Table 2 Univariate and Multivariate Model Estimates for Post-HAART Mortality by Baseline Parameters Prior to HAART Initiation, U.S. Military HIV Natural History Study
Baseline Covariate (at HAART initiation) | Univariate Hazard Ratio (95% CI) | Multivariate Hazard Ratio (95% CI) |
|---|---|---|
Gender: Female vs. Male | 0.89 (0.44, 1.80) | --- † |
Age: | ||
per 5 years older if age < 40 years | 1.11 (0.95, 1.30) | 0.91 (0.76, 1.08) |
per 5 years older if age ≥ 40 years | 1.27 (1.12, 1.44)** | 1.32 (1.16, 1.51)** |
Race | ||
Caucasian | 1.00 (Reference) | --- † |
African American | 1.22 (0.91, 1.65) | --- † |
Other | 0.92 (0.54, 1.58) | --- † |
BMI | ||
< 25 | 1.00 (Reference) | --- † |
25 to < 30 | 0.73 (0.52, 1.03) | --- † |
≥ 30 | 0.64 (0.38, 1.10) | --- † |
Unknown | 1.29 (0.87, 1.93) | --- † |
Clinical AIDS event prior to HAART | 4.26 (3.09, 5.87)** | 1.93 (1.33, 2.81)** |
CD4+ count at (cells/mm3) | ||
≤ 50 | 8.91 (5.15, 15.40)** | 2.97 (1.56, 5.65)** |
51-200 | 3.07 (1.76, 5.35) ** | 1.74 (0.97, 3.12) |
201-349 | 1.69 (0.96, 2.98) | 1.39 (0.79, 2.46) |
350-499 | 1.29 (0.71, 2.35) | 1.21 (0.66, 2.19) |
≥ 500 | 1.00 (Reference) | 1.00 (Reference) |
HIV RNA (copies/ml) per one log10 increase | 1.72 (1.44, 2.04)** | 1.36 (1.12, 1.64)* |
Anemia within 3 years | ||
No | 1.00 (Reference) | 1.00 (Reference) |
Yes | 2.61 (1.92, 3.55)** | 1.36 (0.97, 1.92) |
Unknown | 2.29 (0.72, 7.30) | 1.96 (0.40, 5.73) |
Chronic HBV or HCV antibody positive | ||
No | 1.00 (Reference) | 1.00 (Reference) |
Yes | 2.61 (1.88, 3.63)** | 1.96 (1.39, 2.76)** |
Unknown | 0.73 (0.27, 1.99) | 0.98 (0.36, 2.67) |
Year of HIV diagnosis | ||
Before 1996 | 3.35 (2.16, 5.21)** | 2.44 (1.51, 3.93)** |
1996 or after | 1.00 (Reference) | 1.00 (Reference) |
Year of HAART initiation | ||
Before 2000 | 2.13 (1.31, 3.46)* | --- †† |
2000-2010 | 1.00 (Reference) | --- †† |
Time from SC to HAART (years) per 1 year increase | 1.10 (1.06, 1.14)** | --- †† |
Other (non-HAART) ART | 3.28 (2.21, 4.87)** | --- †† |