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Table 3 Univariate and multivariate hazard ratios of the risk of treatment modification in the group of patients over 50 years old

From: Factors associated with the first antiretroviral therapy modification in older HIV-1 positive patients

 

Unvariate

Multivariatea

P value

Hazard ratio

95 % hazard ratio confidence limits

P value

Hazard ratio

95 % hazard ratio confidence limits

Gender

 Male

0.14

0.61

0.31

1.81

0.37

0.71

0.33

1.51

 Female

1.00

1.00

HIV risk group

 MSM

0.08

0.62

0.36

1.06

0.09

0.60

0.33

1.09

 Heterosexual

1.00

1.00

 IDU

0.33

1.41

0.70

2.84

0.58

1.29

0.52

3.21

 Other

0.44

0.70

0.28

1.74

0.50

0.72

0.28

1.85

 Unknown

0.37

0.72

0.35

1.48

0.52

0.78

0.37

1.66

Nadir CD4 value

 Per 100 increase

0.62

1.05

0.87

1.25

0.18

0.84

0.66

1.08

Age in years

 Per 1 year increase

0.87

1.00

0.97

1.04

0.73

1.01

0.97

1.05

Anti-HCV Ab

 Positive

0.22

1.43

0.80

2.54

0.33

0.65

0.28

1.53

 Negative

1.00

1.00

 Unknown

0.55

0.77

0.33

1.81

0.29

0.60

0.23

1.56

Anti-HBc Ab

 Positive

0.50

1.2

0.7

2.06

0.30

1.36

0.76

2.45

 Negative

1.00

1.00

 Unknown

0.29

1.37

0.76

2.46

0.36

1.37

0.70

2.71

Baseline hemoglobin

 Per 1 g/dL increase

0.05

1.02

1.0

1.04

0.14

1.01

0.995

1.04

ARV group

 PI

0.03

1.79

1.06

3.02

0.01

2.17

1.18

3.98

 NNRTI

1.00

1.00

 ITI

0.99

0

0

0

0.99

0

0

 FI

0.99

0

0

0

0.99

0

0

Late presentation

 Yes

0.03

0.61

0.39

0.96

0.02

0.45

0.23

0.90

  1. aAdjusted for all above