4⁺ count^f	563	443	479	386	361	126	11
Mean CD4⁺ count^g	529	445	442	483	457	293	57
Range CD4⁺ count^g	372–711	316–608	280–814	220–789	361–645	126–511	11–124
Slope CD4⁺ count^h	−0.6	−0.7	−0.4	−9.6	−8.2	−13.1	−4.7
HIV-1 RNA (log 10 copies/ml)
HIV-1 RNA^f	5.46	4.90	4.70	4.41	4.27	4.49	4.64
Mean HIV-1 RNA^g	4.68	4.91	4.31	4.23	4.45	4.67	4.49
Range HIV-1 RNA^g	3.61–5.45	4.27–5.08	3.62–4.71	3.89–4.62	4.28–4.62	3.90–4.90	4.09–4.66
Virus characteristics
HIV-1 subtypeⁱ	B	B	B	B	B	B	B
HIV-1 coreceptor tropism^j	R5	R5	R5	R5	R5	R5	D/M

R5 CCR5-tropic virus, D/M dual- or mixed-tropic virus
^a Age at the time of sampling
^b M male
^c MSM men who have sex with men
^d Years since first HIV-seropositive test to time of blood sample collection for this study
^e Number of months that the patient had been monitored up to the blood sample collection date
^f CD4⁺ T-cell count (cells/mm³) and HIV-1 RNA plasma load (log10 copies/ml) at the time the blood sample was obtained
^g Mean and range CD4⁺ T-cell count and HIV-1 RNA plasma load values determined during the clinical follow up time, to the time of blood sample collection for this study and prior to the initiation of antiretroviral treatment
^h Rate of CD4⁺ T-cell count decline (slope) calculated as cells/mm³ per month, using all CD4⁺ cell measurements available at the time the blood sample was obtained
ⁱ HIV-1 subtype determined using the near full-length HIV-1 genome consensus sequences with the Recombinant Identification Program (RIP) from the Los Alamos HIV Sequence Database (https://www.hiv.lanl.gov/content/sequence/RIP/RIP.html) [76]
^j HIV-1 coreceptor tropism determined using sequencing reads corresponding to the V3 region of gp120, env gene with the DEEPGEN™HIV Software Tool Suite [70]

ISSN: 1742-6405