NGX-4010, a capsaicin 8% patch, for the treatment of painful HIV-associated distal sensory polyneuropathy: integrated analysis of two phase III, randomized, controlled trials
© Brown et al.; licensee BioMed Central Ltd. 2013
Received: 31 October 2012
Accepted: 17 January 2013
Published: 28 January 2013
HIV-associated distal sensory polyneuropathy (HIV-DSP) is the most frequently reported neurologic complication associated with HIV infection. NGX-4010 is a capsaicin 8% dermal patch with demonstrated efficacy in the treatment of HIV-DSP. Data from two phase III, double-blind studies were integrated to further analyze the efficacy and safety of NGX-4010 and explore the effect of demographic and baseline factors on NGX-4010 treatment in HIV-DSP.
Data from two similarly designed studies in which patients with HIV-DSP received NGX-4010 or a low-concentration control patch (capsaicin 0.04% w/w) for 30 or 60 minutes were integrated. Efficacy assessments included the mean percent change from baseline in Numeric Pain Rating Scale (NPRS) scores to Weeks 2–12. Safety and tolerability assessments included adverse events (AEs) and pain during and after treatment.
Patients (n = 239) treated with NGX-4010 for 30 minutes demonstrated significantly (p = 0.0026) greater pain relief compared with controls (n = 100); the mean percent change in NPRS scores from baseline to Weeks 2–12 was −27.0% versus − 15.7%, respectively. Patients who received a 60-minute application of NGX-4010 (n = 243) showed comparable pain reductions (−27.5%) to patients treated for 30 minutes, but this was not statistically superior to controls (n = 115). NGX-4010 was effective regardless of gender, baseline pain score, duration of HIV-DSP, or use of concomitant neuropathic pain medication, although NGX-4010 efficacy was greater in patients not receiving concomitant neuropathic pain medications. NGX-4010 was well tolerated; the most common AEs were application-site pain and erythema, and most AEs were mild to moderate. The transient increase in pain associated with NGX-4010 treatment decreased the day after treatment and returned to baseline by Day 2.
A single 30-minute application of NGX-4010 provides significant pain relief for at least 12 weeks in patients with HIV-DSP and is well tolerated.
C107 = NCT00064623; C119 = NCT00321672
KeywordsNGX-4010 Capsaicin 8% patch HIV-associated distal sensory polyneuropathy Neuropathic pain
HIV-associated distal sensory polyneuropathy (HIV-DSP) is the most frequently reported neurologic complication associated with HIV infection. It can be caused by the virus itself  or by the use of antiretroviral drugs; for example, some nucleoside reverse transcriptase inhibitors have been shown to have a dose-dependent toxic effect in 15–30% of patients . The clinical presentation of HIV-DSP is similar regardless of whether it is caused by HIV itself or is due to the toxicity of antiretroviral drugs.
HIV-DSP presents with predominantly symmetrical signs of distal sensory loss and reduction or loss of ankle reflexes. Symptomatic HIV-DSP reflects the involvement of both small and large sensory nerve fibers and includes distal painful dysesthesias, allodynia, severe burning pain, pins and needles, and numbness [1, 2]. These symptoms usually begin in the feet and may progress bilaterally up the legs and to the arms in severe HIV-DSP.
In a recent US study, 881 of 1,539 (57%) individuals infected with HIV showed evidence of HIV-sensory neuropathy, which encompasses HIV-DSP caused by the virus and toxic DSP due to dideoxynucleoside antiretroviral therapy . Of those with DSP, 38% reported neuropathic pain . Very few neuropathic pain treatments, however, have demonstrated efficacy in clinical trials for patients with HIV-associated neuropathy. For example, the tricyclic antidepressant amitriptyline , the anticonvulsant pregabalin , and topical treatments such as lidocaine  and low-dose (0.075%) capsaicin cream  have all failed to show significant pain relief when compared with controls. By contrast, three small, randomized, placebo-controlled studies showed that smoking cannabis reduced daily pain compared with smoking identical placebo cigarettes from which the cannabinoids had been removed [9–11]. Other neuropathic pain therapies such as duloxetine and venlafaxine have not been studied in patients with HIV-DSP  while the results of a single published study investigating opioid use among patients with HIV suggested those receiving opioids experienced more pain than those patients who did not receive opioids . Furthermore, many of these agents, which are not approved by the Food and Drug Administration or the European Medicines Agency, are associated with unwanted side effects and burdensome treatment regimens . Sedation and dizziness are common adverse events (AEs) associated with gabapentin and pregabalin, whereas nausea can be common with duloxetine . Gabapentin and pregabalin also require slow dose titration, as does amitriptyline . In addition, cumbersome regimens must be followed for treatment with lidocaine patches and low-dose capsaicin creams; the lidocaine patch is licensed to be worn for 12 hours followed by a 12-hour treatment break , and capsaicin cream requires application several times a day . A recent systematic review of randomized controlled studies concluded that evidence of efficacy exists only for capsaicin 8%, smoked cannabis, and recombinant-human nerve growth factor (rhNGF) . However, rhNGF did not demonstrate evidence for the expected nerve fiber regeneration  and was not developed further for clinical use.
