Increasing Hepatitis C treatment uptake among HIV-infected patients using an HIV primary care model

Table 1 Characteristics of the patients assessed for hepatitis C treatment consideration according to clinic model

Clinic model	Hepatology	HIV primary care	P value
	(n = 163)	(n = 196)
Median age - years (range)	45(26–73)	48(19–75)	0.02^a
Sex: Male (%)	137(84)	165(84)	0.97^b
Race
White	115	138	0.20^c
Black	39	50
Asian	0	3
Other/unknown	9	5
Ethnicity
Hispanic	35	26	0.03^c
Not-Hispanic	121	167
Unknown	7	3
HIV risk factors
Gay/bisexual	79	78	0.003^c
Heterosexual	24	46
Intravenous drug use	3	8
Hemophilia	8	5
combination	25	47
Other/unknown	24	12
Median CD4+ cell count - cells/mm³ (range)¹	372 (29–1179)	431 (38–1612)	0.05^a
Median HIV load - log₁₀ copies/mL (range)	2.6 (2.6–5.8)	2.6 (2.6–6.6)	0.12^a
Number on HAART therapy - %	132 (81)	172 (88)	0.08^b
Hepatitis C genotype²
Genotype 1,4	125	158	0.68^c
Genotype 2,3	31	35	0.68^c
Median HCV load - log₁₀ copies/mL (range)³	6.29 (1.9–8.4)	6.43 (2.2–8.4)	0.43^a
Liver biopsy scores ⁴
F0-2	39	42	0.95^c
F3,4	37	39	0.95^c
Any neuropsychiatry history – %	100 (61%)	119 (61%)	0.85^b
On any psychiatry medications - %	75 (46%)	88 (45%)	0.83^b
Drugs or alcohol use within 3months of HCV treatment consideration
No	71	115	0.0001^c
yes	45	72
unknown	47	9
Median hemoglobin levels - g/dL (range)	14.7 (9–18.7)	14.3 (7.7–17.6)	0.13^a
Median platelet count -1000/mm³ (range)	184 (44–531)	208 (41–548)	0.004^a
Median ALT - U/L (range)	68 (20–980)	57 (12–1280)	0.51^a
Median INR (range)	1.1 (0.9–2.3)	1.0 (0.9–2.6)	0.05^a

ALT = Alanine aminotransferase ; AST = Aspartate aminotransferase; INR = International normalized ratio.
¹ CD4+ counts available in 150 of 163 patients in the hepatology model and in all patients in HIV primary care model.
² HCV genotype was not available in seven patients in hepatology model and one in HIV primary care model.
³ Liver biopsies: 70 in hepatology and 67 in HIV primary care models.
⁴ Two patients in the hepatology model had no available HCV viral load.
^a Wilcoxon Rank-Sum Test.
^b Chi-square Test.
^c Fisher’s exact Test.

ISSN: 1742-6405