Table 2 Multivariate regression analysis of associations between cell subsets and intelligent quotients
From: Association between lymphocyte and monocyte subsets and cognition in children with HIV
Multivariate regression analysis | ||||
|---|---|---|---|---|
Coefficient (95% CI), p value | ||||
Cellsubsets | Median (IQR) | Full-scale IQ | Verbal IQ | Performance IQ |
Cell counts | ||||
Total T | 2079 (1547,2666) | −9.8 (−42.8, 23.2), p 0.55 | −10.1 (−37.7, 17.6), p 0.46 | −10.0 (−46.0, 26.0), p 0.57 |
B | 321 (247,481) | −40.0 (−63.8, -16.2), p 0.002 | −31.7 (−52.2, -11.3), p 0.004 | −37.1 (−62.4, -11.9), p 0.005 |
Natural killer | 297 (152,386) | 7.0 (−8.9, 22.8), p 0.38 | 3.3 (−10.1, 16.7), p 0.62 | 8.5 (−8.7, 25.6), p 0.32 |
Helper T | 594 (362,795) | −8.5 (−34.7, 17.6), p 0.51 | −8.4 (−30.3, 13.5), p 0.44 | −8.4 (−36.6, 19.9), p 0.55 |
Cytotoxic T | 1360 (970,1697) | −3.4 (−36.6, 29.8), p 0.84 | −6.7 (−34.5, 21.1), p 0.62 | −2.1 (−38.4, 34.3), p 0.91 |
Naïve helper T | 314 (168,417) | −6.5 (−21.5, 8.6), p 0.39 | −6.4 (−18.9, 6.2), p 0.31 | −5.8 (−22.2, 10.6), p 0.47 |
Naïve cytotoxic T | 311 (240,451) | −5.7 (−27.3, 15.8), p 0.59 | −3.4 (−21.5, 14.8), p 0.70 | −6.9 (−30.6, 16.8), p 0.55 |
Activated helper T | 67 (39,98) | 4.4 (−16.5, 25.3), p 0.67 | 2.9 (−14.7, 20.4), p 0.74 | 1.9 (−20.0, 23.8), p 0.86 |
Activated cytotoxic T | 584 (460,865) | −7.7 (−38.1, 22.7), p 0.61 | −6.6 (−32.2, 18.9), p 0.60 | −11.1 (−43.4, 21.2), p 0.49 |
Memory helper T | 228 (168,305) | −2.2 (−30.8, 26.5), p 0.88 | −7.0 (−31.0, 16.9), p 0.55 | 0.7 (−29.4, 30.7), p 0.96 |
Memory cytotoxic T | 683 (543,908) | −27.2 (−57.5, 3.0), p 0.08 | −25.3 (−50.4, -0.3), p 0.048 | −26.0 (−58.3, 6.3), p 0.11 |
Activated monocytes | 58 (33,115) | 17.4 (−3.3, 38.1), p 0.10 | 11.3 (−6.1, 28.7), p 0.19 | 15.9 (−7.2, 38.9), p 0.17 |
Perivascular monocytes | 31 (12,59) | −4.2 (−15.4, 6.9), p 0.44 | −2.9 (−12.1, 6.3), p 0.52 | −6.3 (−18.0, 5.4), p 0.28 |
Cell percentages | ||||
CD4/CD8 | 0.4 (0.4,0.5) | −17.4 (−60.5, 25.6), p 0.41 | −11.3 (−47.7, 25.1), p 0.53 | −19.7 (−66.6, 27.2), p 0.40 |
Total T | 76.1 (69.5.80.3) | 11.1 (−121.0, 143.2), p 0.86 | 10.2 (−100.8, 121.2), p 0.85 | 8.0 (−131.3, 147.2), p 0.91 |
B | 12.4 (9.3.15.9) | −43.5 (−71.8, -15.1), p 0.004 | −32.2 (−56.9, -7.5), p 0.012 | −45.5 (−76.5, -14.5), p 0.005 |
Natural killer | 8.5 (5.8,12.3) | 11.9 (−5.6, 29.5), p 0.17 | 7.4 (−7.5, 22.4), p 0.32 | 14.3 (−5.0, 33.5), p 0.14 |
Helper T | 20.6 (16.1,22.9) | −8.6 (−64.0, 46.8), p 0.75 | −7.3 (−53.8, 39.3), p 0.75 | −8.7 (−69.9, 52.6), p 0.77 |
Cytotoxic T | 50.3 (44.5,54) | 37.4 (−37.8, 112.5), p 0.32 | 21.0 (−42.7, 84.7), p 0.51 | 43.4 (−37.0, 123.8), p 0.28 |
Naïve helper T | 49.5 (42,60.2) | −12.2 (−39.8, 15.4), p 0.37 | −12.1 (−35.2, 10.9), p 0.29 | −10.4 (−40.8, 20.1), p 0.49 |
Naïve cytotoxic T | 24.1 (18.2,29.4) | −9.9 (−42.5, 22.8), p 0.54 | −1.2 (−28.9, 26.4), p 0.93 | −12.9 (−47.5, 21.6), p 0.45 |
Activated helper T | 10.9 (8.7-15.4) | 8.0 (−10.7, 26.7), p 0.39 | 6.7 (−9.0, 22.4), p 0.39 | 6.2 (−14.4, 26.8), p 0.54 |
Activated cytotoxic T | 49.7 (39,59.6) | −10.2 (−54.3, 34.0), p 0.64 | −2.0 (−39.2, 35.2), p 0.91 | −20.6 (−68.0, 26.7), p 0.38 |
Memory helper T | 10.9 (9.9,13.3) | 8.0 (−27.5, 43.4), p 0.65 | 0.7 (−29.1, 30.6), p 0.96 | 12.4 (−25.6, 50.4), p 0.51 |
Memory cytotoxic T | 34.2 (29.9,41.4) | −26.2 (−63.3, 10.8), p 0.16 | −23.2 (−54.2, 7.9), p 0.14 | −26.6 (−67.3, 14.0), p 0.19 |
Activated monocytes | 11.1 (8.1,16.7) | 22.0 (−3.9, 47.9), p 0.09 | 18.0 (−3.3, 39.4), p 0.09 | 18.1 (−11.1, 47.3), p 0.21 |
Perivascular monocytes | 6.5 (2.1,10.1) | −6.7 (−19.4, 6.1), p 0.29 | −3.8 (−14.4, 6.9), p 0.47 | −9.5 (−22.8, 3.8), p 0.15 |