First-line antiretroviral therapy and dyslipidemia in people living with HIV-1 in Cameroon: a cross-sectional study

Table 5 Determinants of abnormal lipid profile in 138 first-line ART treated individuals in Yaounde, Cameroon

Outcome variables	Explanatory variables	OR	p^a	Ajusted OR	p^b
		(95%CI)		(95% CI)
TC ≥ 200 (mg/dl)	Sex (Women vs. Men)	0.99 (0.48-2.04)	0.99	0.96 (0.45-2.03)	0.93
	Age > 40 years	1.38 (0.69-2.76)	0.36	1.41 (0.69-2.91)	0.35
	BMI > 25 kg/m²	1.22 (0.59-2.52)	0.59	1.06 (0.49-2.29)	0.88
	Treatment duration > 2 years	2.07 (1.03-4.17)	0.04	2.08 (1.01-4.27)	0.05
	d4T vs. AZT regimen	0.75 (0.36-1.56)	0.44	0.78 (0.32-1.81)	0.55
	NVP vs. EFV regimen	0.79 (0.26-2.41)	0.67	0.79 (0.21-2.99)	0.73
	Past history of tuberculosis	0.80 (0.39-1.62)	0.54	0.85 (0.41-1.80)	0.68
LDL-c ≥ 130 (md/dl)	Sex (Women vs. Men)	0.70 (0.33-1,51)	0.32	0.67 (0.32-1.40)	0.29
	Age > 40 years	0.74 (0.36-1.54)	0.38	0.57 (0.28-1.18)	0.23
	BMI > 25 kg/m²	2.23 (1.04-4.80)	0.02	2.65 (1.24-5.68)	0.01
	Treatment duration > 2 years	0.93 (0.45-1.93)	0.83	0.87 (0.42-1.80)	0.71
	d4T vs. AZT regimen	1.73 (0.79-3.78)	0.13	1.71 (0.72-4.06)	0.22
	NVP vs. EFV regimen	1.18 (0.34-4.01)	0.77	0.99 (0.26-3.72)	0.98
	Past history of tuberculosis	1.54 (0.73-3.25)	0.22	1.72 (0.89-3.62)	0.15
TC/HDL-c ratio ≥ 5	Sex (Women vs. Men)	1.79 (0.79-4.14)	0.13	1.61 (0.73-3.54)	0.23
	Age > 40 years	0.67 (0.31-1.43)	0.26	0.72 (0.34-1.50)	0.38
	BMI > 25 kg/m²	0.99 (0.45-2.16)	0.97	0.88 (0.41-1.89)	0.74
	Treatment duration > 2 years	1.93 (0.60-2.97)	0.08	1.90 (0.89-4.06)	0.1
	d4T vs. AZT regimen	1.33 (0.60-2.97)	0.44	1.56 (0.66-3.73)	0.31
	NVP vs. EFV regimen	1.01 (0.27-3.58)	1	0.68 (0.17-2.65)	0.58
	Past history of tuberculosis	0.72 (0.34-1.56)	0.37	0.77 (0.37-1.63)	0.5

BMI, body mass index; OR, odds ratio; CI, confidence interval; LDL-c, LDL cholesterol; TC, total cholesterol; HDL-c, HDL cholesterol; p^a, p value for unadjusted odds ratio; p^b, p value for adjusted odds ratio

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