Preformulation and stability in biological fluids of the retrocyclin RC-101, a potential anti-HIV topical microbicide

Table 3 Summarized results for detection of RC-101 by LC-MS/MS

		Time (h)
Sample Code	Sample Description	0	2	6	12	24	48	72*
A	Blank HVF	-	-	-	-	-	-	-
B	RC-101 solution combined with HVF	+	+	+	+	+	+	+
C	RC-101 solution control	+	+	+	+	+	+	+
D	RC-101 film combined with HVF	+	+	+	+	+	+	+
E	RC-101 film control	+	+	+	+	+	+	+
G	Placebo film control	-	-	-	-	-	-	-
A_F	Blank HVF frozen	-	-	-	-	-	-	NA
B_F	RC-101 solution with frozen HVF	+	+	+	+	+	+	NA
A_BV+	Blank HVF BV⁺	-	-	-	-	-	-	NA
B _BV+	RC-101 solution with HVF BV⁺	-	-	-	-	-	-	NA

(-) represents absence of RC-101 peak; (+) represents presence of RC-101 peak detected by LC-MS/MS. *only one pool of sample analyzed up to 72 h. NA = not analyzed samples at this time point.

ISSN: 1742-6405