Preformulation and stability in biological fluids of the retrocyclin RC-101, a potential anti-HIV topical microbicide

Table 1 Summary of RC-101, in solution and formulated, samples combined with HVF.

Sample Code	Sample Description	HVF	RC-101 (100 μg/mL) SOLUTION	Water	RC-101 100 μg/ FILM*	Placebo FILM*
A	Blank HVF	100 mg	-----	100 μL	-----	-----
B	RC-101 solution combined with HVF	100 mg	100 μL	-----	-----	-----
C	RC-101 solution control	-----	100 μL	100 μL	-----	-----
D	RC-101 film combined with HVF	100 mg	-----	-----	100 mg	-----
E	RC-101 film control	-----	-----	100 μL	100 mg	-----
F	Placebo film combined with HVF	Not performed	-----	-----	-----	-----
G	Placebo film control	-----	-----	100 μL	-----	100 mg
A_F	Blank HVF frozen	100 mg	-----	100 μL	-----	-----
B_F	RC-101 solution with frozen HVF	100 mg	100 μL	-----	-----	-----
A_BV+	Blank HVF BV⁺	100 mg	-----	100 μL	-----	-----
B _BV+	RC-101 solution with HVF BV⁺	100 mg	100 μL	-----	-----	-----

Amounts correspond to one time point.
*RC-101 film and placebo film were initially dissolved in 1 mL of water prior to addition to HVF. Amounts in the films columns correspond to the solution of the film in 1 mL of water.

ISSN: 1742-6405