Amino acid | Codon | pol | gag | ||||
---|---|---|---|---|---|---|---|
Naive (N = 532) | Treated (N = 52) | P value | Naive (N = 524) | Treated (N = 54) | P value | ||
Alanine | GCU | 15.60 ± 0.17 | 13.87 ± 0.52 | 0.0018** | 23.10 ± 0.17 | 23.58 ± 0.65 | 0.7689 |
GCC | 19.66 ± 0.12 | 20.72 ± 0.42 | 0.0189* | 18.38 ± 0.19 | 18.49 ± 0.58 | 0.9689 | |
GCA | 63.25 ± 0.12 | 63.72 ± 0.34 | 0.1477 | 49.08 ± 0.22 | 48.46 ± 0.61 | 0.5766 | |
GCG | 1.48 ± 0.07 | 1.68 ± 0.20 | 0.0932 | 9.43 ± 0.12 | 9.47 ± 0.40 | 0.7388 | |
Arginine | CGU | 0.09 ± 0.02 | 0.14 ± 0.08 | 0.3506 | 0.15 ± 0.03 | 0.20 ± 0.12 | 0.6272 |
CGC | 0.06 ± 0.02 | 0.05 ± 0.05 | 0.7593 | 0.23 ± 0.04 | 0.19 ± 0.11 | 0.8865 | |
CGA | 3.33 ± 0.07 | 3.04 ± 0.15 | 0.2125 | 3.03 ± 0.10 | 3.30 ± 0.35 | 0.4781 | |
CGG | 3.09 ± 0.05 | 3.41 ± 0.20 | 0.0621 | 5.58 ± 0.10 | 6.02 ± 0.33 | 0.2211 | |
AGA | 60.65 ± 0.27 | 63.90 ± 0.72 | 0.0002*** | 56.80 ± 0.26 | 57.27 ± 0.78 | 0.5734 | |
AGG | 32.77 ± 0.27 | 29.47 ± 0.71 | 0.0001*** | 34.20 ± 0.27 | 33.01 ± 0.90 | 0.0845 | |
Asparagine | AAU | 74.66 ± 0.25 | 76.56 ± 0.59 | 0.0189* | 62.61 ± 0.34 | 63.48 ± 0.89 | 0.4616 |
AAC | 25.34 ± 0.25 | 23.44 ± 0.59 | 0.0189* | 37.39 ± 0.34 | 36.52 ± 0.89 | 0.4616 | |
Aspartic acid | GAU | 59.40 ± 0.21 | 60.58 ± 0.59 | 0.1349 | 47.57 ± 0.40 | 49.08 ± 1.31 | 0.1854 |
GAC | 40.60 ± 0.21 | 39.42 ± 0.59 | 0.1349 | 52.43 ± 0.40 | 50.92 ± 1.31 | 0.1854 | |
Cysteine | UGU | 86.81 ± 0.33 | 86.76 ± 1.05 | 0.8285 | 80.66 ± 0.56 | 81.56 ± 1.45 | 0.8737 |
UGC | 13.19 ± 0.33 | 13.24 ± 1.05 | 0.8285 | 19.34 ± 0.56 | 18.44 ± 1.45 | 0.8737 | |
Glutamic acid | GAA | 72.48 ± 0.16 | 73.05 ± 0.62 | 0.2699 | 65.35 ± 0.27 | 66.64 ± 0.82 | 0.1509 |
GAG | 27.52 ± 0.16 | 26.95 ± 0.62 | 0.2699 | 34.65 ± 0.27 | 33.36 ± 0.82 | 0.1509 | |
Glutamine | CAA | 59.33 ± 0.15 | 59.62 ± 0.63 | 0.4549 | 59.93 ± 0.33 | 55.65 ± 1.05 | 0.0006*** |
CAG | 40.67 ± 0.15 | 40.38 ± 0.63 | 0.4549 | 40.07 ± 0.33 | 44.35 ± 1.05 | 0.0006*** | |
Glycine | GGU | 10.21 ± 0.08 | 11.24 ± 0.24 | 0.0001*** | 2.52 ± 0.11 | 3.16 ± 0.40 | 0.2888 |
GGC | 5.42 ± 0.10 | 5.45 ± 0.27 | 0.9708 | 21.22 ± 0.16 | 20.00 ± 0.52 | 0.0279* | |
GGA | 54.09 ± 0.15 | 54.47 ± 0.51 | 0.5641 | 46.95 ± 0.28 | 48.74 ± 0.72 | 0.0483* | |
GGG | 30.28 ± 0.16 | 28.84 ± 0.54 | 0.0076** | 29.31 ± 0.23 | 28.10 ± 0.67 | 0.0936 | |
Histidine | CAU | 67.75 ± 0.35 | 70.96 ± 1.00 | 0.0043** | 59.17 ± 0.56 | 63.59 ± 1.92 | 0.0136* |
CAC | 32.25 ± 0.35 | 29.04 ± 1.00 | 0.0043** | 40.83 ± 0.56 | 36.41 ± 1.92 | 0.0136* | |
Isoleucine | AUU | 29.95 ± 0.11 | 30.74 ± 0.30 | 0.0073** | 23.52 ± 0.25 | 22.33 ± 0.79 | 0.1297 |
AUC | 15.23 ± 0.09 | 14.46 ± 0.29 | 0.0325* | 15.73 ± 0.25 | 19.56 ± 0.82 | <0.0001*** | |
