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Table 2 Factors associated with failure to achieve viral suppression 6 months after switching ART regimen (n = 80)

From: Virologic outcomes of second-line antiretroviral therapy in Eastern European country of Georgia

  Total N Detectable viral load
   n (%) Bivariate Multivariate
    RR (95% CI) RR (95% CI)
Age     
<37 years 35 7 (20.0) 0.90 (0.38-2.12)  
≥37 years 45 10 (22.2) 1  
Sex     
Men 57 13 (22.8) 1.31 (0.48-3.60) 0.50 (0.17-1.45)
Women 23 4 (17.4) 1 1
Mode of HIV transmission     
IDU 49 12 (24.5) 1.52 (0.59-3.89) 1.34 (0.64-2.83)
non-IDU 31 5 (16.1) 1 1
HCV infection     
anti-HCV+ 42 9 (21.4) 1.02 (0.44-2.37)  
anti-HCV- 38 8 (21.1) 1  
Tuberculosis     
History of TB 31 6 (19.4) 0.86 (0.36-2.09)  
No history of TB 49 11 (22.5) 1  
Viral load at failure on initial ART     
≥100,000 21 9 (42.9) 3.16 (1.40-7.12) 3.39 (1.46-7.89)
<100,000 59 8 (13.6) 1 1
ART regimen after switch     
ATV/r-based 20 4 (20.0) 0.92 (0.34-2.51)  
LPV/r-based 60 13 (21.7) 1  
6-month adherence after regimen switch     
<80% 19 10 (52.6) 5.01 (1.80-13.87) 5.09 (1.89-13.70)
80- < 100% 23 3 (13.0) 1.24 (0.30-5.05) 1.48 (0.36-6.12)
100% 38 4 (10.5) 1 1
Number of resistance mutations     
>2 mutations 21 3 (14.3) 0.60 (0.19-1.89)  
≤2 mutations 59 14 (23.7) 1  
Drug class resistance     
Single class (NRTI or NNRTI) 11 3 (27.3) 1.34 (0.46-3.93)  
Dual class (NRTI + NNRTI) 69 14 (20.3) 1