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Table 3 Virologic Outcomes of EI-AED Compared to Non-AED Subjects

From: Virologic outcomes of HAART with concurrent use of cytochrome P450 enzyme-inducing antiepileptics: a retrospective case control study

 

EI-AED

(N = 19)

Non-AED

(N = 190)

OR (95% CI) or

Difference ± SE

Adjusted for VL at

HAART Initiation

OR (95% CI) or

Difference ± SE

First HAART/AED Overlap

    

   Virologic failure

10/16 (62.5%)

62/146 (42.5%)

2.26 (0.78 - 6.54)

P = 0.134

4.30 (1.02 - 18.07)

P = 0.046

   Average VL during period (log10)

3.3 ± 1.3 (n = 19)

2.9 ± 1.2 (n = 184)

0.4 ± 0.3;

P = 0.198

0.3 ± 0.3;

P = 0.195

   VL <400 at 6 months

4/12 (33.3%)

89/160 (55.6%)

0.40 (0.12 - 1.38)

P = 0.146

0.30 (0.06 - 1.48)

P = 0.139

   VL <400 at 12 months

4/11 (36.4%)

80/125 (64.0%)

0.32 (0.09 - 1.16)

P = 0.083

0.17 (0.03 - 0.89)

P = 0.036

  1. OR (odds ratio): Odds of virologic event for EI-AED cases versus odds for non-AED controls; VL, viral load (copies/mL)