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Figure 5 | AIDS Research and Therapy

Figure 5

From: Pre-clinical development as microbicide of zinc tetra-ascorbo-camphorate, a novel terpenoid derivative: Potent in vitro inhibitory activity against both R5- and X4-tropic HIV-1 strains without significant in vivo mucosal toxicity

Figure 5

Effects of low and high concentrations (1 and 20 μM) of C14 on cervicovaginal mucosa in the New Zealand White rabbit model. Rabbit cervicovaginal epithelium was treated with 1 or 20 μM of C14. The vaginal tracts were surgically excised, formalin fixed, and paraffin embedded by standard histological protocols. To assess gross tissue morphology, sections were stained with hematoxylin and eosin. (A) Normal histopathological aspect of the mucosal epithelium of the rabbit #436 that was treated with C14 (1 μM) for 10 days (× 300). (B) Vascular congestion of the mucosal epithelium of the rabbit #435 that was treated with C14 (20 μM) for 10 days (× 300). (C) Vascular congestion of the mucosal epithelium of the rabbit #436 that was treated with C14 (1 μM) for 10 days (× 100). (D) Erosion of the mucosal epithelium of the rabbit #432 that was treated with C14 (20 μM) for 10 days (× 300).

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AIDS Research and Therapy

ISSN: 1742-6405

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