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Table 3 Increase in AZT-induced % Inhibition of HIV-1 replication by the addition of non-toxic doses of WR1065a

From: Antiretroviral activity of the aminothiol WR1065 against Human Immunodeficiency virus (HIV-1) in vitro and Simian Immunodeficiency virus (SIV) ex vivo

Expt. Number % HIV-1 Inhibition WR1065 alone (Concentration) % HIV-1 Inhibition AZT alone (Concentration) % HIV-1 Inhibition AZT + WR1065 Increase in % inhibition HIV-1 with added WR1065 a
1 65.2%
(26.0 μM)
71.8%
(1.9 ηM)
86.6% 14.8%
2 20.0%
(26.0 μM)
38.8%
(1.9 ηM)
61.4% 29.9%
3 67.4%
(18.5 μM)
31.5%
(2.2 ηM)
81.9% 50.4%
  1. a In each experiment two identical AZT standard curves for inhibition of virus replication were compared; one curve had 1.9-23.0 ηM AZT alone and the second curve had 1.9-23.0 ηM AZT plus a constant non-toxic amount (see table) of WR1065 added to each AZT concentration. The only informative concentrations of AZT were the 1.9 and 2.2 ηM doses that alone gave % Inhibition values well below 80%. A representative set of curves (experiment 3) including all points is shown in Figure 2.