NGX-4010 is a capsaicin 8% (w/w) dermal patch licensed in 2009 in the EU for the treatment of peripheral neuropathic pain in non-diabetic adults either alone or in combination with other medicinal products for pain; and indicated in the US for the management of neuropathic pain associated with post-herpetic neuralgia. NGX-4010 was developed to rapidly deliver a high dose of capsaicin directly to the source of pain with a single application. Capsaicin is a highly selective agonist for the Transient Receptor Potential Vanilloid 1 (TRPV1) receptor, which is a ligand-gated non-selective cation channel that is highly expressed in nociceptors and is critical for pain transmission and modulation . As a component of small nerve fibers, C fibers are involved in HIV-DSP  and, as TRPV1 expression is altered on C fibers following nerve injury , these fibers may play a role in the neuropathic pain experienced by individuals with HIV-DSP. TRPV1 is therefore a logical target for treating neuropathic pain. Exposure of TRPV1 receptors to high concentrations of capsaicin initially causes depolarization, action potential initiation, and burning pain [19, 20]. This is followed by a defunctionalization and reduction in the density of epidermal nerve fibers, resulting in inhibition of pain transmission [19–21]. The effect is reversible, with regrowth of epidermal nerve fibers evident 12 weeks after exposure to capsaicin .
Summary of randomized, double-blind, controlled trials of NGX-4010 in patients with HIV-DSP
Number of patients
Mean percent change in NPRS “average pain for past 24 hours” during Weeks 2–12 post application compared with baseline (%)
Single 30-, 60-, or 90-minute application of NGX-4010 patch versus low-concentration (0.04%) capsaicin control patch
(p = 0.0007†versus control)
(p = 0.291†versus control)
(p = 0.0046†versus control)
(p = 0.0026†versus control)
Single 30- or 60-minute application of NGX-4010 patch versus low-concentration (0.04%) capsaicin control patch
(p = 0.1031‡versus control)
(p = 0.4884‡versus control)
(p = 0.0967‡versus control)
To analyze in more detail the efficacy and safety of NGX-4010 in patients with HIV-DSP, an integrated analysis of the 30- and 60-minute NGX-4010 applications from the two double-blind, controlled HIV-DSP studies was performed. This integrated analysis also investigated the effects of demographic factors, disease duration and severity, and the use of concomitant neuropathic pain medication, which are often difficult to evaluate in individual studies due to the limited sample size.
Demographic and baseline characteristics from the integrated population of the two phase III HIV-DSP studies
(n = 482)
(n = 239)
(n = 243)
(n = 215)
(n = 100)
(n = 115)
Age, mean (SD), years
Male, n (%)
White, n (%)
Duration of pain, mean (SD), years
Baseline NPRS score, mean (SD)
Receiving concomitant neuropathic pain medication at study entry,* n (%)
Receiving Ntox antiretroviral therapy at baseline,† n (%)
CD4 count, mean x106/l (SD)
Viral load, HIV RNA copies/ml, median
The percentage of patients terminating the studies before the end of the 12-week double-blind period was 8% for the combined NGX-4010 group and 8% for the combined control group (Figure 1). Reasons for premature termination were AEs, being lost to follow-up, death, non-compliance, unsatisfactory therapeutic response, and other. Five patients (three in the 60-minute NGX-4010 group, one in the 60-minute control group, and one in the 30-minute control group) withdrew from the study due to AEs. In only two of these patients were the AEs judged to be related to study medication and both consisted of application-site pain. Both patients were in the 60-minute NGX-4010 group. Three patients died during the 12-week observation period; two deaths in the 60-minute NGX-4010 group were due to sepsis and pre-existing arteriosclerosis and one death in the 60-minute control group was due to a presumed drug overdose. No deaths were considered to be related to study drug treatment.
