Skip to main content

Advertisement

Table 2 Standard bicarbonate levels and case fatality rates for severe symptomatic hyperlactataemia cases (2003-2008)

From: Reduced referral and case fatality rates for severe symptomatic hyperlactataemia in a South African public sector antiretroviral programme: a retrospective observational study

Time Period Number of severe SHL cases Number who had SHCO3 performed (%) Median SHCO3 (IQR)1 Number with SHCO3 level <15 mmol/l (%)2 Number of deaths (case fatality rate as%)3
2003 4 3 (75) 14.2 (5.1-19.8) 2 (66.7) 0 (0)
2004 15 14 (93.3) 15.5 (4.9-18) 7 (50) 5 (33.3)
2005 67 55 (82.1) 17.6 (13.5-20) 19 (34.5) 7 (10.4)
2006 99 89 (89.9) 19.8 (17-21.3) 13 (14.6) 5 (5.1)
2007 53 49 (92.5) 20.1 (18-21.2) 6 (12.2) 3 (5.7)
2008 16 16 (100) 20 (17.3-21.4) 2 (12.5) 0 (0)
Entire
period
254 226 (89) 19.1 (15.8-20.9) 49 (21.7) 20 (7.9)
  1. 1 Median standard bicarbonate level: p for trend < 0.001 (for period 2003-2008).
  2. 2 Proportion with standard bicarbonate < 15 mmol/l: p for trend < 0.001 (for period 2003-2008). The proportion was calculated using the number who had standard bicarbonate performed during that year as denominator, see column 3.
  3. 3Case fatality rate: p for trend = 0.002 (for period 2004 - 2008; 2003 was excluded as case fatality rate peaked in 2004).
  4. SHL = Symptomatic Hyperlactataemia, SHCO3 = Standard bicarbonate in mmol/l (normal range 21-26 mmol/l), IQR = interquartile range.