Table 1 Case load and referral rates for severe symptomatic hyperlactataemia cases (2003-2008)
Time Period | Number of severe SHL cases | Cumulative adult ART exposure (years) | Referral rate: cases/1000 py ART exposure (95% CI) | IRR(95% CI) | Cumulative ART exposure 6-18 months (years) | Referral rate: cases/1000 py 6-18 months on ART (95% CI) | IRR(95%CI) |
|---|---|---|---|---|---|---|---|
2003 | 4 | 436 | 9.2 (3.4-24.4) | 0.45 (0.16-1.24) | 219 | 18.3 (6.9-48.7) | 0.46 (0.17-1.26) |
2004 | 15 | 1361 | 11.0 (6.6-18.3) | 0.54 (0.31-0.95) | 547 | 27.4 (16.5-45.5) | 0.69 (0.39-1.21) |
2005 | 67 | 3292 | 20.4 (16.0-25.9) | 1.0 (ref) | 1689 | 39.7 (31.2-50.4) | 1.0 (ref) |
2006 | 99 | 6069 | 16.3 (13.4-19.9) | 0.8 (0.59-1.09) | 3284 | 30.1 (24.8-36.7) | 0.76 (0.56-1.04) |
2007 | 53 | 8771 | 6.0 (4.6-7.9) | 0.3 (0.21-0.43) | 4442 | 11.9 (9.1-15.6) | 0.30 (0.21-0.43) |
2008 | 16 | 12014 | 1.3 (0.8-2.2) | 0.07 (0.04-0.11) | 4488 | 3.6 (2.2-5.8) | 0.09 (0.05-0.16) |
Entire Period | 254 | 31943 | 8.0 (7.0-9.0) | - | 14669 | 17.3 (15.3-19.6) | - |