Integrated efficacy data for the 30- and 60-minute treatment groups
(n = 482)
(n = 239)
(n = 243)
(n = 215)
(n = 100)
(n = 115)
LS mean change (SE) in NPRS score from baseline to Weeks 2–12
95% CI of LS mean
Patients with ≥30% reduction in NPRS score from baseline to Weeks 2–12, n (%)
95% CI of OR
PGIC at Week 12
n = 438
n = 220
n = 218
n = 196
n = 92
n = 104
Very much/much/slightly improved, n (%)
Similarly, a comparable percentage of patients in the 30- and 60-minute groups (40% for each) responded to NGX-4010 treatment (≥30% decrease in NPRS score from baseline to Weeks 2–12), but only the 30-minute NGX-4010 treatment resulted in a significantly greater percentage of responders compared with controls (Table 3). Patients treated with NGX-4010 for 30 minutes had a 2.2-fold higher likelihood of being a responder compared with patients treated with control for 30 minutes. The reduction in pain in response to NGX-4010 treatment was confirmed by the results of the Patient Global Impression of Change (PGIC). A comparable percentage of patients in the 30- and 60-minute groups (65% and 69%, respectively) felt slightly, much, or very much improved, and this was significantly different from control in both treatment groups (Table 3).
The most common treatment-related AEs*
System organ class preferred term, n(%)
(n = 482)
(n = 239)
(n = 243)
(n = 215)
(n = 99)
(n = 116)
Number of patients reporting ≥1 treatment-related AE
General disorders and administration-site conditions
In the 30-minute treatment groups, 10 (4%) NGX-4010-treated patients and three (3%) control patients reported one or more serious adverse event (SAE). In the 60-minute treatment groups, 19 (8%) NGX-4010-treated patients and eight (7%) control patients reported one or more SAEs. None of the reported SAEs was considered to be related to the study drug.
No clinically important mean changes in hematology, serum chemistry, or vital signs were observed in the NGX-4010 or control groups except for small transient elevations in mean systolic and diastolic blood pressure (<4 mmHg) during and shortly after NGX-4010 application.
Summary of tolerability on the treatment day
(n = 482)
(n = 239)
(n = 243)
(n = 215)
(n = 99)
(n = 116)
Change in NPRS score from pre-topical anesthetic time point at the last observation*
Patients with at least 90% of the intended patch application duration, n (%)
Patients using medication for treatment-related discomfort on Days 0–5, n (%)
Maximum dermal irritation‖ score on Day 0, n (%)
As expected, on the day of treatment there were significant differences in the distribution of maximum dermal assessment scores between the total NGX-4010 and control groups (p < 0.0001). A total of 60% of NGX-4010-treated patients and 44% of control patients had a maximum dermal assessment score of >0. Dermal irritation was commonly mild in the NGX-4010-treatment groups, with dermal assessment scores ≥2 (definite erythema, readily visible, minimal edema, or minimal papular response) being reported in only a few patients (2% and 5%, for the 30- and 60-minute NGX-4010 groups, respectively).
The similarity of the demographic and baseline characteristics of the patients from the two multicenter, randomized, double-blind, controlled phase III studies (Table 2), together with comparable study designs, enrollment, and assessment criteria allowed data from the two studies to be combined. The integrated analyses from the two phase III studies demonstrated that a single 30-minute application of NGX-4010 provides significant pain relief — as demonstrated by a decrease in NPRS score — for patients with HIV-DSP for at least 12 weeks. This decrease in the NPRS score of patients receiving a 30-minute NGX-4010 application was supported by the analysis of patient-reported outcomes using the PGIC. The PGIC provides a global assessment of patient improvement that is independent of NPRS score collection. This measurement is recommended in chronic pain studies by the Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials  and is more sensitive to treatment effects in neuropathic pain than pain intensity measurements . Using the PGIC, 12 weeks after a single application of NGX-4010, 65% of patients felt slightly, much, or very much improved compared with 41% of control patients.
The reduction in NPRS score following the 60-minute application of NGX-4010 was not significantly different from control. This is likely due to the large effects of the control patch observed in study C119 . Interestingly, there was a significant improvement using the PGIC in the 60-minute treatment compared with the control group.
The data presented here show no evidence of increased efficacy with increased NGX-4010 treatment duration and support the selection of the 30-minute dose for treatment of peripheral neuropathic pain in patients with HIV-associated neuropathy. By contrast, for patients with post-herpetic neuralgia who typically experience neuropathic pain on the torso as opposed to the extremities, treatment duration is 60 minutes [27, 28].
