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Table 2 Results of laboratory parameters according to ABC use*

From: Markers of inflammation and coagulation indicate a prothrombotic state in HIV-infected patients with long-term use of antiretroviral therapy with or without abacavir

Laboratory parameter ABC-containing regimen (n = 27) Non-ABC-containing regimen (n = 54) Reference range for the general population
aPTT (sec) 30.8 (29.5-33.9) 31.4 (29.4-33.7) 25.0-38.0
PT (sec) 11.5 (11.0-12.0) 11.7 (11.1-12.2) 10.7-12.9
Fibrinogen (g/L) 2.9 (2.5-3.2) 2.7 (2.3-3.5) 1.9-4.0
FVIII (%) 119 (103-175) 119 (100-144) 63-173
vWF (%) 112 (89-185) 124 (100-168) 50-150
D-dimer (mg/L) 0.4 (0.2-0.4) 0.2 (0.2-0.4) <1.00
F1+2 (pmol/L) 213 (177-276) 196 (122-257) 53-271
PC (%) 115 (98-138) 116 (98-127) 70-120
PS total (%) 105 (90-115) 104 (86-114) 58-130
PS free (%) 81 (68-102) 82 (70-99) 63-137
ETP (nM.min) 1844 (1620-2052) 1740 (1602-1959) 1155-2606
ETP peak (nM) 381 (345-394) 374 (339-414) 194-503
APCsr 2.2 (1.7-4.0) 2.5 (1.9-3.3) <1.6
VEGF (pg/ml) 37 (27-47) 33 (23-51) 31-86
IL-6 (pg/ml) <1.0 (-) <1.0 (-) <4.0
hsCRP (mg/L) 1.6 (0.4-5.3) 1.6 (0.5-3.3) <1.0
  1. *The results are shown as median values (interquartile range)
  2. ABC = abacavir; fVIII = factor VIII; vWF = von Willebrand factor; F1+2 = prothrombin fragment 1+2; PC = protein C; PS = protein S; ETP = endogenous thrombin potential; APCsr = activated protein C sensitivity ratio; VEGF = vascular endothelial growth factor; hsCPR = high-sensitivity C-reactive protein