Table 2 Estimated glomerular filtration rate change

Increased

Lithium

30.4% (7/23)

39.1% (9/23)

39.1% (9/23)

34.8% (8/23)

39.1% (9/23)

56.5% (13/23)

Placebo

40% (12/30)

50% (15/30)

43.3% (13/30)

33.3% (10/30)

43.3% (13/30)

46.7% (14/30)

p = 0.518^a

p = 0.621^a

p = 0.095^a

p = 0.012^a

p = 0.095^a

p = 0.506^a

Grade 1

Decreased 0.1% to <10% from baseline

Lithium

34.8% (8/23)

13% (3/23)

8.7% (2/23)

26.1% (6/23)

17.4% (4/23)

8.7% (2/23)

Placebo

23.3% (7/30)

16.7% (5/30)

20% (6/30)

23.3% (7/30)

30% (9/30)

20% (6/30)

p = 0.495^a

p = 0.264^b

p = 0.229^b

p = 0.817^a

p = 0.233^b

p = 0.229^b

Grade 2

Decreased 10 to <30% from baseline

Lithium

26.0% (6/23)

26.1% (9/23)

43.5% (10/23)

21.7% (5/23)

34.8% (8/23)

23% (6/23)

Placebo

26.7% (8/30)

13.3% (5/30)

30% (9/30)

33.3% (10/30)

13.3% (4/30)

30% (9/30)

p = 0.971^a

p = 0.164^a

p = 0.765^a

p = 0.484^a

p = 0.145^a

p = 0.814^b

Grade 3

Decreased ≥30 to <50% from baseline

Lithium

8.7% (2/23)

8.7% (2/23)

8.7% (2/23)

8.7% (2/23)

8.7% (2/23)

8.7% (2/23)

Placebo

0%

0%

3.3% (1/30)

0%

13.3% (4/30)

3.3% (1/30)

p = 0.202^b

p = 0.202^b

p = 0.418^b

p = 0.202^b

p = 0.493^b

p = 0.418^b

Grade 4

Decreased ≥50% from baseline

Lithium

0%

0%

0%

0%

0%

0%

Placebo

0%

0%

0%

3.3% (1/30)

0%

0%

p = 574^b

Creatinine not measured^c

Lithium

0%

0%

0%

4.3% (1/23)

0%

0%

Placebo

0%

10% (3/30)

3.3% (1/30)

3.3% (1/30)

0%

0%

p = 0.197^b

p = 0.574^b

p = 0.687^b