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Table 1 CCR5 and CD45 genotypes in exposed uninfected subjects (ESN), HIV-1 seropositive patients and general population control groups.

From: Partial protective effect of CCR5-Delta 32 heterozygosity in a cohort of heterosexual Italian HIV-1 exposed uninfected individuals

Genotype

ESN (%) (n = 30)

HIV-1 seropositive (%) (n = 120)

Pc

General Population (%) (n = 120)

Pd

CCR5a

wt/wt

24 (80)

111 (92.5)

0.04

108 (90)

ns

 

Δ32/wt

6 (20)

9 (7.5)

0.04

12 (10)

ns

 

Δ32/Δ32

0 (0)

0 (0)

ns

0 (0)

ns

CD45b

Wt/wt

29 (97)

117 (97.5)

ns

117 (97.5)

ns

 

C77G/wt

1 (3)

3 (2.5)

ns

3 (2.5)

ns

 

C77G/C77G

0 (0)

0 (0)

ns

0 (0)

ns

  1. a WT/WT, homozygous wild type CCR5 genotype; Delta32/Delta32 for homozygous mutant for 32-bp deletion in CCR5 gene and Delta32/wt for heterozygous.
  2. b WT/WT, homozygous wild type CD45 genotype; C77G/C77G for homozygous mutant for the point mutation in exon 4 of CD45 gene and C77G/wt for heterozygous.
  3. c P value calculated comparing ESN individuals vs HIV-1 seropositive control group; p = ns, non significant.
  4. d P value calculated comparing ESN individuals vs General Population control group; p = ns, non significant.