A transient increase in pain compared with baseline was seen on Day 0 in patients receiving NGX-4010, due to the treatment procedure. However, treatment-related pain was short-lived, with NPRS scores for patients treated with NGX-4010 for 30 minutes returning to baseline by Day 2. Thereafter, NPRS scores in patients receiving a 30-minute NGX-4010 application continued to decline and NGX-4010-treated patients achieved a greater pain reduction than those in the control group by Day 5 and on each subsequent day through Day 84. Weekly NPRS scores demonstrated significantly greater reductions in pain for NGX-4010-treated patients compared with controls each week from Week 2 to study completion (Week 12).
Subgroup analyses showed greater pain reduction in patients treated with NGX-4010 compared with those treated with control in all subgroups regardless of gender, baseline pain score, concomitant neuropathic pain medication, and HIV-DSP duration. However, NGX-4010 was more effective in patients not using concomitant neuropathic pain medications compared with those using concomitant neuropathic pain medications. This result is not unexpected as it has been shown previously that the additional reduction of neuropathic pain obtained with an add-on drug is generally not as large as the benefit obtained with monotherapy [29, 30]. This may be because some of the pathophysiologic mechanisms implicated in the generation and maintenance of neuropathic pain overlap or converge to a common pathway, resulting in a less than additive effect even for medications that act via different mechanistic pathways. Furthermore, patients already taking several concomitant neuropathic pain medications may be more treatment resistant or more difficult to treat. It is therefore important to note that a significant treatment effect was seen with NGX-4010 compared with control, despite two-thirds of the patients using concomitant neuropathic pain medication at study entry and during the study (Table 2). Gender, baseline pain score, and the duration of HIV-DSP did not influence NGX-4010 efficacy, indicating that pain relief can be achieved with NGX-4010 treatment even in those patients with high pain levels or long disease duration.
Although NGX-4010 application does cause some treatment-related pain, it is generally mild or moderate and transient. The vast majority of patients were able to tolerate >90% of the intended NGX-4010 application. Most common treatment-related AEs were application-site reactions; systemic effects were limited to small, transient elevations in mean systolic and diastolic blood pressure shortly after NGX-4010 application due to treatment-associated increases in pain.
With the current lack of effective treatment for pain associated with HIV-DSP, a therapy such as NGX-4010, which can deliver rapid and prolonged pain relief for at least 3 months after a single 30-minute application, may be of great benefit to patients with HIV-DSP. In addition to its efficacy, there are few systemic AEs associated with NGX-4010 , unlike other available therapies, and repeated applications of NGX-4010 do not result in an increased incidence of application-site AEs, dermal irritation, intolerability, or impaired neurologic function . Efficacy has been demonstrated when NGX-4010 is used alone as well as in combination with other systemic medications for neuropathic pain. Treatment with NGX-4010 neither increases the pill burden nor the potential for systemic drug–drug interactions, two important considerations for patients with HIV-DSP, who may already be taking several medications. Data from these two phase III clinical trials have led to the approval of NGX-4010 for the treatment of HIV-DSP in the EU and have resulted in NGX-4010 being given a level A efficacy rating in the European Federation of Neurological Sciences guidelines for HIV neuropathy .
Details of each of the studies included in this analysis have been reported previously [22, 23]. Both studies were approved by institutional review boards/independent ethics committees and conducted in accordance with the ethical principles of the Declaration of Helsinki, Good Clinical Practice guidelines, and applicable regulatory requirements.
Both studies recruited patients who were ≥18 years of age with a diagnosis of HIV-DSP for ≥2 months and an average baseline NPRS score  of 3–9. Patients taking other pain medications such as anticonvulsants, non-selective serotonin reuptake inhibitor (non-SSRI) antidepressants (e.g., tricyclic antidepressants, serotonin–norepinephrine reuptake inhibitors), opioids, non-steroidal anti-inflammatory drugs, salicylates, or acetaminophen had to be on stable doses for ≥21 days before patch application and remain on stable doses throughout the study period. Exclusion criteria in both studies included the prior use of NGX-4010 and use of a topical medication on the painful area within 21 days before the NGX-4010 application day.
Patients were randomly assigned to receive treatment with an NGX-4010 (QUTENZA™/Qutenza®) patch (capsaicin 640 μg/cm2, 8% w/w; NeurogesX, Inc., San Mateo, CA, USA) or a low-concentration control patch (capsaicin 3.2 μg/cm2, 0.04% w/w). The control patch produced local erythema and a burning sensation to provide effective blinding in the studies.
