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Table 1 Toxicity and antiviral activity of zinc tetra-ascorbo-camphorate derivative ("C14") on macrophages, dendritic cells and peripheral blood lymphocytes by using the primary X4-tropic HIV-1NDK and R5-tropic HIV-1Ba-L.

From: Pre-clinical development as microbicide of zinc tetra-ascorbo-camphorate, a novel terpenoid derivative: Potent in vitro inhibitory activity against both R5- and X4-tropic HIV-1 strains without significant in vivo mucosal toxicity

Antiviral molecules CC50a IC50b
  DC T cells MΦ* DC* T cells*
     HIV-1 Ba-L HIV-1 NDK HIV-1 Ba-L HIV-1 NDK HIV-1 Ba-L HIV-1 NDK
C14 >10 >10 >10 1.3 ± 01 0.02 ± 0.0 1.3 ± 0.1 1.8 ± 0.1 0.8 ± 0.0 0.7 ± 0.1
Enfuviritid (T20) >10 >10 >10 0.08 ± 0.1 8 ± 0.5 0.3 ± 0.0 0.8 ± 0.3 0.4 ± 0.2 6.7 ± 0.2
  1. *Mean ± 1 standard deviation
  2. aTerpenoid derivative C14 concentration (μM) that causes 50% cytotoxicity (CC50) on primary cells (MΦ, DC, T cells)
  3. bTerpenoid derivative C14 concentration (μM) that induces 50% infection inhibition (IC50) on primary cells (MΦ, DC, PBL)by primary X4-HIV-1NDKor R5-HIV-1Ba-L, expressed as mean ± 1 standard deviation MΦ: Macrophages; DC: Dendritic cells