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Table 2 HLA-G DNA sequence variant dissimilarities/similarities between Mother-child pairs and risk of perinatal HIV-1 transmission

From: HLA-G DNA sequence variants and risk of perinatal HIV-1 transmission

HLA-G Mutation Position   N = 20 HIV-1 Transmitting group N = 14 HIV-1-non-Transmitting group P-Value (2-sided) OR (95%CI)
Exon-2      
Codon 31 Dissimilar 2 (10.0%)* 2 (14.3%)* 0.987 0.67 [0.08–5.39]
  Similar 18 (90.0%) 12 (85.7%)   
Codon 57 Dissimilar 8 (40.0%) 13 (92.9%) 0.003 0.05 [0.00–0.47]9
  Similar 12 (60.0%) 1 (7.1%)   
Exon-3      
Codon 93 Dissimilar 4 (20.0%) 6 (42.9%) 0.290 0.33 [0.07–1.53]
  Similar 16 (80.0%) 8 (57.1%)   
Codon 107 Dissimilar 1 (5.0%) 0 (0.0%) 0.806 2.23 [0.09–58.81]
  Similar 19 (95.0%) 14(100.0%)   
Codon 110 Dissimilar 5 (25.0%) 3 (21.4%) 0.866 1.22 [0.24–6.23]
  Similar 15 (75.0%) 11 (78.6%)   
Codon 130 Dissimilar 1 (5.0%) 0 (0.0%) 0.806 2.23 [0.09–58.81]
  Similar 19 (95.0%) 14 (100.0%)   
Exon-4      
Codon 256 Dissimilar 10 (50.0%) 2 (14.3%) 0.060 6.0 [1.06–34.00]
  Similar 10 (50.0%) 12 (85.7%)   
Codon 257 Dissimilar 10 (50.0%) 3 (21.4%) 0.150 3.67 [0.78–17.25]
  Similar 10 (50.0%) 11 (78.6%)   
Codon 269 Dissimilar 5 (25.0%) 0 (0.0%) 0.174 10.3 [0.52–203.07]
  Similar 15 (75.0%) 14 100.0%)   
Codon 272 Dissimilar 0 (0.0%) 2 (14.3%) 0.359 0.12 [0.01–2.75]
  Similar 20 (100.0%) 12 (85.7%)   
Intron 6      
3401 Dissimilar 0 (0.0%) 0 (0.0%) undefined undefined
  Similar 20 (100.0%) 14 (100.0%)   
Intron 7      
3579 Dissimilar 2(90.0%) 5 (35.7%) 0.090 0.2 [0.03–1.24]
  Similar 18 10.0%) 9 (64.3%)   
3585 Dissimilar 9 (45.0%) 6 (42.9%) 0.820 1.09 [0.28–4.32]
  Similar 11 (55.0%) 8 (57.1%)   
3619 Dissimilar 11 (55.0%) 6 (42.9%) 0.727 1.63 [0.41–6.46]
  Similar 9 (45.0%) 8 (57.1%)   
Exon 8-3UTR      
3742 Dissimilar 4 (20.0%) 10 (71.4%) 0.004 0.1 [0.02–0.49]
  Similar 16 (80.0%) 4 (28.6%)   
3743 Dissimilar 2 (10.0%) 12 (85.7%) 0.00001 0.02 [0.00–0.15]
  Similar 18 (90.0%) 2 (14.3%)   
3777 Dissimilar 5 (25.0%) 9 (64.3%) 0.03 0.19 [0.04–0.82]
  Similar 15 (75.0%) 5 (35.7%)   
  1. *Percentage of similarity and dissimilarity; N, number of pairs in the given group;
  2. Data from 34 mother-child pairs with HLA-G DNA sequence variants as compared to the previously published wild-type HLA 6.0 sequence by Geraghty (1987). Mother-child pairs matching with the same HLAG DNA sequence variants at the above HLA-G sequence positions are considered similar; Mother with a mismatched HLAG DNA sequence variants at one or more of these positions with the child is considered dissimilar.