Long-term CD4+ lymphocyte response following HAART initiation in a U.S. Military prospective cohort

Table 2 Average Change in CD4+ Count by Time Since HAART Initiation: All Participants and Viral Suppressors in U.S. Military HIV Natural History Study

CD4+ strata	Estimated CD4+ count change and 95% CI (cells/mm³) by time segment (Years from HAART initiation)
at HAART start	0-0.5 yrs	0.5-4.0 yrs	>4.0 yrs
	(change/half-year)	(change/year)	(change/year)
≤200 cells/mm³
All participants	109 (93, 126)	36 (30, 43)	8.6 (3.3, 14.0)
Viral suppressors	147 (123, 172)	66 (56, 75)	13.6 (6.0, 21.2)
201-349 cells/mm³
All participants	149 (135, 162)	34 (28, 39)	3.5 (-1.3, 8.4)
Viral suppressors	171 (155, 188)	54 (48, 60)	14.4 (8.5, 20.4)
350-499 cells/mm³
All participants	151 (136, 166)	22 (16, 28)	1.5 (-3.4, 6.4)
Viral suppressors	177 (159, 195)	51 (44, 57)	12.0 (6.1, 17.8)
≥500 cells/mm³
All participants	93 (75, 110)	24 (17, 30)	-8.1 (-13.9, -2.4)
Viral suppressors	119 (98, 139)	56 (48, 63)	16.2 (9.8, 22.6)

* Significant (P < 0.05) differences in first-phase slopes: (1) All participants: ≤200 vs. 201-349; <200 vs. 350-499; 201-349 vs. ≥500; 350-499 vs. ≥500; (2) VL suppressors: 201-349 vs. ≥500; 350-499 vs. ≥500;
** Significant (P < 0.05) differences in second-phase slopes: (1) All participants: ≤200 vs. 350-499; (2) VL suppressors: None;
*** Significant (P < 0.05) differences in third-phase slopes: (1) All participants: ≤200 vs. ≥500; 201-349 vs. ≥500; 2) VL suppressors: None
(All P-values calculated with multiple comparisons adjustment)
HAART = Highly active antiretroviral therapy; CI = Confidence Interval

ISSN: 1742-6405