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  1. Research

    Determinants to antiretroviral treatment non-adherence among adult HIV/AIDS patients in northern Ethiopia

    Adhering 95% and above of antiretroviral therapy reduces the rate of disease progression and death among people’s living human immunodeficiency virus. Though manifold factors have reported as determinant facto...

    Berhe Beyene Gebrezgabher, Yigzaw Kebede, Melaku Kindie, Desalegn Tetemke, Mebrahtu Abay and Yalemzewod Assefa Gelaw

    AIDS Research and Therapy 2017 14:16

    Published on: 21 March 2017

  2. Research

    Impaired human immunodeficiency virus type 1 replicative fitness in atypical viremic non-progressor individuals

    Progression rates from initial HIV-1 infection to advanced AIDS vary significantly among infected individuals. A distinct subgroup of HIV-1-infected individuals—termed viremic non-progressors (VNP) or controll...

    Jan Weber, Richard M. Gibson, Lenka Sácká, Dmytro Strunin, Jan Hodek, Jitka Weberová, Marcela Pávová, David J. Alouani, Robert Asaad, Benigno Rodriguez, Michael M. Lederman and Miguel E. Quiñones-Mateu

    AIDS Research and Therapy 2017 14:15

    Published on: 20 March 2017

  3. Research

    Joint longitudinal data analysis in detecting determinants of CD4 cell count change and adherence to highly active antiretroviral therapy at Felege Hiwot Teaching and Specialized Hospital, North-west Ethiopia (Amhara Region)

    Adherence and CD4 cell count change measure the progression of the disease in HIV patients after the commencement of HAART. Lack of information about associated factors on adherence to HAART and CD4 cell count...

    Awoke Seyoum, Principal Ndlovu and Zewotir Temesgen

    AIDS Research and Therapy 2017 14:14

    Published on: 16 March 2017

  4. Research

    Effect of Moringa oleifera Lam. leaf powder on the pharmacokinetics of nevirapine in HIV-infected adults: a one sequence cross-over study

    Moringa oleifera Lam., an herb commonly consumed by HIV-infected people on antiretroviral therapy, inhibits cytochrome P450 3A4, 1A2 and 2D6 activity in vitro; and may alter the pharma...

    Tsitsi G. Monera-Penduka, Charles C. Maponga, Alan R. Wolfe, Lubbe Wiesner, Gene D. Morse and Charles F. B. Nhachi

    AIDS Research and Therapy 2017 14:12

    Published on: 14 March 2017

  5. Research

    Possible misdiagnosis of HIV associated lymphoma as tuberculosis among patients attending Uganda Cancer Institute

    Early diagnosis of HIV associated lymphoma is challenging because the definitive diagnostic procedure of biopsy, requires skills and equipment that are not readily available. As a consequence, diagnosis may be...

    Paul Buyego, Lydia Nakiyingi, Henry Ddungu, Stephen Walimbwa, Damalie Nalwanga, Steven J Reynolds and Rosalind Parkes-Ratanshi

    AIDS Research and Therapy 2017 14:13

    Published on: 14 March 2017

  6. Research

    Characterization of occult hepatitis B virus infection among HIV positive patients in Cameroon

    Occult hepatitis B infection (OBI) among HIV positive patients varies widely in different geographic regions. We undertook a study to determine the prevalence of occult hepatitis B infection among HIV infected...

    George Gachara, Tshifhiwa Magoro, Lufuno Mavhandu, Emmaculate Lum, Helen K. Kimbi, Roland N. Ndip and Pascal O. Bessong

    AIDS Research and Therapy 2017 14:11

    Published on: 8 March 2017

  7. Research

    HIV care in Yangon, Myanmar; successes, challenges and implications for policy

    Approximately 0.8% of adults aged 18–49 in Myanmar are seropositive for Human Immunodeficiency Virus (HIV). Identifying the demographic, epidemiological and clinical characteristics of people living with HIV (...

