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Table 3 Adjusted Covariate Estimates * for CD4+ Cell Response Post-HAART for All Participants, U.S. Military HIV Natural History Study

From: Long-term CD4+ lymphocyte response following HAART initiation in a U.S. Military prospective cohort

Covariate Estimate (95% CI) P-value
Age at HAART start   
   Effect of 10 years older if < 40 years old 4.3 (-9.3, 17.9) 0.54
   Effect of 10 years older if > 40 years old - 7.7 (-23.3, 7.9) 0.34
Female (vs. Male) 23.0 (-8.8, 54.8) 0.16
Race   
   Caucasian Reference  
   African American -7.4 (-20.5, 5.7) 0.27
   Hispanic -35.0 (-57.8, -12.2) 0.003
   Other -0.7 (-35.4, 33.9) 0.97
Clinical AIDS event prior to HAART start -23.3 (-46.1, -0.5) 0.045
Pre -HAART nadir CD4+ count (cells/mm3)   
≤ 200 Reference  
201-349 57.2 (31.4, 83.0) <.001
350-499 160.8 (129.2, 192.5) <.001
≥ 500 236.5 (196.4, 276.6) <.001
Baseline VL at HAART start (copies/ml) **   
< 1000 57.2 (32.5, 81.8) <.001
1000-9999 40.2 (19.5, 60.8) <.001
10,000-99,999 14.4 (-2.5, 31.3) 0.10
≥ 100,000 Reference  
Years from SC to HAART initiation   
   ≤ 1.5 Reference  
   > 1.5 to 4.0 -28.3 (-47.8, -8.8) 0.005
   > 4.0 to 8.5 -44.1 (-65.3, -23.0) <.001
   > 8.5 -50.6 (-73.4, -27.9) <.001
Year of HAART initiation   
   1995-1999 -12.8 (-36.6, 10.9) 0.29
   2000-2003 -34.4 (-60.3, -8.4) 0.01
   2004-2009 Reference  
Any ART prior to HAART start -16.4 (-34.4, 1.6) 0.07
  1. * Aside from baseline CD4+ count and time interval after HAART start
  2. ** Analysis adjusted for those for whom VL was missing/unknown.
  3. HAART = Highly active antiretroviral therapy; ART = Antiretroviral therapy;
  4. VL = HIV Viral load; SC = Seroconversion;