Patients were pre-treated with a topical local anesthetic cream (L.M.X.4 lidocaine 4%; Ferndale Laboratories, Inc., Ferndale, MI, USA) for 60 minutes before patch application. Both the NGX-4010 and control patches were applied for 30, 60, or 90 minutes in study C107  and for 30 or 60 minutes in study C119 . After patch removal, the treatment area was cleansed with a proprietary cleansing gel (NeurogesX, Inc.) formulated to remove residual capsaicin. A rapid-onset, opioid-based oral pain medication (e.g., oxycodone hydrochloride oral solution, 1 mg/ml) could be administered at the onset of treatment-associated discomfort and as needed while in the clinic. Following patch removal, local cooling could be used. Patients could also take a short-term regimen of an opioid-based oral pain medication (e.g., hydrocodone bitartrate/acetaminophen 5 mg/500 mg) for treatment-related discomfort for up to 5 or 7 days post treatment, depending on the study.
The studies included either a ≥5 day  or ≥14 day  baseline screening period. Assessments were also carried out on the day of treatment (Day 0), at the termination visit (Week 12), and, depending on the study, at interim visits at Weeks 1 and 4 or 4 and 8 during the 12-week blinded observation period. The primary efficacy endpoint was the mean percent change from baseline in NPRS scores for “average pain for the past 24 hours” from Weeks 2–12. Patients recorded their “average pain for the past 24 hours” every evening at 9:00 pm in paper pain diaries from the baseline screening period until the evening before the termination visit.
Other efficacy measurements included the percentage of patients with ≥30% mean decrease in NPRS score from baseline during Weeks 2–12 and the percentage of those feeling improved according to the PGIC at Week 12. In this assessment patients reported how they felt after treatment compared with before treatment on a 7-point scale with −3 indicating “very much worse” to +3 indicating “very much improved” and 0 indicating “no change”.
Safety and tolerability assessments included AEs, vital signs, clinical laboratory tests, physical examination, dermal assessment (0- to 7-point severity score) , “pain now” NPRS scores during and after patch application, early patch removal, and use of medication for treatment-related discomfort during Days 0 to 5.
Data from patients receiving NGX-4010 and control patches for 30 or 60 minutes were integrated from both phase III HIV-DSP studies. The 90-minute NGX-4010 dose was not included in these analyses as it was not evaluated in study C119 . Intent-to-treat efficacy analyses consisted of all patients who received any study treatment and had at least 3 days of available NPRS scores during the baseline period. The primary efficacy endpoint was the percent change in NPRS scores from baseline during Weeks 2–12. Changes in NPRS scores from baseline to Weeks 2–12 were compared between treatment groups using a pre-specified gender-stratified ANCOVA model with baseline pain score, pre-topical anesthetic pain score, and percent change in pain score after topical anesthetic treatment as covariates. To avoid the potentially confounding effect of opioid medications allowed during Days 0–5, Week 1 NPRS scores were not included in the primary endpoint analysis. In addition, least square means of the difference between treatment groups and the 95% confidence interval (CI) were calculated.
Missing post-treatment NPRS scores were imputed using a modified last observation carried forward approach. If the NPRS score was missing on post-treatment Days 0–8 or on Day 8 and one or more consecutive days, then the baseline score was imputed for those days. If the NPRS score was missing for any day after Day 8, then the missing score was imputed by the last available non-imputed score recorded before that day. If all post-treatment NPRS scores were missing (including Day 0), all scores were imputed using the baseline score. NPRS baseline scores were calculated using all available screening scores that were not biased by pain medication changes  or using all available screening scores between Day −14 and Day −1 . For the weekly and the daily NPRS scores, missing scores were not imputed.
The percentage of responders (classified as those achieving ≥30% reduction in NPRS score from baseline) was compared between groups using logistic regression analyses, with baseline pain score, gender, pre-topical anesthetic pain score, and percent change in pain score after topical anesthetic treatment as covariates. In addition, odds ratios and the 95% CI of observing responses in the NGX-4010 group compared with the control group were estimated. The percentage of patients reporting improvements according to the PGIC was compared between treatment groups using Fisher’s exact test. For both the primary endpoint and responder analysis, the treatment effect was assessed by gender, baseline pain score (median NPRS score of < and ≥6.07), HIV-DSP duration (median of < and ≥5.2 years), and concomitant neuropathic pain medication use at study entry (defined as receiving an anticonvulsant, non-SSRI antidepressant or opioid on Day −1 and for at least 7 consecutive days) in patients treated for 30 minutes.