    Ne Myo Aung, Josh Hanson, Tint Tint Kyi, Zaw Win Htet, David A. Cooper, Mark A. Boyd, Mar Mar Kyi and Htin Aung Saw

    AIDS Research and Therapy 2017 14:10

    Published on: 4 March 2017

  8. Research

    Late presentation increases risk and costs of non-infectious comorbidities in people with HIV: an Italian cost impact study

    Late presentation (LP) at the time of HIV diagnosis is defined as presentation with AIDS whatever the CD4 cell count or with CD4 <350 cells/mm. The objective of our study was to assess the prevalence of non-in...

    Giovanni Guaraldi, Stefano Zona, Marianna Menozzi, Thomas D. Brothers, Federica Carli, Chiara Stentarelli, Giovanni Dolci, Antonella Santoro, Ana Rita Domingues Da Silva, Elisa Rossi, Julian Falutz and Cristina Mussini

    AIDS Research and Therapy 2017 14:8

    Published on: 16 February 2017

  9. Short report

    H1N1 influenza vaccination in HIV-infected women on effective antiretroviral treatment did not induce measurable antigen-driven proliferation of the HIV-1 proviral reservoir

    Antigen-induced activation and proliferation of HIV-1-infected cells is hypothesized to be a mechanism of HIV persistence during antiretroviral therapy. The objective of this study was to determine if prolifer...

    Thor A. Wagner, Hannah C. Huang, Christen E. Salyer, Kelly M. Richardson, Adriana Weinberg, Sharon Nachman and Lisa M. Frenkel

    AIDS Research and Therapy 2017 14:7

    Published on: 13 February 2017

  10. Research

    Renal safety of lithium in HIV-infected patients established on tenofovir disoproxil fumarate containing antiretroviral therapy: analysis from a randomized placebo-controlled trial

    The prevalence of bipolar disorder in HIV-infected patients is higher than the general population. Lithium is the most effective mood stabiliser, while tenofovir disoproxil fumarate (TDF) is frequently used as...

    Eric H. Decloedt, Maia Lesosky, Gary Maartens and John A. Joska

    AIDS Research and Therapy 2017 14:6

    Published on: 4 February 2017

  11. Review

    Feasibility of antiretroviral treatment monitoring in the era of decentralized HIV care: a systematic review

    Regular monitoring of HIV patients who are receiving antiretroviral therapy (ART) is required to ensure patient benefits and the long-term effectiveness and sustainability of ART programs. Prompted by WHO reco...

    Minh D. Pham, Lorena Romero, Bruce Parnell, David A. Anderson, Suzanne M. Crowe and Stanley Luchters

    AIDS Research and Therapy 2017 14:3

    Published on: 19 January 2017

  12. Research

    Does antiretroviral treatment change HIV-1 codon usage patterns in its genes: a preliminary bioinformatics study

    Codon usage bias has been described for various organisms and is thought to contribute to the regulation of numerous biological processes including viral infections. HIV-1 codon usage has been previously shown...

    Navaneethan Palanisamy, Nathan Osman, Frédéric Ohnona, Hong-Tao Xu, Bluma Brenner, Thibault Mesplède and Mark A. Wainberg

    AIDS Research and Therapy 2017 14:2

    Published on: 7 January 2017

  13. Research

    Early virological failure and HIV drug resistance in Ugandan adults co-infected with tuberculosis

    This cross-sectional study took place in the integrated tuberculosis (TB) clinic of a large outpatient clinic for HIV-infected patients in Kampala, Uganda. The purpose of this study was to describe the proport...

    Amrei von Braun, Christine Sekaggya-Wiltshire, Alexandra U. Scherrer, Brian Magambo, Andrew Kambugu, Jan Fehr and Barbara Castelnuovo

    AIDS Research and Therapy 2017 14:1

    Published on: 5 January 2017

  14. Review

    Integrated therapy for HIV and cryptococcosis

    Cryptococcosis has been one of the most common opportunistic infections and causes of mortality among HIV-infected patients, especially in resource-limited countries. Cryptococcal meningitis is the most common...

