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Table 1 Characteristics of the patients assessed for hepatitis C treatment consideration according to clinic model

From: Increasing Hepatitis C treatment uptake among HIV-infected patients using an HIV primary care model

Clinic model Hepatology HIV primary care P value
  (n = 163) (n = 196)  
Median age - years (range) 45(26–73) 48(19–75) 0.02a
Sex: Male (%) 137(84) 165(84) 0.97b
Race    
White 115 138 0.20c
Black 39 50
Asian 0 3
Other/unknown 9 5
Ethnicity    
Hispanic 35 26 0.03c
Not-Hispanic 121 167
Unknown 7 3
HIV risk factors    
Gay/bisexual 79 78 0.003c
Heterosexual 24 46
Intravenous drug use 3 8
Hemophilia 8 5
combination 25 47
Other/unknown 24 12
Median CD4+ cell count - cells/mm3 (range)1 372 (29–1179) 431 (38–1612) 0.05a
Median HIV load - log10 copies/mL (range) 2.6 (2.6–5.8) 2.6 (2.6–6.6) 0.12a
Number on HAART therapy - % 132 (81) 172 (88) 0.08b
Hepatitis C genotype2    
Genotype 1,4 125 158 0.68c
Genotype 2,3 31 35
Median HCV load - log10 copies/mL (range)3 6.29 (1.9–8.4) 6.43 (2.2–8.4) 0.43a
Liver biopsy scores 4    
F0-2 39 42 0.95c
F3,4 37 39
Any neuropsychiatry history – % 100 (61%) 119 (61%) 0.85b
On any psychiatry medications - % 75 (46%) 88 (45%) 0.83b
Drugs or alcohol use within 3months of HCV treatment consideration    
No 71 115 0.0001c
yes 45 72
unknown 47 9
Median hemoglobin levels - g/dL (range) 14.7 (9–18.7) 14.3 (7.7–17.6) 0.13a
Median platelet count -1000/mm3 (range) 184 (44–531) 208 (41–548) 0.004a
Median ALT - U/L (range) 68 (20–980) 57 (12–1280) 0.51a
Median INR (range) 1.1 (0.9–2.3) 1.0 (0.9–2.6) 0.05a
  1. ALT = Alanine aminotransferase ; AST = Aspartate aminotransferase; INR = International normalized ratio.
  2. 1 CD4+ counts available in 150 of 163 patients in the hepatology model and in all patients in HIV primary care model.
  3. 2 HCV genotype was not available in seven patients in hepatology model and one in HIV primary care model.
  4. 3 Liver biopsies: 70 in hepatology and 67 in HIV primary care models.
  5. 4 Two patients in the hepatology model had no available HCV viral load.
  6. a Wilcoxon Rank-Sum Test.
  7. b Chi-square Test.
  8. c Fisher’s exact Test.