Table 1 Characteristics of HIV Subgroups
Characteristic | EI-AED | NEI-AED | Non-AED | EI-AED vs. NEI-AED (p-values) | EI-AED vs. Non-AED (p-values) |
|---|---|---|---|---|---|
Number, n | 19 | 85 | 190 | ||
Demographics (n, % or mean ± SD) | |||||
Age at HIV diagnosis (y) | 30.2 ± 10.0 | 32.5 ± 8.9 | 30.0 ± 7.9 | 0.331 | 0.912 |
Age at first HAART/AED overlap or index HAART (y) | 40.1 ± 8.7 | 45.1 ± 9.0 | 38.7 ± 9.1 | 0.027 | 0.522 |
Female | 1 (5.3) | 13 (15.3) | 18 (9.5) | 0.249 | 0.544 |
Race/ethnicity | 0.323 | 0.137 | |||
European American | 13 (68.4) | 46 (54.1) | 89 (46.8) | ||
African American | 6 (31.6) | 32 (37.6) | 84 (44.2) | ||
Other | 0 (0.0) | 7 (8.2) | 17 (8.9) | ||
Year of HIV diagnosis (median, range) | 1988 (1985 - 2000) | 1990 (1986 - 1999) | 1990 (1985 - 2000) | 0.145 | 0.122 |
CD4+ at HIV diagnosis (cells/uL) | 632 ± 398 | 525 ± 321 | 483 ± 235 | 0.340 | 0.068 |
CD4+ at first HAART/AED overlap or index HAART (cells/uL) | 310 ± 290 | 380 ± 247 | 364 ± 232 | 0.329 | 0.392 |
Viral load (log10) at first HAART/AED overlap or index HAART (copies/mL) | 3.8 ± 1.6 | 3.1 ± 1.4 | 3.6 ± 1.4 | 0.075 | 0.572 |
AIDS-defining event prior to first HAART/AED overlap or index HAART | 11 (57.9) | 35 (41.2) | 40 (21.1) | 0.187 | <.001 |
HAART regimen at first HAART/AED overlap or index HAART (n, %) | 0.189 | 0.543 | |||
PI-based | 12 (63.2) | 35 (41.2) | 117 (61.6) | ||
NNRTI-based | 5 (26.3) | 29 (34.1) | 36 (18.9) | ||
PI + NNRTI | 2 (10.5) | 21 (24.7) | 37 (19.5) | ||
Number of HAART/AED overlap periods (n, %) | 0.343 | --- | |||
1 | 7 (36.8) | 47 (55.3) | --- | ||
2 | 5 (26.3) | 17 (20.0) | --- | ||
≥ 3 | 7 (36.8) | 21 (24.7) | --- | ||
Months of HAART/AED overlap (median, range) | |||||
First overlap period | 7.0 (1.0 - 96.4) | 9.1 (1.3 - 65.4) | --- | 0.231 | --- |
All overlap periods | 21.3 (1.0 - 155.4) | 22.1 (1.6 - 120.3) | --- | 0.798 | --- |
Year of first HAART/AED overlap or index HAART (median, range) | 1998 (1996 - 2006) | 2003 (1996 - 2009) | 1998 (1996 - 2006) | 0.002 | 1.000 |
HAART use prior to first HAART/AED overlap or index HAART (n, %) | 0.010 | 0.523 | |||
No prior HAART | 4 (21.1) | 6 (7.1) | 40 (21.1) | ||
<1 year | 4 (21.1) | 7 (8.2) | 37 (19.5) | ||
1-2 years | 2 (10.5) | 7 (8.2) | 31 (16.3) | ||
2-3 years | 4 (21.1) | 6 (7.1) | 17 (8.9) | ||
>3 years | 5 (26.3) | 59 (69.4) | 65 (34.2) | ||
Duration of first HAART/AED overlap or index HAART (n, %) | 0.144 | 0.495 | |||
<1 year | 10 (52.6) | 22 (25.9) | 69 (36.3) | ||
1-2 years | 4 (21.1) | 22 (25.9) | 63 (33.2) | ||
2-3 years | 2 (10.5) | 15 (17.6) | 31 (16.3) | ||
>3 years | 3 (15.8) | 26 (30.6) | 27 (14.2) |