Table 2 Factors associated with failure to achieve viral suppression 6 months after switching ART regimen (n = 80)
From: Virologic outcomes of second-line antiretroviral therapy in Eastern European country of Georgia
Total N | Detectable viral load | |||
|---|---|---|---|---|
n (%) | Bivariate | Multivariate | ||
RR (95% CI) | RR (95% CI) | |||
Age | ||||
<37 years | 35 | 7 (20.0) | 0.90 (0.38-2.12) | |
≥37 years | 45 | 10 (22.2) | 1 | |
Sex | ||||
Men | 57 | 13 (22.8) | 1.31 (0.48-3.60) | 0.50 (0.17-1.45) |
Women | 23 | 4 (17.4) | 1 | 1 |
Mode of HIV transmission | ||||
IDU | 49 | 12 (24.5) | 1.52 (0.59-3.89) | 1.34 (0.64-2.83) |
non-IDU | 31 | 5 (16.1) | 1 | 1 |
HCV infection | ||||
anti-HCV+ | 42 | 9 (21.4) | 1.02 (0.44-2.37) | |
anti-HCV- | 38 | 8 (21.1) | 1 | |
Tuberculosis | ||||
History of TB | 31 | 6 (19.4) | 0.86 (0.36-2.09) | |
No history of TB | 49 | 11 (22.5) | 1 | |
Viral load at failure on initial ART | ||||
≥100,000 | 21 | 9 (42.9) | 3.16 (1.40-7.12) | 3.39 (1.46-7.89) |
<100,000 | 59 | 8 (13.6) | 1 | 1 |
ART regimen after switch | ||||
ATV/r-based | 20 | 4 (20.0) | 0.92 (0.34-2.51) | |
LPV/r-based | 60 | 13 (21.7) | 1 | |
6-month adherence after regimen switch | ||||
<80% | 19 | 10 (52.6) | 5.01 (1.80-13.87) | 5.09 (1.89-13.70) |
80- < 100% | 23 | 3 (13.0) | 1.24 (0.30-5.05) | 1.48 (0.36-6.12) |
100% | 38 | 4 (10.5) | 1 | 1 |
Number of resistance mutations | ||||
>2 mutations | 21 | 3 (14.3) | 0.60 (0.19-1.89) | |
≤2 mutations | 59 | 14 (23.7) | 1 | |
Drug class resistance | ||||
Single class (NRTI or NNRTI) | 11 | 3 (27.3) | 1.34 (0.46-3.93) | |
Dual class (NRTI + NNRTI) | 69 | 14 (20.3) | 1 | |