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Table 1 Case load and referral rates for severe symptomatic hyperlactataemia cases (2003-2008)

From: Reduced referral and case fatality rates for severe symptomatic hyperlactataemia in a South African public sector antiretroviral programme: a retrospective observational study

Time Period Number of severe SHL cases Cumulative adult ART exposure (years) Referral rate: cases/1000 py ART exposure (95% CI) IRR(95% CI) Cumulative ART exposure 6-18 months (years) Referral rate: cases/1000 py 6-18 months on ART (95% CI) IRR(95%CI)
2003 4 436 9.2
(3.4-24.4)
0.45
(0.16-1.24)
219 18.3
(6.9-48.7)
0.46
(0.17-1.26)
2004 15 1361 11.0
(6.6-18.3)
0.54
(0.31-0.95)
547 27.4
(16.5-45.5)
0.69
(0.39-1.21)
2005 67 3292 20.4
(16.0-25.9)
1.0 (ref) 1689 39.7
(31.2-50.4)
1.0 (ref)
2006 99 6069 16.3
(13.4-19.9)
0.8
(0.59-1.09)
3284 30.1
(24.8-36.7)
0.76
(0.56-1.04)
2007 53 8771 6.0
(4.6-7.9)
0.3
(0.21-0.43)
4442 11.9
(9.1-15.6)
0.30
(0.21-0.43)
2008 16 12014 1.3
(0.8-2.2)
0.07
(0.04-0.11)
4488 3.6
(2.2-5.8)
0.09
(0.05-0.16)
Entire
Period
254 31943 8.0
(7.0-9.0)
- 14669 17.3 (15.3-19.6) -
  1. 1 Incidence rate ratio was calculated using 2005 as reference period.
  2. SHL = Symptomatic Hyperlactataemia, ART = Antiretroviral therapy, py = patient years, CI = Confidence interval, IRR = Incidence rate ratio.