    Sirawat Srichatrapimuk and Somnuek Sungkanuparph

    AIDS Research and Therapy 2016 13:42

    Published on: 29 November 2016

  15. Research

    Infection of rhesus macaques with a pool of simian immunodeficiency virus with the envelope genes from acute HIV-1 infections

    New simian–human immunodeficiency chimeric viruses with an HIV-1 env (SHIVenv) are critical for studies on HIV pathogenesis, vaccine development, and microbicide testing. Macaques are typically exposed to sing...

    Kendall C. Krebs, Meijuan Tian, Mohammed Asmal, Binhua Ling, Kenneth Nelson, Kenneth Henry, Richard Gibson, Yuejin Li, Weining Han, Robin J. Shattock, Ronald S. Veazey, Norman Letvin, Eric J. Arts and Yong Gao

    AIDS Research and Therapy 2016 13:41

    Published on: 25 November 2016

  16. Research

    Cases of antiretroviral-associated gynaecomastia reported to the National HIV & Tuberculosis Health Care Worker Hotline in South Africa

    Gynaecomastia is associated with exposure to antiretroviral therapy (ART), in particular efavirenz. There is limited data on clinical characteristics of patients with ART-associated gynaecomastia in resource-l...

    Christine Njuguna, Annoesjka Swart, Marc Blockman, Gary Maartens, Briony Chisholm, Annemie Stewart, Anri Uys and Karen Cohen

    AIDS Research and Therapy 2016 13:40

    Published on: 16 November 2016

  17. Research

    HIV sero-discordance among married HIV patients initiating anti-retroviral therapy in northern Vietnam

    In many countries in Asia, the HIV epidemic is in a concentrated phase, with high prevalence in certain risk groups, such as men who inject drugs. There is also a rapid increase of HIV among women. The latter ...

    Vu Van Tam, Do Duy Cuong, Tobias Alfven, Ho Dang Phuc, Nguyen Thi Kim Chuc, Nguyen Phuong Hoa, Vinod Diwan and Mattias Larsson

    AIDS Research and Therapy 2016 13:39

    Published on: 15 November 2016

  18. Research

    Trends in clinical characteristics and outcomes of Pre-ART care at a large HIV clinic in Nairobi, Kenya: a retrospective cohort study

    The success of antiretroviral therapy in resource-scarce settings is an illustration that complex healthcare interventions can be successfully delivered even in fragile health systems. Documenting the success ...

    Jared O. Mecha, Elizabeth N. Kubo, Lucy W. Nganga, Peter N. Muiruri, Lilian N. Njagi, Immaculate N. Mutisya, Justine J. Odionyi, Syokau C. Ilovi, Mary Wambui, Christopher Githu, Richard Ngethe, Elizabeth M. Obimbo and Zipporah W. Ngumi

    AIDS Research and Therapy 2016 13:38

    Published on: 14 November 2016

  19. Research

    Re-focusing HIV prevention messages: a qualitative study in rural Uganda

    After 30 years, the human immunodeficiency virus (HIV) remains an epidemic of global concern. To support the increasing emphasis on biomedical interventions for prevention requires a renewed and reframed focus...

    Sanyukta Mathur, Dina Romo, Mariko Rasmussen, Neema Nakyanjo, Fred Nalugoda and John S. Santelli

    AIDS Research and Therapy 2016 13:37

    Published on: 11 November 2016

  20. Research

    Quasi-Poisson versus negative binomial regression models in identifying factors affecting initial CD4 cell count change due to antiretroviral therapy administered to HIV-positive adults in North–West Ethiopia (Amhara region)

    CD4 cells are a type of white blood cells that plays a significant role in protecting humans from infectious diseases. Lack of information on associated factors on CD4 cell count reduction is an obstacle for i...

    Awoke Seyoum, Principal Ndlovu and Temesgen Zewotir

    AIDS Research and Therapy 2016 13:36

    Published on: 9 November 2016

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