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Table 1 Toxicity and antiviral activity of zinc tetra-ascorbo-camphorate derivative ("C14") on macrophages, dendritic cells and peripheral blood lymphocytes by using the primary X4-tropic HIV-1NDK and R5-tropic HIV-1Ba-L.

From: Pre-clinical development as microbicide of zinc tetra-ascorbo-camphorate, a novel terpenoid derivative: Potent in vitro inhibitory activity against both R5- and X4-tropic HIV-1 strains without significant in vivo mucosal toxicity

Antiviral molecules

CC50a

IC50b

 

MΦ

DC

T cells

MΦ*

DC*

T cells*

    

HIV-1 Ba-L

HIV-1 NDK

HIV-1 Ba-L

HIV-1 NDK

HIV-1 Ba-L

HIV-1 NDK

C14

>10

>10

>10

1.3 ± 01

0.02 ± 0.0

1.3 ± 0.1

1.8 ± 0.1

0.8 ± 0.0

0.7 ± 0.1

Enfuviritid (T20)

>10

>10

>10

0.08 ± 0.1

8 ± 0.5

0.3 ± 0.0

0.8 ± 0.3

0.4 ± 0.2

6.7 ± 0.2

  1. *Mean ± 1 standard deviation
  2. aTerpenoid derivative C14 concentration (μM) that causes 50% cytotoxicity (CC50) on primary cells (MΦ, DC, T cells)
  3. bTerpenoid derivative C14 concentration (μM) that induces 50% infection inhibition (IC50) on primary cells (MΦ, DC, PBL)by primary X4-HIV-1NDKor R5-HIV-1Ba-L, expressed as mean ± 1 standard deviation MΦ: Macrophages; DC: Dendritic cells
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AIDS Research and Therapy

ISSN: 1742-6405

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