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Figure 2 | AIDS Research and Therapy

Figure 2

From: HIV-1 reverse transcriptase mutations that confer decreased in vitro susceptibility to anti-RT DNA aptamer RT1t49 confer cross resistance to other anti-RT aptamers but not to standard RT inhibitors

Figure 2

Comparison of polymerase-dependent RNase H activities of wild type (WT), and mutant RTs. HIV-1 RT and template·primer substrates were combined and time course reactions were performed with a 5'-end labeled 142nt RNA template and 30nt DNA primer for 0, 10, 30, 60, 120 and 300 seconds. Cleavage products were resolved by denaturing 6%. The product sizes are indicated to the left of the panel.

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AIDS Research and Therapy

ISSN: 1742-6405

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