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Table 2 Average Change in CD4+ Count by Time Since HAART Initiation: All Participants and Viral Suppressors in U.S. Military HIV Natural History Study

From: Long-term CD4+ lymphocyte response following HAART initiation in a U.S. Military prospective cohort

CD4+ strata Estimated CD4+ count change and 95% CI (cells/mm3) by time segment (Years from HAART initiation)
at HAART start 0-0.5 yrs 0.5-4.0 yrs >4.0 yrs
  (change/half-year) (change/year) (change/year)
≤200 cells/mm3    
   All participants 109 (93, 126) 36 (30, 43) 8.6 (3.3, 14.0)
   Viral suppressors 147 (123, 172) 66 (56, 75) 13.6 (6.0, 21.2)
201-349 cells/mm3    
   All participants 149 (135, 162) 34 (28, 39) 3.5 (-1.3, 8.4)
   Viral suppressors 171 (155, 188) 54 (48, 60) 14.4 (8.5, 20.4)
350-499 cells/mm3    
   All participants 151 (136, 166) 22 (16, 28) 1.5 (-3.4, 6.4)
   Viral suppressors 177 (159, 195) 51 (44, 57) 12.0 (6.1, 17.8)
≥500 cells/mm3    
   All participants 93 (75, 110) 24 (17, 30) -8.1 (-13.9, -2.4)
   Viral suppressors 119 (98, 139) 56 (48, 63) 16.2 (9.8, 22.6)
  1. * Significant (P < 0.05) differences in first-phase slopes: (1) All participants: ≤200 vs. 201-349; <200 vs. 350-499; 201-349 vs. ≥500; 350-499 vs. ≥500; (2) VL suppressors: 201-349 vs. ≥500; 350-499 vs. ≥500;
  2. ** Significant (P < 0.05) differences in second-phase slopes: (1) All participants: ≤200 vs. 350-499; (2) VL suppressors: None;
  3. *** Significant (P < 0.05) differences in third-phase slopes: (1) All participants: ≤200 vs. ≥500; 201-349 vs. ≥500; 2) VL suppressors: None
  4. (All P-values calculated with multiple comparisons adjustment)
  5. HAART = Highly active antiretroviral therapy; CI = Confidence Interval