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  1. Research

    Late presentation increases risk and costs of non-infectious comorbidities in people with HIV: an Italian cost impact study

    Late presentation (LP) at the time of HIV diagnosis is defined as presentation with AIDS whatever the CD4 cell count or with CD4 <350 cells/mm. The objective of our study was to assess the prevalence of non-in...

    Giovanni Guaraldi, Stefano Zona, Marianna Menozzi, Thomas D. Brothers, Federica Carli, Chiara Stentarelli, Giovanni Dolci, Antonella Santoro, Ana Rita Domingues Da Silva, Elisa Rossi, Julian Falutz and Cristina Mussini

    AIDS Research and Therapy 2017 14:8

    Published on: 16 February 2017

  2. Short report

    H1N1 influenza vaccination in HIV-infected women on effective antiretroviral treatment did not induce measurable antigen-driven proliferation of the HIV-1 proviral reservoir

    Antigen-induced activation and proliferation of HIV-1-infected cells is hypothesized to be a mechanism of HIV persistence during antiretroviral therapy. The objective of this study was to determine if prolifer...

    Thor A. Wagner, Hannah C. Huang, Christen E. Salyer, Kelly M. Richardson, Adriana Weinberg, Sharon Nachman and Lisa M. Frenkel

    AIDS Research and Therapy 2017 14:7

    Published on: 13 February 2017

  3. Research

    Renal safety of lithium in HIV-infected patients established on tenofovir disoproxil fumarate containing antiretroviral therapy: analysis from a randomized placebo-controlled trial

    The prevalence of bipolar disorder in HIV-infected patients is higher than the general population. Lithium is the most effective mood stabiliser, while tenofovir disoproxil fumarate (TDF) is frequently used as...

    Eric H. Decloedt, Maia Lesosky, Gary Maartens and John A. Joska

    AIDS Research and Therapy 2017 14:6

    Published on: 4 February 2017

  4. Review

    Feasibility of antiretroviral treatment monitoring in the era of decentralized HIV care: a systematic review

    Regular monitoring of HIV patients who are receiving antiretroviral therapy (ART) is required to ensure patient benefits and the long-term effectiveness and sustainability of ART programs. Prompted by WHO reco...

    Minh D. Pham, Lorena Romero, Bruce Parnell, David A. Anderson, Suzanne M. Crowe and Stanley Luchters

    AIDS Research and Therapy 2017 14:3

    Published on: 19 January 2017

  5. Research

    Does antiretroviral treatment change HIV-1 codon usage patterns in its genes: a preliminary bioinformatics study

    Codon usage bias has been described for various organisms and is thought to contribute to the regulation of numerous biological processes including viral infections. HIV-1 codon usage has been previously shown...

    Navaneethan Palanisamy, Nathan Osman, Frédéric Ohnona, Hong-Tao Xu, Bluma Brenner, Thibault Mesplède and Mark A. Wainberg

    AIDS Research and Therapy 2017 14:2

    Published on: 7 January 2017

  6. Research

    Early virological failure and HIV drug resistance in Ugandan adults co-infected with tuberculosis

    This cross-sectional study took place in the integrated tuberculosis (TB) clinic of a large outpatient clinic for HIV-infected patients in Kampala, Uganda. The purpose of this study was to describe the proport...

    Amrei von Braun, Christine Sekaggya-Wiltshire, Alexandra U. Scherrer, Brian Magambo, Andrew Kambugu, Jan Fehr and Barbara Castelnuovo

    AIDS Research and Therapy 2017 14:1

    Published on: 5 January 2017

  7. Review

    Integrated therapy for HIV and cryptococcosis

    Cryptococcosis has been one of the most common opportunistic infections and causes of mortality among HIV-infected patients, especially in resource-limited countries. Cryptococcal meningitis is the most common...

    Sirawat Srichatrapimuk and Somnuek Sungkanuparph

    AIDS Research and Therapy 2016 13:42

    Published on: 29 November 2016

  8. Research

    Infection of rhesus macaques with a pool of simian immunodeficiency virus with the envelope genes from acute HIV-1 infections

    New simian–human immunodeficiency chimeric viruses with an HIV-1 env (SHIVenv) are critical for studies on HIV pathogenesis, vaccine development, and microbicide testing. Macaques are typically exposed to sing...

    Kendall C. Krebs, Meijuan Tian, Mohammed Asmal, Binhua Ling, Kenneth Nelson, Kenneth Henry, Richard Gibson, Yuejin Li, Weining Han, Robin J. Shattock, Ronald S. Veazey, Norman Letvin, Eric J. Arts and Yong Gao

    AIDS Research and Therapy 2016 13:41

    Published on: 25 November 2016

  9. Research

    Cases of antiretroviral-associated gynaecomastia reported to the National HIV & Tuberculosis Health Care Worker Hotline in South Africa

    Gynaecomastia is associated with exposure to antiretroviral therapy (ART), in particular efavirenz. There is limited data on clinical characteristics of patients with ART-associated gynaecomastia in resource-l...

