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Table 3 Summarized results for detection of RC-101 by LC-MS/MS

From: Preformulation and stability in biological fluids of the retrocyclin RC-101, a potential anti-HIV topical microbicide

  Time (h)
Sample Code Sample Description 0 2 6 12 24 48 72*
A Blank HVF - - - - - - -
B RC-101 solution combined with HVF + + + + + + +
C RC-101 solution control + + + + + + +
D RC-101 film combined with HVF + + + + + + +
E RC-101 film control + + + + + + +
G Placebo film control - - - - - - -
AF Blank HVF frozen - - - - - - NA
BF RC-101 solution with frozen HVF + + + + + + NA
ABV+ Blank HVF BV+ - - - - - - NA
B BV+ RC-101 solution with HVF BV+ - - - - - - NA
  1. (-) represents absence of RC-101 peak; (+) represents presence of RC-101 peak detected by LC-MS/MS. *only one pool of sample analyzed up to 72 h. NA = not analyzed samples at this time point.