Table 3 Adjusted Covariate Estimates * for CD4+ Cell Response Post-HAART for All Participants, U.S. Military HIV Natural History Study

Age at HAART start

   Effect of 10 years older if < 40 years old

4.3 (-9.3, 17.9)

0.54

   Effect of 10 years older if > 40 years old

- 7.7 (-23.3, 7.9)

0.34

Female (vs. Male)

23.0 (-8.8, 54.8)

0.16

Race

   Caucasian

Reference

   African American

-7.4 (-20.5, 5.7)

0.27

   Hispanic

-35.0 (-57.8, -12.2)

0.003

   Other

-0.7 (-35.4, 33.9)

0.97

Clinical AIDS event prior to HAART start

-23.3 (-46.1, -0.5)

0.045

Pre -HAART nadir CD4+ count (cells/mm³)

≤ 200

Reference

201-349

57.2 (31.4, 83.0)

<.001

350-499

160.8 (129.2, 192.5)

<.001

≥ 500

236.5 (196.4, 276.6)

<.001

Baseline VL at HAART start (copies/ml) **

< 1000

57.2 (32.5, 81.8)

<.001

1000-9999

40.2 (19.5, 60.8)

<.001

10,000-99,999

14.4 (-2.5, 31.3)

0.10

≥ 100,000

Reference

Years from SC to HAART initiation

   ≤ 1.5

Reference

   > 1.5 to 4.0

-28.3 (-47.8, -8.8)

0.005

   > 4.0 to 8.5

-44.1 (-65.3, -23.0)

<.001

   > 8.5

-50.6 (-73.4, -27.9)

<.001

Year of HAART initiation

   1995-1999

-12.8 (-36.6, 10.9)

0.29

   2000-2003

-34.4 (-60.3, -8.4)

0.01

   2004-2009

Reference

Any ART prior to HAART start

-16.4 (-34.4, 1.6)

0.07