    Christine Njuguna, Annoesjka Swart, Marc Blockman, Gary Maartens, Briony Chisholm, Annemie Stewart, Anri Uys and Karen Cohen

    AIDS Research and Therapy 2016 13:40

    Published on: 16 November 2016

  10. Research

    HIV sero-discordance among married HIV patients initiating anti-retroviral therapy in northern Vietnam

    In many countries in Asia, the HIV epidemic is in a concentrated phase, with high prevalence in certain risk groups, such as men who inject drugs. There is also a rapid increase of HIV among women. The latter ...

    Vu Van Tam, Do Duy Cuong, Tobias Alfven, Ho Dang Phuc, Nguyen Thi Kim Chuc, Nguyen Phuong Hoa, Vinod Diwan and Mattias Larsson

    AIDS Research and Therapy 2016 13:39

    Published on: 15 November 2016

  11. Research

    Trends in clinical characteristics and outcomes of Pre-ART care at a large HIV clinic in Nairobi, Kenya: a retrospective cohort study

    The success of antiretroviral therapy in resource-scarce settings is an illustration that complex healthcare interventions can be successfully delivered even in fragile health systems. Documenting the success ...

    Jared O. Mecha, Elizabeth N. Kubo, Lucy W. Nganga, Peter N. Muiruri, Lilian N. Njagi, Immaculate N. Mutisya, Justine J. Odionyi, Syokau C. Ilovi, Mary Wambui, Christopher Githu, Richard Ngethe, Elizabeth M. Obimbo and Zipporah W. Ngumi

    AIDS Research and Therapy 2016 13:38

    Published on: 14 November 2016

  12. Research

    Re-focusing HIV prevention messages: a qualitative study in rural Uganda

    After 30 years, the human immunodeficiency virus (HIV) remains an epidemic of global concern. To support the increasing emphasis on biomedical interventions for prevention requires a renewed and reframed focus...

    Sanyukta Mathur, Dina Romo, Mariko Rasmussen, Neema Nakyanjo, Fred Nalugoda and John S. Santelli

    AIDS Research and Therapy 2016 13:37

    Published on: 11 November 2016

  13. Research

    Quasi-Poisson versus negative binomial regression models in identifying factors affecting initial CD4 cell count change due to antiretroviral therapy administered to HIV-positive adults in North–West Ethiopia (Amhara region)

    CD4 cells are a type of white blood cells that plays a significant role in protecting humans from infectious diseases. Lack of information on associated factors on CD4 cell count reduction is an obstacle for i...

    Awoke Seyoum, Principal Ndlovu and Temesgen Zewotir

    AIDS Research and Therapy 2016 13:36

    Published on: 9 November 2016

  14. Review

    Targeting vulnerable populations: a synthetic review on alcohol use and risky sexual behaviour among migrant populations

    Research has demonstrated a link between alcohol use and risky sexual behaviour among different types of migrant populations. Therefore, research investigating risk factors associated with alcohol consumption ...

    Emilia Maria Vaz Martins-Fonteyn, Nina Sommerland, Herman Meulemans, Olivier Degomme, Ines Raimundo and Edwin Wouters

    AIDS Research and Therapy 2016 13:33

    Published on: 22 September 2016

  15. Review

    Stem cell transplantation in strategies for curing HIV/AIDS

    HIV-1 can persist in a latent form in resting memory CD4+ cells and macrophages carrying an integrated copy of the HIV genome. Because of the presence of these stable reservoir cells, eradication by antiretrov...

    Gero Hütter

    AIDS Research and Therapy 2016 13:31

    Published on: 13 September 2016

  16. Review

    Dolutegravir(DTG, S/GSK1349572) combined with other ARTs is superior to RAL- or EFV-based regimens for treatment of HIV-1 infection: a meta-analysis of randomized controlled trials

    The first-generation integrase inhibitors (INIs) raltegravir (RAL) and elvitegravir (EVG) have shown efficacy against HIV infection, but they have the limitations of once-more daily dosing and extensive cross-...

    Junjun Jiang, Xi Xu, Wenqin Guo, Jinming Su, Jiegang Huang, Bingyu Liang, Hui Chen, Ning Zang, Yanyan Liao, Li Ye and Hao Liang

    AIDS Research and Therapy 2016 13:30

    Published on: 8 September 2016

  17. Research

    The effect of Tenofovir on renal function among Ugandan adults on long-term antiretroviral therapy: a cross-sectional enrolment analysis

    WHO recommends using Tenofovir containing first line antiretroviral therapy (ART), however, Tenofovir has been reported to be associated with renal impairment and dysfunction. We compared renal function among ...

    Tino Salome, Ivan Kasamba, Billy Nsubuga Mayanja, Patrick Kazooba, Jackson Were, Pontiano Kaleebu and Paula Munderi

    AIDS Research and Therapy 2016 13:28

    Published on: 30 August 2016

  18. Review

    Antiretroviral treatment regardless of CD4 count: the universal answer to a contextual question

    After a period where it was recommended to start antiretroviral therapy (ART) early, the CD4 threshold for treating asymptomatic adults dropped to 200/mm3 at the beginning of the 2000s. This was mostly due to a g...

    Serge P. Eholié, Anani Badje, Gérard M. Kouame, Jean-Baptiste N’takpe, Raoul Moh, Christine Danel and Xavier Anglaret

    AIDS Research and Therapy 2016 13:27

    Published on: 26 July 2016

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