Safety and tolerability analyses
AEs were coded using the Medical Dictionary for Regulatory Activities version 9.0. Medication use for treatment-related discomfort (from Days 0–5) and the percentage of patients completing the intended patch duration were compared using Fisher’s exact test. The percentages of patients reporting each level of dermal response were compared using the Cochran–Mantel–Haenszel test. The maximum changes in “pain now” NPRS score from the pre-topical anesthetic time point during and after patch application were summarized and compared using the Wilcoxon rank sum test.
Patients were analyzed as randomized for the efficacy analyses and as treated for the safety analyses.
Analysis of covariance
Numerical Pain Rating Scale
Patient Global Impression of Change
Recombinant-human nerve growth factor
Transient Receptor Potential Vanilloid 1.
Funding for these studies was provided by NeurogesX, Inc. Editorial assistance was provided by Adelphi Communications, supported by Astellas Pharma Europe Ltd.
- Ferrari S, Vento S, Monaco S, Cavallaro T, Cainelli F, Rizzuto N, Temesgen Z: Human immunodeficiency virus-associated peripheral neuropathies. Mayo Clin Proc. 2006, 81: 213-219. 10.4065/81.2.213View ArticlePubMedGoogle Scholar
- Gonzalez-Duarte A, Robinson-Papp J, Simpson DM: Diagnosis and management of HIV-associated neuropathy. Neurol Clin. 2008, 26: 821-832. 10.1016/j.ncl.2008.04.001View ArticlePubMedGoogle Scholar
- McArthur JC, Brew BJ, Nath A: Neurological complications of HIV infection. Lancet Neurol. 2005, 4: 543-555. 10.1016/S1474-4422(05)70165-4View ArticlePubMedGoogle Scholar
- Ellis RJ, Rosario D, Clifford DB, McArthur JC, Simpson D, Alexander T, Gelman BB, Vaida F, Collier A, Marra CM, Ances B, Atkinson JH, Dworkin RH, Morgello S, Grant I: Continued high prevalence and adverse clinical impact of human immunodeficiency virus-associated sensory neuropathy in the era of combination antiretroviral therapy: the CHARTER study. Arch Neurol. 2010, 67: 552-558. 10.1001/archneurol.2010.76PubMed CentralView ArticlePubMedGoogle Scholar
- Kieburtz K, Simpson D, Yiannoutsos C, Max MB, Hall CD, Ellis RJ, Marra CM, McKendall R, Singer E, Dal Pan GJ, Clifford DB, Tucker T, Cohen B: A randomized trial of amitriptyline and mexiletine for painful neuropathy in HIV infection. AIDS clinical trial group 242 protocol team. Neurology. 1998, 51: 1682-1688. 10.1212/WNL.51.6.1682View ArticlePubMedGoogle Scholar
- Simpson DM, Schifitto G, Clifford DB, Murphy TK, Durso-De Cruz E, Glue P, Whalen E, Emir B, Scott GN, Freeman R: Pregabalin for painful HIV neuropathy: a randomized, double-blind, placebo-controlled trial. Neurology. 2010, 74: 413-420. 10.1212/WNL.0b013e3181ccc6efPubMed CentralView ArticlePubMedGoogle Scholar
- Estanislao L, Carter K, McArthur J, Olney R, Simpson D: A randomized controlled trial of 5% lidocaine gel for HIV-associated distal symmetric polyneuropathy. J Acquir Immune Defic Syndr. 2004, 37: 1584-1586. 10.1097/00126334-200412150-00010View ArticlePubMedGoogle Scholar
- Paice JA, Ferrans CE, Lashley FR, Shott S, Vizgirda V, Pitrak D: Topical capsaicin in the management of HIV-associated peripheral neuropathy. J Pain Symptom Manage. 2000, 19: 45-52. 10.1016/S0885-3924(99)00139-6View ArticlePubMedGoogle Scholar
- Abrams DI, Jay CA, Shade SB, Vizoso H, Reda H, Press S, Kelly ME, Rowbotham MC, Petersen KL: Cannabis in painful HIV-associated sensory neuropathy: a randomized placebo-controlled trial. Neurology. 2007, 68: 515-521. 10.1212/01.wnl.0000253187.66183.9cView ArticlePubMedGoogle Scholar
