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Table 2 Results of laboratory parameters according to ABC use*

From: Markers of inflammation and coagulation indicate a prothrombotic state in HIV-infected patients with long-term use of antiretroviral therapy with or without abacavir

Laboratory parameter

ABC-containing regimen (n = 27)

Non-ABC-containing regimen (n = 54)

Reference range for the general population

aPTT (sec)

30.8 (29.5-33.9)

31.4 (29.4-33.7)

25.0-38.0

PT (sec)

11.5 (11.0-12.0)

11.7 (11.1-12.2)

10.7-12.9

Fibrinogen (g/L)

2.9 (2.5-3.2)

2.7 (2.3-3.5)

1.9-4.0

FVIII (%)

119 (103-175)

119 (100-144)

63-173

vWF (%)

112 (89-185)

124 (100-168)

50-150

D-dimer (mg/L)

0.4 (0.2-0.4)

0.2 (0.2-0.4)

<1.00

F1+2 (pmol/L)

213 (177-276)

196 (122-257)

53-271

PC (%)

115 (98-138)

116 (98-127)

70-120

PS total (%)

105 (90-115)

104 (86-114)

58-130

PS free (%)

81 (68-102)

82 (70-99)

63-137

ETP (nM.min)

1844 (1620-2052)

1740 (1602-1959)

1155-2606

ETP peak (nM)

381 (345-394)

374 (339-414)

194-503

APCsr

2.2 (1.7-4.0)

2.5 (1.9-3.3)

<1.6

VEGF (pg/ml)

37 (27-47)

33 (23-51)

31-86

IL-6 (pg/ml)

<1.0 (-)

<1.0 (-)

<4.0

hsCRP (mg/L)

1.6 (0.4-5.3)

1.6 (0.5-3.3)

<1.0

  1. *The results are shown as median values (interquartile range)
  2. ABC = abacavir; fVIII = factor VIII; vWF = von Willebrand factor; F1+2 = prothrombin fragment 1+2; PC = protein C; PS = protein S; ETP = endogenous thrombin potential; APCsr = activated protein C sensitivity ratio; VEGF = vascular endothelial growth factor; hsCPR = high-sensitivity C-reactive protein