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Figure 2 | AIDS Research and Therapy

Figure 2

From: Pre-clinical development as microbicide of zinc tetra-ascorbo-camphorate, a novel terpenoid derivative: Potent in vitro inhibitory activity against both R5- and X4-tropic HIV-1 strains without significant in vivo mucosal toxicity

Figure 2

Evaluation of C14 inhibitory activity on HIV-1 DNA content into primary cells. Monocyte-derived macrophages (A), monocyte-derived dendritic cells (B) and T cells (C) were incubated with R5 or X4 viruses in the presence of increasing concentrations of C14 or an unique dose of T 20 (5 μM) for 3 hours at 37°C. Cells were then washed and cultured in fresh medium for 3 days. DNA was extracted and the viral DNA was quantified by real time PCR. Means are representative of 3 independent experiments and assays were performed in triplicates. *, p ≤ 0.05; **, p ≤ 0.01 between untreated and treated cells.

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AIDS Research and Therapy

ISSN: 1742-6405

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