- Ellis RJ, Toperoff W, Vaida F, van den BG, Gonzales J, Gouaux B, Bentley H, Atkinson JH: Smoked medicinal cannabis for neuropathic pain in HIV: a randomized, crossover clinical trial. Neuropsychopharmacology. 2009, 34: 672-680. 10.1038/npp.2008.120PubMed CentralView ArticlePubMedGoogle Scholar
- Ware MA, Wang T, Shapiro S, Robinson A, Ducruet T, Huynh T, Gamsa A, Bennett GJ, Collet JP: Smoked cannabis for chronic neuropathic pain: a randomized controlled trial. CMAJ. 2010, 182: E694-E701. 10.1503/cmaj.091414PubMed CentralView ArticlePubMedGoogle Scholar
- O'Connor AB, Dworkin RH: Treatment of neuropathic pain: an overview of recent guidelines. Am J Med. 2009, 122 (10 Suppl): S22-S32.View ArticlePubMedGoogle Scholar
- Koeppe J, Armon C, Lyda K, Nielsen C, Johnson S: Ongoing pain despite aggressive opioid pain management among persons with HIV. Clin J Pain. 2010, 26: 190-198. 10.1097/AJP.0b013e3181b91624View ArticlePubMedGoogle Scholar
- Phillips TJ, Cherry CL, Cox S, Marshall SJ, Rice AS: Pharmacological treatment of painful HIV-associated sensory neuropathy: a systematic review and meta-analysis of randomised controlled trials. PLoS One. 2010, 5: e14433- 10.1371/journal.pone.0014433PubMed CentralView ArticlePubMedGoogle Scholar
- Schifitto G, Yiannoutsos C, Simpson DM, Adornato BT, Singer EJ, Hollander H, Marra CM, Rubin M, Cohen BA, Tucker T, Koralnik IJ, Katzenstein D, Haidich B, Smith ME, Shriver S, Millar L, Clifford DB, McArthur JC: Long-term treatment with recombinant nerve growth factor for HIV-associated sensory neuropathy. Neurology. 2001, 57: 1313-1316. 10.1212/WNL.57.7.1313View ArticlePubMedGoogle Scholar
- Caterina MJ, Julius D: The vanilloid receptor: a molecular gateway to the pain pathway. Annu Rev Neurosci. 2001, 24: 487-517. 10.1146/annurev.neuro.24.1.487View ArticlePubMedGoogle Scholar
- Polydefkis M, Yiannoutsos CT, Cohen BA, Hollander H, Schifitto G, Clifford DB, Simpson DM, Katzenstein D, Shriver S, Hauer P, Brown A, Haidich AB, Moo L, McArthur JC: Reduced intraepidermal nerve fiber density in HIV-associated sensory neuropathy. Neurology. 2002, 58: 115-119. 10.1212/WNL.58.1.115View ArticlePubMedGoogle Scholar
- Ma W, Zhang Y, Bantel C, Eisenach JC: Medium and large injured dorsal root ganglion cells increase TRPV-1, accompanied by increased alpha2C-adrenoceptor co-expression and functional inhibition by clonidine. Pain. 2005, 113: 386-394. 10.1016/j.pain.2004.11.018View ArticlePubMedGoogle Scholar
- Bley KR: TRPV1 agonist approaches for pain management. Vanilloid Receptor TRPV1 in Drug Discovery. Edited by: Gomtsyan A, Faltynek CR. 2010, 325-347. Hoboken, NJ, USA: John Wiley & Sons, IncView ArticleGoogle Scholar
- Szallasi A, Blumberg PM: Vanilloid (capsaicin) receptors and mechanisms. Pharmacol Rev. 1999, 51: 159-212.PubMedGoogle Scholar
- Kennedy WR, Vanhove GF, Lu SP, Tobias J, Bley KR, Walk D, Wendelschafer-Crabb G, Simone DA, Selim MM: A randomized, controlled, open-label study of the long-term effects of NGX-4010, a high-concentration capsaicin patch, on epidermal nerve fiber density and sensory function in healthy volunteers. J Pain. 2010, 11: 579-587. 10.1016/j.jpain.2009.09.019View ArticlePubMedGoogle Scholar
- Simpson DM, Brown S, Tobias J: Controlled trial of high-concentration capsaicin patch for treatment of painful HIV neuropathy. Neurology. 2008, 70: 2305-2313. 10.1212/01.wnl.0000314647.35825.9cView ArticlePubMedGoogle Scholar
- Clifford DB, Simpson DM, Brown S, Moyle G, Brew BJ, Conway B, Tobias JK, Vanhove GF: A randomized, double-blind, controlled study of NGX-4010, a capsaicin 8% dermal patch, for the treatment of painful HIV-associated distal sensory polyneuropathy. J Acquir Immune Defic Syndr. 2012, 59: 126-133. 10.1097/QAI.0b013e31823e31f7View ArticlePubMedGoogle Scholar