AUA | 54.82 ± 0.08 | 54.80 ± 0.29 | 0.9037 | 60.75 ± 0.20 | 58.10 ± 0.81 | 0.0003*** | |
Leucine | UUA | 39.10 ± 0.14 | 39.49 ± 0.51 | 0.5880 | 44.21 ± 0.23 | 42.06 ± 0.79 | 0.0027** |
UUG | 10.72 ± 0.11 | 10.75 ± 0.33 | 0.8305 | 13.01 ± 0.14 | 12.63 ± 0.43 | 0.6161 | |
CUU | 12.19 ± 0.12 | 11.78 ± 0.32 | 0.1110 | 12.48 ± 0.15 | 12.01 ± 0.41 | 0.2454 | |
CUC | 6.62 ± 0.06 | 6.30 ± 0.24 | 0.1421 | 10.57 ± 0.11 | 10.52 ± 0.38 | 0.9979 | |
CUA | 19.65 ± 0.17 | 18.96 ± 0.48 | 0.2819 | 12.12 ± 0.25 | 15.19 ± 0.67 | <0.0001*** | |
CUG | 11.72 ± 0.11 | 12.71 ± 0.30 | 0.0054** | 7.62 ± 0.13 | 7.59 ± 0.50 | 0.7665 | |
Lysine | AAA | 72.28 ± 0.14 | 72.47 ± 0.39 | 0.6021 | 66.80 ± 0.23 | 66.78 ± 0.72 | 0.9256 |
AAG | 27.72 ± 0.14 | 27.53 ± 0.39 | 0.6021 | 33.20 ± 0.23 | 33.22 ± 0.72 | 0.9256 | |
Phenylalanine | UUU | 65.69 ± 0.19 | 66.09 ± 0.71 | 0.5312 | 61.11 ± 0.36 | 58.32 ± 1.28 | 0.0214* |
UUC | 34.31 ± 0.19 | 33.91 ± 0.71 | 0.5312 | 38.89 ± 0.36 | 41.68 ± 1.28 | 0.0214* | |
Proline | CCU | 26.08 ± 0.13 | 26.53 ± 0.35 | 0.1652 | 29.76 ± 0.18 | 28.69 ± 0.61 | 0.1140 |
CCC | 18.13 ± 0.13 | 18.04 ± 0.40 | 0.8455 | 14.29 ± 0.17 | 13.69 ± 0.69 | 0.1897 | |
CCA | 54.53 ± 0.10 | 54.64 ± 0.32 | 0.7969 | 52.49 ± 0.18 | 54.31 ± 0.73 | 0.0072** | |
CCG | 1.25 ± 0.07 | 0.80 ± 0.16 | 0.0330* | 3.46 ± 0.13 | 3.32 ± 0.48 | 0.3902 | |
Serine | UCU | 6.62 ± 0.12 | 6.64 ± 0.33 | 0.9876 | 2.01 ± 0.11 | 3.38 ± 0.43 | 0.0005*** |
UCC | 3.41 ± 0.09 | 3.39 ± 0.31 | 0.7542 | 11.96 ± 0.14 | 12.59 ± 0.47 | 0.2148 | |
UCA | 26.98 ± 0.14 | 26.83 ± 0.53 | 0.9924 | 32.96 ± 0.20 | 32.27 ± 0.73 | 0.7226 | |
UCG | 0.77 ± 0.06 | 1.12 ± 0.21 | 0.0563 | 0.89 ± 0.09 | 1.28 ± 0.36 | 0.4649 | |
AGU | 39.58 ± 0.23 | 39.35 ± 0.79 | 0.6742 | 15.17 ± 0.22 | 14.56 ± 0.71 | 0.3236 | |
AGC | 22.63 ± 0.17 | 22.67 ± 0.52 | 0.7640 | 37.02 ± 0.24 | 35.91 ± 0.90 | 0.3998 | |
Threonine | ACU | 30.57 ± 0.12 | 30.39 ± 0.44 | 0.4910 | 25.24 ± 0.20 | 25.23 ± 0.62 | 0.8150 |
ACC | 13.88 ± 0.10 | 13.28 ± 0.36 | 0.1156 | 28.67 ± 0.20 | 28.53 ± 0.85 | 0.5475 | |
ACA | 54.44 ± 0.11 | 55.11 ± 0.40 | 0.0659 | 44.77 ± 0.20 | 45.10 ± 0.73 | 0.8720 | |
ACG | 1.11 ± 0.06 | 1.23 ± 0.19 | 0.6161 | 1.32 ± 0.10 | 1.14 ± 0.33 | 0.4743 | |
Tyrosine | UAU | 69.25 ± 0.17 | 68.61 ± 0.61 | 0.3502 | 86.34 ± 0.41 | 83.80 ± 1.47 | 0.2448 |
UAC | 30.75 ± 0.17 | 31.39 ± 0.61 | 0.3502 | 13.66 ± 0.41 | 16.20 ± 1.47 | 0.2448 | |
Valine | GUU | 15.04 ± 0.11 | 15.57 ± 0.34 | 0.1411 | 10.46 ± 0.20 | 11.03 ± 0.57 | 0.4377 |
GUC | 12.87 ± 0.10 | 12.85 ± 0.32 | 0.9003 | 9.38 ± 0.19 | 8.56 ± 0.62 | 0.1446 | |
GUA | 58.66 ± 0.14 | 57.82 ± 0.37 | 0.0379* | 57.59 ± 0.30 | 57.85 ± 0.99 | 0.5363 | |
GUG | 13.43 ± 0.12 | 13.76 ± 0.36 | 0.2377 | 22.58 ± 0.25 | 22.57 ± 0.82 | 0.8879 |