Table 2 HLA-G DNA sequence variant dissimilarities/similarities between Mother-child pairs and risk of perinatal HIV-1 transmission
From: HLA-G DNA sequence variants and risk of perinatal HIV-1 transmission
HLA-G Mutation Position | N = 20 HIV-1 Transmitting group | N = 14 HIV-1-non-Transmitting group | P-Value (2-sided) | OR (95%CI) | |
|---|---|---|---|---|---|
Exon-2 | |||||
Codon 31 | Dissimilar | 2 (10.0%)* | 2 (14.3%)* | 0.987 | 0.67 [0.08–5.39] |
Similar | 18 (90.0%) | 12 (85.7%) | |||
Codon 57 | Dissimilar | 8 (40.0%) | 13 (92.9%) | 0.003 | 0.05 [0.00–0.47]9 |
Similar | 12 (60.0%) | 1 (7.1%) | |||
Exon-3 | |||||
Codon 93 | Dissimilar | 4 (20.0%) | 6 (42.9%) | 0.290 | 0.33 [0.07–1.53] |
Similar | 16 (80.0%) | 8 (57.1%) | |||
Codon 107 | Dissimilar | 1 (5.0%) | 0 (0.0%) | 0.806 | 2.23 [0.09–58.81] |
Similar | 19 (95.0%) | 14(100.0%) | |||
Codon 110 | Dissimilar | 5 (25.0%) | 3 (21.4%) | 0.866 | 1.22 [0.24–6.23] |
Similar | 15 (75.0%) | 11 (78.6%) | |||
Codon 130 | Dissimilar | 1 (5.0%) | 0 (0.0%) | 0.806 | 2.23 [0.09–58.81] |
Similar | 19 (95.0%) | 14 (100.0%) | |||
Exon-4 | |||||
Codon 256 | Dissimilar | 10 (50.0%) | 2 (14.3%) | 0.060 | 6.0 [1.06–34.00] |
Similar | 10 (50.0%) | 12 (85.7%) | |||
Codon 257 | Dissimilar | 10 (50.0%) | 3 (21.4%) | 0.150 | 3.67 [0.78–17.25] |
Similar | 10 (50.0%) | 11 (78.6%) | |||
Codon 269 | Dissimilar | 5 (25.0%) | 0 (0.0%) | 0.174 | 10.3 [0.52–203.07] |
Similar | 15 (75.0%) | 14 100.0%) | |||
Codon 272 | Dissimilar | 0 (0.0%) | 2 (14.3%) | 0.359 | 0.12 [0.01–2.75] |
Similar | 20 (100.0%) | 12 (85.7%) | |||
Intron 6 | |||||
3401 | Dissimilar | 0 (0.0%) | 0 (0.0%) | undefined | undefined |
Similar | 20 (100.0%) | 14 (100.0%) | |||
Intron 7 | |||||
3579 | Dissimilar | 2(90.0%) | 5 (35.7%) | 0.090 | 0.2 [0.03–1.24] |
Similar | 18 10.0%) | 9 (64.3%) | |||
3585 | Dissimilar | 9 (45.0%) | 6 (42.9%) | 0.820 | 1.09 [0.28–4.32] |
Similar | 11 (55.0%) | 8 (57.1%) | |||
3619 | Dissimilar | 11 (55.0%) | 6 (42.9%) | 0.727 | 1.63 [0.41–6.46] |
Similar | 9 (45.0%) | 8 (57.1%) | |||
Exon 8-3UTR | |||||
3742 | Dissimilar | 4 (20.0%) | 10 (71.4%) | 0.004 | 0.1 [0.02–0.49] |
Similar | 16 (80.0%) | 4 (28.6%) | |||
3743 | Dissimilar | 2 (10.0%) | 12 (85.7%) | 0.00001 | 0.02 [0.00–0.15] |
Similar | 18 (90.0%) | 2 (14.3%) | |||
3777 | Dissimilar | 5 (25.0%) | 9 (64.3%) | 0.03 | 0.19 [0.04–0.82] |
Similar | 15 (75.0%) | 5 (35.7%) |