- US Food and Drug Administration Center for Drug Evaluation and Research : Guidance for industry: Skin irritation and sensitization testing of generic transdermal drug products. 1999,http://www.fda.gov/ohrms/dockets/98fr/990236Gd.pdf#search=%22HillTop%20Research%2C%20Inc.%20dermal%20irritation%22, Washington, DC, USA: US Department of Health and Human Services, Google Scholar
- Dworkin RH, Turk DC, Farrar JT, Haythornthwaite JA, Jensen MP, Katz NP, Kerns RD, Stucki G, Allen RR, Bellamy N, Carr DB, Chandler J, Cowan P, Dionne R, Galer BS, Hertz S, Jadad AR, Kramer LD, Manning DC, Martin S, McCormick CG, McDermott MP, McGrath P, Quessy S, Rappaport BA, Robbins W, Robinson JP, Rothman M, Royal MA, Simon L, Stauffer JW, Stein W, Tollett J, Wernicke J, Witter J: Core outcome measures for chronic pain clinical trials: IMMPACT recommendations. Pain. 2005, 113: 9-19. 10.1016/j.pain.2004.09.012View ArticlePubMedGoogle Scholar
- Haanpää M, Attal N, Backonja M, Baron R, Bennett M, Bouhassira D, Cruccu G, Hansson P, Haythornthwaite JA, Iannetti GD, Jensen TS, Kauppila T, Nurmikko TJ, Rice AS, Rowbotham M, Serra J, Sommer C, Smith BH, Treede RD: NeuPSIG guidelines on neuropathic pain assessment. Pain. 2011, 152: 14-27. 10.1016/j.pain.2010.07.031View ArticlePubMedGoogle Scholar
- Backonja M, Wallace MS, Blonsky ER, Cutler BJ, Malan P, Rauck R, Tobias J: NGX-4010, a high-concentration capsaicin patch, for the treatment of postherpetic neuralgia: a randomised, double-blind study. Lancet Neurol. 2008, 7: 1106-1112. 10.1016/S1474-4422(08)70228-XView ArticlePubMedGoogle Scholar
- Webster LR, Malan TP, Tuchman MM, Mollen MD, Tobias JK, Vanhove GF: A multicenter, randomized, double-blind, controlled dose finding study of NGX-4010, a high-concentration capsaicin patch, for the treatment of postherpetic neuralgia. J Pain. 2010, 11: 972-982.View ArticlePubMedGoogle Scholar
- Gilron I, Bailey JM, Tu D, Holden RR, Weaver DF, Houlden RL: Morphine, gabapentin, or their combination for neuropathic pain. N Engl J Med. 2005, 352: 1324-1334. 10.1056/NEJMoa042580View ArticlePubMedGoogle Scholar
- Gilron I, Bailey JM, Tu D, Holden RR, Jackson AC, Houlden RL: Nortriptyline and gabapentin, alone and in combination for neuropathic pain: a double-blind, randomised controlled crossover trial. Lancet. 2009, 374: 1252-1261. 10.1016/S0140-6736(09)61081-3View ArticlePubMedGoogle Scholar
- Vanhove GF, Wallace M, Irving G, Backonja M, Webster LR, Tobias JK: Integrated safety analyses of NGX-4010, an 8% capsaicin patch, in patients with peripheral neuropathic pain. 13th World Congress on Pain; August 29-September 2, 2010. 2010, Abstract [PH 101], Montréal, Québec, CanadaGoogle Scholar
- Simpson DM, Gazda S, Brown S, Webster LR, Lu SP, Tobias JK, Vanhove GF: Long-term safety of NGX-4010, a high-concentration capsaicin patch, in patients with peripheral neuropathic pain. J Pain Symptom Manage. 2010, 39: 1053-1064. 10.1016/j.jpainsymman.2009.11.316View ArticlePubMedGoogle Scholar
- Attal N, Cruccu G, Baron R, Haanpaa M, Hansson P, Jensen TS, Nurmikko T: EFNS guidelines on the pharmacological treatment of neuropathic pain: 2010 revision. Eur J Neurol. 2010, 17: 1113-1188. 10.1111/j.1468-1331.2010.02999.xView ArticlePubMedGoogle Scholar
- Farrar JT, Young JP, LaMoreaux L, Werth JL, Poole RM: Clinical importance of changes in chronic pain intensity measured on an 11-point numerical pain rating scale. Pain. 2001, 94: 149-158. 10.1016/S0304-3959(01)00349-9View ArticlePubMedGoogle Scholar
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