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Table 2 Multivariate regression analysis of associations between cell subsets and intelligent quotients

From: Association between lymphocyte and monocyte subsets and cognition in children with HIV

   Multivariate regression analysis
Coefficient (95% CI), p value
Cellsubsets Median (IQR) Full-scale IQ Verbal IQ Performance IQ
Cell counts
Total T 2079 (1547,2666) −9.8 (−42.8, 23.2), p 0.55 −10.1 (−37.7, 17.6), p 0.46 −10.0 (−46.0, 26.0), p 0.57
B 321 (247,481) −40.0 (−63.8, -16.2), p 0.002 −31.7 (−52.2, -11.3), p 0.004 −37.1 (−62.4, -11.9), p 0.005
Natural killer 297 (152,386) 7.0 (−8.9, 22.8), p 0.38 3.3 (−10.1, 16.7), p 0.62 8.5 (−8.7, 25.6), p 0.32
Helper T 594 (362,795) −8.5 (−34.7, 17.6), p 0.51 −8.4 (−30.3, 13.5), p 0.44 −8.4 (−36.6, 19.9), p 0.55
Cytotoxic T 1360 (970,1697) −3.4 (−36.6, 29.8), p 0.84 −6.7 (−34.5, 21.1), p 0.62 −2.1 (−38.4, 34.3), p 0.91
Naïve helper T 314 (168,417) −6.5 (−21.5, 8.6), p 0.39 −6.4 (−18.9, 6.2), p 0.31 −5.8 (−22.2, 10.6), p 0.47
Naïve cytotoxic T 311 (240,451) −5.7 (−27.3, 15.8), p 0.59 −3.4 (−21.5, 14.8), p 0.70 −6.9 (−30.6, 16.8), p 0.55
Activated helper T 67 (39,98) 4.4 (−16.5, 25.3), p 0.67 2.9 (−14.7, 20.4), p 0.74 1.9 (−20.0, 23.8), p 0.86
Activated cytotoxic T 584 (460,865) −7.7 (−38.1, 22.7), p 0.61 −6.6 (−32.2, 18.9), p 0.60 −11.1 (−43.4, 21.2), p 0.49
Memory helper T 228 (168,305) −2.2 (−30.8, 26.5), p 0.88 −7.0 (−31.0, 16.9), p 0.55 0.7 (−29.4, 30.7), p 0.96
Memory cytotoxic T 683 (543,908) −27.2 (−57.5, 3.0), p 0.08 −25.3 (−50.4, -0.3), p 0.048 −26.0 (−58.3, 6.3), p 0.11
Activated monocytes 58 (33,115) 17.4 (−3.3, 38.1), p 0.10 11.3 (−6.1, 28.7), p 0.19 15.9 (−7.2, 38.9), p 0.17
Perivascular monocytes 31 (12,59) −4.2 (−15.4, 6.9), p 0.44 −2.9 (−12.1, 6.3), p 0.52 −6.3 (−18.0, 5.4), p 0.28
Cell percentages
CD4/CD8 0.4 (0.4,0.5) −17.4 (−60.5, 25.6), p 0.41 −11.3 (−47.7, 25.1), p 0.53 −19.7 (−66.6, 27.2), p 0.40
Total T 76.1 (69.5.80.3) 11.1 (−121.0, 143.2), p 0.86 10.2 (−100.8, 121.2), p 0.85 8.0 (−131.3, 147.2), p 0.91
B 12.4 (9.3.15.9) −43.5 (−71.8, -15.1), p 0.004 −32.2 (−56.9, -7.5), p 0.012 −45.5 (−76.5, -14.5), p 0.005
Natural killer 8.5 (5.8,12.3) 11.9 (−5.6, 29.5), p 0.17 7.4 (−7.5, 22.4), p 0.32 14.3 (−5.0, 33.5), p 0.14
Helper T 20.6 (16.1,22.9) −8.6 (−64.0, 46.8), p 0.75 −7.3 (−53.8, 39.3), p 0.75 −8.7 (−69.9, 52.6), p 0.77
Cytotoxic T 50.3 (44.5,54) 37.4 (−37.8, 112.5), p 0.32 21.0 (−42.7, 84.7), p 0.51 43.4 (−37.0, 123.8), p 0.28
Naïve helper T 49.5 (42,60.2) −12.2 (−39.8, 15.4), p 0.37 −12.1 (−35.2, 10.9), p 0.29 −10.4 (−40.8, 20.1), p 0.49
Naïve cytotoxic T 24.1 (18.2,29.4) −9.9 (−42.5, 22.8), p 0.54 −1.2 (−28.9, 26.4), p 0.93 −12.9 (−47.5, 21.6), p 0.45
Activated helper T 10.9 (8.7-15.4) 8.0 (−10.7, 26.7), p 0.39 6.7 (−9.0, 22.4), p 0.39 6.2 (−14.4, 26.8), p 0.54
Activated cytotoxic T 49.7 (39,59.6) −10.2 (−54.3, 34.0), p 0.64 −2.0 (−39.2, 35.2), p 0.91 −20.6 (−68.0, 26.7), p 0.38
Memory helper T 10.9 (9.9,13.3) 8.0 (−27.5, 43.4), p 0.65 0.7 (−29.1, 30.6), p 0.96 12.4 (−25.6, 50.4), p 0.51
Memory cytotoxic T 34.2 (29.9,41.4) −26.2 (−63.3, 10.8), p 0.16 −23.2 (−54.2, 7.9), p 0.14 −26.6 (−67.3, 14.0), p 0.19
Activated monocytes 11.1 (8.1,16.7) 22.0 (−3.9, 47.9), p 0.09 18.0 (−3.3, 39.4), p 0.09 18.1 (−11.1, 47.3), p 0.21
Perivascular monocytes 6.5 (2.1,10.1) −6.7 (−19.4, 6.1), p 0.29 −3.8 (−14.4, 6.9), p 0.47 −9.5 (−22.8, 3.8), p 0.15
  1. Regression analysis was performed with an outcome variable of log10 transformed T cell subset percentages and counts, versus cognitive outcomes adjusted for potential confounders (age, gender, HIV RNA, education of primary caregiver and household income).
  2. IQ Intelligence quotient.