Table 3 Occurrence of first event of opportunistic illnesses in the two Brazilian national cohorts of children with AIDS (n = 1,859)
| Â | Â | Cohort-HIV Diagnosis | Â | Â | |
|---|---|---|---|---|---|
Opportunistic illness | Total N (%) | Pre-HAART Era N (%) | HAART Era N (%) | OR (95% CI) | P |
Invasive bacterial infection (excluding meningitis and septicemia) | 791 (42.6) | 359 (58.6) | 432 (34.7) | 2.66 (2.19-3.24) | < 0.001 |
P. jirovecii pneumonia | 298 (16.0) | 134 (21.9) | 164 (13.2) | 1.85 (1.44-2.37) | < 0.001 |
Bacterial meningitis or sepsis | 195 (10.5) | 103 (16.8) | 92 (7.4) | 2.53 (1.89-3.39) | < 0.001 |
Wasting syndrome | 179 (9.6) | 91 (10.0) | 88 (9.3) | 1.09 (0.80-1.48) | 0.637 |
HIV encephalopathy | 145 (7.8) | 54 (8.8) | 91 (7.3) | 1.23 (0.86-1.74) | 0.270 |
Cytomegalovirus infection | 106 (5.7) | 40 (6.5) | 66 (5.3) | 1.25 (0.83-1.87) | 0.289 |
Candidiasis | 101 (5.4) | 35 (5.7) | 66 (5.3) | 1.08 (0.71-1.65) | 0.744 |
Cryptosporidiosis | 50 (2.7) | 36 (5.9) | 14 (1.1) | 5.49 (3.13-9.62) | < 0.001 |
Herpes simplex, gingivostomatitis | 39 (2.1) | 20 (2.2) | 19 (2.0) | 1.09 (0.58-2.06) | 0.872 |
Cerebral toxoplasmosis | 33 (1.8) | 13 (2.1) | 20 (1.6) | 1.33 (0.66-2.68) | 0.457 |
Herpes simplex, mucocutaneous | 25 (1.3) | 10 (1.6) | 15 (1.2) | 1.36 (0.61-3.04) | 0.521 |
Disseminated mycobacterial disease | 22 (1.2) | 9 (1.5) | 13 (1.0) | 1.41 (0.60-3.31) | 0.494 |
Isosporiasis | 21 (1.1) | 11 (1.2) | 10 (1.1) | 1.14 (0.48-2.69) | 0.829 |
Lymphoma | 17 (0.9) | 7 (1.1) | 10 (0.8) | 1.43 (0.54-3.75) | 0.450 |
Cryptococcosis | 15 (0.8) | 10 (1.6) | 5 (0.4) | 4.12 (1.52-11.14) | 0.010 |
Kaposi's sarcoma | 3 (0.2) | 2 (0.3) | 1 (0.1) | 4.08 (0.44-37.42) | 0.254 |
Leukoencephalopathy | 3 (0.2) | 3 (0.5) | 0 (0.0) | - | - |
Salmonellosis | 2 (0.1) | 1 (0.2) | 1 (0.1) | 2.03 (0.13-30.79) | 0.551 |
Histoplasmosis | 0 (0.0) | 0 (0.0) | 0 (0.0) | - | - |
Coccidioidomycosis | 0 (0.0) | 0 (0.0) | 0 (0.0) | - | - |